Grants for For profit organizations other than small businesses - Science and Technology

This funding opportunity supports U.S.-based small businesses in developing and manufacturing therapeutic extracellular vesicles for regenerative medicine applications, focusing on tissue and organ repair.

The Historic Downtown Kennewick Partnership, in collaboration with the City of Kennewick’s Community Development Department, has relaunched the Downtown Kennewick Façade Improvement Grant Program. This initiative aims to enhance the visual appeal of downtown Kennewick by fostering a cohesive image, promoting coordinated signage and store graphics, and complementing existing building façades. The program offers grants ranging from $10,000 to $100,000, with up to $25,000 per storefront, to support improvements. This program aligns with the broader mission of revitalizing and developing the downtown area, contributing to economic growth and community pride. The primary beneficiaries of this program are property owners and businesses within the designated target area of downtown Kennewick. The impact goals are centered on creating a more attractive and vibrant downtown environment, which in turn is expected to draw more visitors and customers, stimulate local commerce, and encourage further investment in the area. By improving the aesthetics of storefronts, the program directly addresses the need for a unified and appealing commercial district. The program prioritizes eligible improvements such as cleaning and painting, new awnings, canopies, and signs, gutters and downspouts, exterior wall repairs, building-mounted lighting, door and window repairs and replacements, and accessibility improvements. A key focus is on ensuring projects comply with the City of Kennewick Façade Improvement Program Underwriting Guidelines and are evaluated for consistency with an approved color palette by the Historic Downtown Kennewick Partnership’s Design Committee. The committee specifically encourages a sophisticated and restrained application of color, using vibrant hues for highlights and trim, and softer tones for main building elements. Expected outcomes include a visibly improved downtown area with enhanced curb appeal and a more unified architectural style. Measurable results will likely involve the number of storefronts that undergo renovations, the total investment leveraged by the grants, and potentially increased foot traffic or business activity in the revitalized areas. The underlying theory of change is that by investing in physical improvements and enhancing the aesthetic quality of downtown façades, the program will create a more inviting and economically dynamic environment, leading to increased community engagement and sustained revitalization efforts. The program’s strategic priorities are clearly focused on visual improvement and adherence to design guidelines to achieve these broader community development goals.

This fellowship supports U.S.-based documentary filmmakers working on impactful projects by providing funding, mentorship, and networking opportunities to enhance their storytelling skills.

The FY24 DMDRP CTRA mechanism supports advanced translational research that will accelerate the movement of promising ideas in DMD research into clinical applications. Translational research may be defined as an integration of basic science and clinical observations. However, applicants should not view translational research as a one-way continuum from bench to bedside. The research plan must involve a reciprocal flow of ideas and information between applied and clinical research. As such, applications must include preliminary and/or published data relevant to DMD to support the proposed research project.This mechanism is intended to support established projects that have moved beyond the realm of basic research and proof of concept studies and have the potential to result in a near-term impact in clinical research or the clinic. Research projects investigating therapies that will be efficacious across the life span, including infants, toddlers, and non-ambulatory individuals, are strongly encouraged. Pilot, proof-of-principle clinical trials, and correlative studies to better inform development of drugs, devices, and other interventions are allowed.Early-Career Partnering PI Option: The FY24 DMDRP encourages applications that include meaningful and productive collaborations between investigators. In an effort to promote enhanced research capacity within the DMD field, the FY24 CTRA includes an option for an Early-Career Partnering Principal Investigator (PI). The Partnering PI Option is structured to accommodate two PIs. One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The Early-Career PI will be identified as the Partnering PI. Both PIs should contribute significantly to the development and execution of the proposed research project. If recommended for funding, each PI will be named on separate awards to the recipient organization(s). Each award will be subject to separate reporting, regulatory, and administrative requirements. For individual submission requirements for the Initiating and Partnering PI, refer to Section II.D.2, Content and Form of the Application Submission.The FY24 DMDRP CTRA offers two funding levels (refer to Section II.D.5 Funding Restrictions). Only one funding level category may be chosen per application, and the choice of application category is at the discretion of the applicant. The following are generalized descriptions of the scope of the research appropriate for each funding level:Funding Level 1: Funding Level 1 is intended to support smaller, less complex preclinical and/or clinical research. Pilot clinical trials are allowed. The proposal/applications direct costs budgeted for the entire period of performance should not exceed $650,000.Funding Level 2: Funding Level 2 is intended to support larger, more complex preclinical and/or clinical research. Pilot clinical trials are allowed. The proposal/applications direct costs budgeted for the entire period of performance should not exceed $1.35M.Additionally, both funding levels will support an Early-Career Partnering PI Option at the same maximum direct costs and periods of performance, respectively.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Both pilot clinical trials and clinical research are permitted under this mechanism.A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.All investigators applying to FY24 DMDRP funding opportunities and conducting clinical research are encouraged to consult the Strategies to Promote Diversity in Muscular Dystrophy Research Participation developed by the MDCC.

This funding opportunity provides financial support for the design and operation of a facility that extracts and refines rare earth elements from unconventional sources, aimed at strengthening domestic supply chains and reducing reliance on foreign materials.

This funding opportunity provides $100,000 to established for-profit businesses in Cook County, Illinois, to support their growth through capital investments in workforce expansion, equipment, and facility upgrades.

Project is to increase the capacity of partner countries to develop, adopt, and implement legal frameworks that protect individual data privacy while educating key stakeholders and enabling trusted cross-border data flows and digital trade.

This funding opportunity supports Arizona-based institutions conducting clinical research on ibogaine's potential therapeutic uses for neurological diseases, encouraging collaboration among academic, nonprofit, and private sectors.

This funding opportunity provides financial support for research and management projects focused on conserving Chinook and Chum salmon in the Yukon River, with an emphasis on community engagement and capacity building among local residents.

This funding supports Southern nonprofit organizations and government entities in enhancing their artistic programming and professional development through travel and training opportunities.

The Alaska Community Foundation (ACF) is seeking applications for its Kodiak Community Foundation Grants program, targeting charitable organizations and programs within the Kodiak Archipelago Area. This grant opportunity aligns with the ACF's broader mission to support diverse community needs, with a focus on local impact in the Kodiak region. The program aims to address a wide range of needs, ensuring that funding contributes to the well-being and development of the community. The target beneficiaries of these grants are charitable organizations and programs operating in the Kodiak Archipelago. The impact goals are broad, encompassing health and wellness, education, outdoor activities, arts and culture, and community development. The foundation's strategic priority is to empower local initiatives that directly benefit the residents of the Kodiak area, reflecting a theory of change that grassroots efforts are crucial for sustainable community growth. The program prioritizes projects that address a broad spectrum of community needs. While specific outcomes are not rigidly defined beyond these categories, the expectation is that funded projects will contribute to an improved quality of life, enhanced community resources, and increased opportunities for residents in the aforementioned areas. Measurable results would likely be defined by individual grant recipients based on their specific project goals, within the broader framework of the foundation's focus areas. Funding information indicates average awards range from $1,000 to $3,000, with a potential for higher or lower amounts, and grant projects must be completed within one year of the award. The eligibility criteria emphasize support for 501(c)(3) public charitable organizations, faith-based organizations providing social services, federally recognized Tribes or Tribal non-profit organizations, and city or borough governments. This structured approach ensures that resources are directed towards credible and impactful entities capable of delivering on the grant's objectives.

This program provides financial assistance to small, independently owned businesses in Wakefield, Massachusetts, to help them enhance their digital marketing efforts and expand their online presence.

This grant provides funding for research and development projects aimed at improving the equipment and support systems for U.S. Army soldiers, focusing on enhancing their survivability, mobility, and overall effectiveness in the field.

This funding opportunity supports collaborative research projects that aim to develop clinical applications addressing health issues related to military toxic exposures, targeting independent researchers and their partners.

This funding opportunity supports clinical research aimed at improving burn care for military personnel, focusing on practical applications that enhance treatment in challenging environments.

This grant provides financial assistance to municipalities, non-profit land conservation organizations, and water companies in Connecticut for acquiring land to preserve open spaces and protect water supplies.

The "DoD Bone Marrow Failure, Investigator-Initiated Research Award" is a grant that provides two levels of funding: one for expanding mature research ideas and key discoveries in bone marrow failure, and another for supporting the development of new drugs for bone marrow failure treatment, with the ultimate goal of improving patient care and finding effective treatments and cures.

The DoD Peer Reviewed Cancer, Impact Award is a grant aimed at funding advanced research projects that can quickly translate promising findings into clinical applications, with the goal of making a significant, near-term impact on critical cancer issues and improving patient outcomes.

The National Bycatch Reduction Engineering Program (BREP) - FY2025 aims to fund innovative research and development projects that reduce bycatch of non-target species in fisheries, promoting sustainable practices and protecting marine ecosystems.

The DoD Kidney Cancer, Academy of Kidney Cancer Investigators - Early-Career Scholar Award is a grant aimed at supporting early-career scholars in conducting kidney cancer research, providing them with funding, networking, and collaborative opportunities, and mentorship for a period of four years, with the ultimate goal of advancing kidney cancer research and developing highly productive kidney cancer researchers.