Federal Science and Technology Grants

This funding opportunity supports U.S. institutions in developing open-source science projects that improve the accessibility and reproducibility of NASA research, encouraging community engagement and collaboration.

This funding opportunity provides financial support to state governments and Indian tribes for modernizing and expanding emergency alert systems to improve public safety communication.

The FY24 ALSRP Therapeutic Idea Award (TIA) supports new, innovative, high-risk, high-gain ideas aimed at Amyotrophic Lateral Sclerosis (ALS) drug or therapy discovery. The studies supported by this award mechanism are expected to be hypothesis-driven and generate preliminary data for future avenues of therapeutic investigation. Projects that focus primarily on pathophysiology of ALS without development of a therapy are outside the scope of this funding opportunity.Applications may demonstrate the ability to achieve interpretable results in the absence of preliminary data supporting the hypothesis. While the inclusion of preliminary data is not prohibited, the strength of the application should rely on the approach.The key elements of this award mechanism are:Innovation: Research deemed innovative may introduce a new paradigm, challenge current paradigms, introduce novel concepts or technologies, or exhibit other uniquely creative qualities that may lead to potential therapeutics for ALS.Impact: The FY24 TIA can be for a specific ALS subtype and does not have to broadly apply to all patients. Research should be non-incremental and pioneer transformative results that could lay the foundation for a new direction in the field of ALS therapy development. Incremental research does not meet the intent of this funding opportunity.Strong Scientific Rationale: Projects that address in the intent of the mechanism should include a well-formulated, testable hypothesis based on strong scientific rationale that holds translational potential to improve ALS treatment and/or advance a novel treatment modality.Biomarkers: Applicants are required to include consideration to biomarker(s) development in parallel with their proposed Therapeutic Idea Award research for eventual clinical trials. Efforts should be mechanism-specific and may include development of target engagement biomarkers, objective pharmacodynamic biomarkers to measure the biological effect of an investigational therapeutic, or predictive/cohort-selective biomarkers that indicate whether a specific therapy will be effective in an individual patient or patient subgroup, including pre-symptomatic gene carriers. Development of markers for the purposes of diagnosis, prognosis, or measurement of disease progression apart from consideration of the therapeutic development process will not be supported and instead investigators should consider the Clinical Outcomes and Biomarkers Award (HT942524ALSRPCOBA).

The US Geological Survey is offering a funding opportunity to a CESU partner for research in biogeochemistry to evaluate the bioaccessibility of lead and other elements in contaminated soils from variety of environments.

The NIST-Hawaii Partnership in Plastic Pollution Research is seeking applications from eligible applicants to establish an institutional award, as described in the Department of Commerce Grants and Cooperative Agreements Manual, Chapter 6.A.2 (20 April 2021), for activities to partner on the nations priority plastic pollution research with efforts focusing on the Hawaiian Island region. Eligible applicants should describe how they can host and interact with at least three NIST scientists with office, laboratory and other appropriate facilities to perform multi-disciplinary plastic pollution research with the intent to establish a long-term partnership between NIST and the recipient, as discussed in Section I.1. The proposal should also include a description of administrative, research and outreach/educational support that would be offered by the applicant in the partnership to achieve world-class research in the field of plastic pollution.

This funding opportunity supports innovative research projects aimed at developing new therapies for Amyotrophic Lateral Sclerosis (ALS), encouraging high-risk ideas that include biomarker development to guide future clinical applications.

This program provides funding to rural communities for projects that improve access to education and healthcare through advanced telecommunications technologies.

This funding opportunity supports research and technology development in advanced telecommunications systems for various industries, including healthcare and transportation, targeting academic institutions, nonprofits, and businesses to foster innovation and collaboration.

This grant provides funding for U.S. Government exchange alumni to develop innovative programs that enhance skills, entrepreneurship, and leadership among young professionals in Equatorial Guinea.

This funding opportunity provides financial support for research initiatives that enhance fire management practices and preparedness in response to changing wildfire conditions, targeting a diverse range of eligible applicants including nonprofits, educational institutions, and tribal organizations nationwide.

To implement a project aimed at advancing U.S. foreign policy and national security priorities by supporting initiatives that make decision-making structures and processes in fragile, conflict, or crisis-affected contexts more reflective of and responsive to the needs and perspectives of partner states to ensure strategic trade control systems meet international standards and by engaging on bilateral, regional and multilateral levels with foreign governments to aid in the establishment of independent capabilities to regulate transfers of weapons of mass destruction, WMD-related items, conventional arms, and related dual-use items, and to detect, interdict, investigate, and prosecute illicit transfers of such items.

The EHDA supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the TSC research field. The studies supported by this award mechanism are expected to generate preliminary data for future avenues of scientific investigation. The proposed research project should include a well-formulated, testable hypothesis based on a strong scientific rationale and study design. Applications should demonstrate the ability to achieve interpretable results in the absence of preliminary data supporting the hypothesis.The following are important aspects of the EHDA: Innovation: Innovative research may introduce a new paradigm, challenge existing paradigms, examine existing problems from new perspectives, or exhibit other highly creative qualities. Research that is an incremental advance upon published data is not considered innovative and is not consistent with the intent of the award mechanism. Although not all-inclusive, the following examples are ways in which the proposed research project may be innovative: Explores a novel idea and/or research question in TSC research and/or patient care. Uses or develops novel methods or technologies to address a question in TSC research and/or patient care. Applies or adapts existing methods or technologies for novel TSC research or clinical purposes that differ fundamentally from those originally intended.

This funding opportunity supports a wide range of organizations in developing innovative treatments and testing strategies to prevent and modify epilepsy and other neurological disorders.

This funding opportunity supports researchers aiming to enhance existing breast cancer clinical studies by extending follow-up activities, improving data analysis, and maximizing the use of previously collected patient data and biospecimens.

This funding opportunity is designed for partners affiliated with the Great Lakes-Northern Forest CESU to conduct research that supports the restoration and management of coastal ecosystems in the Great Lakes Basin, focusing on issues like invasive species and nutrient dynamics.

This funding opportunity supports researchers at universities and national laboratories in the U.S. to conduct innovative, hypothesis-driven studies in basic plasma science and engineering, focusing on understanding complex plasma behaviors and processes.

This funding opportunity is designed to support U.S.-based small businesses in developing innovative quantum computing solutions for complex energy-related challenges in computational chemistry and materials science.

The US Geological Survey is offering a funding opportunity to a CESU partner for research on applications of isotopic and elemental geochemistry to ecologic as well as surface and groundwater hydrologic problems. Essential components of the funding opportunity are: 1) student, faculty, and laboratory support for application, refinement, and development of geochemical methods, that 2) address solute and water sources and transport pathways, through 3) application of a wide range of stable and radioisotopic systems (ranging from hydrogen, helium, and lithium through uranium and lead), by 4) analysis of the isotopic and elemental composition of diverse sample media (including plant and animal tissue, sediment, rock, and aqueous phases, especially high salinity brine).

With this solicitation, NIJ seeks applications for funding of rigorous, independent evaluation projects funded under the OJP Community-Based Violence Intervention and Prevention Initiative (CVIPI). This solicitation includes two funding categories: 1) Evaluation research of programmatic sites funded under the OJP FY23 and FY24 CVIPI solicitations; and 2) evaluation research of other community-violence programs.

This funding opportunity supports U.S. and eligible international institutions in developing innovative research and technology projects for lunar surface exploration, adaptable to various landing sites on the Moon.