Federal Science and Technology Grants

This grant provides funding for innovative research to develop organoid systems that can process information and interact with technology, targeting researchers and engineers in fields like biology, computer science, and engineering.

This funding opportunity supports researchers and organizations conducting innovative studies and technology development related to ocean surface topography and its impact on Earth's systems.

This ISO seeks solution summaries and proposals for projects that fall within the general scope of the ARPA-H Scalable Solutions mission office. SSO expands what is technically possible by developing approaches that will leverage an interdisciplinary approach and collaborative networks to address challenges of geography, distribution, manufacturing, data and information, thereby improving health care access and affordability. In the United States, many communities and remote areas lack access to timely and quality health care, which leads to disparities in health outcomes for those populations. Bottlenecks during the manufacturing processes of products and health technologies also lead to delays and limited availability, preventing effective distribution of health care solutions to areas of need, especially in emergencies.ARPA-H SSO seeks solutions to improve the scalability and affordability of health care solutions, bridge gaps in underserved areas, and extend remote access to expertise by developing location-specific interventions, telemedicine solutions, and mobile health clinics. Solutions should focus on rapid innovation and the use of partnerships, as well as flexible distribution networks and streamlined manufacturing processes. The following SSO interest areas categorize the ground-breaking solutions we seek to support:Scalable Technologies and Interventions: Approaches to improve affordability and equitable access to health care that are adaptable to various geographic, demographic, economic contexts and can be rapidly deployed at scale (e.g., drug-repurposing*, telemedicine, point-of-care diagnostics, and modular health care infrastructure). Tailored solutions for the pediatric population that provide parity in access to treatments and other health care interventions with the adult population and adapt to the pediatric patients changing physiology and developmental status over the course of years. Transformational approaches to reduce or eliminate health disparities, including tools and models for product design and care delivery that scale novel approaches in human factors and human-centered design to respond to full diversity of patients. Tools to enable the scaling of provider and institutional capabilities (e.g., school nurses and schools, walk-in clinics, homesteading care) to address unmet health care access needs and expand availability of critical services. Foundational capabilities to accelerate diagnoses and reduce the cost of treatments for rare diseases wherever patients are, without the need for specialized facilities or healthcare expertise.* Solution summaries and proposals that focus on testing drugs for effectiveness for other disease states or use cases, are unlikely to be funded unless including additional R, or providing gains in cost reduction, accessibility, and/or equity.Collaborative Distribution Networks: Methods for standardization, automation, and democratization of complex procedures 5 including, but not limited to, histopathology, rare disease diagnosis and treatment, and surgical interventions to ensure access and delivery to populations diverse in demographics, geographies, and resources at scale. Approaches to enhance delivery of effective healthcare solutions in rural or low resource settings, including but not limited to "last mile delivery, at-home monitoring, imaging, drug delivery, telehealth augmentation, and support for remote medical procedures with limited need for specialized training. Technologies to enable the deployment of critical healthcare resources rapidly, equitably, and securely at scale to the point of need in permissive and non-permissive (i.e., damaged infrastructure, cyber-denied) environments during a public health crisis or natural disaster. Solutions to scale education and training of critical healthcare resources for health care providers and patients to ensure information integrity to prevent negative impacts to resource use/uptake. Innovative information technology, data and analytic products and technologies to enable ordering, inventory management, situational awareness, allocation planning and demand forecasting of critical healthcare resources during a public health crisis or natural disaster.Biomanufacturing Innovations*: Innovative manufacturing technologies and approaches that reduce cost, shorten the timeline for production, advance domestic competitiveness and reduce supply chain risk of biologics, cellular and gene therapies, pharmaceuticals, medical devices and personal protective equipment. New approaches to support predictable, programable biological production of conventional and novel materials reliability at scale in a cost-effective sustainable manner. Novel solutions to reduce the reliance on specialized handling and cold chain management of pharmaceuticals and biologics. Scalable innovations to advance and strengthen biomanufacturing supply chain and resolve bottlenecks including:o Advances in production of active pharmaceutical ingredients, process consumables, and other critical materials (i.e., enzymes, cell lines, etc);o Novel biomanufacturing-related data products, technologies or models to integrate into supply chain situational awareness systems;o Alternative materials and new manufacturing capabilities for personal protective equipment; ando Improvement of capabilities sustainably re-shore manufacturing and utilize a broad array of readily accessible and cost-efficient feedstocks as part of strengthening the local and national industry base. Analytics and novel sensor systems to precisely manage bioproduction, real-time release assays, and predictive capabilities to inform tuning of biological chassis for efficient and effective scale-up of manufacturing to industrial scale.*ARPA-H is not interested in approaches that merely increase capacity reservation.Other high-quality submissions that propose revolutionary technologies that meet the goals of SSO will be considered even if they do not address the topics listed above.Proposals are expected to use innovative approaches to enable revolutionary advances in medicine and healthcare, and the science and technology underlying these areas. While approaches that are disease agnostic are encouraged, ARPA-H welcomes proposals that bring radically new insights to address specific diseases including, but not limited to, cancer, diabetes, neurological diseases, pediatric and maternal/fetal health, infectious diseases, and cardiovascular disease.Specifically excluded are proposals that represent an evolutionary or incremental advance in the current state of the art or technology that has reached the clinical trial stage. An example of this type of proposal might include the request to fund clinical trials of an otherwise developed product. Additionally, proposals directed towards policy changes, traditional education and training, or center coordination, formation, or development, and construction of physical infrastructure are outside the scope of the ARPA-H mission.

This funding opportunity supports partnerships that enhance research and education in astronomy and astrophysics, particularly for institutions serving historically underrepresented groups, by providing authentic research experiences and fostering an inclusive environment.

This funding opportunity provides financial support for collaborative research projects focused on natural resource management and environmental assessment, specifically targeting pre-identified federal, state, tribal, and academic partners working with the U.S. Geological Survey.

This funding opportunity supports U.S.-based researchers and institutions in studying carbon dynamics to improve understanding of their effects on ecosystems and climate change.

The GEL-ICS program will build a cohesive group of leaders working on issues in cyberspace who are committed to the UN-affirmed Framework of Responsible State Behavior and will be equipped with the necessary knowledge and global connections to be effective advocates and champions of the Framework through the fellowship and other activities.

Supports research on the processes by which energy in diverse forms is generated by the Sun, transported to the Earth, and ultimately deposited in the terrestrial environment. Major topics include space weather impacts, helioseismology, the solar dynamo, the solar activity cycle, magnetic flux emergence, solar flares and eruptive activity, coronal mass ejections, solar wind heating, solar energetic particles, interactions with cosmic rays, and solar wind/magnetosphere boundary problems. Upcoming due dates: Full proposal accepted anytime There are no deadlines or target dates for proposals sent in to any of the Geospace Section core programs. However, we recommend that PIs try to send in proposals early in the fiscal year. Program guidelines Apply to PD 98-1523 as follows: Full proposals submitted via Research.gov: NSF Proposal & Award Policies & Procedures Guide proposal preparation guidelines apply. Full proposals submitted via Grants.gov: NSF Grants.gov Application Guide guidelines apply. See Grants.gov Proposal Processing in Research.gov for more information.

This funding opportunity supports U.S.-based institutions in developing advanced technologies and instruments for heliophysics research, with potential participation from international organizations under specific conditions.

This funding opportunity provides financial support to state governments and federally recognized Native American tribes for managing the impacts of a deadly bat disease and promoting species conservation efforts.

Through this new initiative, the Directorate for Education and Human Resources (EHR) and the newly established Directorate for Technology, Innovation and Partnerships(TIP)seek tosupport experiential learning opportunitiesfor individualsfromdiverseprofessional and educationalbackgroundsthat willincrease access to, and interest in, career pathways inemerging technologyfields (e.g.,advanced manufacturing, advanced wireless, artificial intelligence, biotechnology,quantum information science,semiconductors, and microelectronics). As NSF seeks to support the development of technologies in such fields, similar support will be needed to foster and grow a diverse science, technology, engineering, and mathematics (STEM) workforce to contribute to such innovation. Largescalesocietal challenges like climate change and clean energy also requireaSTEMworkforcethatbringsvaried perspectives and expertise to further accelerate the translation of science and engineering discoveries into large-scale solutions. Moreover, as current and new emerging technologies continue to evolve, unforeseen issues around security, safety and privacy will impact thepreparationof the workforce.Emerging technologiesare also dynamicandrapidly changing, with career entry and advancement often requiring "learning-by-doing" experience, even for those with some STEM education.Therefore, NSF recognizes that a competitiveemerging technology workforcemust includeindividualsfrom traditional and nontraditional education pathways as well as those individuals who may have stopped out of traditional educational pathways. The ExLENT program willsupportinclusiveexperiential learningopportunitiesdesigned toprovide cohorts of diverse learnerswiththe crucial skills needed to succeed inemerging technologyfieldsand prepare themto enterthe workforce ready to solve our Nationsmost pressing scientific and societal challenges.Furthermore, theExLENTprogram will directly support NSFsprioritytobuild adiverse workforce1inemerging technologiesto assurethe Nations competitiveness in STEM. Key goals of the program are to (1) expand access to career-enhancing experientiallearning opportunitiesfor a broader, more diverse population, including adult learners interested in re-skilling and/or upskilling (e.g., those who face or who have faced significant barriers to accessing a formal STEM education);(2)promotecross sectorpartnershipsbetweenorganizationsinemerging technologyfields and those with expertise in workforce development;and (3) develop a workforce aligned with regional economies based onemergingtechnologiesacross the Nation, in alignment with the mission of the TIP Directorate.

This funding opportunity supports early-career researchers in ovarian cancer clinical trials by providing financial resources, mentorship, and professional development through a specialized academy.

To complement DIVs ongoing efforts, this Annual Program Statement (APS) is a specific call for DIVs new Stage 4 Initiative to help support the scale-up and integration of Stage 4 innovations from the existing DIV portfolio into broader USAID programming and budgets. Applicants who are interested in applying for DIVs core funding (Stages 1 through 3 and Evidence Generation grants) should visit www.usaid.gov/div/apply and should not submit a concept note under this APS. Potential applicants should read the rules below closely regarding the prerequisites for submitting a concept note to an addendum issued under this APS.

This funding opportunity provides financial support for research and training initiatives aimed at improving employment outcomes for individuals with disabilities by evaluating the impact of various employment policies.

This funding opportunity provides financial support for U.S.-based organizations to conduct research on innovative construction technologies and policies that can help increase the availability of affordable housing nationwide.

This funding opportunity is designed for non-U.S.-based research entities to develop innovative AI technologies that improve maritime security through enhanced scene perception for unmanned vessels in complex marine environments.

This grant provides funding for innovative research projects aimed at improving the diagnosis and treatment of health conditions related to the September 11 attacks, specifically targeting first responders and survivors affected by these events.

The 2025 NOAA Hawaii Bay Watershed Education and Training (B-WET) program aims to enhance environmental literacy and stewardship among K-12 students and teachers in Hawaii through hands-on learning experiences that connect them with local environmental issues, Indigenous Knowledge, and climate science.

This grant provides funding and opportunities for companies and coalitions developing innovative energy storage solutions that enhance the integration of renewable energy systems and improve the efficiency of the electricity grid.

This grant provides funding to support partnerships among academic institutions, government, and industry in EPSCoR-eligible jurisdictions to enhance research infrastructure and capacity in STEM fields.