Grants for Nonprofits - Health

This funding opportunity is designed to establish a center that will coordinate and advance research on whole person health by integrating diverse biomedical knowledge and fostering collaboration among researchers.

This funding opportunity supports researchers with active NCI U01 awards who want to integrate innovative cancer research technologies to improve their studies and advance cancer prevention, detection, diagnosis, and treatment.

This funding opportunity supports research to uncover genetic factors related to mental disorders in diverse populations, particularly those of non-European ancestry, while promoting community engagement and career development for early-career researchers.

Allergic reactions to drugs and vaccines are a serious public health concern. For the purpose of this notice of funding opportunity (NOFO), allergic reactions include not only IgE-mediated reactions, but other immune-mediated and largely unpredictable drug and vaccine reactions. Based on data from 2013-2014, each year in the United States there are an estimated 200,000 emergency department visits for adverse events related to antibiotics. In children 5 or younger, antibiotics cause more than half (56%) of estimated emergency department visits for adverse drug events and 82% of these visits are due to allergic reactions. Allergic reactions to antibiotics include immediate life-threatening reactions such as anaphylaxis, severe cutaneous reactions including Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms, and less severe reactions that still limit further use of the drugs. A label of antibiotic allergy leads to the use of alternative, frequently more expensive antibiotics, often with lower efficacy, which may contribute to antibiotic resistance as well as increased mortality and morbidity in hospitalized patients. While allergic reactions to vaccines are less common, the inability to receive a vaccine due to an allergy is problematic to the individual, and the perceived risk of allergic reactions to vaccines contributes to vaccine hesitancy creating a public health issue. Objectives The objective of this NOFO is to solicit innovative projects to study the mechanisms and management of vaccine or antibiotic drug allergy (research on allergic responses to anti-viral, anti-fungal and anti-parasitic drugs will also be considered). The scope of research into antibiotic or vaccine allergic reactions includes, but is not limited to, the following: IgE-mediated and other mechanisms of immediate allergic antibiotic or vaccine reactions Non-IgE-mediated urticarial reactions to antibiotics or vaccines Delayed-type hypersensitivity reactions to antibiotics or vaccines Severe cutaneous adverse antibiotic or vaccine reactions Biomarkers to identify people at risk for reaction or to confirm reactions to specific antibiotics or vaccines Host factors that may predispose to allergic reactions including, but not limited to, host microbiome, genetics, or inflammatory conditions Mechanisms by which specific infections may increase the risk of an allergic reaction to an antibiotic or vaccine Immunomodulatory approaches to treating or preventing immunologic adverse antibiotic or vaccine reactions A secondary objective of this NOFO is to expand the number of investigators working in the field of vaccine and antibiotic drug allergy. Early-stage investigators are encouraged to apply. UG3/UH3 phase transition and Milestones This funding opportunity is designed as a two-stage cooperative agreement in which Project Scientists from NIAID will work with the investigative team. It will support projects that are organized into a two-year UG3 phase followed by a three-year UH3 phase. The UG3 phase may include pilot, observational, or hypothesis-generating high-risk projects. Preliminary data may be helpful but are not required. The use of electronic health records to identify potential participants for mechanistic studies is allowed. The use of human samples such as those related to clinically indicated and routinely used interventions or tests is encouraged. The UG3 must include milestones to determine the success of the project at the end of this phase. Milestones may be negotiated or re-negotiated after award as this program includes the flexibility to quickly revise milestones and/or aims within the scope of the original peer-reviewed application. Following the completion of the UG3 phase, NIAID staff will review the progress made and make the determination on whether the project will continue to the UH3 phase. NIAID support for the UH3 is contingent upon progress made during the UG3 phase, meeting the milestones, programmatic priorities, the original UG3/UH3 peer review recommendations, and the availability of funds. Some projects might not transition from the UG3 to the UH3 phase. Projects supported by the UH3 phase are required to be hypothesis driven, mechanistic, and extend the work initiated by the UG3 phase. Program Director/Principal Investigator (PD/PI) Meeting Attendance A kick-off meeting and annual meetings will be organized by NIAID to facilitate interactions among recipients to share approaches, data, and methods, with the aim of developing a cadre of dedicated researchers to conduct antibiotic and vaccine allergy and advance mechanistic research. These meetings will convene yearly in the Rockville, Maryland area and will be held in person, though a virtual component will be available to allow broader participation from laboratory members. The PD/PI from each award is expected to attend the kickoff meeting and annual meetings in person. Applications that propose the following topics will be considered non-responsive and will not be reviewed: Adverse drug reactions that are predictable and/or related to pharmacologic properties of the drug such as toxicity or overdose Investigation into drugs that are not antibiotics or vaccines (however research on anti-viral, anti-fungal and anti-parasitic drugs is allowed) Investigations into Guillain-Barré Syndrome or drug-induced autoimmune reactions Investigations of central nervous system and other neurologic adverse responses Investigations into the pathogens rather than host allergic responses to the antibiotics or vaccines Applications that do not propose mechanistic research in the UH3 phase Vaccines that are administered via a route that is not the same route of administration as approved by the FDA Vaccines that are used as an immunotherapeutic (e.g. allergen immunotherapy) HIV/AIDS research

This funding opportunity supports collaborative research teams of diverse experts to tackle ambitious challenges in dental, oral, and craniofacial science, focusing on innovative solutions like non-opioid pain therapies and health disparity-reducing technologies.

The Los Angeles County Department of Economic Opportunity (DEO) is launching the Commercial Acquisition Fund (CAF) to provide grants to qualifying nonprofit organizations. This program aims to support the acquisition of vacant or abandoned land and buildings in communities severely impacted by the COVID-19 pandemic. The DEO's mission, through the CAF, aligns with revitalizing economically distressed areas and fostering community resilience by empowering local nonprofit entities to drive economic recovery and development. The target beneficiaries of the CAF are communities in Los Angeles County identified as "highest and high need areas" based on the County’s COVID-19 Vulnerability and Recovery Index in the Equity Explorer Tool. The program prioritizes addressing the negative impacts of the pandemic by facilitating the conversion of underutilized commercial properties into assets that can serve community needs. The impact goal is to stimulate economic activity, improve local infrastructure, and create opportunities for growth in these vulnerable regions. The CAF focuses on the acquisition of vacant or abandoned commercial properties. The program is funded by $10 million in American Rescue Plan Act (ARPA) funds, demonstrating a strategic priority to leverage federal resources for local recovery efforts. Grants will be awarded as recoverable funds, ranging from $500,000 to $2,000,000, indicating a significant investment in each project to ensure substantial impact. The expected outcomes include the successful acquisition and redevelopment of commercial properties, leading to job creation, increased access to essential services, and enhanced community well-being. Measurable results will be tied to the number of properties acquired, the economic benefits generated in the target areas, and the overall improvement in the COVID-19 Vulnerability and Recovery Index. The DEO’s theory of change posits that by empowering qualified nonprofit organizations to acquire and redevelop commercial properties, it can directly address economic disparities and foster sustainable recovery in the communities most affected by the pandemic.

The Guernsey County Foundation, in partnership with the Foundation for Appalachian Ohio, is offering grants to nonprofits, schools, and public organizations. This program aims to benefit Guernsey County residents and communities by funding projects and programs that align with the Foundation's mission of advancing opportunities across five key areas. These areas, known as the Pillars of Prosperity, include arts and culture, community and economic development, education, environmental stewardship, and health and human services. The program is designed to foster local initiatives that address pressing needs and unlock potential within the county. The primary beneficiaries of these grants are individuals of all ages within Guernsey County. The program emphasizes supporting those who are actively leading efforts to create opportunities and meet critical community needs. The impact goals are centered around strengthening the county across the five Pillars of Prosperity, ultimately leading to a more vibrant and prosperous community for all residents. The program's priorities and focuses are clearly defined by the Pillars of Prosperity. This includes supporting cultural enrichment, fostering economic growth and development, improving educational outcomes, promoting environmental sustainability, and enhancing the health and well-being of the population. The Foundation is particularly interested in initiatives that demonstrate a clear strategy for creating lasting positive change within these areas. While specific measurable results are not explicitly detailed in the provided information, the expectation is that funded projects will contribute tangibly to the advancement of opportunities in the five stated areas. The Foundation's strategic priorities are to empower local individuals and organizations to spearhead impactful efforts, thereby driving community-led solutions. The underlying theory of change is that by investing in these key areas through local initiatives, Guernsey County will experience significant improvements in quality of life and overall community strength. Funding requests range between $500 and $10,000, indicating a focus on supporting a variety of projects, both small and medium in scale, that can collectively contribute to these broader goals.

This funding opportunity supports researchers in developing innovative tools to measure human behavior and synchronize these measurements with brain activity, aiming to advance our understanding of brain-behavior relationships and improve interventions for neurobehavioral conditions.

This funding opportunity provides financial support to nonprofit organizations that implement programs benefiting the communities of Dalton, Marshallville, and Orrville, Ohio, focusing on youth development, life skills, emergency assistance, and health services.

The Community Foundation's Impact Grant program offers broad support for various purposes, including field of interest and special purpose funds, as well as assistance for individuals served by nonprofits or government agencies. This program aligns with the foundation's mission to address diverse community needs within Frederick County, Maryland, by providing flexible funding to a wide array of organizations. The target beneficiaries for these grants are the residents of Frederick County, Maryland, who benefit directly from the programs and services offered by eligible organizations. The impact goals are to improve various sectors including health and human services, historic preservation, the arts, agriculture, civic causes, animal well-being, education, and youth programs. By supporting these areas, the foundation aims to foster a stronger, more vibrant, and healthier community. The program prioritizes organizations that demonstrate a direct benefit to Frederick County. Eligible applicants include existing 501c3 nonprofit organizations, government/quasi-governmental agencies seeking funding for extraordinary projects not covered by tax revenue, religious organizations requesting support for non-sectarian activities, and civic groups that are not 501c3s but are working on community causes. The minimum grant request is $500, with grants typically being less than $1000 and lasting for a one-year duration. Expected outcomes include enhanced service delivery in critical areas, preservation of cultural assets, promotion of civic engagement, and improved well-being for individuals and animals in Frederick County. The foundation's strategic priorities are to provide accessible funding that supports a broad spectrum of community needs, ensuring that a diverse range of organizations can access resources to implement impactful programs. This approach reflects a theory of change where strategic investments in key community areas, through diverse and capable organizations, lead to significant and lasting positive change for the residents of Frederick County. Grants must be used between January 1, 2025, and December 31, 2025.

This funding opportunity is designed to support the establishment of collaborative research centers that enhance the study and treatment of bone, muscle, and orthopaedic conditions through shared resources and multidisciplinary approaches.

This funding opportunity provides financial assistance to birth centers facing economic challenges, particularly those serving low-income or rural communities, to help cover membership fees to the American Association of Birth Centers.

This grant provides financial support to nonprofit organizations in South Hampton Roads, Virginia, focusing on education, community enrichment, and sustainability initiatives to improve the quality of life in the region.

This grant provides financial support to nonprofit organizations that create programs promoting health and wellness through physical activity for youth in northwest Ohio and southeast Michigan.

This funding opportunity provides financial support to Colorado nonprofit organizations and schools to create accessible arts education projects for historically marginalized youth, fostering collaboration with professional artists and addressing community needs.

This funding opportunity supports researchers in analyzing existing oral health data or developing new statistical methods to improve data analysis, with a focus on establishing causal relationships rather than just identifying correlations.

The "Access and Manipulation of Brain Cell Subtypes Implicated in Aging and AD/ADRD" grant aims to fund innovative research strategies that use advanced tools to target and manipulate specific brain cells affected by aging, Alzheimer's Disease, and related dementias, in order to better understand these conditions and their impact on brain function.

This funding opportunity supports innovative research on how communication between mitochondria and the nucleus affects Alzheimer’s Disease and related dementias, inviting applications from universities, nonprofits, and other organizations.

The Heartland Regional Food Business Center is offering Business Builder Subawards ranging from $5,000 to $50,000 to support small food and farm businesses in selected states and counties, aiming to expand local and regional food markets, increase business acumen, and strengthen food systems in response to COVID-19, with projects to be completed within a year.

This grant provides financial support to nonprofit organizations in Brown, Door, Kewaunee, and Oconto counties, focusing on capacity-building efforts to enhance their sustainability and effectiveness, particularly for those led by people of color and serving older populations.