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Federal Capacity Building Grants

Explore 219 grant opportunities

Developmental AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional)
$3,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

May 25, 2026

Date Added

Mar 23, 2024

This funding opportunity supports research centers focused on improving mental health and addressing health disparities related to HIV/AIDS, particularly for early-career and underrepresented researchers.

Health
State governments
Fetal, Infant, and Child Death Review Program
$5,149,000
U.S. Department of Health and Human Services (Health Resources and Services Administration)
Federal

Application Deadline

Jan 20, 2027

Date Added

Aug 3, 2026

This funding opportunity provides financial support to various organizations and governments for improving the review and prevention of fetal, infant, and child deaths through coordinated data collection and technical assistance.

Health
Nonprofits
Fund for the Improvement of Postsecondary Education – Special Projects
$167,000,000
U.S. Department of Education (Office of Postsecondary Education)
Federal

Application Deadline

Not specified

Date Added

Nov 24, 2025

This funding opportunity provides financial support to colleges, universities, and nonprofit organizations for innovative projects that address critical issues in higher education, such as integrating artificial intelligence, promoting civil discourse, reforming accreditation, and developing short-term workforce programs.

Education
Nonprofits
Cancer Advancement through Partnerships in Research and Infrastructure (CAPRI) (U54 Clinical Trial Optional)
$9,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 25, 2027

Date Added

Aug 29, 2025

This funding opportunity supports partnerships between smaller, resource-limited institutions and established cancer research centers to enhance cancer research capacity, infrastructure, and training across the nation.

Health
Public and State controlled institutions of higher education
AmeriCorps State and National Native Nation Planning Grants
$240,000
AmeriCorps
Federal

Application Deadline

Not specified

Date Added

Apr 22, 2026

This funding opportunity provides financial support to federally recognized Indian Tribes and tribal organizations for developing new AmeriCorps programs that address local community needs through national service and volunteerism.

Community Development
Native American tribal organizations
READY Local Governments Training Program
$50,000
Appalachian Regional Commission
Federal

Application Deadline

Not specified

Date Added

Jul 15, 2026

This program provides training and funding opportunities to local governments in economically distressed areas of the Appalachian Region, helping them improve their capacity to secure and manage federal grants for community development projects.

Capacity Building
City or township governments
READY Nonprofits Capacity Building Grant
$25,000
Appalachian Regional Commission
Federal

Application Deadline

Not specified

Date Added

Feb 3, 2025

This initiative provides training and funding opportunities for nonprofit organizations in the Appalachian region to strengthen their operations and better serve their communities.

Capacity Building
Nonprofits
Rural Healthcare Provider Transition Project (RHPTP)
Contact for amount
U.S. Department of Health and Human Services (Health Resources and Services Administration)
Federal

Application Deadline

Not specified

Date Added

Jun 9, 2026

This program provides tailored technical assistance to small rural hospitals and certified rural health clinics to help them transition to value-based care models, improving patient outcomes and operational efficiency.

Health
Nonprofits
Drug-Free Communities (DFC) Support Program Competing Continuation (Year 6)
$125,000
U.S. Department of Health and Human Services (Centers for Disease Control - NCIPC)
Federal

Application Deadline

Mar 31, 2027

Date Added

Jul 29, 2026

This funding opportunity supports community coalitions across the U.S. that work to prevent and reduce substance use among youth, particularly those that have previously received DFC grants.

Health
Nonprofits
Solid Waste Management Grants
$4,000,000
U.S. Department of Agriculture (Rural Development)
Federal

Application Deadline

Not specified

Date Added

Jun 27, 2025

This funding opportunity provides financial support to nonprofit organizations, public bodies, academic institutions, and Native American Tribes to deliver technical assistance and training for improving solid waste management and reducing environmental pollution in rural communities.

Environment
Nonprofits
U.S.-Africa Strategic Investment Program
$50,000,000
U.S. Department of State (Bureau of African Affairs)
Federal

Application Deadline

Not specified

Date Added

Jul 24, 2026

This funding opportunity provides financial support for innovative projects that promote responsible development of critical minerals and enhance commercial diplomacy in sub-Saharan Africa, benefiting U.S. and African businesses alike.

Business and Commerce
For profit organizations other than small businesses
Centers for Genomics Research Capacity Building
$5,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Jul 18, 2025

This funding opportunity is designed to strengthen genomic research capabilities at U.S. biomedical institutions with limited NIH support, promoting innovative projects and workforce development in genomics.

Health
Nonprofits
Rural Communities Opioid Response Program - Community Systems Development
$500,000
U.S. Department of Health and Human Services (Health Resources and Services Administration)
Federal

Application Deadline

Apr 6, 2027

Date Added

Aug 17, 2026

This funding opportunity provides financial support to rural communities for developing and expanding behavioral health systems to effectively address substance use disorders through coordinated, evidence-based services.

Health
Nonprofits
Rapid Response Opioid and Pain Management ECHO Funding Opportunity
Contact for amount
U.S. Department of Health and Human Services (Centers for Disease Control and Prevention)
Federal

Application Deadline

Not specified

Date Added

Nov 14, 2025

This opportunity provides technical assistance to state, territorial, and local health agencies receiving CDC funding to improve their financial and administrative processes for more effective use of overdose prevention resources.

Capacity Building
State governments
Laura Bush 21st Century Librarian Program
$1,000,000
U.S. Institute of Museum and Library Services (Office of Library Services)
Federal

Application Deadline

Not specified

Date Added

Jan 15, 2026

This program provides funding to libraries, archives, and educational institutions to develop a skilled and diverse workforce capable of meeting the evolving information needs of communities across the United States.

Education
State governments
NIDA Core "Center of Transformative Science" Grant Program
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

May 8, 2026

This funding opportunity supports research centers that foster collaboration and innovation in the fields of substance use, addiction, and HIV, encouraging interdisciplinary approaches and career development for investigators across various organizations.

Health
State governments
Capacity Building for National Immunization Programs in the Eastern Mediterranean Region
$75,000,000
U.S. Department of Health and Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 12, 2027

Date Added

Sep 1, 2026

This funding opportunity is designed to strengthen national immunization programs in Eastern Mediterranean countries, focusing on improving vaccine access and disease prevention efforts.

Health
State governments
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center
$1,750,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Aug 28, 2025

This funding opportunity provides resources to a wide range of organizations to develop and implement integrated healthcare models that address the dual challenges of chronic pain and opioid use disorder, promoting collaboration and sustainability in diverse health settings.

Health
State governments
Comprehensive Centers Program: National, Regional, and Content Centers
$6,750,000
U.S. Department of Education (Office of Elementary and Secondary Education)
Federal

Application Deadline

Not specified

Date Added

May 20, 2026

This grant provides funding to organizations that support state and local education agencies in improving educational outcomes and closing achievement gaps for underserved student populations across the United States.

Education
Nonprofits