Grants for Independent School Districts

The main objective of this NOFO is to foster development and testing of technologies adaptable to aging-related changes in older adults (aged 65 years or older) with T1D to improve diabetes management and quality of life. Older adults may have increased vulnerability to hypoglycemia, cognitive impairment and/or multiple co-morbidities which may affect the risks and benefits of these technologies in this population. Projects will be funded to a) develop and test new technologies and b) to adapt and test existing technologies. It is expected that aging-adaptive diabetes technologies that address barriers for use among older adults with T1D will improve usability, adoption and adherence decreasing the risk of hypoglycemia (and hypoglycemia unawareness) while enhancing glycemic control, facilitating better diabetes management, and improving quality of life for these individuals and their caregivers.

This Notice of Funding Opportunity (NOFO) requests applications to explore human pancreatic tissues and the immune compartment for the discovery of specific signaling or processing pathways that may contribute to the asymptomatic phase of T1D, the discovery of early biomarkers of T1D pathogenesis, the development of diagnostic tools for the detection and staging of early T1D in at-risk or recently-diagnosed individuals, and/or the identification and biological validation of therapeutic targets for the development of preventative or early treatment strategies. Successful applicants will join the Consortium on Beta Cell Death and Survival (CBDS), whose mission is to better define and detect the mechanisms of beta cell stress and destruction central to the development of T1D in humans, with the long-term goal of protecting the residual beta cell mass in T1D patients as early as possible in the disease process, and of preventing the progression to autoimmunity. The CBDS is part of a collaborative research framework, the Human Islet Research Network (HIRN, https://hirnetwork.org/), whose overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. This NOFO will only support studies with a primary focus on increasing our understanding of human disease biology (as opposed to rodent or other animal models). This NOFO will not accept applications proposing a clinical trial.

This funding opportunity supports research aimed at improving primary care delivery and outcomes, particularly focusing on enhancing access, equity, and the overall quality of healthcare for patients and communities.

The California Department of Education (CDE), Early Education Division (EED) announces the availability of approximately $32.7 million to expand California State Preschool Program (CSPP) services statewide, as appropriated in the 2021 Budget Act. The CSPP funds are available for local educational agency (LEA) applicants to provide full-day/full year, part-day/part-year, or any combination thereof, of CSPP services.; The California Department of Education (CDE), Early Education Division (EED) announces the availability of approximately $32.7 million to expand California State Preschool Program (CSPP) services statewide to eligible children and families, as appropriated in the 2021 Budget Act. The CSPP funds are available for local educational agency (LEA) applicants to provide full-day/full year, part-day/part-year, or any combination thereof, of CSPP services. Funding will be allocated by county, and within each county by the Local Planning Council (LPC) priority area. Funding awards will be made based on the LPC priority in the order of highest passing score first. In the event that a county does not fully utilize its allocation, the funding will be redistributed to other applicants, based on the LPC priority followed by highest score. In the event of any tie in scoring, the applicant with headquarters in the service delivery area(s) specified in the Request for Application (RFA) will be given preference over applications with the same score that are not headquartered in the specified area(s), per California Code of Regulations, Title 5 (5 CCR) Section 17723. The CDE encourages all eligible applicants to apply. The CSPP funds will be used to provide services for eligible children beginning in fiscal year (FY) 2024–25.

This Notice of Funding Opportunity (NOFO) invites applications for Diabetes Research Centers (DRCs) that are designed to support and enhance the national research effort in diabetes, its complications, and related endocrine and metabolic diseases. The purpose of this Centers program is to bring together basic and clinical investigators to enhance communication, multidisciplinary collaboration, and effectiveness of ongoing research in Diabetes Research Center topic areas. By providing shared access to specialized technical resources (research cores) and supporting a Pilot and Feasibility Program (P and F), DRCs are intended to create an environment that provides the capability for accomplishments greater than those that would be possible by individual research project grant support alone. New Center programs that bring in diverse perspectives, propose unique scientific themes, or provide innovative resources are encouraged. Emphasis will be placed on Center programs that propose enhanced synergies with other NIDDK-funded programs as well as providing a rich mentoring environment for future diabetes researchers. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

The Office of Refugee Resettlement (ORR), within the Administration for Children and Families (ACF), announces the availability of funds for the National Refugee Leadership and Lived Experience Council (NRLLEC) Program. The NRLLEC is a new program funded by the Office of Refugee Resettlement (ORR) that designs, implements, evaluates, and promotes national-level councils consisting of refugees and other ORR-eligible populations who have resettled into communities throughout the United States within the last five years. The NRLLEC Program will facilitate a National Young Adult Leadership Council comprised of members ages 18 to 24 every year for three years, as well as two additional councils with thematic focus to be determined in consultation with ORR. The NRLLEC Program will design, implement, evaluate, and promote five councils during the three-year project period. The programs primary goal is to positively impact the lives of council members and their refugee and larger communities by building council members capacity to serve as leaders. In addition, ORR recognizes that its engagement with these groups will enhance its ability to gather information from individual members firsthand about their lived experiences integrating into the United States. This will help inform ORR and its recipient network about how to best meet refugee needs through enhancing or changing ORR guidance, programming, and future councils. The NRLLEC Program will foster inclusivity, with council members attuned to the diversity, demographics, needs, and viewpoints of ORRs eligible population (https://www.acf.hhs.gov/orr/programs/refugees/factsheets). The NRLLEC Program will not seek consensus advice from council members.

The purpose of this notice of funding opportunity (NOFO) is to support investigators who will form large, electronically-generated cohorts in Latin America of HIV-negative men who have sex with men (MSM), transgender women (TGW), people who inject drugs (PWID), and/or female sex-workers and follow them to study the epidemiology of HIV incidence. Continued follow-up of those persons who acquire HIV will be required to study the epidemiology of viral suppression. Comparisons of participants by seroconverstion status will provide information on geographic and socially defined areas of high HIV incidence as well as on both personal and structural vulnerabilities to HIV infection. Among participants who seroconvert, comparisons of those becoming rapidly engaged in care and who reach non-detectable HIV levels to those whose virus remains detectable will inform on the treatment of HIV in Latin American countries. This NOFO will allow digital trials to determine optimal study approaches, or to pilot evidence-based digital (mHealth and online) HIV prevention and treatment interventions to both reduce HIV incidence and improve treatment in the most vulnerable populations.Letter of Intent Due Date(s) 30 days prior to the application due date

USAID/Rwanda Strengthening Equitable Education for the Deaf (SEED) The overall objective of the Strengthening Equitable Education for the Deaf (SEED) Activity is to improve reading outcomes for pre-primary and lower primary school learners who are deaf or hard of hearing (D/HH) by the end of Primary 3 (P3 or Grade 3) in Rwanda. This Activity seeks to achieve this objective through three intermediate (3) results: Improve parental, community, and youth capacity to support Rwandan Sign Language (RSL) acquisition and literacy for learners who are deaf and hard of hearing; Improve access to quality, relevant bilingual RSL (Rwandan Sign Language (RSL) to Kinyarwanda and English literacy) teaching methodologies to improve reading outcomes for pre-primary and lower primary learners who are deaf or hard of hearing; and Strengthen national and decentralized Government of Rwanda (GOR) systems to better serve learners who are deaf or hard of hearing

This program will support projects to identify and characterize factors associated with gender-affirming hormone therapy (GAHT) that may impact/contribute significantly to the prevention and treatment of HIV and/or co-infections with other sexually transmitted infections (STI)s in transgender individuals. For this funding opportunity GAHT is defined as a medical intervention, including but not limited to estrogen and/or testosterone treatment, that results in acquisition of secondary sex characteristics that align with an individual's gender identity. A growing body of data indicates that GAHT may impact the effectiveness and implementation of biomedical HIV prevention or treatment strategies and/or co-infections with other STIs. A number of factors in transgender populations present research challenges including variability in GAHT regimens, use of auxiliary drugs during GAHT care, access to participants, and access to existing cohorts, datasets, and samples. Consideration of appropriate controls, including cis-gender men and women is also a barrier. Recent studies demonstrating recruitment and retention of participants undergoing GAHT provide the opportunity to build on those studies and provide confidence that these critical studies are feasible.Letter of Intent Due Date(s) 30 days prior to the application due date

This funding opportunity supports physician-scientists with clinical doctorate degrees who are transitioning to independent research careers in non-malignant hematology, enabling them to advance their research on blood disorders.

The purpose of this Alzheimers Disease-Related Dementia (ADRD) initiative is to promote the development and distribution of innovative technologies, methods, protocols, and biomedical materials that enhance combined human neuropathology and neuroimaging research with data aimed at understanding the underlying pathophysiology of in vivo imaging results typically associated with vascular contributions to cognitive impairment and dementia (VCID) in TBI-related dementia and other ADRD diagnoses. Resources developed under this FOA must follow open data sharing practices and are intended to expand the broader research communitys capacity to perform research aimed at neuropathologically-informed understanding of the vascular pathophysiology of clinically-relevant, in vivo neuroimaging findings.Letter of Intent Due Date(s) Not Applicable

The "Specialized Programs of Research Excellence (SPOREs) in Cancer Health Disparities and Minority Health (CHD-MH)" grant is designed to fund research programs that aim to improve the prevention, early detection, diagnosis, and treatment of cancer in underserved and/or underrepresented populations, with a focus on translating research findings into real-world applications.

To equip California youth with knowledge and skills to live tobacco-, vape-, and nicotine-free by providing leadership and guidance for the development and implementation of school-based education, intervention, counseling, and youth development activities.;  The Tier 1, Cohort T Grant is available for a three-year period from July 1, 2024, to June 30, 2027.  The grant award period is for three years; however, if funded, one Grant Award Notification (GAN) will be issued.  County offices of education (COEs), school districts, direct-funded charter schools, and consortia of qualifying local educational agencies (LEAs) serving grades six through twelve (6–12) in California are eligible to apply if they meet the eligibility requirements. To receive TUPE grant funding, all TUPE grantees are required to: (1) adopt tobacco-free campus policies that prohibit the use of products containing tobacco and nicotine, including, but not limited to, smokeless tobacco, snuff, chew, clove cigarettes, and electronic cigarettes (e-cigarettes), and (2) conduct the district-level CHKS Core Module with the subgroup population of students in grades five or six, and seven, nine, and eleven.

The purpose of this notice of funding opportunity (NOFO) is to support the evaluation of early-stage diagnostics and novel diagnostic strategies for Tuberculosis (TB) in the context of existing clinical algorithms in TB endemic countries. Evaluation studies should: 1) perform proof-of principle studies of novel diagnostic tests and strategies for TB, including among people living with HIV (PLWH) and 2) provide feedback to diagnostic developers and policy makers on the performance of the technologies and most effective strategies for use of the diagnostic technologies in an endemic setting.

This program provides funding to public school districts and area career and technical schools for necessary improvements to their facilities.

This funding opportunity supports collaborative research projects in neurology, encouraging diverse teams to tackle significant scientific questions that advance the field through interdependent studies.

Notice of Funding Opportunity Description Background Although vaccines are among the most effective approaches to control viral diseases, developing a prophylactic or therapeutic HIV vaccine has proven elusive. There are no licensed vaccines for HIV. Strategies for induction of HIV broadly neutralizing antibodies will likely require repeated exposures over long periods, including immunization with distinct antigens in sequential order. Such immunization strategies will require development of technologies for controlled vaccine release. Recent advances in materials-based science, controlled release technologies, delivery systems, and immunology provide opportunities to enhance the quality, potency and durability of vaccine-induced T cell and antibody responses to HIV-1. Materials-based approaches can be engineered to improve the stability, spatiotemporal release, and presentation of multiple vaccine components; for example, by controlling the time frame and dose of vaccine delivery over days to weeks. Recent studies have shown that a slow-release vaccine is superior to bolus administration at inducing breadth, potency, and durability of antibody responses to HIV antigens by prolonging antigen exposure in the germinal centers, thereby enhancing the maturation of B cells and generating stronger humoral immune responses. Further research is needed to elucidate the mechanisms underlying the immunological improvements observed with slow-release vaccine delivery and to translate such concepts into clinical application. It will be crucial to determine how the duration of exposure to vaccine components impacts immune cell biology, and how to calibrate vaccine release to improve responses while avoiding immune exhaustion and over-activation. Advancing safe, effective, and well-tolerated controlled release vaccines is an unmet need that may enhance vaccine effectiveness and practicality, leading to better adherence to complex regimens, fewer adverse reactions, and cost savings. Finally, iterative behavioral studies during product development to determine vaccine/provider product expectation/preferences are critical to facilitate product uptake and use.

The purpose of this notice of funding opportunity (NOFO) is to invite applications for the Centers for Research in Emerging Infectious Diseases (CREID) Network Coordination Center (CC). The CREID Network, comprised of all recipients under this NOFO and the companion NOFO [insert NOFO number here], serves to expand knowledge on re-emerging and emerging infectious diseases (re/EIDs) around the globe where outbreaks are most likely to occur while developing expertise, capacity, and readiness to address outbreak-related research. The CC will serve to advance, facilitate, and coordinate select scientific, data and resource management, communication, administrative, and leadership efforts during both outbreak and non-outbreak periods among the CREID Networks centers and stakeholders in a collaborative and cooperative fashion.

The purpose of this notice of funding opportunity (NOFO) is to invite applications for Research Centers (RC) to support the Centers for Research in Emerging Infectious Diseases (CREID) Network. The CREID network serves to expand knowledge on re-emerging and emerging infectious diseases (re/EIDs) around the globe where outbreaks are most likely to occur. Multi- and inter-disciplinary teams of domestic and international investigators will conduct innovative, collaborative One Health (approach that recognizes the health of humans is interconnected with that of animal health and the shared environment) based research projects and will mount a rapid and effective research response to outbreaks through coordination, collaboration, and cooperation across the CREID Network.

The Volunteer Fire Capacity (VFC) Program is a federally funded grant program that allows California to provide local and rural fire departments with minor firefighting, training, communications and safety equipment for their volunteer firefighters. The VFC Program is not intended for major equipment (fire engines, vehicles, etc.) or Capital repairs. The VFC Program has a 50/50 match requirement which means that the applying department must be able to meet the intended grant award, dollar for dollar. Awards for departments are set at a minimum of $500 with a maximum of $20,000. Amounts may be adjusted based on the grant funding available. For additional information please contact Megan Esfandiary at Megan.Esfandiary@fire.ca.gov or Bryan Giambrone at Bryan.Giambrone@fire.ca.gov.