Federal Science and Technology Grants

This grant provides funding for innovative research aimed at developing new methods and tools to protect military personnel from diseases transmitted by insects, while also improving pest control strategies for bed bugs and filth flies.

Orthopaedic injuries have a profound impact on military readiness and return to work/activity/duty. In the military, extremity battle wounds comprise approximately 50% of injuries reported in the Department of Defense Trauma Registry. Additionally, orthopaedic injuries and conditions that occur outside of combat (e.g., during training, leisure activities, resultant from old injuries) present one of the greatest threats to the readiness of our Service Members and military. Early stabilization, treatment, and rehabilitation of orthopaedic injuries in both civilian and military populations have led to better outcomes, particularly in the prevention of secondary complications and in minimizing morbidity. Availability of orthopaedic care and treatment as early as possible, or as close to the point of injury as possible, also minimizes limb loss and affects military readiness.Although the PRORP is interested in supporting military-focused research, research supported by the PRORP is expected to also apply to all individuals who have sustained a major orthopaedic injury.With the initiation of the Arthritis Research Program, the FY24 PRORP may not fund arthritis research; however, research that addresses conditions or health abnormalities related to arthritis is permitted provided the proposed research addresses the selected Focus Area.The PRORP CTRA is intended to support high-impact and/or emerging clinical research that may not be ready for a full-scale randomized controlled clinical trial. Projects should demonstrate potential to impact the standard of care, both immediate and long-term, as well as contribute to evidence-based guidelines for the evaluation and care of military, Veterans, and all patients with orthopaedic injuries. One goal of the FY24 PRORP CTRA is to translate current and emerging techniques and interventions into the clinical space to better serve military and non-military patients. A holistic approach that takes into account the health, functional abilities, and quality of life of individuals who have sustained an orthopaedic injury should be considered. Another goal is to identify the most effective diagnosis, treatment, rehabilitation, and prevention options available to support critical decision-making for patients, clinicians, other caregivers, and policymakers.The FY24 PRORP CTRA differs from the FY24 PRORP Clinical Trial Award (CTA) in that the CTRA allows for clinical research projects that may or may not include a clinical trial, whereas the CTA is restricted to clinical trials only.Funding from this award mechanism must support clinical research and may not be used for animal research.Clinical research encompasses research with patient samples, data, and interaction with patients that may or may not be considered a clinical trial. Clinical research is observational in nature and includes: (1) Research that does not seek to evaluate the effects of interventions. Research conducted with human subjects (or on material of human origin such as data, tissues, specimens, and cognitive phenomena) for which an investigator (or colleague) directly interacts with human subjects but does not seek to assess the effects of an intervention, qualifies as clinical research. Patient-oriented research may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies. (2) Epidemiologic and behavioral studies that do not seek to study the safety, effectiveness, and/or efficacy outcomes of an intervention. (3) Outcomes research and health services research that do not fit under the definition of clinical trial. Excluded from the definition of clinical research are in vitro studies that utilize human tissues that cannot be linked to a living individual. Note: Studies that meet the requirements for exemption under 46.104(d)(4) of the Common Rule are not considered clinical research as defined by the CDMRP. Exemption category 4 refers to secondary research for which consent is not required.A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For more information, a Human Subject Resource Document is provided at https://cdmrp.health.mil/pubs/pdf/Human%20Subjects%20Resource%20Document_DEC2022.pdf.Proposed studies submitted to the CTRA may be interventional and may involve some retrospective data analysis. Note that purely retrospective or database-related research is not allowed under this funding opportunity. Small pilot clinical trials with human subjects are allowable.Key aspects of the PRORP CTRA mechanism: Preliminary Data Are Required: Inclusion of preliminary data relevant to the proposed clinical research is required. Study Population: The application should demonstrate the availability of and access to a suitable patient population that will support a meaningful outcome for the study. The application should include a discussion of how accrual goals will be achieved, as well as the strategy for inclusion of women and minorities in the clinical research appropriate to the objectives of the study. Studies utilizing human biospecimens or datasets that cannot be linked to a specific individual, gender, ethnicity, or race (typically classified as exempt from Institutional Review Board [IRB] review) are exempt from this requirement. Intervention Availability: The application should demonstrate the documented availability of and access to the drug/compound, device, and/or other materials needed, as appropriate, for the proposed duration of the study. Statistical Analysis and Data Management Plans: The application should include a clearly articulated statistical analysis plan, a power analysis reflecting sample size projections that will answer the objectives of the study, and a data management plan that includes use of an appropriate database to safeguard and maintain the integrity of the data. If proposing a clinical trial that requires oversight by a Regulatory Agency, the trial must use a 21 CFR 11-compliant database and appropriate data standards.For the purposes of this funding opportunity, Regulatory Agency refers to the U.S. Food and Drug Administration (FDA) or any relevant international regulatory agency unless otherwise noted.If the proposed clinical research involves the use of a drug that has not been approved by the relevant Regulatory Agency for the country where the research will be conducted, then submission of an Investigational New Drug (IND) application, or equivalent, that meets all requirements under 21 CFR 312 may be required. It is the responsibility of the applicant to provide evidence from the IRB of record or the relevant Regulatory Agency if an IND, or equivalent, is not required. If an IND, or equivalent, is required, the regulatory application must be submitted to the relevant Regulatory Agency within 12 months of the CTRA award start date. The IND, or equivalent, should be specific for the product and indication to be tested in the proposed clinical trial. For more information on IND applications specifically, the FDA has provided guidance at https://www.fda.gov/drugs/types-applications/investigational-new-drug-ind-application.If the investigational product is a device, then submission of an Investigational Device Exemption (IDE), or equivalent, application that meets all requirements under 21 CFR 812 may be required. It is the responsibility of the applicant to provide evidence if an IDE, or equivalent, is not required. If an IDE, or equivalent, is required, the IDE application, or equivalent, must be submitted to the relevant Regulatory Agency within 12 months of the CTRA award start date. The IDE, or equivalent, should be specific for the device and indication to be tested in the proposed clinical trial.Womens Health: The CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women's health outcomes and/or advancing knowledge for women's health. Applications proposing research that solely address womens health may also consider the FY24 PRORP WHRA mechanism, Funding Opportunity Number HT942524PRORPWHRA.Use of Department of Defense (DOD) or VA Resources: If the proposed research involves access to DOD or VA resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. Refer to Section II.D.2.b.ii, Full Application Submission Components, for detailed information.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated total costs budgeted for the entire period of performance for an FY24 PRORP CTRA should not exceed $1.5M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $6.0M to fund approximately four CTRA applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

The multi-agency Ecology and Evolution of Infectious Diseases program supports research on the ecological, evolutionary, organismal, and social drivers that influence the transmission dynamics of infectious diseases. The central theme of submitted projects must be the quantitative, mathematical, or computational understanding of pathogen transmission dynamics. The intent is discovery of principles of infectious disease (re)emergence and transmission and testing mathematical or computational models that elucidate infectious disease systems. Projects should be broad, interdisciplinary efforts that go beyond the scope of typical studies. They should focus on the determinants and interactions of (re)emergence and transmission among any host species, including but not limited to humans, non-human animals, and/or plants. This includes, for example, the spread of pathogens; the influence of environmental factors such as climate; the population dynamics and genetics of vectors and reservoir species or hosts; how the physiology or behavior of the pathogen, vector, or host species biology affects transmission dynamics; the feedback between ecological transmission and evolutionary dynamics; and the cultural, social, behavioral, and economic dimensions of pathogen transmission and disease. Research may be on zoonotic, environmentally-borne, vector-borne, enteric, or respiratory pathogens of either terrestrial, aquatic, or marine systems and organisms, including diseases of animals and plants, at any scale from specific pathogens to inclusive environmental systems. Proposals for research on disease systems of public health concern toLow- or Middle-Income Countries (LMICs) are strongly encouraged, as are disease systems of concern in agricultural systems. Investigators are encouraged to develop the appropriate multidisciplinary team, including for example, anthropologists, modelers, ecologists, bioinformaticians, genomics researchers, social scientists, economists, oceanographers, mathematical scientists, behaviorists, epidemiologists, evolutionary biologists, entomologists, immunologists, parasitologists, microbiologists, bacteriologists, virologists, pathologists or veterinarians, with the goal of integrating knowledge across disciplines to enhance our ability to predict and control infectious diseases.

This program provides funding to U.S. colleges and universities to foster collaborative research partnerships with industry and government, focusing on innovative solutions to critical national challenges while developing a skilled workforce in science and engineering.

This funding opportunity provides financial support to organizations working to strengthen export controls and compliance measures against the Chinese Communist Party's efforts to acquire advanced technologies for military and economic purposes.

The Fiscal Year 2025 Air Force Young Investigator Research Program (YIP) intends to support individual early in career scientists and engineers who have received Ph.D. or equivalent degrees by 01 April 2017 or later showing exceptional ability and promise for conducting basic research. The program objective is to foster creative basic research in science and engineering; enhance early career development of outstanding young investigators; and increase opportunities for the young investigator to recognize the Air Force and Space Force mission and related challenges in science and engineering.Individual awards are made to U.S. institutions of higher education, industrial laboratories, for- profit, or non-profit research organizations where the principal investigator (PI) is employed on a full-time basis and holds a regular, non-contractor position. A YIP PI must be a U.S. citizen, national, or permanent resident. Researchers working at a Federally Funded Research and Development Center, or a Department of Defense (DoD) Laboratory are not eligible for this competition.YIP awards are funded up to $150,000 per year for three years, for a total of $450,000. No single year may exceed $150,000. Please review the remainder of this announcement for additional information.Under this competition, an anticipated thirty-seven (37) traditionally funded YIPs and two YIPs funded in partnership with the Laboratory for Physical Sciences (LPS) in the Quantum Information Sciences research discipline may be awarded. There may be potential for an additional 37 YIPs funded from other AFOSR research funding. All actions are based on the availability of funds.

This funding opportunity provides financial support for research consortia focused on improving the diagnosis and treatment of rare diseases through collaborative, patient-centered clinical studies involving multiple institutions and patient advocacy groups.

This funding opportunity provides financial support for research projects that enhance understanding of climate variability in the eastern equatorial Pacific, targeting institutions, non-profits, and governments involved in climate science and modeling.

Background The Water Resources Development Act (WRDA) of 2000 authorized the Comprehensive Everglades Restoration Plan (CERP) as a framework for modifications and operational changes to the Central and Southern Florida Project needed to restore the south Florida ecosystem. Provisions within WRDA 2000 provided for specific authorization for an adaptive assessment and monitoring program. The CERP Monitoring and Assessment Plan (MAP) was developed as a framework for measuring and understanding system responses to CERP, determining how well CERP is meeting its goals and objectives, and identifying opportunities for improving the performance of CERP where needed. REstoration, COordination, VERification (RECOVER) is a multiagency, multidisciplinary group responsible for implementing the CERP MAP. Wading birds are a dominant guild of predators in the Everglades ecosystem and their breeding population responses are considered to be integrative and reflective of many aspects of wetland habitat and systemwide hydrologic conditions; thus wading birds have been identified as a key suite of indicator species of restoration success. Restoration has been centered on several trophic hypotheses regarding wading birds (e.g., appropriate hydrology will increase fish and macroinvertebrate populations, enhanced foraging opportunities will increase wading bird breeding, and the return of flow to coastal regions will restore wading bird nesting in those areas). Without the appropriate monitoring of wading bird colonies, these hypotheses cannot be assessed and CERP may not achieve its goals. To determine if restoration effects are system-wide or local, it is necessary to monitor all patches of wading bird breeding activity across the south Florida ecosystem. The Lake Okeechobee basin is just one patch of the landscape hosting breeding wading birds, but the information gathered is vital to determine the success of CERP. This project will draw upon prior research conducted in the Everglades and in Lake Okeechobee basin and will continue to study how CERP restoration influences breeding and reproductive success of wading bird populations. Program Description/Objective The purpose of this research is to continue a long-term dataset used to record and monitor changes in annual numbers and reproductive success of breeding wading bird populations in the Lake Okeechobee basin. The project objectives include: Objective 1: Provide an annual summary with monthly temporal resolution of the size, location, and species composition of nesting colonies of wading birds breeding in the Lake Okeechobee basin. Objective 2: Provide an annual summary of quantitative information on nest success and nest productivity of the wading bird community; and Objective 3: The standardization of methods and integration of results from all projects monitoring wading birds in the south Florida ecosystem. Additionally, there is potential work related to using blue-listed unmanned aerial vehicles to develop and assess alternative monitoring methods of wading bird breeding activity. The budget and scope should be developed as an Optional Task in addition to the work described above. There is also potential work related to the development of a predictive model of Lake Okeechobee wading bird breeding to be used as a RECOVER Performance Measure. The budget and scope should be developed as an Optional Task in addition to the work described above. Public Benefit This project will play a critical role in building the knowledge base for the population dynamics of wading birds near and in Lake Okeechobee as it relates to ecological conditions including restoration. Data to be collected includes nesting characteristics such as breeding timing, colony formation and size, nesting characteristics, nesting success, and species interactions. Wading birds are an ecological indicator of ecosystem health which is important to the public. Improvements in ecosystem health as result of ecological restoration and habitat management provide a direct benefit to the public by improving outdoor recreation opportunities and the economy of South Florida.

This grant provides funding to support the development of emerging climate scientists and innovators from diverse backgrounds at research institutions, focusing on professional growth and community engagement to address climate change challenges.

This grant provides funding for innovative cancer research projects that address the unique health needs of military personnel, veterans, and their families, focusing on specific cancer types and strategic goals related to prevention, diagnosis, treatment, and survivorship.

This funding opportunity is designed for organizations affiliated with the Great Lakes Northern Forests CESU Program to develop a user-friendly tool for assessing the impact of contaminated sediments on aquatic life.

This funding opportunity supports a wide range of research in Earth and space sciences, inviting universities, non-profits, private companies, and international entities to advance scientific knowledge and technology development aligned with NASA's strategic goals.

This grant enables U.S. and UK researchers to collaborate on engineering and physical sciences projects by submitting a single proposal for joint funding and review, streamlining international research efforts.

PLEASE NOTE: this program has MANDATORY Notices of Intent, which are due via NSPIRES by April 15, 2024. See the full posting on NSPIRES for details. Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package. The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) 2024 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2024. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates (Tables 2 and 3), a table that provides a very top level summary of proposal contents (Table 1), and the full text of the ROSES-2024 "Summary of Solicitation", may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2024. This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2024table2 and http://solicitation.nasaprs.com/ROSES2024table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH24ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on C.8 Lunar Data Analysis Program (.pdf) to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read C.1 Planetary Science Research Program Overview (.pdf) from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview. Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2024 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at sara@nasa.gov, but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list. Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2024 blog feed for amendments, clarifications, and corrections to at https://science.nasa.gov/researchers/solicitations/roses-2024/, and (3) The ROSES-2024 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar).

The NOAA Climate Program Office (CPO) has issued a funding opportunity under its FY2025 Atmospheric Chemistry, Carbon Cycle, and Climate (AC4) Program. This program seeks to fund research that advances understanding of the Earth System, focusing specifically on the urban atmosphere and the impacts of climate and air quality mitigation strategies. Proposals are encouraged to address processes influencing atmospheric trace gases and aerosols and to support carbon and pollution management by contributing to improved models and data. The AC4 Program will accept proposals for research projects with budgets averaging $250,000 per year over a period of 2-3 years, with total anticipated awards ranging from 8 to 10. Proposals may be funded as grants; however, cooperative agreements may be issued if NOAA anticipates substantial involvement in project implementation, such as collaboration between NOAA scientists and recipients. Federal agencies are ineligible to receive these funds, but eligible applicants include institutions of higher education, nonprofits, commercial organizations, international entities, and state, local, and tribal governments. This opportunity does not have a cost-sharing requirement. Key submission deadlines are as follows: Letters of Intent (LOIs) are strongly encouraged and should be submitted via email by September 18, 2024, though submission of an LOI is not required to proceed with a full application. The deadline for full applications is December 9, 2024, at 11:59 p.m. ET. Applications must be submitted through Grants.gov, and applicants are urged to complete all necessary registrations well in advance. Required documents include project narratives, data management plans, diversity statements, budget tables and narratives, current and pending support, and vitae for all principal investigators (PIs). NOAA emphasizes diversity, equity, inclusion, and accessibility (DEIA) in its funded activities and requires a DEIA statement to highlight how the project will advance participation of underrepresented groups in STEM fields. NOAA will review applications based on criteria including technical merit, qualifications, project costs, and the significance of expected contributions to NOAA’s climate research goals. Reviews will occur in two stages: an initial technical review by subject matter experts, followed by a program relevance assessment. Selection factors include geographical balance, research priority alignment, and participation of targeted groups. Award notifications are expected in spring 2025, contingent on federal appropriations, with project start dates around September 1, 2025. For questions, applicants may reach out to the CPO or consult specific competition managers listed in the NOFO. Further details on submission requirements, NOAA policies, and guidance on Grants.gov are provided in the official announcement and on the CPO website.

With this solicitation, NIJ seeks applications to support the operations of the Committee on Law and Justice of the National Academies of Sciences, Engineering, and Medicine and its work to develop knowledge to inform public policy interventions that: support the fair and impartial administration of justice for all Americans, restore trust in the Justice System, and support the reduction of crime and recidivism.

This funding opportunity supports innovative research aimed at improving the quality of life for melanoma survivors and their families through evidence-based practices and psychosocial interventions.

This funding opportunity provides financial support to state, local, Tribal, and territorial governments for researching, mapping, and assessing landslide hazards to improve public safety and community resilience.

This funding opportunity supports small businesses and innovators in developing advanced ruggedized sensor systems to improve vehicle safety and visibility, particularly in challenging driving conditions for both military and civilian applications.