Federal Science and Technology Grants

Project Title: Ecosystem Management Technical Assistance to Promote Carbon Sequestration, Navy Region Southeast A cooperative agreement is being offered ONLY to members of the Cooperative Ecosystem Studies Units (CESU) Program Region(s) identified above. Award will be made upon mutual agreement and acceptance of the terms and conditions contained in the request for proposal and the of the recipients CESU Master Agreement. Note the established CESU Program indirect rate is 17.5%. Responses to this Request for Statements of Interest will be used to identify potential organizations for this project. Approximately $1,008,700 is expected to be available to support this project for the base period. Additional funding may be available to the successful recipient for optional tasks and/or follow on work in subsequent years. NOTE: This project will be awarded under the authority of 10 USC 670c-1, Sikes Act: For projects for the implementation and enforcement of integrated natural resources management plans, priority shall be given to award to Federal and State agencies having responsibility for the conservation or management of fish or wildlife. Period of Performance. The base period of agreement will extend 24 months from date of award. There may be up to four 12-month follow-on periods based on availability of funding. Description of Anticipated Work: See attached Statement of Objectives NOTE: At this time we are only requesting that you demonstrate available qualifications and capability for performing similar or same type of work by submitting a Statement of Interest. A full proposal and budget are NOT requested at this time. Submission of Your Statement of InterestStatements of Interest are due by 12:00 P.M., Central Time, on 15 August 2024.Submit your Statement of Interest via e-mail attachments or direct questions to:Sandy JustmanGrants SpecialistUSACE, Fort Worth DistrictEmail: sandra.justman@usace.army.milOffice: 817-886-1073Kathy S. MitchellProject ManagerUSACE, Fort Worth DistrictEmail: kathy.s.mitchell@usace.army.milOffice: 817-886-1709Review of Statements Received: All statements of interest received from a member of the CESU Region(s) identified above will be evaluated by a board comprised of one or more people at the receiving installation or activity, who will determine which statement(s) best meetthe program objectives: offer the most highly qualified Principal Investigator, have the most relevant experience and the highest capability to successfully meet the program objectives. Submitters whose statements are determined to best meet the program objectives will beinvited to submit a full proposal.Please see the Related Documents Tab for the full RSOI Package Details for submittal and project information.

This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change.Considering the current healthcare challenges that we face today, the goal of achieving better health outcomes is a moving target that requires daring and adaptable solutions. HSF awardees will develop innovative technologies, tools, and platforms that can be applied to a broad range of diseases. The following interest areas define the ground-breaking research we seek to support:Breakthrough Technologies: Paradigm shifting technologies that will change how we approach the diagnosis, treatment, and impact of diseases and conditions. Novel approaches to improve maternal and fetal medicine, decrease maternal morbidity and mortality during birth, and the post-partum period. Efforts should include new technology to monitor, detect, and/or treat maternal and/or fetal complications with less invasive and traumatic methods. Foundational advances in genetic, epigenetic, cellular, tissue, and organ replacement therapies that enable personalized medical interventions at scale in a manner that is accessible, cost-effective, and designed to impact the communities of greatest need. Interventions that target and reverse disease pathogenesis and/or enhance plasticity to address diseases of the nervous, neuromuscular, skeletal, lymphatic, cardiovascular, and other organ systems. Novel approaches to diagnose and treat diseases of the lymphatic system, particularly rare diseases, with a focus on the effects of genetic expression in the lymphatic system and/or models demonstrating the relationship between lymphatic dysfunction and health and disease.Transformative Tools: Novel, agile solutions that will move from bench to bedside quickly, facilitating revolutionary advances in medical care. Development of tools that counter idiosyncratic, off-target, or chronic effects of medicines that are commonly used or that are being used experimentally to treat or prevent disease. Development of bionics to restore sight, hearing, taste, or smell. Site-selective neuromodulation to regulate specific physiological functions and treat chronic health conditions such as inflammation, pain, and metabolic or endocrine disorders. Synthetic biology approaches to diagnosing, treating, and/or curing a multitude of diseases. Novel physics and/or chemistry-based approaches to improve imaging that reduces cost, increases availability, expands capability, improves resolution, reduces exposure to radiation, and accommodates pediatric patient populations. Integrated sensing and delivery devices for treating and diagnosing chronic health conditions, including mental health conditions or substance use disorders. Miniaturization of complex hardware to enable broader access to pediatric and other patient populations, as well as portability, such as diagnostic, treatment, imaging, or other devices.Platform Systems: Adaptable, multi-application systems and technologies that are reconfigurable for a wide variety of clinical needs Novel molecular platform approaches, including the modulation of host systems, delivery to targets with spatial and temporal precision, and mitigation of off-target effects to accelerate interventions that dramatically improve health outcomes. New approaches to accelerate and routinize mammalian and microbial cellular engineering to enable next generation therapeutic applications, develop multiscale interventions, and automate hypothesis generation and discovery to expand those applications to disease states in which cellular therapies have not traditionally been employed. Innovative approaches at the intersection of artificial intelligence, high performance computing (including quantum computing) and biological systems, including enabling de novo design of biomolecules with entirely new phenotypes.Other high-quality submissions that propose revolutionary technologies that meet the goals of HSF will be considered even if they do not address the topics listed above.Proposals are expected to use innovative approaches to enable revolutionary advances in medicine and healthcare, and the science and technology underlying these areas. While approaches that are disease agnostic are encouraged, ARPA-H welcomes proposals that bring radically new insights to address specific diseases including, but not limited to, cancer, diabetes, neurological diseases, pediatric and maternal/fetal health, infectious diseases, and cardiovascular disease.Specifically excluded are proposals that represent an evolutionary or incremental advance in the current state of the art or technology that has reached the clinical trial stage. An example of this type of proposal might include the request to fund clinical trials of an otherwise developed product. Additionally, proposals directed towards policy changes, traditional education and training, or center coordination, formation, or development, and construction of physical infrastructure are outside the scope of the ARPA-H mission.

The FY24 PCRP Early Investigator Research Award supports prostate cancer-focused research opportunities for individuals in the early stages of their careers under the guidance of one or more designated mentors. This opportunity allows early-career investigators to develop a research project, investigate a problem or question in prostate cancer research, and further their intellectual development as prostate cancer researchers of the future. All application components for the FY24 PCRP Early Investigator Research Award are to be written by the Principal Investigator (PI), with appropriate direction from the mentor(s).Key elements of this award mechanism are as follows: Principal Investigator: The postdoctoral investigator is considered the PI of the application and must exhibit strong potential for and commitment to pursuing a career as an investigator at the forefront of prostate cancer research; however, the PI is not required to have previous prostate cancer research experience. The PI must have 3 years or less of postdoctoral research experience (excluding clinical residency or clinical fellowship training) as of March 31, 2025. The PCRP strongly encourages applications from PIs who demonstrate a commitment to pursuing a career focused on prostate cancer health disparity research. Mentor(s): Applications must include at least one mentor appropriate to the proposed research project who has experience in prostate cancer research and mentoring as demonstrated by a record of active funding, recent publications, and successful mentorship. The primary mentor can be a junior faculty member, in which case the PI is encouraged to include a secondary mentor with a more robust track record in prostate cancer research and mentorship. Applications that focus on prostate cancer health disparity should include at least one mentor with experience in prostate cancer health disparity research. The selected mentor(s) should also demonstrate a clear commitment to the development of the PI toward independence as a prostate cancer researcher. Research Approach: Proposed research ideas are required to address one or more of the FY24 PCRP Overarching Challenges. Projects that specifically address the FY24 PCRP Overarching Challenge to advance health equity and reduce disparities in prostate cancer are strongly encouraged. The scientific rationale and experimental methodology should demonstrate in-depth analysis of the research problem presented. The feasibility of the research design and methods should be well defined, and a clear plan should be articulated as to how the proposed goals of the project can be achieved. Inclusion of preliminary data relevant to prostate cancer and the proposed project is encouraged but not required. Any preliminary data provided should be from the PI, mentor(s), or member(s) of the collaborating team. Additionally, required resources should be identified and supported through documentation. Research involving human subjects and human anatomical substances is permitted; however, clinical trials are not allowed under this funding opportunity. Researcher Development Plan: The PI must outline an individualized, prostate cancer-focused researcher development plan, which should include a clearly articulated strategy for acquiring the necessary skills, competence, and expertise that will enable the PI to successfully complete the proposed research project and foster the PIs development as an independent prostate cancer researcher. An environment appropriate to the proposed mentoring and research project must be clearly described, although any deficiencies of resources and/or mentorship at the PIs institution can be mitigated through collaboration(s) with other institutions. If the PI will be utilizing resources at another institution to successfully complete the proposed project, then the PI is strongly encouraged to designate a co-mentor at the collaborating institution.Investigators are strongly encouraged to incorporate the following components into their study design, where appropriate, in order to maximize the potential impact of the proposed research project: authentication of proposed cell lines; statistical rigor of preclinical animal experiments; and incorporation of experiments to assess clinical relevance and translatability of findings. Studies utilizing data derived from large patient studies that include long-term health records, biospecimen repositories, and pre-existing research and apply state-of-the-art genomic and/or proteomic analysis, bioinformatics, and/or mathematical models to such data are also encouraged. Investigators are highly encouraged to provide a letter of support indicating access to and the availability of any resources required to support the study.A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, the CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 PCRP priorities.Innovative research involving nuclear medicine and related techniques to support early diagnosis, more-effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies.Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research.All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (http://www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies.Clinical trials are not allowed. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated direct costs budgeted for the entire period of performance for an FY24 PCRP Early Investigator Research Award should not exceed $300,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $6.24M to fund approximately 13 Early Investigator Research Award applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

This funding opportunity supports clinical research projects that extend or enhance existing breast cancer studies, requiring collaboration with consumer advocates to improve outcomes for patients and the community.

The NSF CISE Directorate supports research and education projects that develop new knowledge in all aspects of computing, communications, and information science and engineering, as well as advanced cyberinfrastructure, through the following core programs: Division of Computing and Communication Foundations (CCF): Algorithmic Foundations (AF) program; Communications and Information Foundations (CIF) program; Foundations of Emerging Technologies (FET) program; and Software and Hardware Foundations (SHF) program. Division of Computer and Network Systems (CNS): Computer Systems Research (CSR) program; and Networking Technology and Systems (NeTS) program. Division of Information and Intelligent Systems (IIS): Human-Centered Computing (HCC) program; Information Integration and Informatics (III) program; and Robust Intelligence (RI) program. Office of Advanced Cyberinfrastructure (OAC): OAC Core Research (OAC Core) program; Proposers are invited to submit proposals in several project classes, which are defined as follows: Small Projects -- up to $600,000 total budget with durations up to three years: projects in this class may be submitted to CCF, CNS, and IIS only; Medium Projects -- $600,001 to $1,200,000 total budget with durations up to four years: projects in this class may be submitted to CCF, CNS, and IIS only; and OAC Core Projects -- up to $600,000 total budget with durations up to three years: projects in this class may be submitted to OAC only. A more complete description of these project classes can be found in SectionII. Program Descriptionof this document.

This grant provides funding to support research and initiatives that promote diversity, equity, inclusion, and accessibility for individuals with disabilities in STEM fields and education.

This grant provides funding for educational institutions, nonprofits, businesses, and government entities to conduct high-risk, high-reward basic research that advances scientific knowledge in areas critical to the U.S. Air Force and Space Force.

The US Geological Survey is offering a funding opportunity to a CESU partner for research on wild horse population demography and ecology throughout the Western USA. This research will be comprised of a combination of field-based data collection and research, and data analyses through modelling techniques. The National Academies of Science (NAS) conducted a science review of the Bureau of Land Management (BLM) wild horse and burro program in 2013. An outcome of this NAS review was a number of recommendations for new research, identification of data gaps, and knowledge needs. The aim is to fill some of those data needs with collaborative research conducted jointly by USGS and CESU partner.

This funding opportunity supports small pilot projects that enhance understanding of the human virome, inviting collaborations from various organizations, including educational institutions and nonprofits, to develop innovative tools and methods for studying the interactions between viruses and human health.

This funding opportunity supports research on terrestrial ecosystems, focusing on plant-soil-microbe interactions and the ecological challenges of coastal and degraded lands, aimed at universities, nonprofits, and private organizations in the U.S.

This project seeks to develop and prototype advanced electronic warfare solutions for unmanned platforms, inviting technology vendors to collaborate and innovate in addressing current gaps in electromagnetic spectrum operations.

This grant provides funding for university students in the U.S. to develop innovative aeronautics projects while also engaging in crowdfunding to support their research efforts.

This program provides funding to enhance research opportunities and collaborations at Minority-Serving Institutions, aiming to diversify the STEM workforce in the social, behavioral, and economic sciences.

Project Title: Natural Resources Support - Black Abalone at Vandenberg SFB, California A cooperative agreement is being offered ONLY to members of the Cooperative Ecosystem Studies Units (CESU) Program Region(s) identified above. Award will be made upon mutual agreement and acceptance of the terms and conditions contained in the request for proposal and the of the recipient's CESU Master Agreement. Note the established CESU Program indirect rate is 17.5%. Responses to this Request for Statements of Interest will be used to identify potential organizations for this project. Approximately $50,000.00 is expected to be available to support this project for the base period. Additional funding may be available to the successful recipient for optional tasks and/or follow on work in subsequent years. NOTE: This project will be awarded under the authority of 16 USC 670c-1, Sikes Act: For projects for the implementation and enforcement of integrated natural resources management plans, priority shall be given to award to Federal and State agencies having responsibility for the conservation or management of fish or wildlife. Period of Performance: The base period of agreement will extend 18-months from date of award (3-month administrative period for project preparation, 12-months of technical support/field work, 3-month administrative period to complete deliverables). There may be up to five 18-month follow-on periods based on availability of funding. Description of Anticipated Work: See attached Statement of Objectives NOTE: At this time we are only requesting that you demonstrate available qualifications and capability for performing similar or same type of work by submitting a Statement of Interest. A full proposal and budget are NOT requested at this time. Submission of Your Statement of Interest1. Statements of Interest are due by 12:00 P.M., Central Time, on 17 June 2024.2. Submit your Statement of Interest via e-mail attachments or direct questions to:Sandy JustmanGrants SpecialistUSACE, Fort Worth DistrictEmail: nicholas.a.aprea@usace.army.milOffice: 817-886-1073David LeptienProject ManagerUSACE, Fort Worth DistrictEmail: david.b.leptien@usace.army.milOffice: 402-889-5570Review of Statements Received: All statements of interest received from a member of the CESU Region(s) identified above will be evaluated by a board comprised of one or more people at the receiving installation or activity, who will determine which statement(s) best meet the program objectives: offer the most highly qualified Principal Investigator, have the most relevant experience and the highest capability to successfully meet the program objectives. Submitters whose statements are determined to best meet the program objectives will be invited to submit a full proposal. Review Related Documents Tab for the full Project Details.

This grant provides funding for research projects that address the abuse, neglect, and financial exploitation of older adults, targeting a variety of organizations including governments, nonprofits, and educational institutions.

This project will develop novel microbes with increased capability to dissolve and capture REE from solid sources such as crushed ore and e-waste. The project will also examine approaches to increase the selectivity and affinity of biomolecules for different REE. Additionally, the project will investigate different technologies/approaches that improve scalability of REE recovery processes (e.g. concentration and monitoring of REEs during processing). The ultimate goal of this effort is to develop methods that accelerate our ability to recover individual or discrete mixtures of REE from domestic primary and secondary sources. Objective 1: Increase the selectivity and affinity of biomolecules for different REE. We will create semi-synthetic platforms for specific lanthanide-binding, relying on modification of proteins and spores using designed chemical structures for chelation moieties. We anticipate that these will greatly improve the already robust concentration of lanthanides by spores and proteins, while providing methods for tuning protein/spore affinity and selectivity. The specificities of both the semi-synthetic and protein-alone chelators will be further modified using computational models to design peptides and proteins with a variety of affinities and specificities for REE.Objective 2: Technologies/approaches that improve scalability of REE recovery processes. We will alter the surfaces of fluorescent proteins in order to create protein biosensors that can bind lanthanides with high affinity and selectivity, and also allow FRET detection both in vitro and in vivo of lanthanides (samarium, europium, terbium, and dysprosium). Such biosensors will serve as extraordinary tools for monitoring the efficiencies of processing streams and of the efficacies of different technologies. We will also work with ERDC researchers to examine novel approaches to condense process streams to increase efficiency of downstream processing events. Objective 3: Develop novel microbes with increased capability to dissolve and capture REE from solid matrices. Microbes will be metabolically engineered to dissolve REE and capture REE from solid matrices. Organisms will be able to concentrate lanthanides, and then themselves be concentrated from waste streams. This will increase the amount of leached REE dissolved in leachate and increase the amount of REE isolated after purification Results from these objectives will be communicated to ERDC regularly in interim reports and transferred to the Public using conference presentations and the peer-reviewed literature. All methods and protocols will accompany the results and meet peer-review scrutiny for any interim reports.

This grant invites government, academic, and industry collaborators to propose innovative research projects that enhance air warfare and weapons technology for the Navy and Marine Corps.

This grant provides funding for research teams to study agricultural emissions and their effects on air quality and climate, utilizing advanced technologies and collaborative efforts to enhance understanding and data sharing in this field.

This funding opportunity is designed for research organizations affiliated with the Great Lakes Northern Forest Cooperative Ecosystem Studies Unit to study the growth and diet of alewife in Lake Michigan's nearshore areas, aiming to improve understanding of larval survival and population recruitment.

The Saltonstall-Kennedy Act established a fund (known as the S-K fund) used by the Secretary of Commerce to provide grants or cooperative agreements for fisheries research and development projects addressing aspects of U.S. fisheries, including, but not limited to, harvesting, processing, marketing, and associated business infrastructures (seesection IV, F; Funding Restrictions). Under this authority, grants and cooperative agreements are made on a competitive basis (subject to availability of funding) to assist in carrying out projects to expand domestic and foreign markets related to U.S. commercial and recreational fisheries. The term U.S. fisheries refers to any marine fishery (including the Great Lakes) that encompasses commercial, recreational, charter, subsistence, wild capture, and aquaculture that is, or may be, engaged in by citizens or nationals of the United States or other eligible applicants. The objective of the S-K Research and Development Program, referred to throughout this document as the S-K Competitive Grant Program, is to promote U.S. fisheries by assisting the fishing community to address marketing and research needs. The term fishing community means harvesters, marketers, growers, processors, recreational fishermen, charter fishermen, fishermen, and persons providing them with goods and services. Proposals submitted to this competition must address at least one of the following priorities: Promotion, and Marketing; Development, Infrastructure and Capacity Building; Science or Technology that Enhances Sustainable U.S. Fisheries. This Notice of Funding Opportunity (NOFO) includes information on application requirements and criteria for proposals requesting a maximum of $500,000 in Federal funding for up to a two-year period. Matching funds are not required, nor will they be considered during the evaluation process. Awards are anticipated to start no earlier than September 1, 2025. NOTE: No awards will be funded under this current NOFO. Pre-Proposal submissions under this NOFO are eligible to submit a full proposal under a separate Notice of Funding Opportunity (NOFO), NOAA-NMFS-FHQ-2025-26868, which will post in Grants.gov on September 26, 2024. NEW REGISTRATION REQUIREMENTS: All applicants must complete and maintain three registrations: Sam.gov, Grants.Gov, and eRA Commons. The registration process for all three systems can take 4 to 6 weeks, so applicants should begin activity as soon as possible. SUBMISSION CHECKLIST FOR ERA REQUIREMENTS Below is a submission checklist for eRA Requirements. This is not an exhaustive list of everything you need for a successful application. All items below should be checked before you submit your application in Grants.gov. SAM.gov Registration and approved UEI eRA Commons Registration Grants.gov Registration PD/PI Account Created PD/PI Commons ID entered exactly on Box 4 on the SF-424 UEI entered exactly on Box 8c. of the SF-424 Congressional District formatted correctly (ex. VA-001) All PDFs flattened File sizes are less than 100 MB File page sizes are 8 12 x 11 File names are shorter than 50 characters (including spaces) File names do not include invalid characters (, diacritical marks) If you have any questions, please reach out to the eRA HelpDesk or the Agency Contact listed in your NOFO.