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Grants for Independent School Districts

Explore 4,415 grant opportunities available for Independent School Districts

HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)
$350,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 28, 2025

Date Added

Mar 27, 2024

This funding opportunity provides financial support for researchers developing innovative, non-opioid treatments for various types of pain, with a focus on early-stage studies and collaboration with underrepresented populations.

Education
State governments
2024 D.E. & Jane Clark Fund
$10,000
Oregon Community Foundation
Private

Application Deadline

Jul 15, 2024

Date Added

Mar 25, 2024

The D.E. & Jane Clark Fund, established by the Oregon Community Foundation in 2013, is dedicated to supporting the general operations of nonprofits within Baker County and the town of North Powder. This fund focuses on charitable purposes, targeting organizations that contribute positively to these areas. The grant program offers financial support with an average grant size of $2,500, and considers applications from nonprofits with 501(c)(3) status, churches, and schools. Eligible proposals undergo a committee review process, with grants awarded during the fall season. The application window is open annually from June 1 to July 15, strictly disallowing multiyear funding requests. Applicants must use the MyOCF portal for submission, with required attachments including IRS 501(c)(3) tax-exempt status letters and organizational financial documents. Grant sizes typically range between $2,000 and $10,000. Grant renewed every year. Grant annual opening/closing deadline: June 1st to July 15th

Community Development
Nonprofits
FY24 Nonpoint Source Pollution Control Financial Assistance Program - Watershed-Based Planning (Section 319(h))
$750,000
Illinois Environmental Protection Agency
State

Application Deadline

May 1, 2024

Date Added

Mar 24, 2024

The Illinois EPA is seeking proposals for projects aimed at addressing nonpoint source (NPS) pollution to enhance the quality of Illinois' surface and groundwater. Funded through the Clean Water Act's Section 319(h), this program supports the development and implementation of watershed-based planning projects. These projects may include creating new watershed-based plans, updating existing plans, providing technical assistance for NPS pollution control, and conducting environmental and social indicator monitoring. The goal is to prevent, eliminate, or reduce water quality impairments through strategic planning and community engagement. Grant renewed every year.

Environment
Nonprofits
2024 Fall Heartland Area Community Grants
Contact for amount
Heartland Community Foundation
Private

Application Deadline

Nov 15, 2024

Date Added

Mar 24, 2024

The Heartland Area Action Fund, Stockton Community Fund, and Ellis, Rooks, and Trego County Legacy Funds are designed to support a wide range of charitable needs within the Heartland area, aiming to enhance the quality of life across these communities. The funds are unrestricted, allowing for flexible support of various community needs and populations, but some are geographically restricted to specific areas within Kansas, including Ellis, Rooks, Trego Counties, and the city of Stockton. Eligible applicants for these grants include 501(c)(3) nonprofit organizations, educational institutions, government entities, and religious organizations. Other individuals or organizations not falling into these categories are encouraged to partner with a fiscal agent that does. There's a universal grant application process for all requests, with two application cycles annually. Grant renewed every year. Grant Fall annual opening/ closing deadline: September 15th to November 15th

Community Development
Nonprofits
Racial Equity Research Grants
$75,000
Spencer Foundation
Private

Application Deadline

Jun 27, 2024

Date Added

Mar 24, 2024

The Racial Equity Research Grants program supports education research projects that will contribute to understanding and ameliorating racial inequality in education. We are interested in funding studies that aim to understand and disrupt the reproduction and deepening of inequality in education, and which seek to (re)imagine and make new forms of equitable education. Thus, we are interested in research projects that seek to envision educational opportunities in a multiplicity of education systems, levels, settings, and developmental ranges and that reach beyond documenting conditions and paradigms that contribute to persistent racial inequalities. Our goal for this program is to support rigorous, intellectually ambitious, and technically sound research that is relevant to the most pressing questions and compelling opportunities in relation to racial equity in education. In this cycle of funding, we will continue to fund scholarship focused on a range of communities and issues with respect to equity. We encourage proposals from across the methodological spectrum, including qualitative methods, mixed-methods, and quantitative methods. We want to especially encourage Racial Equity proposals that focus on the following areas: (1) innovative forms of measurement and assessment, (2) artificial intelligence (AI), and (3) current political challenges in k-12 and higher education around diversity, equity, and inclusion. As with other Spencer grant programs, this program is “field-initiated” in that proposal submissions are not required to be developed around a particular research topic, discipline, design, method, or geographic location. We will be accepting applications for projects ranging from one to five years with budgets up to $75,000. The Racial Equity Research Grants program supports education research projects that will contribute to understanding and disrupting racial inequality in education and work to reimagine generative possibilities to advance educational equity, with budgets up to $75,000 for projects ranging from one to five years. While the field of education has long focused on issues of rising inequality across the globe, we now find ourselves in a time of increased urgency given the current intersections of the COVID19 public health crisis, rapid shifts in educational systems, economic challenges, and growing civil resistance to systemic racism, Indigenous erasure, and anti-Blackness. There is perhaps no issue of greater importance right now than racial inequality across all systems and structures. We believe that educational research can play an important role in developing new forms of education that are humane, equitable, and just. As such, there is a pressing need for robust approaches to scholarship that can contribute consequentially to achieving equity in education. We encourage a wide range of methodological approaches to creatively and ambitiously engage in advancing racial equity. This program is “field-initiated” in that proposal submissions are not required to focus on a particular research topic, discipline, design, or method. We hope that scholars will identify the most compelling and needed areas of research. For instance, scholars might focus on: instructional challenges and innovations; racial and geographic disparities and promising directions for engaging and supporting children, families, and communities; informal learning environments and informal educators; assessment challenges and opportunities; climate change and equity, social-emotional learning and well-being; educator and leader development; digital learning environments; systems change and policy making; and intersections between housing, health, and education. We are interested in proposals at all levels and in all settings of learning, including early childhood, higher education, and in schools, families, and communities across the world. We are also interested in studies that seek to understand the situated experiences of minoritized groups, including but not limited to, Black, Latine/x, AAPI, and Indigenous communities. In addition, we are interested in studies that focus on those learners who are multiply marginalized, including intersections with English language learners, immigrants, students with disabilities, highly mobile and institutionalized youth (e.g., foster youth or those in youth prisons), LGTBQIA+ youth, and those in rural communities. Finally, we encourage proposals that are reflective of other international, national, and local contexts. We recognize that the experiences of inequality, as well as the histories and structures producing it, will vary. Thus, we expect to fund proposals that explore meanings and possibilities of equity, as well as explanations of inequality, in a variety of ways. For example, engaging and understanding issues of coloniality may be central to scholarship focused on and with Indigenous communities. We see wrestling with these complexities as necessary to cultivating educational equity. Finally, we especially welcome proposals that advance strength-based perspectives and push beyond solely documenting current paradigms. Our goal for this program is to support rigorous, intellectually ambitious, and technically sound research that is relevant to the most pressing questions and compelling opportunities in relation to racial equity in education. We seek to support scholarship that develops new foundational knowledge that may have a significant impact on practice and policy. We value work that fosters creative and open-minded scholarship, engages in deep inquiry, and examines robust questions related to education and inequality. We also value work that is engaging emerging possibilities. We invite proposals that aim to grow the current scope of research on racial equity, develop new knowledge through interdisciplinary scholarly engagement, and include collaboration in the service of increasing the impact of educational research. To this end, this program supports proposals from multiple disciplinary and methodological perspectives, both domestically and internationally, and from scholars at various stages in their careers. We anticipate that proposals will span a wide range of topics and disciplines. We expect and welcome methodological diversity in answering pressing questions; thus, we are open to projects that utilize a wide array of research methods including quantitative, qualitative, mixed-methods, ethnographies, design-based research, participatory methods, and historical research, to name a few. We are also interested in methodological research that can enable and support research on and with racialized communities that build capacity for equitable educational systems. This could include exploration of methods appropriate in small samples and populations, the development of new measures and indices, and studies regarding the impact of methods and algorithms on reducing or promoting inequality. We are open to projects that might incorporate data from multiple and varied sources or work closely with practitioners or community members over the life of the project. We expect that projects will interrogate the systems and structures that are associated with racial inequities. We seek proposals that focus on a strengths-based, rather than a deficit oriented, approach. A strengths-based perspective affirms and extends the knowledge, resources, goals, capacities, and interests of individuals, families, and communities, and identifies and builds upon existing assets and resources. LOI: May 29th 2024

Education
Nonprofits
2024 Fall Heartland Healthy Living Fund
Contact for amount
Heartland Community Foundation
Private

Application Deadline

Nov 15, 2024

Date Added

Mar 24, 2024

The Heartland Healthy Living Fund is a grant initiative designed to improve public health in Ellis, Rooks, and Trego Counties, Kansas. Established by the Kansas Health Foundation, this fund is part of the Giving Resources to our World (GROW II) match grant challenge. It aims to support programs and projects that promote healthy living by encouraging healthy lifestyles, behaviors, and environments. Grants will focus on preventative measures rather than healthcare services or support for existing illnesses. Grant renewed every year. Grant Fall annual opening/ closing deadline: September 15th to November 15th

Community Development
Nonprofits
FY24 Nonpoint Source Pollution Control Financial Assistance Program - Watershed-Based Plan Implementation and Other Activities (Section 319(h))
$4,000,000
Illinois Environmental Protection Agency
State

Application Deadline

May 1, 2024

Date Added

Mar 24, 2024

The Illinois Environmental Protection Agency (Illinois EPA) offers the Section 319(h) Grant Program to address nonpoint source (NPS) pollution affecting Illinois’ water resources. This program, funded through the Clean Water Act, supports projects that prevent, eliminate, or reduce water quality impairments caused by NPS pollution. Prioritized projects include those implementing approved watershed-based plans or Total Maximum Daily Load (TMDL) Implementation Plans, with activities ranging from BMP implementation to monitoring and outreach efforts. The program encourages applications that demonstrate a comprehensive approach to NPS pollution control and offer sustainable environmental benefits. Grant renewed every year.

Environment
Nonprofits
2024 Fall Dane G. Hansen Community Grant Fund
Contact for amount
Heartland Community Foundation
Private

Application Deadline

Nov 15, 2024

Date Added

Mar 24, 2024

About the Fund The Dane G. Hansen Foundation of Logan, KS, partners with the Greater Salina Community Foundation (GSCF) and the Greater Northwest Kansas Community Foundation (GNWKCF) to help improve the quality of life for communities in 26 counties of Northwest Kansas. GSCF and 11 of its affiliate foundations are allocated funding for grants to distribute to 14 counties for charitable projects through a competitive application process. What do the funds support? Grants will be awarded to projects or programs that address the following areas: Education: Enhances the learning environment and expands opportunities for students. Provides increased self-reliance on personal life skills and workforce capability. Health Care: Ensures access to quality health services and promotes healthy life practices. Community Social Services & Security: Enhance access to social services needed for individuals of special needs and supports systems to provide community disaster relief and general community emergencies. Conservation & Environment: Support efforts to improve and maintain high air and water quality, appreciation for our natural environment and enhances economic and social benefits of outdoor resources. Arts & Culture: Provide cultural and artistic opportunities to enhance the quality of life for local residents and to encourage tourism and the exchange of ideas. Community Beautification: Support efforts to improve and maintain public spaces to enhance community pride and encourage socialization among residents. Preference will be given to applications that include community involvement and volunteerism. Grants may not be awarded to: reduce or replace regular budgetary needs for programs or projects that are tax-supported support endowment or operational expenses Grant renewed every year. Grant Fall annual opening/ closing deadline: September 15th to November 15th

Community Development
Nonprofits
Spring Heartland Area Community Grants
Contact for amount
Heartland Community Foundation
Private

Application Deadline

May 15, 2024

Date Added

Mar 24, 2024

The Heartland Area Action Fund, Stockton Community Fund, and Ellis, Rooks, and Trego County Legacy Funds are designed to support a wide range of charitable needs within the Heartland area, aiming to enhance the quality of life across these communities. The funds are unrestricted, allowing for flexible support of various community needs and populations, but some are geographically restricted to specific areas within Kansas, including Ellis, Rooks, Trego Counties, and the city of Stockton. Eligible applicants for these grants include 501(c)(3) nonprofit organizations, educational institutions, government entities, and religious organizations. Other individuals or organizations not falling into these categories are encouraged to partner with a fiscal agent that does. There's a universal grant application process for all requests, with two application cycles annually. Grant renewed every year. Grant Spring annual opening/ closing deadline: March 15th to May 15th

Community Development
Nonprofits
FY25 Program Enhancement Projects for Adult Education - Section 225 Corrections Education
$25,000
Connecticut Department of Education
State

Application Deadline

May 3, 2024

Date Added

Mar 24, 2024

Under the broader Program Enhancement Projects for Adult Education, Section 225 targets corrections education and education for other institutionalized individuals in Connecticut. This initiative seeks to provide educational services to those likely to leave correctional institutions within five years, aiming to enhance their literacy, employment, and reintegration prospects. It emphasizes the importance of basic skills and literacy for effective societal participation. Funded through the Workforce Innovation and Opportunity Act (WIOA), the project promotes collaboration to meet the educational needs of this specific population, with a commitment to multi-year funding that spans from fiscal year 2025 to 2028. Grant renewed every year. It will be a 4-year program ( last application probably around May 2027)

Education
Nonprofits
FY25 Program Enhancement Projects for Adult Education - Section 243 Integrated English Literacy and Civics Education (IELCE)
$25,000
Connecticut Department of Education
State

Application Deadline

May 3, 2024

Date Added

Mar 24, 2024

Under the broader Program Enhancement Projects for Adult Education, Section 243 focuses on Integrated English Literacy and Civics Education (IELCE). This program supports English language learners in improving their literacy and understanding of American civics, aiming for better integration, employment, and educational opportunities. Eligible providers are encouraged to propose projects that combine IELCE educational services with integrated education and training (IET), reflecting the Workforce Innovation and Opportunity Act’s (WIOA) objectives. This funding opportunity, spanning fiscal years 2025 through 2028, promotes collaborations to fulfill the educational needs of English language learners in Connecticut. Grant renewed every year. It will be a 4-year program ( last application probably around May 2027)

Education
Nonprofits
Spring Heartland Healthy Living Fund
Contact for amount
Heartland Community Foundation
Private

Application Deadline

May 15, 2024

Date Added

Mar 24, 2024

The Heartland Healthy Living Fund is a grant initiative designed to improve public health in Ellis, Rooks, and Trego Counties, Kansas. Established by the Kansas Health Foundation, this fund is part of the Giving Resources to our World (GROW II) match grant challenge. It aims to support programs and projects that promote healthy living by encouraging healthy lifestyles, behaviors, and environments. Grants will focus on preventative measures rather than healthcare services or support for existing illnesses. Grant renewed every year. Grant Spring annual opening/ closing deadline: March 15th to May 15th

Community Development
Nonprofits
FY25 Program Enhancement Projects for Adult Education - AEFLA Section 231 Comprehensive Adult Education Services
$25,000
Connecticut Department of Education
State

Application Deadline

May 3, 2024

Date Added

Mar 24, 2024

The Program Enhancement Project for Adult Education, as part of the AEFLA Section 231 Comprehensive Adult Education Services, aims to expand and enhance educational programs for adults in Connecticut. With an emphasis on improving basic skills and literacy, the project facilitates effective participation in society and the workforce. It supports a variety of activities including adult literacy, workplace education, family literacy, and English language acquisition, among others. This initiative, funded through the Workforce Innovation and Opportunity Act (WIOA), encourages collaborations to avoid service duplication, address local needs, and ensure seamless educational transitions. The project is open for proposals from eligible agencies with the intent to award multi-year grants, ensuring sustained impact from fiscal year 2025 through 2028. Grant renewed every year. It will be a 4-year program ( last application probably around May 2027)

Education
Nonprofits
Spring Dane G. Hansen Community Grant Fund
Contact for amount
Heartland Community Foundation
Private

Application Deadline

May 15, 2024

Date Added

Mar 24, 2024

About the Fund The Dane G. Hansen Foundation of Logan, KS, partners with the Greater Salina Community Foundation (GSCF) and the Greater Northwest Kansas Community Foundation (GNWKCF) to help improve the quality of life for communities in 26 counties of Northwest Kansas. GSCF and 11 of its affiliate foundations are allocated funding for grants to distribute to 14 counties for charitable projects through a competitive application process. What do the funds support? Grants will be awarded to projects or programs that address the following areas: Education: Enhances the learning environment and expands opportunities for students. Provides increased self-reliance on personal life skills and workforce capability. Health Care: Ensures access to quality health services and promotes healthy life practices. Community Social Services & Security: Enhance access to social services needed for individuals of special needs and supports systems to provide community disaster relief and general community emergencies. Conservation & Environment: Support efforts to improve and maintain high air and water quality, appreciation for our natural environment and enhances economic and social benefits of outdoor resources. Arts & Culture: Provide cultural and artistic opportunities to enhance the quality of life for local residents and to encourage tourism and the exchange of ideas. Community Beautification: Support efforts to improve and maintain public spaces to enhance community pride and encourage socialization among residents. Preference will be given to applications that include community involvement and volunteerism. Grants may not be awarded to: reduce or replace regular budgetary needs for programs or projects that are tax-supported support endowment or operational expenses Grant renewed every year. Grant Spring annual opening/ closing deadline: March 15th to May 15th

Community Development
Nonprofits
Technologies and Assays for Therapeutic Genome Editing INDs (U01, Clinical Trial Not Allowed)
$2,000,000
Department of Health and Human Services - National Institutes of Health
Federal

Application Deadline

Jul 26, 2024

Date Added

Mar 23, 2024

The purpose of this Notice Of Funding Opportunity (NOFO) is to solicit applications on the optimization and characterization of technologies and assays with the potential for utilization and adoption in regulatory submissions of genome editing therapeutics. The NIH Somatic Cell Genome Editing (SCGE) Program is funded through the NIH Common Fund, which supports cross-cutting programs that are expected to have exceptionally high impact. All Common Fund initiatives invite investigators to develop bold and innovative approaches to address problems that may seem intractable or to seize new opportunities that offer the potential for transformation of research processes. The simplicity and broad applicability of targeted and programmable genome editing approaches, including but not limited to those based on CRISPR-Cas9, raise the possibility of a fundamentally new way to treat a variety of genetic diseases. However, many challenges need to be overcome before such techniques could be widely used in the clinic. To maximize the potential of genome editing technology, the SGCE program was developed to accelerate the translation of genome editing technology into clinical applications. Based on input received from stakeholders from academia, industry, and regulatory agencies, as well as the substantial progress in the field of genome editing since the launch of the first five-year phase of the SCGE program, the second five-year phase of SCGE will focus on translating and accelerating safe and effective somatic cell genome editing therapeutics into the clinic. Specifically, SCGE Phase 2 will support the following initiatives: 1) Technologies and Assays for Therapeutic Genome Editing INDs; 2) IND-enabling Studies of Somatic Genome Editing Therapeutic Leads; 3) IND-enabling and Platform Clinical Trials of Somatic Genome Editing for Multiple Diseases and 4) Somatic Cell Genome Editing Translational Coordination and Dissemination Center (TCDC). The SCGE Program will involve collaborative research by a consortium of award recipients with differing expertise to develop, optimize and demonstrate improved candidate genome editing therapeutics as treatments for human disease. Recipients from all four SCGE program components will form a consortium, governed by a steering committee of investigators and NIH staff that will develop consensus policies and procedures for Consortium-wide activities such as data and resource sharing. Collectively, these initiatives are intended to substantially expand the number of genetic diseases treated by in vivo genome editing, ultimately allowing this technology to achieve its potential as a therapeutic platform to treat genetic disease. Program Formation and Governance The awards funded under this NOFO will be cooperative agreements (see Section VI.2. Cooperative Agreement Terms and Conditions of Award). Close interactions among the recipients and NIH will be required to maintain this complex program. The whole SCGE Program governance will rest with the SCGE Program Steering Committee in collaboration with NIH Program Officials, with advice from Program Consultants providing critical scientific and managerial insights, and subject to oversight by the NIH SCGE Working Group. The NIH SCGE Working Group consists of NIH Programmatic Staff from multiple Institutes and Centers of the NIH as well as the Office of the Director. This group will be primarily responsible for the stewardship of the SCGE Program. The SCGE Working Group is co-chaired by the Director of the National Center for Advancing Translational Sciences (NCATS) and the Director of the National Institute for Neurological Disorders and Stroke (NINDS). It reports to the Directors of the Office of Strategic Coordination/Common Fund and the Division of Program Coordination, Planning, and Strategic Initiatives for final funding decisions. Research Objectives The purpose of this 3-year U01 NOFO is to support the optimization and evaluation of IND-enabling technologies and assays to help accelerate the clinical development and evaluation of novel somatic cell genome editing therapeutics to treat a broad array of rare and common diseases. Examples of technologies and assays that would be responsive to this NOFO include those for Chemistry, Manufacturing and Controls (CMC), potency, pharmacology/toxicity, detection and measurement of on/off-target effects, immune responses, and cell tracking studies. Applicants should have an IND-enabling technology or assay to be optimized, with supportive preliminary data, at the time of submission. Projects should focus on further development and rigorous characterization of the technology and/or assay for utilization and adoption in regulatory submissions. This NOFO is intended to bring assays to the point where they could be integrated with future clinical trials/studies. Research Scope This program will support the optimization, refinement, and establishment of acceptability criteria of technologies and assays that will provide data on the efficacy and safety of somatic cell genome editing technologies and delivery systems in future regulatory submissions. In Investigational New Drug Applications (INDs) submitted to the U.S. Food and Drug Administration (FDA), sufficient CMC information should be provided to assure safety, identity, quality, purity, and strength (including potency) of the investigational product entering clinical trials. CMC activities include the establishment of manufacturing processes and product characteristics, as well as defining product testing methods to ensure that the product is safe, effective, and consistent between batches. To guide the CMC development plan, it is important to establish the Critical Quality Attributes (CQAs), a set of criteria to which a drug product should conform to be considered acceptable for its intended use. Establishing acceptable CQAs for genome editing therapeutics can be challenging due to the biological complexity of the products. Nevertheless, the risk associated with genome editing therapies can be reduced by developing appropriate analytical procedures and assays to help define suitable CQAs and ensure high-quality clinical products that meet the quality requirements for nonclinical and clinical trial materials. Process control techniques developed for protein drug production are not always applicable to cell and gene therapies. While a few in vivo somatic cell genome editing therapeutics have entered the clinic targeting the liver and eye, a comprehensive suite of technologies and assays to help define the CQAs of the genome editing product(s) have yet to be generated. Some examples of CMC challenges during the development of genome editing products include suitable potency assays to demonstrate relevant biological activity and to help determine dosage, pertinent assays to inform editing-related immunogenicity, safety and efficacy, manufacturing procedures suitable for scale-up for a multifaceted product, and other optimized bioanalytical assays to fulfill CMC-related activities. A combination of assays may be required when a single assay may not provide adequate CMC data due to a complex mechanism of action or multiple activities of a preliminary therapeutic agent. To support the clinical advancement and regulatory approval of the ever-increasing number of genome editing therapeutics, there is a need for appropriate fit-for-purpose CMC and analytical methodologies to be optimized and qualified for eventual implementation into genome editing therapeutic programs as these programs transition from research into clinical stages. Also in 2023, the FDA Modernization Act 2.0 permits the utilization of new approach methodologies (NAMs) to animal testing, including non-animal or human biology-based test methods, such as cell-based assays, microphysiological systems, or bioprinted or computer models to predict drug toxicity, metabolism, and other absorption, distribution, metabolism, and excretion (ADME) properties. NAMs can now be used to seek FDA exemptions for assessing drug safety and effectiveness during the preclinical phase. Some applicable assays have been developed by investigators in academic laboratories or small biotechnical companies for research purposes but require adaptation and/or comprehensive analysis to meet regulatory requirements during the review of clinical products. Applications responsive to this NOFO will fill this gap as these technologies and assays are critical during preclinical development and the manufacturing process, and would impact product quality, safety and efficacy during clinical application. Successful assays and associated protocols will be shared with the broader community via the Translational Coordination and Dissemination Center (TCDC) and SCGE Toolkit that will be the primary output of this collaborative Common Fund-sponsored program. Examples of product and process characterization assays supported by this NOFO include, but are not limited to: Technologies that enable more informative assessment of patient adaptive and/or innate immune (immunogenicity) responses to genome editors and vectors during clinical trials, including the presence or development of anti-drug antibodies, potential biological consequences, and whether those responses change over time or in response to redosing New approach methodologies that complement traditional animal research, including microphysiological systems, organoids, and other 3- dimensional cell models, that recapitulate critical aspects of normal human physiology and provide quantifiable and predictive measurements of genome editing effects Computer-based technologies, for example artificial intelligence or machine learning, for generating predictive models of individual or population-based biological response(s) to genome editing-based intervention Technologies to detect on and off-target editing in gene-edited animals (or humans) in a non-invasive manner, including but not limited to the use of cell-free DNA obtained from blood or other tissue compartments that can be readily accessed non-invasively (e.g. saliva, exhaled breath condensate, urine, stool) Methods to assess or predict the potential clinical impact of undesired off-target effects, including but not limited to cytotoxicity, genotoxicity, mutagenicity and tumorigenicity potential In vitro and in vivo assays for clinically relevant evaluation of the pharmacokinetic and pharmacodynamic properties of a genome delivery or editing reagent, including durability of editing, bioavailability, bioactivity, cell/tissue specificity, and/or dose-prediction in clinical trials Potency assays to assess specificity and sensitivity measurements of the functionality and efficiency of genome editing product, including vector infectivity and identity, editor activity, and other parameters as appropriate Process development technologies for scale-up and cGMP manufacturing of genome editing products Bioanalytical methods for final product identity and potential contamination Technologies for tracking and monitoring of genome editing therapies in vivo, which may include amongst others, in utero therapeutic products Applications addressing the following topics will be deemed non-responsive and will not be reviewed: Exploratory research for new technology development that lack supporting unpublished and/or preliminary data Assays that are not applicable to genome editing INDs Discovery or development of new genome editing therapeutic products Assays/technologies for non-somatic cell editing Projects proposing clinical trials Technologies that can be broadly applicable to more than one genome editing therapeutic product and/or indication are encouraged Funds from the NIH will be made available through the U01 cooperative agreement award mechanism. Awards will be up to 3 years in duration and will include milestones to evaluate progress. During the initial two years of funding, it is expected that investigators will complete the necessary studies to establish an assay profile and performance criteria (Accuracy [Relative], Analytical Measurement Range, Parallelism, Precision, Selectivity, Specificity, and Stability, as applicable) of sufficient quality for the likely utilization of the technology or assay to support IND-submission of genome editing therapeutic products. As part of the NIH SCGE Consortium, Consortium-generated animal and/or human samples from genome-editing therapeutic studies are expected to become available, and applicants are encouraged to collaborate with other SCGE Consortium members to help evaluate the utility and performance of the assay(s). It is anticipated that in the remainder of the award period, projects will continue to perform assay optimization and further define the analytical parameters using relevant samples, including samples from other consortium members as scientifically appropriate. NIH's Interest in Diversity Every facet of the United States scientific research enterprise—from basic laboratory research to clinical and translational research to policy formation–requires superior intellect, creativity and a wide range of skill sets and viewpoints. NIH’s ability to help ensure that the nation remains a global leader in scientific discovery and innovation is dependent upon a pool of highly talented scientists from diverse backgrounds who will help to further NIH's mission. Research shows that diverse teams working together and capitalizing on innovative ideas and distinct perspectives outperform homogenous teams. Scientists and trainees from diverse backgrounds and life experiences bring different perspectives, creativity, and individual enterprise to address complex scientific problems. There are many benefits that flow from a diverse NIH-supported scientific workforce, including: fostering scientific innovation, enhancing global competitiveness, contributing to robust learning environments, improving the quality of the research, advancing the likelihood that underserved or health disparity populations participate in, and benefit from health research, and enhancing public trust. NIH encourages applicants to include a diverse group of scientists in their research programs, including individuals from underrepresented backgrounds (see NOT-OD-20-031, Notice of NIH’s Interest in Diversity and NOT-OD-22-019, Reminder: Notice of NIH’s Encouragement of Applications Supporting Individuals from Underrepresented Ethnic and Racial Groups as well as Individuals with Disabilities). See Section VIII. Other Information for award authorities and regulations.

Health
State governments
AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional)
$7,500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

May 7, 2026

Date Added

Mar 23, 2024

This funding opportunity provides financial support to research institutions for developing interdisciplinary centers focused on improving mental health and HIV/AIDS outcomes through innovative studies and community engagement.

Health
State governments
Urban Health Activity
$34,000,000
USAID-UGA (Uganda USAID-Kampala)
Federal

Application Deadline

May 20, 2024

Date Added

Mar 23, 2024

Notice of Funding Opportunity summary:The United States Agency for International Development (USAID) is seeking applications for aCooperative Agreement from qualified entities to implement the Urban Health Activity. Eligibilityfor this award is not restricted.USAID intends to make an award to the applicant who best meets the objectives of this fundingopportunity based on the merit review criteria described in SECTION E of this Notice of FundingOpportunity (NOFO), subject to a risk assessment. The applicant receiving an award will be theRecipient. Eligible parties interested in submitting an application are encouraged to read thisNOFO thoroughly to understand the type of program sought, application submissionrequirements, and selection process.Activity short summary:USAID/Uganda plans to award a five-year Cooperative Agreement to enhance health systemresilience and improve the survival and well-being of the residents of Kampala city, Mukono, andWakiso districts (hereafter referred to as the Target Districts) (the Activity). The Activity willstrengthen public and private health systems at the facility and community levels to deliverresponsive, timely, evidence-based, quality services. The Activity will strengthen maternal,newborn, and child health (MNCH); malaria; family planning (FP) / reproductive health (RH);nutrition; and Global Health Security (GHS) services in the Target Districts.

Health
State governments
National Organizations of State and Local Officials (NOSLO): State Health Services and Financing
$500,000
HHS-HRSA (Health Resources and Services Administration)
Federal

Application Deadline

May 23, 2024

Date Added

Mar 23, 2024

Organizations of State and Local Officials (NOSLO) Program: State Health Services and Financing to fund a national level organization with an in-depth understanding of, and experience with, providing technical assistance and support to State Medicaid Directors and other health care payment officials to assist states in leveraging HRSA programs and collaborating with Medicaid to improve access to quality health care for high need communities. Activities should include but are not limited to fostering collaborations to address maternal health disparities, bolster the health workforce, integrate behavioral health into primary care, and expand access to care for people in high need communities, such as those who live rural areas, are exiting incarceration, have HIV, and youth with unmet behavioral health needs. The successful recipient is expected to provide tailored technical assistance to State Medicaid Directors and other health care payment officials to address HRSAs priorities and maximize the benefits of and potential collaborations with HRSA programs through: Communication and information sharing between HRSA and State Medicaid Directors and other health care payment officials, and Training; data collection, sharing, and analysis; convenings, (e.g., learning exchanges on priority topics); and other activities that enable State Medicaid Directors and other health care payment officials to operate in a responsive, coordinated, and effective manner.

Health
State governments
FY25 CTE Education Career Pathway RFP
Contact for amount
Illinois State Board of Education (ISBE)
State

Application Deadline

May 3, 2024

Date Added

Mar 23, 2024

The FY 2025 CTE Education Career Pathway RFP, accessible through the ISBE Web Application Security (IWAS) system, is aimed at entities capable of supporting career and technical education (CTE) activities as outlined in 23 Ill. Adm. Code 256.400. The RFP for the FY 2025 planning year does not require an initial allocation or itemized budget; approved applicants will later submit an amended application with detailed financials and agreements as directed by ISBE. The application deadline is May 3, 2024, at 4:00 p.m. Grant renewed every year.

Education
Public and State controlled institutions of higher education
Developmental AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional)
$3,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

May 7, 2026

Date Added

Mar 23, 2024

This funding opportunity provides support for U.S.-based research centers focused on innovative studies at the intersection of mental health and HIV/AIDS, aiming to address health disparities and improve treatment and prevention strategies.

Health
State governments

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