Federal Science and Technology Grants

The PRP IIRA supports highly rigorous, multidisciplinary, high-impact research projects that have the potential to make an important contribution to Parkinsons research. This award mechanism supports the full spectrum of research from basic science through clinical research.

This grant provides funding for researchers and small teams to develop innovative mathematical frameworks that enhance national security applications in areas like supply chains, communications, and mission planning.

This funding opportunity is exclusively for Northwestern University to support the management and coordination of a large-scale research initiative focused on refining heart failure subtypes and advancing personalized clinical trials.

The purpose of the RRTCs, which are funded through the Disability and Rehabilitation Research Projects and Centers Program, is to achieve the goals of, and improve the effectiveness of, services authorized under the Rehabilitation Act through well-designed research, training, technical assistance, and dissemination activities in important topical areas as specified by NIDILRR. These activities are designed to benefit people with disabilities, family members, rehabilitation service providers, policymakers and other research stakeholders. The purpose of this particular RRTC is to conduct research, training, technical assistance, and related activities to contribute to improved employment outcomes among people with intellectual and developmental disabilities. NIDILRR plans to make one grant under this opportunity. The grant will have a 60-month project period, with five 12-month budget periods.

This grant provides funding for organizations to conduct sea turtle nesting surveys and conservation efforts at Wake Island Airfield, specifically targeting members of the Cooperative Ecosystem Studies Units in the Pacific Northwest, Hawaii-Pacific Islands, or California.

This funding opportunity provides financial support for a wide range of organizations to develop innovative research and tools aimed at enhancing national security through advancements in cognitive and information warfare strategies.

This funding opportunity provides financial support for research and evaluation projects aimed at improving policing practices, enhancing community relations, and ensuring evidence-based policymaking, targeting a wide range of eligible applicants including government entities, educational institutions, and nonprofit organizations.

The purpose of the Switzer Research Fellowships program is to build research capacity by providing support to highly qualified individuals, including individuals with disabilities, to conduct research on rehabilitation, independent living, and other experiences and outcomes of people with disabilities. Fellows must conduct original research that is focused on the experiences and outcomes of people with disabilities in one or more of NIDILRRs three outcome domains: (1) community living and participation; (2) employment; or (3) health and function. The purpose of this particular Switzer Fellowship opportunity is to support doctoral candidates as they conduct their dissertation research. NIDILRR plans to make five fellowship awards under this opportunity. Applicants must demonstrate their formal academic status as doctoral candidates. Fellowship awards will have one 12-month project period.

This program provides funding for researchers to conduct innovative studies that improve the lives of people with disabilities, particularly focusing on diverse populations and community participation.

This funding opportunity provides financial support to a variety of organizations working to enhance Türkiye's civilian nuclear energy infrastructure while ensuring compliance with international safety and nonproliferation standards.

The objective of this research proposal is to develop physiologically based pharmacokinetic (PBPK) model-based mechanistic in vitro in vivo correlations (IVIVCs) for two major types of long acting injectables (LAIs) such as crystalline suspensions and polymer-based implants by considering their distinct characteristics. The goal of the project is to develop a bottom-up mechanistic PBPK model for these two LAI categories by accounting for the influence of critical formulation attributes of each LAI drug product type to predict its in vivo release mechanism. The model formulation parameters and relevant physiology should be informed with suitable in vitro and in vivo experiments. A suitable preclinical animal model can be used to validate the PBPK model based IVIVCs for both LAI suspensions and polymer based implants. The use of PBPK modelling provides a unique opportunity to understand how the physicochemical properties of drug molecules/polymer, implant specific properties, critical formulation attributes, and physiology, among other things, influence the in vivo release mechanisms of LAI drug products and their disposition characteristics. Moreover, once developed, a mechanistic PBPK model can help to define the 'safe space' for critical formulation attributes relevant to the reference listed drug (RLD) product, explain sources of PK variability and extrapolate predictions to human subjects by leveraging animal model data and by accounting for species-specific physiological differences.

This grant provides funding for researchers and organizations to study and improve understanding of Earth's energy and water cycles using NASA data and methodologies.

This funding opportunity provides financial support to the Research Triangle Institute International to enhance forensic science practices through training and technical assistance for law enforcement and criminal justice agencies across the United States.

This funding opportunity supports U.S. researchers and select international organizations in conducting studies using data from the X-ray Imaging and Spectroscopy Mission to advance our understanding of high-energy astrophysics.

This grant provides funding for researchers and organizations to develop and utilize artificial intelligence and machine learning techniques on heliophysics data, enhancing our understanding of solar and space phenomena.

TheMacrosystems Biology and NEON-Enabled Science (MSB-NES): Research on Biological Systems at Regional to Continental Scalesprogram will support quantitative, interdisciplinary, systems-oriented research on biosphere processes and their complex interactions with climate, land use, and changes in species distributionatregional to continental scales as well as training activities to broaden participation of researchers in Macrosystems Biology and NEON-EnabledScience. MSB-NES projects that use data and/or resources fromthe National Ecological Observatory Network(NEON) are encouraged. Substantive NEON-enabled projects rely on data and/or samples collected by NEON and/or co-locate research activities at NEON sites. Projects may develop tools that will explicitly enhance the processing, use, and/or analysis of NEON data or collections, in the context of addressing a specific research question or hypothesis. However, proposals primarily focused on tool development that can be used for a broad class of research questions or for topics that meet the needs of a community of researchers should be directed toward the Infrastructure Innovation for Biological Research (Innovation) or Infrastructure Capacity for Biological Research (Capacity) programs in the Division of Biological Infrastructure.

The FY24 KCRP Postdoctoral and Clinical Fellowship Award supports recent doctoral or medical school graduates in pursuit of innovative, high-impact kidney cancer research during their postdoctoral and/or clinical fellowship and allows them to obtain the necessary experience for an independent career as a leader in kidney cancer research. Applicants must demonstrate that the proposed research has high potential to lead to, or make, significant advancements in kidney cancer research and/or patient care. Applicants for this award must also exhibit a strong desire to pursue a career in kidney cancer research, with clear evidence for a researcher development plan that will lead to a successful independent career in kidney cancer. The critical components of this award mechanism are: Impact: Research supported by the FY24 KCRP Postdoctoral and Clinical Fellowship Award will have the potential for a major impact and accelerate progress toward ending kidney cancer. The impact may be short term or long term, but must move beyond an incremental advance. Applications are expected to identify the kidney cancer patients or at-risk individuals who would ultimately benefit from the proposed research. Research Strategy: The research proposed as part of the Postdoctoral and Clinical Fellowship Award must have high potential to lead to or make breakthroughs in kidney cancer. The scope of the research may include innovative, high-risk/high-reward research in the early stages of idea development or research already supported by preliminary data with the potential to make significant advancements toward clinical translation. The research strategy should demonstrate sound rationale, logical reasoning, and, if available, preliminary data. The proposed research should show evidence of rigorous experimental design, sufficient experimental details, appropriate controls, a statistical plan, and consideration of pitfalls and alternatives. Principal Investigator (PI): Under this award mechanism, the postdoctoral or clinical fellow is considered the PI and, as such, is expected to write the project narrative, researcher development plan, and other application components, with appropriate guidance from the mentor. While the PI is not required to have previous experience in kidney cancer research, the proposed project and researcher development plan must focus on kidney cancer. Applications must emphasize the PIs potential for success in becoming an independent kidney cancer researcher based on their qualifications, achievements/honors (including first-author publications and funding), and letters of recommendation. Mentor: The mentor (or co-mentor, if applicable) must possess the appropriate experience in kidney cancer research and/or patient care, to include recent publications and a record of active funding, and clearly demonstrate a commitment to guiding the PIs research and development as a researcher. If the mentor is not an experienced kidney cancer researcher, then formal co mentorship by an established kidney cancer researcher is required. The application must include information about the mentors experience in conducting innovative research and how they intend to support the PIs endeavors in kidney cancer. Mentorship by an investigator without an established record of mentoring pre- and/or postdoctoral trainees may be offset by the overall strength of the researcher development plan. Researcher Development Plan: Applications must provide details on the suitability of the PIs overall researcher development plan for attaining the goals of this award mechanism. Applications must elaborate on the qualities of the research environment in which the candidate will work, provide details on the individualized kidney cancer-focused researcher development plan, and describe how it will facilitate the PIs career development as an independent, innovative kidney cancer researcher. A multidisciplinary research approach to kidney cancer is highly encouraged, but not required; however, if there are multidisciplinary aspects, they should be clearly outlined in the application. Organizational-Level Emphasis: The following areas of emphasis are broadly applicable to many CDMRP programs, not just the KCRP. Investigators are encouraged to consider addressing these areas in their applications if doing so is appropriate for their line of research, addresses the FY24 KCRP strategic priorities and/or focus areas described in Section II.A.1 and Section II.A.2. Nuclear Medicine: Innovative research involving nuclear medicine and related techniques to support early diagnosis, more effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies. Womens Health: CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women's health outcomes and/or advancing knowledge for women's health. Metastatic Cancer Task Force: A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 KCRP priorities. Rigorous Study Design: All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (https://www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies. Military Service Involvement: Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. Research involving human subjects and human anatomical substances is permitted; however, clinical trials are not allowed under this program announcement. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes. Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials. For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes: (1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies. (2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. (3) Outcomes research and health services research that do not fit under the definition of clinical trial. Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule. The funding instrument for awards made under the program announcement will be grants (31 USC 6304). The anticipated direct costs budgeted for the entire period of performance for an FY24 KCRP Postdoctoral and Clinical Fellowship Award should not exceed $195,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information. Awards supported with FY24 funds will be made no later than September 30, 2025. The CDMRP expects to allot approximately $2.18M to fund approximately seven Postdoctoral and Clinical Fellowship Award applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

This funding opportunity supports organizations that provide comprehensive care for individuals with spinal cord injuries, enabling them to conduct research and improve health outcomes, community living, and employment opportunities for this population.

This funding opportunity provides financial support to organizations that will deliver specialized training and technical assistance to law enforcement agencies nationwide, enhancing their capabilities to combat illicit drug distribution and improve public safety related to substance use.

This funding opportunity supports researchers investigating health issues related to military toxic exposures, providing financial resources for studies ranging from basic research to clinical trials.