Grants for State governments - Federal

This funding opportunity announcement (FOA) invites research projects that seek to explain the underlying mechanisms, processes, and trajectories of social relationships and how these factors affect outcomes in human health, illness, recovery, and overall wellbeing. Types of projects submitted under this FOA include mechanistic studies that are classified as clinical trials. Mechanistic studies are defined as studies with the objective to understand the mechanism(s) of action of an intervention, a biological or behavioral process, or the pathophysiology of a disease/condition. See NOT-AT-20-001 and NOT-MH-19-006 for examples of clinical trials that are/are not considered mechanistic studies. Clinical trials that propose to influence a clinical outcome, test safety or feasibility of an intervention, demonstrate the clinical efficacy or effectiveness of an intervention, or analyze the effect size of an intervention on clinical outcomes are ineligible for this FOA. Types of studies that should submit under this FOA include clinical trials that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Researchers proposing basic science experimental studies involving human participants should consider this FOAs companion for basic experimental studies with humans, TEMP-14931, Research on Health, Wellbeing, Illness, and Recovery (R01 Basic Experimental Studies with Humans Required). Applications proposing studies that include, but are not limited to, model animal research or observational studies involving humans should submit under the companion FOA, TEMP-14934, "Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Clinical Trials Not Allowed).

This funding opportunity provides financial support for conservation projects aimed at protecting and recovering endangered and threatened species across the United States, targeting eligible applicants such as state and local governments, educational institutions, tribal organizations, and nonprofits.

This funding opportunity provides financial support to state, tribal, local, and territorial public health systems to enhance their preparedness and response capabilities for various public health emergencies.

The objectives of this project fall under INRMP Goal 2: Manage JBER natural resources under the guidelines and principles of adaptive ecosystem management, which aim to maintain functional ecosystems and natural diversity including sustainable populations, native species, and ecological communities and Objective 2.1: Inventory and monitor JBERs natural resources, including soil, water, wetlands, flora, and fauna, to provide baseline information on ecosystem integrity and health, status of renewable resources, and status of threatened or sensitive species or communities. See full Funding Opportunity Description in Section I.

Authorized by Clean Water Act (CWA) Section 117, 33 USC Section 1267, the Chesapeake Bay Program (CBP) is a unique regional, state, federal, and local partnership that has been directing and conducting the restoration and protection of the Chesapeake Bay. CBP is responsible for supporting the Chesapeake Bay Executive Council (Executive Council) through a number of actions, including the coordination of federal, state, and local efforts to restore and protect living resources and water quality of the Chesapeake Bay and its watershed. The Notice of Funding Opportunity is seeking insightful, expert, and cost-effective applications from eligible applicants to provide the CBPs non-federal partners with updated land use/land cover data, enhanced river corridor data, and landscape metrics and communication products associated with these data to facilitate their application to CBP's outcomes and the CBPs Phase 7 suite of modeling tools. For more information, please see the funding opportunity.

This grant provides funding for interdisciplinary research teams to develop innovative strategies for preventing and treating infections caused by antibiotic-resistant bacteria.

This funding opportunity provides financial support for clean energy projects in rural and remote areas, targeting communities with 10,000 residents or fewer to reduce energy costs and improve access to sustainable energy solutions.

This grant provides funding to organizations working to improve labor conditions in Mexico's key trade sectors, ensuring fair practices that benefit American workers and businesses.

The U.S. Department of the Treasury (Treasury) is pleased to announce that it is seeking applications from eligible applicants for grant funding under the new SSBCI Investing in America SBOP that propose innovative and high-impact models for delivering technical assistance (TA) in the areas of legal, accounting, and financial advisory services to very small businesses (VSBs) and businesses owned and controlled by socially and economically disadvantaged individuals (SEDIowned businesses).The SSBCI Investing in America SBOP is related to and supports the SSBCI Capital Program and the allocation formula-based SSBCI TA Grant Program. The SSBCI Capital Program is a federal program administered by Treasury that provides funding to states, the District of Columbia, territories, and Tribal governments to expand access to capital for small businesses emerging from the pandemic, build ecosystems of opportunity and entrepreneurship, and create high-quality jobs. The formula SSBCI TA Grant Program is also a federal program administered by Treasury that funds the provision of TA services in the areas of legal, accounting, and financial advisory services to eligible small businesses applying for SSBCI funding and other government small business programs.All awards are subject to the availability of appropriated funds and any modifications or additional requirements that may be imposed under applicable law.

This funding opportunity supports research projects that combine imaging techniques and liquid biopsies to improve cancer treatment monitoring and response assessment in clinical settings.

This funding opportunity provides financial support to local and tribal governments for establishing or improving juvenile drug treatment courts to better serve youth with substance use and mental health issues.

This funding opportunity supports early-stage research to develop new therapeutic agents for heart, lung, blood, and sleep disorders, specifically targeting projects that have identified promising small molecules or biologics ready for preclinical testing.

The Metastasis Research Network (MetNet) Research Projects grant aims to fund research projects that use comprehensive, systems-level approaches to address gaps in metastasis research, particularly focusing on themes like dormancy, early dissemination, and cellular or physical microenvironment interactions, with the goal of enhancing our understanding of metastasis as a whole-body, systems-level issue.

The 2025 Regional Ecosystem Research (RER) Program grant, offered by NOAA's NCCOS, aims to fund research projects that enhance understanding of species' habitat usage and connectivity in Marine Protected Areas, with the goal of improving conservation efforts and management plans, particularly in line with the 30x30 initiative.

This funding opportunity supports the establishment of research centers that leverage artificial intelligence and technology to advance studies in aging and Alzheimer's disease, inviting interdisciplinary teams from various organizations to innovate and train in this critical field.

This funding opportunity supports innovative research projects that explore the intersection of HIV and substance use disorders, aiming to develop transformative strategies for prevention, treatment, and potential cures in affected populations.

This funding opportunity supports researchers developing innovative computational tools and methods to advance genomics, particularly those new to the field or from underrepresented groups.

This Notice of Funding Opportunity (NOFO) announces the opportunity to apply for funding under the Health Center Programs Service Area Competition (SAC). The purpose of this funding is to ensure continuity of care in the communities and populations currently served by the Health Center Program. See Program Requirements and Expectations for more details.

This funding opportunity provides financial support to community coalitions in the U.S. focused on preventing and reducing substance use among youth, particularly those aged 18 and under.

This grant provides funding to organizations and government entities to develop training and services that prevent and address various forms of abuse against individuals aged 50 and older.