Federal Health Grants

The purpose of this funding opportunity is to support the development of Clinical Outcome Assessments (COA) for Substance Use Disorders (SUD). The COA development plan is expected to progress into the FDA drug development tool qualification program. This notice of funding opportunity (NOFO) utilizes the UG3/UH3Phased Innovation Awards Cooperative Agreement grant mechanism that includes two phases. The applications responding to this NOFO should contain a COA development plan that will cover both UG3 and UH3 phases. In the first 2-year UG3 phasethe project must have a set of operational milestones to be completed by the end of this period. Once NIDA program has evaluated the progress of the UG3 phase and determined that the UG3 phase has been successfully completed, it transitions to the UH3 phase to be funded for three additional years.The goal of this NOFO is to expand the armamentarium of COA that are FDA qualified as drug development tool (DDT) in the context of use (COI) of a SUD. Achieving this goal will greatly facilitate the development of treatments for SUDs. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

This funding opportunity supports research institutions and organizations in developing innovative technologies to study how neural cell groups in rodents respond to addictive substances, aiming to deepen our understanding of addiction-related behaviors.

This funding opportunity provides financial support to state and local governments, community organizations, and other eligible entities to improve access to long-term services and supports by enhancing their No Wrong Door systems through collaboration and modernization efforts.

This funding opportunity supports innovative research on new screening methods and treatments for severe conditions detectable in newborns, aimed at improving early detection and health outcomes.

This grant provides funding for institutional research training programs to develop skilled neuroscientists through comprehensive training in research, statistics, and communication, specifically targeting advanced graduate students and postdoctoral fellows.

This funding opportunity supports researchers in developing innovative theories and methods to better understand the complex interactions of genetic and non-genetic factors influencing human traits, particularly in relation to health and cancer risk.

The grant titled "Phased Multi-Site Clinical Trial: Testing Prevention of Cardiovascular Disease in Young Adults With High Lifetime Risk Using Surrogate Outcomes - Data Coordinating Center (Collaborative U24 Trial Required)" is aimed at funding the development and implementation of a Data Coordinating Center to manage data, provide statistical support, and ensure overall coordination for a multi-site clinical trial focused on preventing cardiovascular disease in young adults at high risk, while also promoting community engagement, diversity, and health equity.

The "Safety and Early Efficacy Studies of Psychedelic-Assisted Therapy for Chronic Pain in Older Adults" grant aims to fund a network of clinical trials that will study the safety and potential effectiveness of psychedelic drugs in treating chronic pain in older adults, with a focus on those aged 75 and above.

The goal of USAID/Cambodias new five-year community tuberculosis (TB) activity is to accelerate TB case finding and case holding activities to maximize TB outcomes among Cambodians, including vulnerable populations such as Indigenous People. This Activity will build on USAIDs previous investments in community TB control, including the USAID Community Mobilization Initiatives to End Tuberculosis (COMMIT) activity, recommendations from the COMMITs mid-term evaluation, and lessons learned from stakeholders; and further contribute to the National TB Strategic Plan to End TB (2021-2030), World Health Organizations (WHO) End TB Strategy, and USAIDs Global TB Strategy 2023 - 2030. This Activity will focus on improving and streamlining the implementation of the End TB strategy at the community level while strengthening longer-term systems and capacity for: improving access to and demand for high quality TB services and advancing their integration within national health systems, creating an enabling private sector environment for TB control and the provision of TB services, and improving TB Management Information System (MIS) systems and data use, to provide better and more sustainable TB services.

The purpose of this program is to assist in addressing the opioid overdose crisis in Tribal communities by increasing access to FDA-approved medications for the treatment of opioid use disorder (MOUD), and supporting the continuum of prevention, harm reduction, treatment, and recovery support services for opioid use disorder (OUD) and co-occurring substance use disorders.

This funding opportunity provides state agencies with resources to improve and expand respite care services for family caregivers of individuals with disabilities and chronic conditions, enhancing support systems across all ages.

This funding opportunity supports innovative research teams using non-human animal models to develop advanced methods for measuring and analyzing behavior in relation to environmental factors.

HIV infection and substance use are comorbid conditions that bidirectionally and synergistically influence the deleterious outcomes in people who suffer from substance use disorders (SUD). The persistence and transcriptional reactivation of HIV lead to the development of neuropathological complications. Strategies to address viral latency include silencing of HIV transcription and reactivation and clearance. The goal of this initiative is to support research aimed at (1) identification of targets and pathways by which transcriptional activity of HIV can be suppressed in HIV reservoirs including the CNS in people with SUD, and (2) application of emerging small molecule drug discovery approaches to identify novel compounds that can be utilized as pharmacological probes and as drugs to suppress HIV transcription in people with HIV-SUD comorbidity.

This grant provides funding to national organizations focused on improving lupus awareness, diagnosis, treatment, and self-management among affected populations, particularly women aged 15 to 44.

This funding opportunity provides financial support to nonprofit organizations and educational institutions to implement and evaluate anti-stigma interventions that improve access to HIV care and prevention services across the U.S.

This funding opportunity supports small-scale research projects that analyze existing genomic data to advance understanding of dental, oral, and craniofacial health, particularly focusing on health disparities and biological pathways for intervention.

The "Early- and Late-Stage Clinical Trials for the Spectrum of Alzheimer's Disease/Alzheimer's Disease-Related Dementias and Age-Related Cognitive Decline" grant is a $20 million funding opportunity from the National Institutes of Health, aimed at supporting innovative clinical trials that develop and test pharmacological and non-pharmacological interventions for Alzheimer's disease and age-related cognitive decline over a five-year period.

This grant provides funding for researchers to develop a vaccine against Kaposi sarcoma herpesvirus (KSHV), aiming to prevent infection and treat related diseases in affected populations.

This funding opportunity provides financial support to organizations working to prevent Russia from acquiring and using chemical and biological weapons through enhanced security measures, training, and international collaboration.

This funding opportunity provides financial support for researchers to utilize existing data to advance studies on substance use and addiction, encouraging innovative analysis without the need for new data collection.