Grants for State Governments

The National Fish and Wildlife Foundation (NFWF) is soliciting proposals for the Northeast Forests and Rivers Fund (NEFRF), a program dedicated to restoring and sustaining healthy rivers, forests, and grasslands to provide habitat for diverse fish and wildlife populations. This initiative aligns with NFWF's broader mission to protect and restore native wildlife species and their habitats, leveraging public and private funding to achieve significant conservation outcomes. The NEFRF, formerly known as the New England Forests and Rivers Fund, represents a strategic investment in the ecological health of the Northeast region, fostering biodiversity and ecosystem resilience. The program's target beneficiaries include various fish and wildlife populations such as river herring, Atlantic salmon, brook trout, wood turtles, golden-winged warblers, New England cottontails, and bobolinks. Beyond wildlife, the program also aims to benefit agricultural producers, particularly those in Historically Underserved and Special Emphasis categories, by helping them design and implement conservation practices. The impact goals are centered on improving habitat quality and connectivity, enhancing forest conditions, and promoting hayfield management conducive to successful grassland bird breeding. NEFRF's priorities and focuses are outlined in NFWF’s Northeast Watersheds Business Plan (March 2023), specifically targeting strategies for Stream and Riparian Habitat, and Upland Forests and Grasslands. Key implementation strategies for 2024 include restoring stream and riparian habitats, improving forest management for age and structural diversity, and promoting hayfield management. A significant portion of funding, approximately $625,000, is set aside for projects that assist agricultural producers in adopting conservation practices beneficial to target species like northeast turtles and golden-winged warblers, while also increasing Farm Bill program participation. Additionally, the program encourages projects that involve community outreach, engagement, collaborative management, and the incorporation of traditional knowledge and community input. Expected outcomes and measurable results include improved habitat for specific fish and wildlife species, enhanced age and structural diversity in forest blocks, successful grassland bird breeding, and increased participation of agricultural producers in conservation programs. Projects are expected to contribute to measurable conservation benefits through community input, co-design processes, and engagement with community-level partners (e.g., municipalities, NGOs, community organizations, community leaders) to ensure project design, implementation, maintenance, and long-term sustainability post-grant award. The grant duration is three years, with projects expected to start no later than six months after the award date. The NFWF's strategic priorities for the NEFRF reflect a theory of change that posits by investing in targeted habitat restoration, improved land management, and community engagement, ecological health will be restored and sustained, benefiting both wildlife and human communities. Funding is provided by a consortium of partners including the U.S. Department of Agriculture’s Forest Service and Natural Resources Conservation Service, the U.S. Fish and Wildlife Service, Zoetis Foundation, and Sylvamo, underscoring a collaborative approach to conservation. The program encourages a holistic view of conservation, integrating scientific best practices with local community needs and traditional knowledge to achieve robust and lasting environmental improvements across Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, Vermont, and parts of New York.

The Master-Apprentice Artist Award, offered by the Southwest Folklife Alliance (SFA), provides direct financial support to master traditional artists in Arizona. Its core mission is to facilitate the intergenerational transmission of art, culture, and heritage practices from master artists to apprentice learners. This aligns with SFA's broader goal of strengthening community-based traditions throughout the Southwestern United States, emphasizing the vital role of mentorship and hands-on experience in cultural preservation. Target beneficiaries include master traditional artists and culture bearers residing in Arizona, as well as apprentices aged 16 and older (or younger if immediate family of the master artist). The program prioritizes masters and apprentices within the same cultural community and aims to support underrepresented traditional art forms with few remaining local practitioners. The impact goal is to ensure the continuity and vitality of diverse traditional art forms, fostering a new generation of skilled practitioners and preserving cultural heritage. The program focuses on a one-on-one teaching-learning relationship, where funds can cover artist fees, raw materials, and essential travel. Traditional master artists receive $5,000, and apprentices receive $500. SFA's strategic priority is to identify and support artists who demonstrate mastery of their art form, community recognition, and the ability to effectively share traditional knowledge. This approach reflects a theory of change that informal, community-rooted mentorship is the most effective way to transmit and sustain traditional arts. Expected outcomes include the successful transfer of traditional art skills and knowledge from master to apprentice, leading to a strengthened base of cultural practitioners. Measurable results would involve the number of successful apprenticeships, the continuation or revitalization of specific traditional art forms, and the increased recognition and practice of these traditions within their respective communities. The program ensures that applicants are full-time Arizona residents, further embedding the initiative within the local cultural landscape.

The American-Made Electronics Scrap Recycling Advancement Prize (E-SCRAP) is a $3.95 million challenge sponsored by the U.S. Department of Energy’s (DOE) Advanced Materials and Manufacturing Technologies Office (AMMTO). This three-phase prize aims to stimulate innovative approaches that reduce the costs and environmental impact of critical material recovery from electronic scrap (e-scrap). The program aligns with the DOE's mission to advance energy technology and reduce environmental impact, specifically targeting the challenges within the e-scrap recycling value chain. The target beneficiaries of the E-SCRAP prize are individuals, private entities (for-profits and nonprofits), nonfederal government entities (states, counties, tribes, and municipalities), and academic institutions working in waste collection and management, dismantling and sorting, separation, refining, validation, and material supply. The impact goals are to increase the domestic supply of critical materials from e-scrap, enhance material circularity, and reduce the environmental footprint associated with current recycling processes. The program prioritizes innovative approaches, processes, or technologies that optimize and implement critical material separation and recovery from e-scrap. This includes building partnerships across the recycling value chain, developing and demonstrating innovations, addressing technical, supply chain, or logistical hurdles, and enhancing supply chains to accelerate connectivity between various stages of recycling. Areas of interest include innovations for electronic scrap (communication devices, home appliances, medical/office equipment) and the recovery of critical materials such as aluminum, cobalt, copper, lithium, nickel, and rare earth elements. Expected outcomes include the development and demonstration of new technologies that lead to more efficient and environmentally friendly e-scrap recycling processes. Measurable results will be seen in increased rates of critical material recovery, reduced costs, and a decrease in environmental impact. Competitor teams can win up to $800,000 in cash prizes and $150,000 in national laboratory analysis support. The prize’s strategic priorities are to act as a catalyst for change, fostering innovation and collaboration to strengthen the domestic supply chain of critical materials, thereby contributing to clean energy initiatives and a more circular economy.

The County History Partnership Program (CHPP), established in 2015 by the New Jersey Historical Commission (NJHC), aims to decentralize the administration of local re-granting programs across all 21 New Jersey counties. This initiative directly aligns with the mission to support local history organizations that serve the public, fostering a broader engagement with the state's historical heritage. The program is administered by the Somerset County Cultural & Heritage Commission, which functions as the donor, extending the NJHC's strategic goal of strengthening local historical infrastructure. The primary beneficiaries of this grant are historical societies, organizations, nonprofits, and municipalities responsible for historic structures or archaeological sites. Eligible applicants must be Somerset County-based. The program's impact goals revolve around increasing public access to New Jersey history, expanding knowledge of the state's past, and improving the management capabilities of local history organizations. This approach is intended to create a more robust and accessible local history ecosystem within Somerset County. The grant prioritizes organizations that provide programs or services that achieve these goals. Specifically, applicants must demonstrate a commitment to enhancing public access to history or expanding historical knowledge. Another key focus is on improving the operational and managerial effectiveness of local history organizations, thereby ensuring their long-term sustainability and impact. The foundation's theory of change appears to be that by empowering local organizations with financial support and clear objectives, they can more effectively serve the public and preserve historical assets. Expected outcomes include a more engaged public with New Jersey history, a greater depth of historical knowledge disseminated, and more efficiently run local history organizations. Measurable results would likely include increased participation in historical programs, documented improvements in organizational management, and successful preservation efforts of historic sites. Organizations are also required to have provided public history programs and/or services in Somerset County for the benefit of the general public for at least two years prior to application, and must provide proof of stability and fiscal responsibility, ensuring the grant's investment is directed towards established and accountable entities.

The Land and Water Conservation Fund (LWCF) 2024 Grant aims to support the development and enhancement of public outdoor recreation facilities across the Commonwealth of Kentucky. This state-administered program seeks applications from cities, counties, state agencies, and federal agencies to improve local park amenities and infrastructure. Eligible projects may include the development of campgrounds, picnic areas, sports fields, swimming facilities, boating facilities, fishing amenities, and various recreational trails. Successful applicants are required to match the LWCF grant funding on a 1:1 basis, with grant requests ranging from $25,000 to $250,000. The deadline for application submission is May 31, 2024.

The Rancho Bernardo Community Foundation (RBCF) invites nonprofit organizations to submit grant applications for projects that will enhance the quality of life for those who live, work, and play in Rancho Bernardo. The foundation's purpose and vision are to improve the quality of life and meet emerging needs by increasing responsible and effective philanthropy, building a community endowment, providing annual funds to community organizations, and offering a vehicle for legacy planning. This directly aligns with their mission of fostering community well-being and long-term sustainability within Rancho Bernardo. The grant program targets nonprofit organizations, schools, or government agencies whose projects clearly address Rancho Bernardo-specific issues and needs, and enhance civic engagement, with a clear impact on local residents. The overall impact goal is to improve the quality of life for the community. Funding can be used to expand existing programs, replicate successful programs from other communities, or launch entirely new initiatives, emphasizing practicality and achievability within a 12-month timeframe. RBCF's grantmaking for its 36th year focuses on two key areas: Music and Community Enhancement. For music-related programs, RBCF will award between $1,500 and $5,000 from the RB Symphony on the Green Fund. For community enhancement projects, which aim to inspire community pride, revitalization, and increase the quality of life, grants will range from $1,500 to $10,000. These focus areas reflect the foundation's strategic priority to directly invest in specific sectors that contribute to a vibrant and thriving community. Expected outcomes include projects that demonstrate and/or foster collaboration with other successful entities, have a strategic impact with long-lasting benefits, are based on a proven track record, and target clearly defined, measurable results attainable within a reasonable timeframe. Sustainability is a key criterion, meaning projects should be replicable, repeatable, and/or scalable. The foundation's theory of change posits that by supporting well-managed programs that address unmet needs, foster collaboration, and demonstrate long-term viability, they can effectively contribute to the sustained improvement of the community's quality of life. They particularly seek projects that focus on problem areas, opportunities, or populations not currently funded or serviced by existing entities.

With this solicitation, OJJDP seeks to provide funding to communities to develop intervention and supervision services for youth with problematic or illegal sexual behavior, and to provide treatment services for their victims and families/caregivers. Under this initiative, successful applicants are expected to have an established multidisciplinary team that (1) supports a comprehensive holistic approach to treating youth with problematic or illegal sexual behavior and (2) provides support services to victims and families/caregivers.

The Prince William County Department of Parks & Recreation is offering an Arts Grant to support nonprofit arts organizations in the Greater Prince William area, including Manassas and Manassas Park. This initiative aligns with the department's mission to enrich the cultural landscape of the community by fostering and sustaining artistic endeavors. The grant aims to ensure that both newly established and established nonprofit arts groups have the resources to provide diverse cultural and art performances to citizens across the region. The grant targets all nonprofit organizations engaged in dance, literary arts, media arts, music, theater, visual, and related arts. It has two main granting areas: the New and Emerging Grant, designed to assist start-up nonprofit arts groups within their first three years of existence, and the General Operating Grant, which provides sustained support for established nonprofit organizations. The impact goal is to strengthen the local arts community, promote cultural development, and ensure the continued availability of rich artistic experiences for residents. The program prioritizes organizations that are recognized as non-profits (with a 501(c)3 designation or applied for status for New & Emerging Grants), have completed a season of programs (exception for New & Emerging), and are based in Prince William County, Manassas, and/or Manassas Park. Furthermore, applicants must comply with Title VI of the Civil Rights Act of 1964 and the Americans with Disabilities Act and Section 504 of the Rehabilitation Act of 1973, ensuring inclusivity and non-discrimination. Organizations are also expected to have a significant portion of their members, participants, or services originating from or offered within the community. Expected outcomes include the successful establishment and growth of new arts organizations, and the sustained operation and continued provision of high-quality cultural and artistic programs by established groups. Measurable results could include the number of new organizations supported, the number of programs and performances offered, and the reach of these programs within the community. The grant period for activities is July 1 through June 30, with a deadline of May 8, 2024, for applications. This strategic approach ensures a continuous cycle of support for the arts, reflecting the department's commitment to a vibrant and accessible cultural environment.

The Greenhouse Accelerator Program Juntos Crecemos Edition is a five-month, mentor-guided initiative designed to accelerate emerging Hispanic food and beverage innovations. This program, an extension of the initial Greenhouse Accelerator launched in 2018, is a collaborative effort with PepsiCo Juntos Crecemos, which is part of PepsiCo’s Pep+ transformation agenda. The overarching mission is to provide both short-term and long-term support to Hispanic small businesses, aligning with PepsiCo's broader strategic priorities of driving growth for Hispanic founders within the food and beverage industry in the U.S. and fostering a positive impact through its PepsiCo Positive Strategy. The primary target beneficiaries of this program are up to eight high-potential, emerging Hispanic-owned food and beverage consumer packaged goods small businesses operating in the United States, with net-revenues between $100,000 to $2,000,000 USD in their last financial year. The impact goals are centered on fostering the growth and scalability of these businesses. By providing grants, expert guidance, networking opportunities, and mentorship, the program aims to accelerate pathways for these businesses to launch, scale, and grow their breakthrough innovations, ultimately contributing to the economic empowerment of Hispanic founders. The program prioritizes businesses that demonstrate a clear go-to-market strategy, are post-prototype and ready for review with a multinational corporation, exhibit uniqueness in the market, and possess balanced gender and ethnic diversity. A strong emphasis is also placed on a clear and active social responsibility mission that aligns with PepsiCo’s Juntos Crecemos Strategy and the broader PepsiCo Positive Strategy. The selection committee will also look for scalable business models, indicating the program's focus on long-term sustainability and impact. Expected outcomes include a guaranteed $20,000 USD grant for each finalist, with the winner receiving an additional $100,000 USD, providing crucial financial support. Beyond monetary grants, participants are expected to benefit from expert guidance through learning modules across all aspects of business development, hands-on mentorship for refining business models and strategies, and enhanced impact. The program also offers invaluable access and exposure to the extensive PepsiCo network, industry experts, VCs, and investors, as well as the unlocking of potential collaboration opportunities with PepsiCo. These measurable results collectively aim to strengthen and expand Hispanic-owned businesses in the food and beverage sector.

The Parasol Tahoe Community Foundation's 2024 Community Impact Grant Cycle invites proposals to support organizations making a significant difference in the Tahoe Basin. The foundation's mission, though not explicitly detailed in this description, is clearly aligned with fostering community well-being and addressing critical needs within the Nevada and California areas of the Tahoe Basin. By offering grants ranging from $10,000 to $100,000, with a specific request amount up to $20,000, the foundation aims to empower eligible non-profits to enhance their services and achieve measurable community impact. The primary target beneficiaries are the residents and communities of the Tahoe Basin. Organizations seeking funding must directly provide more than 50% of their services in this region, ensuring that the grants directly benefit local populations. The impact goals are broad, focusing on various community needs that align with the non-profit's mission, as long as they are not among the excluded activities. The foundation seeks to support initiatives that contribute to a stronger, more vibrant Tahoe community, although specific impact metrics are not detailed in this overview. The foundation prioritizes supporting tax-exempt 501(c)(3) public charities or schools that have held their tax-exempt status for at least two years and are incorporated in good standing in Nevada or California. A key focus is on direct service provision within the Tahoe Basin. The grants are not awarded for direct religious activity, political lobbying, special event sponsorships, pass-through funding, or reimbursement of prior expenses. This careful delineation of exclusions highlights the foundation's strategic intent to fund direct, impactful, and non-duplicative community services. While specific strategic priorities and a detailed theory of change are not outlined, the grant cycle implicitly emphasizes strengthening local non-profits and their capacity to serve. The expected outcomes are improved community conditions and enhanced services for Tahoe Basin residents, facilitated by the financial support provided. The measurable results are tied to the successful implementation of projects by the funded organizations, though the specific reporting requirements for these results are not included in this description.

Firelight Media's Documentary Lab is an 18-month fellowship program designed to provide comprehensive support for emerging filmmakers from racially and ethnically underrepresented communities in the United States. This program aligns with Firelight Media's mission to support artful and innovative documentary films that take risks and offer new narratives on pressing contemporary issues. The fellowship includes professional development retreats, customized mentorship from prominent documentary leaders, networking opportunities, and a $25,000 project grant, aiming to foster both project development and career growth. The primary target beneficiaries are filmmakers in the United States and U.S. territories (Puerto Rico, U.S. Virgin Islands, U.S. Samoa, Guam/Northern Mariana Islands) who identify with racially and ethnically underrepresented communities. Specifically, the program is for those directing their first or second feature-length documentary film. The impact goals are to empower these filmmakers to create compelling and diverse stories, enrich the documentary landscape with fresh perspectives, and establish sustainable careers within the industry. The program prioritizes long-form/feature-length documentaries that are currently in early production, production, or post-production stages. Firelight Media is open to various documentary types, including historical, investigative, personal, vérité, and experimental, emphasizing projects that are innovative and challenge conventional narratives. Key focuses include supporting films that address significant societal issues and promoting artistic risk-taking, ensuring the production of impactful and thought-provoking content. Expected outcomes include the successful completion and distribution of feature-length documentaries from diverse voices, leading to increased representation and visibility for underrepresented filmmakers. Measurable results could include the number of films completed, festival selections, distribution deals, and the career advancement of fellows. By investing in these filmmakers and their projects, Firelight Media's strategic priority is to cultivate a more inclusive and dynamic documentary film ecosystem, contributing to a broader understanding of critical social issues through the power of storytelling.

This federal funding program provides resources to local agencies that assist low-income individuals and families in overcoming poverty through essential services and community development initiatives.

The "Type 1 Diabetes TrialNet Clinical Network Hub" grant aims to support the coordination unit for clinical trials focused on preventing and intervening early in type 1 diabetes, by improving communication, outreach, and developing new strategies for better screening, recruitment, and retention of participants.

Governor Greg Abbott and the Texas Division of Emergency Management (TDEM) have announced the opening of applications for the Department of Energy's (DOE) grant program aimed at enhancing the resilience of electric grids against disruptive events. The program is designed to allocate competitive grants to improve infrastructure and reduce the likelihood and impact of such events on the electrical grid. The grant supports weatherization, fire-resistant technologies, monitoring and control systems, vegetation management, adaptive protections, and advanced modeling technologies. This grant opportunity is now active with a closing deadline of June 28, 2024.

The FY24 PCRP Exploration Hypothesis Development Award supports the exploration of highly innovative, untested, potentially high-gain concepts, theories, paradigms, and/or methods that address an important problem relevant to one or more of the FY24 PCRP Overarching Challenges. This award is designed to provide investigators the opportunity to pursue serendipitous observations that may reveal entirely new avenues for investigation. Results of studies conducted through this award may provide the scientific premise upon which a new hypothesis can be based or initial proof of principle of an innovative hypothesis, laying the groundwork for future avenues of scientific investigation. Presentation of preliminary data is inconsistent with the intent of this award mechanism and is therefore strongly discouraged. However, logical reasoning and a sound scientific rationale for the proposed work must be described. Reviewers will be blinded to the identity of the Principal Investigator (PI), collaborator(s), and their organization(s). Refer to Section II.D.2.b.i, Full Application Submission Type, for more information. New for FY24: Clinical research is allowed. For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes: (1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies. (2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. (3) Outcomes research and health services research that do not fit under the definition of clinical trial. Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule. Clinical trials are not allowed. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes. Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials. A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, the CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 PCRP priorities. Innovative research involving nuclear medicine and related techniques to support early diagnosis, more-effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies. Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (https://www.nature.com/nature/ journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies. The funding instrument for awards made under the program announcement will be grants (31 USC 6304). The anticipated direct costs budgeted for the entire period of performance for an FY24 Exploration Hypothesis Development Award should not exceed $150,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information. Awards supported with FY24 funds will be made no later than September 30, 2025. The CDMRP expects to allot approximately $3.60M to fund approximately 15 Exploration Hypothesis Development Award applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030. Research Involving Animals: All research funded by the FY24 PCRP Exploration-Hypothesis Development Award involving new and ongoing research with animals must be reviewed and approved by the USAMRDC Office of Human and Animal Research Oversight (OHARO; previously the Human Research Protection Office), Animal Care and Use Review Office (ACURO), in addition to the local Institutional Animal Care and Use Committee (IACUC) of record. IACUC approval at the time of submission is not required. Allow at least 3 to 4 months for ACURO regulatory review and approval processes for animal studies. Refer to the General Application Instructions for additional information.

The Minnesota Pollution Control Agency (MPCA) is offering approximately $4.5 million in grants to support organics management projects aimed at reducing the amount of organic material sent to landfills or incinerators. This funding is intended for projects that enhance or establish collection, processing (through composting, anaerobic digestion, or feeding to animals), and education/outreach initiatives related to organics management. Eligible entities must serve or operate within Minnesota, and include not-for-profit organizations, businesses, institutions, political subdivisions (e.g., counties, cities), state agencies, and tribal governments. Applications are due by 4 p.m. Central Time on June 10, 2024.

The DoD Peer Reviewed Cancer, Impact Award is a grant aimed at funding advanced research projects that can quickly translate promising findings into clinical applications, with the goal of making a significant, near-term impact on critical cancer issues and improving patient outcomes.

This program provides funding to organizations and local governments in Texas to develop and implement strategies that reduce pollution from diffuse sources, helping to protect and restore water quality in various watersheds.

The FY24 PCRP Data Science Award mechanism supports research where quantitative and analytical approaches, processes, and/or systems are developed and/or used to obtain knowledge and insight from large and/or complex sets of prostate cancer data. If successful, the studies will enable progress toward addressing one or more of the FY24 PCRP Overarching Challenges. It is expected that any resources, tools, or computational processes generated by this award will be openly shared with the prostate cancer research and patient community. This mechanism is intended to fund research built upon the logic, concepts, and methods of one or more of the following research areas as they pertain to prostate cancer: Computational biology Bioinformatics Artificial intelligence and machine learning Epidemiology Analysis of omics data Medical imaging Digital pathology Analysis of other clinically annotated datasetsApplications may combine diverse data types for integrative analysis to increase knowledge about prostate cancer with respect to the FY24 PCRP Overarching Challenges. Applications that propose to develop resources or tools that allow research, clinical care, and patient community access to standardized and harmonized datasets for real-time clinical care applications are of particular interest; however, this award must not be used to support the development of new datasets. Studies utilizing data derived from large patient studies that include long-term health records or repositories with well-annotated and high-quality biospecimens are encouraged.Key Features: Research Approach: Applications may propose development of a new data-science-driven tool or apply an existing tool or method to gather and analyze information from large datasets with the intent of advancing prostate cancer research and patient care relative to the FY24 PCRP Overarching Challenges. Inclusion of preliminary data to support the scientific rationale and feasibility of research approaches is strongly encouraged, but not required. Any preliminary data provided should be from the laboratory of the Principal Investigator(s) (PI[s]) or member(s) of the collaborating team. Applicants are encouraged to include plans for rigorous validation, benchmarking, comparisons, and/or evaluations to assess the quality or utility of the tools and/or approaches that will be used or developed under this award. Any datasets used in the study design must be from established, retrospective databases and be sufficient in size to provide appropriate analytical and statistical power. Prospective recruitment of human subjects and/or clinical trials is not allowed under this funding opportunity. Applicants are expected to provide documentation demonstrating access to the appropriate datasets and/or patient samples in numbers sufficient to achieve robust results. Impact: Applications are required to clearly communicate how the proposed quantitative and/or analytical approaches, processes, and/or systems will address and provide a solution to one or more of the FY24 PCRP Overarching Challenges. The potential impact of the research, both short- and long-term, should be clearly described, including how the anticipated outcomes or products are distinct from existing research efforts in this area and/or how they will significantly outperform current approaches in this area. High-impact research will, if successful, significantly advance prostate cancer research and/or patient care. Data and Resource Sharing Plan: It is expected that any resources, tools, and computational processes that are developed under this award will be openly shared with the prostate cancer research and patient community. Plans must be provided for how additional data generated by future studies will be incorporated to further inform and refine the data science tools, processes, and/or methods generated and/or used in this study. Refer to the CDMRPs Policy on Data Resource Sharing located on the Electronic Biomedical Research Application Portal (eBRAP) Funding Opportunities Forms web page https://ebrap.org/eBRAP/public/Program.htm for more information about the CDMRPs expectations for making data and research resources publicly available.Partnering PI Option: The FY24 PCRP Data Science Award encourages applications that include meaningful and productive collaborations between investigators. The PIs may have expertise in similar or disparate scientific disciplines, but each PI is expected to bring distinct contributions to the application; collaborations between data scientists and clinicians are highly encouraged. The Partnering PI Option is structured to accommodate two PIs. One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The other PI will be identified as a Partnering PI. Both PIs should contribute significantly to the development and execution of the proposed research project, including the Project Narrative, Statement of Work (SOW) and other required components. If recommended for funding, each PI will be named on separate awards to the recipient organization. Each award will be subject to separate reporting, regulatory, and administrative requirements. For individual submission requirements for the Initiating and Partnering PI, refer to Section II.D.2, Content and Form of the Application Submission.A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, the CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 PCRP priorities.Innovative research involving nuclear medicine and related techniques to support early diagnosis, more-effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies.Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research.All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (http://www.nature.com/ nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies.Clinical trials are not allowed. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated direct costs budgeted for the entire period of performance for an FY24 PCRP Data Science Award should not exceed $1.0M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $11.2M to fund approximately seven Data Science Award applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

The FY24 PCRP Physician Research Award supports a mentored research experience to prepare physicians with clinical duties and/or responsibilities for productive careers in prostate cancer research. The mentored physician is considered the Principal Investigator (PI) of the application. This award emphasizes equally the quality of the proposed research project and the career development of the PI, which should prepare physicians for careers in basic, population science, translational, or clinical prostate cancer research. All applications for the FY24 PCRP Physician Research Award are to be written by the PI, with appropriate direction from the mentor(s).Key elements of this award mechanism are as follows: Principal Investigator: Physicians with clinical duties and/or responsibilities who, at the application submission deadline, are either in the last year of an accredited graduate medical education program as a resident or fellow or within 5 years of having initiated a faculty appointment (including Instructor positions) are eligible to apply. The PI must demonstrate a commitment to a career as a physician-scientist and investigator at the forefront of prostate cancer research and clinical practice; however, the PI is not required to have previous prostate cancer research experience. The award is intended to provide protection of the PIs time for prostate cancer research. Applications are strongly encouraged to demonstrate protection of at least 20% of the PIs time for prostate cancer research, which is not required to be exclusive to this award but can include effort dedicated to other prostate cancer research projects. Mentor(s): This award requires the involvement of at least one designated mentor with an established research program in prostate cancer, as evidenced by recent publications, active funding, and successful mentorship. In addition, the mentor(s) must demonstrate a commitment to advancing the PIs career in prostate cancer research. Research Approach: Proposed research ideas are required to address one or more of the FY24 PCRP Overarching Challenges. The scientific rationale and experimental methodology should demonstrate in-depth analysis of the research problem presented. The feasibility of the research design and methods should be well defined, and a clear plan should be articulated as to how the proposed goals of the project can be achieved. The inclusion of preliminary data relevant to prostate cancer and the proposed project is encouraged but not required. Any preliminary data provided should be from the PI, mentor(s), or member(s) of the collaborating team. Additionally, required resources should be identified and supported through documentation. Research involving human subjects is permitted under this funding opportunity but is restricted to studies without clinical trials. Correlative studies associated with an existing clinical trial are particularly encouraged, provided they are determined to be no greater than minimal risk by the Institutional Review Board (IRB) of record and the USAMRDC Office of Human and Animal Research Oversight (OHARO), Office of Human Research Oversight. Researcher Development Plan: An individualized researcher development plan is required and should be prepared with appropriate guidance from the mentor(s). The researcher development plan should include a clearly articulated strategy for acquiring the necessary skills, competence, and expertise that will enable the PI to successfully complete the proposed research project and foster the PIs development as an independent prostate cancer physician-scientist. An environment appropriate to the proposed mentoring and research project must be clearly described, although any deficiencies of resources and/or mentorship at the PIs institution can be mitigated through collaboration(s) with other institutions. If the PI will be utilizing resources at another institution to successfully complete the proposed project, then the PI is strongly encouraged to designate a co-mentor at the collaborating institution. Impact: The proposed research must address and provide a solution to one or more of the FY24 PCRP Overarching Challenges and ultimately should have the potential to make a significant impact on the programs mission of eliminating death and suffering from prostate cancer and enhancing the well-being of Service Members and their Families, Veterans, and all the patients and caregivers who are experiencing the impact of the disease.Investigators are strongly encouraged to incorporate the following components into their study design, where appropriate, in order to maximize the potential impact of the proposed research project: authentication of proposed cell lines; statistical rigor of preclinical animal experiments; and incorporation of experiments to assess clinical relevance and translatability of findings. Studies utilizing data that are derived from large patient studies that include long-term health records, biospecimen repositories, and pre-existing research and apply state-of-the-art genomic and/or proteomic analysis, bioinformatics, and/or mathematical models to such data are also encouraged. Investigators are highly encouraged to provide a letter of support indicating access to and the availability of any resources required to support the study.A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, the CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 PCRP priorities.Innovative research involving nuclear medicine and related techniques to support early diagnosis, more-effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies.Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research.All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (https://www.nature.com/nature/ journal/v490/n7419/full/nature11556.html. While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies.Clinical trials are not allowed. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated direct costs budgeted for the entire period of performance for an FY24 PCRP PRA Award should not exceed $750,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $4.80M to fund approximately four PCRP Physician Research Award applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.