Federal Science and Technology Grants

This grant provides funding for organizations to archive, restore, and develop tools for planetary data, supporting research in space and Earth sciences.

The grant titled "ROSES 2024: C.27 Lucy in the L4 Trojans Participating Scientist Program" is a funding opportunity by NASA's Science Mission Directorate for research and technology in space and Earth sciences, with a specific focus on the Lucy in the L4 Trojans project, and it invites proposals from various types of organizations, both domestic and foreign.

Grant Title: Request for Information (RFI) - Three-Dimensional Characterization of the Subsurface by Advanced Modeling and Sensing Techniques: This grant seeks innovative ideas and technologies to improve the exploration and 3-D mapping of critical mineral deposits in the subsurface, aiming to enhance the accuracy and efficiency of mineral exploration in order to reduce U.S. reliance on foreign sources.

The LRP seeks to improve quality of life of persons with lupus using an intervention at the individual and/or health care system level. This effort is supported through two related, but separate, award mechanisms, the LRP TVDA and the LRP Transformative Vision Award (TVA).The TVDA is intended to provide support to conduct pilot studies that will generate preliminary data and demonstrate feasibility for achieving the aims of a future TVA project.The TVA supports applications that will fulfill an extraordinary vision for dramatically improving the quality of life of persons with lupus in the near term using an intervention at the individual and/or health care system level.Applicants are not required to be awarded a TVDA to submit a TVA application.Examples of suitable LRP TVDA preliminary studies would include development and optimization of an intervention, intervention safety studies, or refinement of trial design.The CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women's health outcomes and/or advancing knowledge for women's health.

This program provides funding to U.S. colleges and universities for collaborative materials research and education initiatives that promote innovation and broaden participation in STEM fields.

This funding opportunity supports U.S. higher education institutions in developing advanced research platforms for innovative materials, focusing on alloys, amorphous, and composite materials, while promoting collaboration and engagement across diverse scientific disciplines.

This funding opportunity provides support for clinical researchers to develop independent careers in patient-centered and comparative effectiveness research, focusing on improving healthcare delivery for underserved populations in the U.S.

This funding opportunity supports innovative, time-sensitive research projects that enhance ongoing clinical studies related to arthritis, musculoskeletal, and skin diseases by leveraging existing patient data and samples.

The "FY25 Ocean Acidification Coastal Research: Uniting Investigations and Shipboard Experiments (OA CRUISE)" grant aims to fund projects that enhance coastal research on ocean acidification, particularly in relation to the upcoming East Coast Ocean Acidification Cruise (ECOA-4) in summer 2026, focusing on the impacts of ocean chemistry changes on marine ecosystems and coastal communities.

This program provides funding for researchers to analyze publicly available data about Mars to improve our understanding of its surface, climate, and potential for supporting life.

This grant provides over $8 million to U.S.-based individuals and organizations for innovative projects that combine solar energy systems with cattle grazing to promote sustainable land use and support rural economies.

The purpose of this NOFO is to solicit applications for the Exploratory Advanced Research (EAR) Program to award cooperative agreements. The NOFO will result in the distribution of up to $2,000,000.The EAR program addresses the need for longer-term, higher risk breakthrough research with the potential for transformational improvements to plan, build, renew, and operate safe, congestion free, and environmentally sound transportation systems. The overall goal of this NOFO is to collect diverse pedestrian data, provide researchers access to this data, and encourage novel approaches for analysis of diverse data in support of increasing the safety and mobility of all people. The authority to enter into a cooperative agreement for this effort is found under 23 U.S.C. 502(b)(3)(C ). And funding for this effort is provided in in BIL (P. L. 117-58) Sec. 11101(c)(1)(A).

This funding opportunity provides financial support to Sea Grant Programs for creating hands-on aquaculture internships that help develop workforce skills in the U.S. aquaculture industry for students and interested individuals, including veterans and commercial fishers.

The Office of Sciences (SC) mission is to deliver scientific discoveries and major scientific tools to transform our understanding of nature and advance the energy, economic, and national security of the United States (U.S.). SC is the Nations largest Federal sponsor of basic research in the physical sciences and the lead Federal agency supporting fundamental scientific research for our Nations energy future. Science for energy, economic and national securitybuilding a foundation of scientific and technical knowledge to spur discoveries and innovations for advancing the Departments mission. SC supports a wide range of funding modalities from single principal investigators to large team-based activities to engage in fundamental research on energy production, conversion, storage, transmission, and use, and on our understanding of the earth systems. The frontiers of scienceexploring natures mysteries from the study of fundamental subatomic particles, atoms, and molecules that are the building blocks of the materials of our universe and everything in it to the DNA, proteins, and cells that are the building blocks of life. Each of the programs in SC supports research probing the most fundamental disciplinary questions.The 21st Century tools of scienceproviding the nations researchers with 28 state-of-the-art national scientific user facilities, the most advanced tools of modern science, propelling the U.S. to the forefront of science, technology development, and deployment through innovation.SC is an established leader of the U.S. scientific discovery and innovation enterprise. Over the decades, SC investments and accomplishments in basic research and enabling research capabilities have provided the foundations for new technologies, businesses, and industries, making significant contributions to our nations economy, national security, and quality of life.

This grant supports researchers in mathematical and statistical sciences to develop innovative tools and theories that address challenges in computation and big data, while fostering collaboration and training for early-career scientists.

This funding opportunity supports innovative research and development of high-temperature geothermal energy technologies to unlock vast electricity production potential from deep rock formations across the United States.

The U.S. National Science Foundations Directorate for Technology, Innovation and Partnerships (TIP) is charged with accelerating use-inspiredand translationalresearch and development (R) to advance U.S. competitiveness in key technology focus areas. The Use-Inspired Acceleration of Protein Design (USPRD) initiative will accelerate the translation of novel approaches to protein design and enable new applications of importance to the U.S. bioeconomy. Significant advances have been made in the ability of researchers to predict the three-dimensional (3D) structure of proteins from primary sequence, and to use that information to design proteins with desired characteristics. These advances have been enabled by: macromolecular modeling; training data available in repositories such as the Protein Data Bank (PDB); the application of artificial intelligence (AI) and machine learning; and high-throughput protein characterization. The improved accuracy of in-silico design has reduced the number of constructs that need to be validated in costly and time-consuming wet lab experiments. USPRD aims to advance protein design and its applications to the next level by: A. Accelerating the use of protein design technologies to enable applications beyond human therapeutics, e.g., applications to advanced materials, biomanufacturing, agriculture and food security, environmental remediation, sustainability, and climate-related challenges. B. Extending the range of accurate prediction models to enable the design of enzymes and families of enzymes. This will require models and tools that account for the dynamic nature of protein structures. USPRD seeks significant breakthroughs in the application of protein design through: a) Use-driven activities that design novel proteins with specific characteristics and demonstrate their application, e.g., the design and characterization of specific enzymes or enzyme families that promote sustainability by degrading specific bio-contaminants. b) Infrastructure components, such as software tools, datasets, and characterization services that can readily be accessed by protein designers. c) Designer-facing components that will ensure the accessibility of the infrastructure components and collaboration with protein designers engaged in the third-party use-driven activities. d) Ecosystem components, such as standards and roadmaps, that help coordinate the actions of multiple parties within the emerging ecosystem. This may also include open-source software and/or data repositories. e) Workforce components focused on the training of translational talent with the skills and passion to engage in use-driven protein design activities. USPRD will use the Ideas Lab process (see PAPPG Chapter II.F.6),starting with an intensive meeting that brings together multiple diverse perspectives. A key aim of this Ideas Lab workshop will be to identify an aggressive (but attainable) set of use-driven activities together with the infrastructure component breakthroughs, designer-facing components, and ecosystem components required to realize them. USPRD includes two tracks: Track I. Use-driven application for small binders. Track II. The design and use of enzymes and families of enzymes.

This funding opportunity provides financial support for cultural and educational programs that promote mutual understanding and cooperation between the United States and Mexico, targeting nonprofit organizations, educational institutions, and individuals who collaborate with Mexican partners.

This funding opportunity is designed to empower emerging leaders in the space sector across the Middle East and North Africa by providing training and resources to enhance collaboration with the United States in space policy and commerce.

This funding opportunity is designed to support the University of Wisconsin in conducting research and developing innovative tools in forensic science to improve public safety and the criminal justice system.