Grants for State governments - Education

This notice of funding opportunity (NOFO) will support projects proposing mechanistic studies that will transform our understanding of polysubstance use in addiction. These hypothesis-based, exploratory projects may investigate mechanisms of polysubstance use at the behavioral, cognitive, cellular, circuit, genetic, epigenetic, pharmacological and/or computational levels. Research on substance use disorders (SUDs) has primarily focused on individual substances although polysubstance use is prevalent. Polysubstance use is the use of more than one addictive substance within a defined interval; the use may be sequential (use of multiple substances on separate occasions), or concurrent/simultaneous. Limiting studies to an individual addictive substance overlooks potential interactions between substances and could influence the translational potential of preclinical research findings. Results from several studies have demonstrated that the use of multiple addictive substances produces pharmacokinetic and behavioral profiles that are distinct from those produced by a single substance. Despite this recognition, little is known about the precise pharmacological mechanisms and interactions that may contribute to such outcomes, or co-morbidities resulting from co-use. There is also a significant lack in our understanding of how the activity of discrete cells, genes, circuits, expression of receptors, ion channels, intrinsic excitability or signaling mechanisms in the reward systems synergize when exposed to distinct classes of drugs simultaneously or sequentially. Even less is known about these mechanisms in brain regions and circuits that underlie negative reinforcement, or how neurotransmitters, neuromodulators or stress interact within these circuits to contribute to the behavioral and pharmacological profiles observed following polysubstance use. In addition, there is a need for behavioral models of polysubstance use that have translational potential. Research Objectives: The National Institute on Drug Abuse (NIDA) seeks to stimulate innovative research that will transform our understanding of the basic mechanisms that underlie polysubstance use in addiction. These studies will investigate novel neurobiological, pharmacological and/or behavioral mechanisms underlying the biobehavioral outcomes of polysubstance use. Research areas and questions of programmatic interest include, but are not limited to: Identification and/or characterization of molecules, genes, cells (including non-neuronal cells), neural pathways, circuits, receptors, ion channels, intrinsic excitability, pharmacological and signaling mechanisms mediating the effects of polysubstance use. Mechanisms underlying the association of early adolescent polysubstance use with SUD’s in adulthood. Sex differences in the development and trajectory of polysubstance use. What are the roles of organizational and activational effects of sex steroids on discrete brain regions and neural circuits, and how is this altered with exposure to polysubstance use? What are the developmental determinants? Are there developmental windows during which polysubstance use would be facilitated? What are the pharmacologic, pharmacokinetic and pharmacodynamic interactions that can impact toxicity, or the SUD trajectory? How do environmental factors interact with brain circuits to influence the development and trajectory of SUDs involving polysubstance use? How does stress interact with brain circuits to influence the development and trajectory of SUDs involving polysubstance use? Are there neurobehavioral risk phenotypes for progression to polysubstance use? What are the neurocognitive and neurobehavioral changes that occur through experience with different patterns of polysubstance use? Applications Not Responsive to this Notice of Funding Opportunity (NOFO) The following types of studies are not responsive to this NOFO and will not be reviewed: The major goal of the project is not targeted at delineating the basic mechanisms underlying polysubstance use in addiction. Projects limited exclusively to the phenomenology of polysubstance use, consequences of polysubstance use, or those focused exclusively on the development of tools or animal models. Projects that do not focus on combinations of two or more addictive substances with well-justified translational and public health relevance. Projects that do not include a psychostimulant, opioid, or cannabinoid in the polysubstance combination. Alcohol may be included in the polysubstance combination. Research that does not pertain to at least one of the stages of the substance use trajectory, including, but not limited to initiation, escalation, withdrawal and/or relapse. Other application considerations: Collaborative research teams to foster the sharing of conceptual and/or technical expertise are strongly encouraged. Applicants using animal models are encouraged to use models reflective of chronic and voluntary drug intake. Preliminary data are not required but may be included if available. In the absence of preliminary data, a strong premise should be provided for testing a novel hypothesis based upon the scientific literature as well as evidence of the team’s ability to carry out the proposed studies through published or technical preliminary data.

This program supports businesses and organizations in Washington State that are working on innovative projects to reduce waste and promote a circular economy through recycling, reuse, and sustainable practices.

This funding opportunity supports nonprofit organizations and schools in Idaho to carry out public arts projects and events, requiring a matching contribution and professional artist compensation.

This funding opportunity supports early-stage researchers in cancer control and population sciences to explore innovative ideas that can significantly advance cancer research and improve healthcare delivery.

This funding opportunity provides financial support to organizations that assist low-income, first-generation adults and other priority groups in accessing postsecondary education and career pathways, including apprenticeships and short-term programs.

This funding opportunity supports researchers conducting basic science studies to explore how sleep and circadian rhythms are connected to substance use disorders, aiming to improve understanding and treatment of these issues.

This grant provides funding to nonprofit organizations in northwest Ohio and southeast Michigan for innovative programs that improve community well-being, focusing on safety, family support, and youth development.

This grant provides funding for researchers to explore the complex interactions between the brain and immune system in the context of HIV and substance use disorders, aiming to identify new therapeutic targets and improve understanding of related neurological issues.

Reissue of RFA-MH-20-128 This Funding Opportunity Announcement (FOA) solicits applications to develop standards that describe experimental protocols that are being conducted as part of the BRAIN Initiative. It is expected that applications will solicit community input at all stages of the process. It is recommended that the first step of standard development will involve sharing data between different key groups in the experimental community in order to ensure that the developing standard will cover the way that all of those groups are collecting data. The developed standard is expected to be made widely available.

This program provides funding to state educational agencies to improve and innovate assessment systems that measure student achievement and growth in elementary and secondary schools.

This initiative provides $10 million to organizations in the U.S. that propose innovative solutions to rebuild public trust in essential institutions like schools, government, media, and healthcare.

This funding opportunity provides resources to educational organizations and agencies to improve student outcomes and enhance instructional quality through targeted technical assistance and capacity-building services.

The AARP Foundation is accepting applications for the Purpose Prize, a national award celebrating individuals aged 50 and older who are leveraging their life experiences to create positive change. Winners will receive $50,000 for their non-profit organization and access to various resources and events. Eligible applicants must be US citizens, at least 50 years old, and have founded a 501(c)(3) or 501(c)(4) non-profit organization. The work being recognized must have been initiated when the applicant was at least 40 years old. For more information, visit The AARP Foundation website.

This funding opportunity supports researchers exploring the use of microorganisms, like bacteria and viruses, to develop innovative methods for cancer imaging, diagnosis, and treatment.

This grant provides funding for junior faculty members to develop their research careers in women's health through mentorship and interdisciplinary studies, including opportunities to lead or participate in clinical trials.

This program provides funding to rural Kansas communities with populations under 5,000 for projects that enhance quality of life, such as childcare improvements, public art, library upgrades, and food retail expansions.

This funding opportunity supports New Jersey Workforce Development Boards in creating partnerships to improve adult literacy and job skills for residents, helping them secure stable employment and achieve self-sufficiency.

This funding opportunity supports researchers in developing and testing innovative devices for diagnosing and treating disorders of the nervous system through small clinical studies and safety assessments.

This grant provides funding for researchers to explore how diet and lipid metabolism influence tumor growth and progression, encouraging innovative studies that connect nutrition science with cancer biology.

The Mississippi Humanities Council offers grants to support projects that engage communities in meaningful dialogue, attract diverse audiences, and are participatory and engaging, applying humanities to everyday life. Grants support public humanities programs, exhibits, planning of larger projects, and the development of original productions in various media. Regular grants : start at $2,500 to $10,000. Regular grants applications are accepted on May 1st and September 1st Grant renewed every year.