Federal Income Security and Social Services Grants

This funding opportunity supports researchers exploring the ethical, legal, and social issues related to human genetic and genomic research, particularly as these technologies become more integrated into healthcare and society.

The purpose of this Funding Opportunity Announcement (FOA) is to correlate immune system development patterns between two or more age groups - neonates, infants, and children and adolescents and further understand the impact of infectious diseases, microbiome and environmental factors on the ontogeny and development of the pediatric immune system, from birth, transitioning into adolescence and adulthood with the focus of impact during pregnancy and post-natal period.Purpose The purpose of this Funding Opportunity Announcement (FOA) is to correlate immune system in general and development patterns in particular, between two or more age groups - neonates, infants, and children and adolescents and further understand the impact of infectious diseases, microbiome and environmental factors on the ontogeny and development of the pediatric immune system, from birth, transitioning into adolescence and adulthood with the focus of impact during pregnancy and post-natal period. Background Worldwide, mortality in children under the age of 5 is predominantly due to infectious diseases and immune modulations associated with these infections. Pediatric immune system is remarkably different from adult immune system and also forms the basis for overall wellbeing and providing an adequate disease encountering status to adulthood. A protected and systematically trained pediatric immune system results in a robust and efficient adult immune system. Moreover, immune system in children responds strongly, rapidly and robustly in comparison to adult immune system to immunization, diet and environmental factors. Knowledge of development of the pediatric immune system in response to exposure to childhood infections and vaccinations, microbiome and the environmental factors can help chart pathways that provide strategies to prevent and treat infectious diseases more efficiently. These variations between pediatric and adult immune systems offer insight into better understanding strategies for developing immune-therapeutics and vaccines against infections. The research focus in the current announcement is multi-disciplinary. The focus however is in the areas of immune ontogeny and development, the mechanisms of infant and neonatal immunity or relationship between ontogeny of immunosuppression, susceptibility to infection during infancy or studies on effect of early infections or vaccinations that train the immune system. It is expected to diversify areas in existing research and draw comparisons between age groups or specific organ system development (for example, projects of interest might investigate immune cell ontogeny in lung alveoli from infancy to adult hood or immune alterations due to exposure to a specific immunogen (like measles or BCG vaccine) at infancy vs adolescence and the chronic effect of air pollution). More specifically, the aim here is to elucidate immune system development patterns in infants, children and adolescents focusing on both the innate immunity and the development of diverse antibodies or T cell maturation, with relevance to chronic infections (not limited to HIV, CMV, TB and the current SARS-CoV2 pandemic as well). Further, the intention is to expand the science to include additional internal factors like microbial metabolites and/or external factors like the environment that modulate the developing immune system so that a research program that is multi-disciplinary can be developed to address the interaction between host and pathogen. Research Scope The over-arching scope of this FOA is: to correlate immune system in general and development patterns in particular, between two or more age groups - neonates, infants, and children and adolescents to understand the evolution or immune ontogeny in human immune system development focusing on either or both, innate and adaptive immune systems with additional focus on internal factors like the microbiome and/or external factors like the environment. Further, the scope can be covered under these following topics and is not limited to: Study in young children vs adolescents vs adults, development of immunity and variations in immune system in physiology and in response to infectious diseases focusing on MTCT diseases (HIV, CMV, TB, Syphilis, SARS-CoV2 etc.), not limited to, broadly neutralizing antibodies (bNAbs), development of mucosal antibodies, germinal center formation and maturation; correlate with T cell development and identification of immunogens that activate T cells without enhancing infection. Characterize the impact of age, environmental factors, microbial metabolites and microbiome composition in relation to the immune responses against acute or chronic infectious diseases not limited to HIV, TB, CMV, SARS-CoV2 etc., and their contribution towards the development of a robust immune system development using novel technologies (RNA seq, imaging of immunogens and cellular interactions, single cell imaging). Understand cellular and soluble immune system components and the developmental pathways, including the microbiome, that regulate these components in specific age-groups. For example, developing immune profiles of HIV exposed un-infected (HEU) infants in comparison with the immune profile of an adolescent living with HIV and how these immune alterations prepare the immune system to encounter future infections. Study the contribution of increased exposure to environmental factors, pathogens, extensive or scheduled immunization early in life on enhanced cross-talk between innate and adaptive immune systems; specific inflammatory responses generated by innate immune factors and their downstream effect on cellular immune development. Delineate the role of human microbiome in health and disease and the environmental factors to observe correlation of immune responses against acute and chronic infections and focus on transfer of microbes and immune factors from human milk to infants. For example, assess alterations in immune profiles of known oral microbial clusters in CMV infected child vs immune profiles in an adolescent. Understand the impact of variations of microbiome in specific organ systems (gut vs oral vs vaginal microbiomes) in age defined profiles and their effect on immune ontogeny with emphasis on Virome . Influence of maternal microbiome on the effect of microbial composition and development of immunity in the offspring; detailed studies exploring placental microbiome and correlation with maternal oral microbial microbiome are encouraged. Projects that will be considered non-responsive for this FOA include, but are not limited to: Applications proposing vaccine advocacy. Applications proposing to focus exclusively on effects of microbiome and not studying the relevance of these effects on immune system development. Applications proposing to focus exclusively on epigenomic approaches. Applications focusing on immunization strategies in infants for altering early immune responses.

The U.S. Embassy Yaound Public Diplomacy Section (PDS) announces the availability of funding through its Public Diplomacy Small Grants Program. This is an annual request for Statements of Interest (SOI), outlining funding priorities, strategic themes, and procedures for submitting requests for funding. Please carefully read and follow all instructions below. The submission of a SOI is the first step in a two-part process. Applicants must first submit a SOI, which is a concise, 3-page concept note designed to clearly communicate a program idea and its objectives before the development of a full proposal application. The purpose of the SOI process is to allow applicants the opportunity to submit program ideas for evaluation prior to undertaking the development of full proposal. Upon review of eligible SOIs, PDS will invite selected applicants to expand their ideas into full proposal applications. Purpose of Small Grants: The PDS grants program supports projects proposed by U.S. and Cameroonian academic, cultural, educational, and other non-profit organizations and/or individuals that promote U.S. values, increase understanding between U.S. and Cameroonian people and institutions, and/or support U.S. Embassy goals of promoting government transparency and accountability, economic prosperity, peace and security, environmental sustainability, and climate adaptation. All programs must include an element of American culture or society, or connection with American expert/s, organization/s, or institution/s that will promote increased understanding of U.S. policy and perspectives. Priority Program Areas: Governance: Projects promoting democratic principles, improved and inclusive governance, transparency, human rights, religious freedom, empowerment of marginalized groups, citizen engagement, including in elections, civic education, and civil society. Prosperity: Projects promoting economic prosperity, entrepreneurship, bilateral trade and investment, countering corruption Security: Projects promoting peace and security, rule of law, alternatives to violence in resolving conflict, tolerance, preventing radicalization to violence, improving mutual understanding between groups, community policing Sustainability and Climate Change: Projects promoting environmental sustainability and addressing climate change Journalism: Projects promoting a professional and independent media, role of informed citizens in a democracy, media literacy, ethical and investigative journalism. Examples of PDS Small Grants Programs include, but are not limited to : U.S. experts conducting lectures, seminars, or speaking tours with Cameroonian audiences Artistic and cultural workshops, joint performances, and exhibitions Cultural heritage conservation and preservation programs Professional and academic exchanges and programs Libraries, community centers, or other institutions that are interested in becoming an American Space Programs developed by an alumnus/a of a U.S. sponsored or supported educational or professional exchange program Projects to promote English language teaching skills or widen access to books and other sources of information about the United States

This grant provides funding to U.S. small businesses for research and development projects that aim to advance health-related technologies and facilitate their commercialization.

This funding opportunity provides financial support to small businesses with active Phase I SBIR or STTR grants from NIH or CDC, helping them accelerate the commercialization of biomedical and public health innovations through training and market research.

This funding opportunity supports research projects that aim to improve the adoption and sustainability of effective health interventions, particularly in underserved communities, while also addressing the reduction of ineffective practices.

The "BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination" grant aims to support the distribution, integration, and minor improvement of existing neuroscience research tools and technologies, as well as user training, to help achieve the goals outlined in the "BRAIN 2025: A Scientific Vision" report.

This funding opportunity supports multidisciplinary research and community projects aimed at reducing health disparities related to environmental factors among disadvantaged populations in the U.S.

The general purpose of the project is to strengthen and advance the recently developed National Respite Care Provider Training (NRCPT), first developed under the Lifespan Respite Care Program: Special Projects to Strengthen Program Development, Implementation and Sustainability (grant number: 90LRSP0001).The grantee will undertake activities intended to foster the following advancements to the NRCPT: 1. Promote and support the broader usage of this resource in new and emerging respite service delivery areas (e.g., states and local communities).2. Identify and leverage opportunities to make the training available in more states and local communities nationwide.3. Develop and test approaches for connecting newly trained providers to caregivers and other service recipients. (e.g., respite registries or similarly accessible modalities).4. Identify and develop for implementation and dissemination methods for retaining respite providers, including opportunities for career advancement and upward mobility.5. Adapt for use among limited English speaking populations, for whom career options are currently limited.6. Identify a pathway for establishing an evidence-base for the NRCPT.Through the above activities, the grantee will achieve the following key outcomes:1. Enhanced awareness and usage of the NRCPT.2. Improved retention of respite providers3. Streamlined access for caregivers to trained respite providers.

This Notice of Funding Opportunity (NOFO) invites grant applications from institutions/organizations that propose to build a Medical Rehabilitation Research Center. The centers will have a specific rehabilitation research theme and be comprised of a research project supported by 3 cores. The 3 cores will have functions within the center as well as functions nationwide. Together, the cores will support: administrative functions (including an optional pilot program), resource sharing, and community engagement and outreach. The Medical Rehabilitation Research Centers will contribute tomedical rehabilitation research infrastructure by developing and disseminating techniques, data, theories, research programs, and expertise with the goal of enhancing the capability of medical rehabilitation investigators to understand mechanisms of functional recovery, develop therapeutic strategies, identify clinical care gaps, and improve the lives of people with disabilities. Applications must include a plan for inclusion of People with Lived Experience (as a required other attachment) that is relevant to the research theme of the center and increases the potential impact of the center.

This funding opportunity supports organizations in analyzing existing data to evaluate the effectiveness of career pathways programs that help low-income individuals, particularly those receiving TANF, achieve better employment outcomes through education and training.

Eligible state agencies funded under this announcement shall use grant funds to advance the provision of respite services through their statewide Lifespan Respite Care system as outlined in The Act. The goal of the program is to enhance state systems and capacities to deliver respite care and related services to family caregivers of children and adults across all age groups, disabilities, and chronic conditions. All programs must from the outset, address the respite needs of all populations regardless of the age, disability, or chronic condition of the care recipient population. Funded applicants will continue to build collaborations and partnerships across the state and carry out key activities including expanding options for volunteers; ensuring adequate respite provider training is offered; identifying gaps in current services and conducting outreach to reduce those gaps; and continue to, or increase efforts to, target underserved populations across the lifespan. ACL will fund up to approximately fifteen (15) cooperative agreements over the course of the 4-year project period.Applications should reflect an understanding of and grounding in the principles and actions contained in the National Strategy to Support Family Caregivers. It is ACLs expectation that using the Strategy as a roadmap or guide, applicants will incorporate the approaches outlined in the Strategy, as applicable, for enhancing their State Lifespan Respite Systems of care.Awardees under this funding opportunity will work with ACL to implement the data collection and reporting requirements, under Section 2904 of the Lifespan Respite Reauthorization Act of 2020.

This funding opportunity provides financial support to state agencies to enhance personalized counseling and education services for Medicare beneficiaries and their families, ensuring they can make informed healthcare decisions.

With this solicitation, OVC seeks to support projects designated for funding in the Consolidated Appropriations Act, 2024 (Public Law 118-42) to improve the functioning of the criminal justice system, to prevent or combat juvenile delinquency, and to assist victims of crime (other than compensation).

The primary purpose of the NIH Mentored Clinical Scientist Research Career Development Awards (K08) program is to prepare qualified individuals for careers that have a significant impact on the health-related research needs of the Nation. This program represents the continuation of a long-standing NIH program that provides support and "protected time" to individuals with a clinical doctoral degree for an intensive, supervised research career development experience in the fields of biomedical and behavioral research, including translational research.

This funding opportunity provides financial support to small businesses engaged in health-related research to enhance diversity by recruiting and mentoring individuals from underrepresented backgrounds.

This grant provides funding to support diverse postdoctoral researchers in transitioning to independent faculty positions while conducting innovative research on pain and substance use disorders.

These projects will be funded under the Projects of National Significance (PNS) within the Developmental Disabilities Assistance and Bill of Rights Act. The project will focus on achieving economic security and mobility for individuals with intellectual and developmental disabilities. The purpose of the project may include providing aid to transition youth with intellectual and developmental disabilties, funding employment and postsecondary education opportunties, and / or assiting with assistive technology devices that may needed to help meet employment goals. Overall, these projects will create opportunities for individuals with developmental disabilities to directly and fully contribute to, and participate in, all facets of community life; and support the development of national and State policies that reinforce and promote, with the support of families, guardians, advocates, and communities, of individuals with developmental disabilities, the self-determination, independence, productivity, and integration and inclusion in all facets of community life of such individuals.Projects funded under this announcement will work toward one or more of the following performance measures:Outcome Measure 1: Number of policies changed to improve the experience of people with ID/DD and their families Output Measure 1.1: Number of people who participated in policy advocacy activities Output Measure 1.2: Number of trainings about policy implemented Output Measure 1.3: Number of policy products created Output Measure 1.4: Number of times policy products were sharedOutcome Measure 2: Number of people with ID/DD and their families who report new or increased leadership roles Output Measure 2.1: Number of tools and resources created related to leadership by people with I/DD and their families Output Measure 2.2: Number of tools and resources shared related to leadership by people with I/DD and their families Output Measure 2.3: Percent of people with I/DD and their families who reported learning new leadership skills Output Measure 2.4: Number of people with I/DD and their family members who train or mentor others as leaders or advocatesOutcome Measure 3: Percent of people with ID/DD and their families who reported increased knowledge of supports needed to help them achieve the life they want Output Measure 3.1: Number of trainings held to increase knowledge of supports available to help achieve a desired life Output Measure 3.2: Number of resources created to increase knowledge of supports available to help individuals achieve the life they want Output Measure 3.3: Number of resources shared to increase knowledge of supports available to help individuals achieve the life they wantOutcome Measure 4: Number of data resources accessed Output Measure 4.1: Number of data resources created Output Measure 4.2: Number of activities to disseminate data

This funding opportunity provides financial support to organizations that develop and implement person-centered, trauma-informed care services for Holocaust survivors and other older adults with trauma histories, along with their family caregivers.

This funding opportunity is designed for organizations currently involved in Down syndrome research to enhance a data coordinating center that will improve health outcomes for individuals with Down syndrome by facilitating data integration and collaboration.