Grants for Public Housing Authorities

This Notice of Funding Opportunity (NOFO) solicits R01 grant applications that propose independent research projects that are within the scientific mission areas of the National Institute on Deafness and Other Communication Disorders (NIDCD). This program is intended to support Early Stage and New Investigators from diverse backgrounds, including those from groups underrepresented in the health-related sciences. Investigators from diverse backgrounds, including those from underrepresented groups (e.g., seeNOT-OD-20-031, Notice of NIHs Interest in Diversity), are eligible to apply. Investigators from categories A-C are particularly encouraged to work with their institutions to apply. Preliminary data are not required for this NOFO. All applications require a letter of affirmation from the applicant institution documenting the Investigators eligibility. Applications that do not include this letter will be administratively withdrawn.

This notice of funding opportuntity (NOFO) encourages applications for investigator-initiated multi site clinical trials (e.g., efficacy, effectiveness, or pragmatic trials) to study the effects of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions), and/or multicomponent interventions that include physical, psychological, and/or nutritional approaches in NCCIH- designated areas of high research priority. Clinical Coordinating Centers (CCC) should develop and implement the proposed fully powered multi-site clinical trial (Phase III and beyond). The objective of a CCC application is to present the scientific rationale and a comprehensive scientific and operational plan for the clinical trial. CCCapplications are expected to describe plans for project management, participant recruitment and retention strategies, performance milestones, scientific conduct, and dissemination of results. CCC applications submitted under this NOFO will utilize a two-phase, milestone-driven cooperative agreement (UG3/UH3) funding mechanism. In addition, an accompanying Data Coordinating Center (DCC) application (U24), submitted under PAR-24-087 proposing a data analysis and data management plan for the clinical project is required. Both a CCC application and a corresponding DCC application need to be submitted simultaneously for consideration by NCCIH. For additional information about the mission, strategic vision, and research priorities of NCCIH, applicants are encouraged to consult the NCCIH website: (https://nccih.nih.gov/about/plans). Applicants are encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO.

This funding opportunity supports researchers conducting multi-site clinical trials to evaluate complementary and integrative health approaches that combine physical and psychological therapies, aiming to gather essential data for future larger-scale studies.

HIV infection and substance use are comorbid conditions that bidirectionally and synergistically influence the deleterious outcomes in people who suffer from substance use disorders (SUD). The persistence and transcriptional reactivation of HIV lead to the development of neuropathological complications. Strategies to address viral latency include silencing of HIV transcription and reactivation and clearance. The goal of this initiative is to support research aimed at (1) identification of targets and pathways by which transcriptional activity of HIV can be suppressed in HIV reservoirs including the CNS in people with SUD, and (2) application of emerging small molecule drug discovery approaches to identify novel compounds that can be utilized as pharmacological probes and as drugs to suppress HIV transcription in people with HIV-SUD comorbidity.

This notice of funding opportunity (NOFO), utilizing the U24 grant funding mechanism, encourages applications for a collaborating Data Coordinating Center (DCC) application that accompanies an investigator-initiated multi site clinical trial (Phase III and beyond) application submitted under companion PAR-21-243. The DCC application must be specific to the companion Clinical Coordinating Center (CCC) application. The objective of the DCC application is to propose a comprehensive plan that provides overall project coordination, and administrative, data management, and biostatistical support for the proposed clinical trial. Both a DCC application and a corresponding CCC application need to be submitted simultaneously for consideration by NCCIH. Trials for which this NOFO applies must be relevant to the research mission of NCCIH and considered a high priority by the Center. For additional information about the mission, strategic vision, and research priorities of NCCIH, applicants are encouraged to consult the NCCIH website (http://www.nccih.nih.gov). Applicants are encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn.Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

This funding opportunity supports U.S. educational institutions in developing programs that train a diverse workforce in research related to diabetes, digestive diseases, and kidney health, through skills courses and research experiences.

The purpose of this funding opportunity is to support the development of Clinical Outcome Assessments (COA) for Substance Use Disorders (SUD). The COA development plan is expected to progress into the FDA drug development tool qualification program. This notice of funding opportunity (NOFO) utilizes the UG3/UH3Phased Innovation Awards Cooperative Agreement grant mechanism that includes two phases. The applications responding to this NOFO should contain a COA development plan that will cover both UG3 and UH3 phases. In the first 2-year UG3 phasethe project must have a set of operational milestones to be completed by the end of this period. Once NIDA program has evaluated the progress of the UG3 phase and determined that the UG3 phase has been successfully completed, it transitions to the UH3 phase to be funded for three additional years.The goal of this NOFO is to expand the armamentarium of COA that are FDA qualified as drug development tool (DDT) in the context of use (COI) of a SUD. Achieving this goal will greatly facilitate the development of treatments for SUDs. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

This funding opportunity supports the development of innovative informatics tools to improve cancer research and management, targeting researchers and institutions focused on enhancing data handling and analysis in the field of oncology.

This funding opportunity supports the development of innovative informatics technologies to improve cancer research and management, targeting researchers and organizations focused on cancer biology, treatment, prevention, and health disparities.

This funding opportunity provides support for the ongoing development and maintenance of valuable informatics tools and resources that enhance cancer research and management, benefiting researchers and the broader cancer community.

This funding opportunity supports researchers in developing innovative informatics methods and algorithms to improve cancer research and management across various areas, including diagnosis, treatment, and prevention.

The purpose of this Notice of Funding Opportunity (NOFO) is to support the development and validation of reagents/tools to support research to characterize cellular and molecular constituents of the bat immune system and for the study of protective innate and adaptive immune mechanisms in bats. The Research Resource Program established by this NOFO will participate within a collaborative research network to advance understanding of the bat immune response. This NOFO will support the establishment and operation of a Bat Immunology Research Resource Program for the development and validation of reagents/tools for use in immunological studies using the bat model system. The recipient will participate in the Bat Immunology Network, which will consist of the Research Resource Program, the research projects supported by RFA-AI-23-068, and possible other participants as determined by NIAID. The Research Resource Program will conduct reagent/tool development and validation using appropriate systems, which includes testing against multiple bat species. While other members of the Bat Immunology Network may assist in validation efforts, reagent/tool validation is the responsibility of the Research Resource Program. Reagents/tools developed by the Research Resource Program will be provided to the research projects of the Bat Immunology Network. Reagents/tools will be made available to the broader research community through technology transfer arrangements, deposition to nonprofit repositories, and/or timely transfer to industry for commercialization. Areas of high priority include, but are not limited to, the development and validation of the following: Soluble immune molecules (e.g., cytokines, chemokines) for use in tissue culture or in vivo animal studies Antibodies or other probes/detection markers for use in cellular phenotyping, functional studies and/or immunoassays

The purpose of this Notice of Funding Opportunity (NOFO) is to support research to characterize cellular and molecular constituents of the bat immune system and to understand protective innate and adaptive immune mechanisms in bats. Research projects supported by this NOFO will form a collaborative research network to advance understanding of the bat immune response. This NOFO will support research projects to characterize the bat immune system, including defining protective innate or adaptive immune molecules and mechanisms. As little is known about the bat immune system, projects may be descriptive in nature or may be supported by limited preliminary data. Projects should emphasize the strength of the conceptual framework and the potential of the project to advance understanding of the bat immune system. Projects may propose the development of critical reagents for the project, though those development and validation activities may be transferred to the Research Resource Program after award. Research areas of high priority include, but are not limited to, the following: Characterization of the cellular constituents of the bat immune system Dissection of the molecules and pathways involved in the regulation of the bat innate and/or adaptive immune system Mechanistic studies of bat immunity, including intrinsic immunity and regulation of inflammation Studies on the quality, magnitude, and kinetics of bat immune responses during pathogenic infection and after pathogen clearance Role of metabolism or other intrinsic factors in bat immune regulation Structural studies of bat immune proteins

This funding opportunity supports researchers in developing small molecule chemical probes to investigate biological processes related to mental health, aging, drug addiction, and eye diseases.

The purpose of the funding opportunity is to expand and advance FDA's Office of Minority Health and Health Equity (OMHHE) work with stakeholders and partners for education, outreach, and public awareness activities on potential risks from skin lightening products containing hydroquinone and/or mercury.Applicants will research and propose innovative and community-based strategies and activities that have the potential to strengthen the science base for education and public health awareness on the use of and potential risks from over-the-counter (OTC) skin lightening products.

This funding opportunity supports research that explores the effects of aging on individuals living with HIV, focusing on improving health outcomes and management strategies for this population.

The purpose of this funding opportunity announcement (FOA) is to support efficient natural history studies alone or in conjunction with the development and validation of clinical outcome assessments (COAs) and/or biomarker studies to address the unmet needs in rare neurodegenerative diseases for children and adults. Through the support of studies with high quality and interpretable data elements, FDA expects to address critical knowledge gaps, remove major barriers to progress in the field, exert a significant and broad impact on a specific rare neurodegenerative disease or multiple rare neurodegenerative diseases with similar pathophysiology, and facilitate rare disease product development.

This funding opportunity provides financial support and technical assistance to develop affordable supportive housing for Hennepin County's most vulnerable residents, including those with extremely low incomes, disabilities, and those experiencing homelessness.

Grant Opportunity: Community Development Block Grant (CDBG) Program Funding Organization: U.S. Department of Housing and Urban Development (HUD) Contact Information: No specific contact information provided Program Description: The CDBG Program is a federally funded program that provides financial resources to states, cities, and counties to address community development needs. It supports the development of urban communities by creating decent housing, suitable living environments, and expanding economic opportunities for low- and moderate-income individuals. Eligibility: Eligible service programs must meet at least one of three national objectives for the CDBG program: benefit low- and moderate-income persons, aid in the prevention or elimination of slums or blight, or meet a community development need with urgency. Grant Opportunity: CDBG Business Grant Program Funding Organization: City of Aliso Viejo Contact Information: Rose Rivera at rrivera@avcity.org Program Description: The CDBG Business Grant Program aims to provide pandemic relief funding to assist small businesses impacted by COVID-19 within the City of Aliso Viejo. Funding will be provided based on compliance with program guidelines, availability of funds, and submission of the required application and supporting documentation. Grant Opportunity: CDBG-CV Funding Organization: U.S. Department of Housing and Urban Development (HUD) Contact Information: No specific contact information provided Program Description: The CDBG-CV program was established under the CARES Act to provide $5 billion in CDBG funds for low-income families and vulnerable citizens affected by the COVID-19 pandemic. The City has received two allocations totaling $414,751 for various activities that meet the national objectives of the CDBG program. Other Relevant Information: - 2023-2027 Consolidated Plan and FY 2023-24 Annual Action Plan outline housing and community development needs within the context of the CDBG program. - Citizen Participation Agreement ensures resident participation in the development of the Consolidated Plan and related documents. - Consolidated Annual Performance & Evaluation Report (CAPER) summarizes progress towards meeting goals outlined in the Consolidated Plan and Annual Action. - Proposed 2020-2024 Orange County Analysis of Impediments to Fair Housing identifies barriers to fair housing and outlines an

This funding opportunity supports innovative research that investigates how aging affects individuals living with HIV, focusing on improving their health outcomes and addressing related challenges.