Grants for Public and State controlled institutions of higher education - Science and Technology

Synthesis Centers are a mechanism used by NSF's Directorate for Biological Science (BIO) to bring together communities that leverage existing data to catalyze discoveries through synthesis, analysis, and integrative training. Research supported by the Division of Integrative Organismal Systems (IOS) in BIO focuses on organisms as integrated units of biological organization, i.e., why they are structured as they are and function as they do. IOS seeks to establish a new Synthesis Center to advance our ability to explain and predict organismal resiliency and plasticity in response to complex and dynamic environmental circumstances encountered over a lifespan through the synthesis of varied data sets and types that bridge multiple scales and levels. The Synthesis Center will enable innovative synthesis and analysis of available biological and related data by providing the vision, infrastructure, and expertise to advance new avenues of inquiry in organismal biology focused on organismal resilience and plasticity. To accomplish this vision, the Synthesis Center will adopt approaches that are based on open science, team science, and data-intensive methods that enable data synthesis, sharing and inclusive collaborations among researchers across multiple levels of biological inquiry that may include genomic, physiological, structural, developmental, behavioral, neural, immunological, and microbiological analyses across some or all the IOS subdisciplines. In addition to supporting data and knowledge synthesis, the Synthesis Center should train new generations of researchers in solving challenging research problems through data-intensive, open, cross-disciplinary, and collaborative science. The Synthesis Center is also expected to serve as an example in effectively engaging diverse scientists from different types of institutions and across multiple disciplines. These types of data syntheses are expected to provide the basis for fundamental scientific discoveries and/or potentially translational, use-inspired research. In doing so, the Synthesis Center will have a profound impact on the progress of science and society.

Microbes and communities of microbes have remarkable genetic, physiological and biochemical diversity, allowing them to flourish in environments all over the planet and in a variety of substrates and hosts. Given their relative importance to ecosystems around the world, to the economy and to health, researchers have studied microbial systems extensively and have a better understanding of their capabilities and impacts on hosts and the environment. In recent years, researchers have increasingly turned to microbes and their diverse capabilities for bioremediation and applications in biotechnology, agriculture, and medicine. Because of advances in molecular biology, synthetic biology and bioengineering, researchers now have the ability to assemble synthetic microbial communities that have novel compositions, genetics and phenotypes and to use these communities to address both fundamental biological questions and a range of societal problems. The goal of this solicitation is to support research that addresses one or more of the three themes: 1) define the underlying mechanisms or rules that drive the formation, maintenance or evolution of synthetic microbial communities, 2) use synthetic microbial communities to address fundamental biological questions, including questions in molecular biology, cellular/organismal biology, ecology and evolution and/or 3) build synthetic communities with biotechnology, bioeconomy or environmental engineering applications, including but not limited to the production of novel biorenewable chemicals, biodegradation of recalcitrant or forever chemicals, enabling a circular bioeconomy, fostering sustainable agriculture and mitigating the impacts of climate change. For theme 3, the emphasis should be on designing communities with novel capabilities and understanding the underlying mechanisms that lead to these novel capabilities. Proposals must address one or more of the three themes noted above. Highest funding priority is given to proposals that have outstanding intellectual merit and broader impacts, while proposals with weaknesses in either category (or those that are perceived as likely to have an incremental impact) will not be competitive. The most competitive broader impacts include assessment plans. Well-conceived broader impacts activities take time and resources; thus, proposers are encouraged to include appropriate costs for broader impacts in the budget. To better understand the societal benefits and risks, as well as the potential for misuse or unintended damage to natural biological systems, synthetic microbial communities proposals should include a careful consideration of the social, ethical, and biosafety/security dimensions of the research. Investigators may choose to address these issues either as part of intellectual merit or broader impacts. Reproducibility in research leads to data that is amenable to more powerful analysis and the potential for reuse of data and greater generation of knowledge. Reproducibility in biological research that is prone to context dependent biological variation presents a unique challenge for the synthetic microbial communities researchers. Investigators must follow or advance best practices in sample collection and preparation, experimental design, data analysis, model generation, and/or validation of mathematical and computational methods to produce scientifically defensible results.

This grant provides funding for researchers in applied mathematics to develop innovative mathematical techniques that address challenges in science and engineering, excluding biological applications.

This funding opportunity provides financial support for research and development projects focused on improving battery technologies, particularly for electric vehicles, and is open to a wide range of applicants including educational institutions, nonprofits, and government entities.

This grant provides funding for early-career researchers to explore the economic impacts of Alzheimer's disease and related dementias, supporting innovative studies on prevention, treatment, and care for affected individuals.

To implement a project aimed at advancing U.S. foreign policy and national security priorities outlined in the Creating Helpful Incentives to Produce Semiconductors (CHIPS) Act of 2022 (Div. A, P.L. 117-167). The Act established a new International Technology Security and Innovation Fund (ITSI Fund) to to support the development and adoption of secure semiconductors, [and] semiconductor supply chains with the goal to make the global semiconductor supply chain more resilient, diversified, and secure.

This funding opportunity provides financial support to accredited institutions that serve Alaska Native and Native Hawaiian students, aiming to enhance education, research, and community development in agriculture and related fields.

The DoD Psychedelic Treatment Research Clinical Trial Award is a funding opportunity aimed at supporting clinical trials that evaluate the use of specific psychedelic substances in treating U.S. Service Members diagnosed with post-traumatic stress disorder (PTSD) and/or traumatic brain injury (TBI), with the goal of advancing research beneficial to Service Members, Veterans, and their families.

Orthopaedic injuries have a profound impact on military readiness and return to work/activity/duty. In the military, extremity battle wounds comprise approximately 50% of injuries reported in the Department of Defense Trauma Registry. Additionally, orthopaedic injuries and conditions that occur outside of combat (e.g., during training, leisure activities, resultant from old injuries, etc.) present one of the greatest threats to the readiness of our Service Members and military. Early stabilization, treatment, and rehabilitation of orthopaedic injuries in both civilian and military populations have led to better outcomes, particularly in the prevention of secondary complications and in minimizing morbidity. Availability of orthopaedic care and treatment as early as possible, or as close to the point of injury as possible, also minimizes limb loss and affects military readiness.Although the PRORP is interested in supporting military-focused research, research supported by the PRORP is expected to also apply to all individuals who have sustained a major orthopaedic injury.With the initiation of the Arthritis Research Program, the FY24 PRORP may not fund arthritis research; however, research that addresses conditions or health abnormalities related to arthritis is permitted provided the proposed research addresses the selected Focus Area.The FY24 PRORP ARA seeks applied research applications focused on advancing optimal treatment and restoration of function for individuals with orthopaedic injuries sustained during combat and service-related activities. Applicants are encouraged to address how the proposed research will support patient care and allow patients to more quickly return to duty/work. It is expected that any research findings would also provide benefit to the general population. To meet the intent of the award mechanism, applications must specifically address an FY24 PRORP ARA Focus Area, listed in Section II.A.1, above.The FY24 PRORP ARA is focused on applied research, defined as work that refines concepts and ideas into potential solutions with a view toward evaluating technical feasibility of promising new knowledge products, pharmacologic agents, behavioral and rehabilitation interventions, diagnostic and therapeutic techniques, clinical guidance, and/or emerging approaches and technologies.Awards may not be used to support fundamental basic research. Basic research is defined as research directed toward greater knowledge or understanding of the fundamental aspects of phenomena and of observable facts without specific applications toward process or products in mind.Research Scope: Research proposed under the FY24 PRORP ARA may include small- to large-scale projects. Upon successful completion, the proposed research is expected to yield knowledge products, approaches, or technologies that have the potential to advance toward clinical translation. Strong transition plans are expected.Inclusion of preliminary and/or published data relevant to the proposed research is required. Applicants must demonstrate logical reasoning for the proposed work. To be competitive, the application must include a sound scientific rationale and a well-formulated, testable hypothesis established through a critical review and analysis of the literature.Studies allowed under the FY24 PRORP ARA may include, but are not limited to: Refinement of concepts and ideas into potential solutions, or research tools, with a view toward evaluating technical feasibility of emerging approaches, technologies, and promising new knowledge products. Evaluation, maturation, and/or down-selection of potential product candidates (drugs, biologic constructs, or devices/systems) in vitro and/or in vivo. Preparation activities needed to support a future clinical trial or regulatory submission.Applications to the FY24 PRORP ARA mechanism must support preclinical applied research and may not be used for clinical research studies. Applicants seeking support for clinical research projects should consider the FY24 PRORP Clinical Translational Research Award (Funding Opportunity Number HT942524PRORPCTRA), Clinical Trial Award (Funding Opportunity Number HT942524PRORPCTA), or Womens Health Research Award (Funding Opportunity Number HT942524PRORPWHRA) mechanisms.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).Rigor of Experimental Design: All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies. Projects that include research on animal models are required to submit Attachment 8, Animal Research Plan, as part of the application package to describe how these standards will be addressed. Applicants should consult the ARRIVE guidelines 2.0 (Animal Research: Reporting In Vivo Experiments) to ensure relevant aspects of rigorous animal research are adequately planned for and, ultimately, reported. The ARRIVE guidelines 2.0 can be found at https://arriveguidelines.org/arrive-guidelines.Womens Health Research: The CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women's health outcomes and/or advancing knowledge for women's health. Applications proposing research that solely address womens health may also consider the FY24 PRORP WHRA mechanism, Funding Opportunity Number HT942524PRORPWHRA.Encouraged Department of Defense (DOD) and/or VA Collaboration: Military relevance is a key feature of this award. Principal Investigators (PIs) are encouraged, but not required, to collaborate with DOD or VA researchers and clinicians.Use of DOD or VA Resources: If the proposed research involves access to DOD or VA resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. Refer to Section II.D.2.b.ii, Full Application Submission Components, for detailed information. Refer to the General Application Instructions, Appendix 1, for additional information.The anticipated total costs budgeted for the entire period of performance for an FY24 PRORP Applied Research Award should not exceed $750,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $3.75M to fund approximately five ARA applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

This funding opportunity provides financial support to organizations that aim to enhance workforce readiness, English language skills, and technology training for youth and early-career professionals in key cities of Cote d'Ivoire, fostering skills that align with U.S. economic and diplomatic interests.

The Biomedical Research Grant (BRG) program at Indiana University School of Medicine (IUSM) is designed for full-time faculty members across all tenure statuses, supporting both new and established researchers. It aims to facilitate the acquisition of preliminary data for those without extramural funding and to assist established investigators in bridging funding gaps. The program offers small grants up to $50,000 for one-year projects. Applicants must have less than $100,000 in direct cost extramural funding to be eligible, focusing on providing interim technical support for research projects.

This grant provides funding for researchers to develop innovative statistical methods and models that enhance data analysis and interpretation across various scientific and engineering fields.

This program provides funding to organizations in New Jersey to develop training and workforce development initiatives in the film and digital media sectors, particularly for individuals from overburdened communities.

This grant provides funding for early career researchers in planetary science to conduct innovative research that aligns with NASA's mission to advance our understanding of space and Earth systems.

This funding opportunity supports alumni of U.S. government-funded exchange programs in Saudi Arabia to develop innovative projects that promote cultural exchange, educational advancement, and bilateral cooperation, while celebrating the United States' 250th anniversary.

This grant provides funding for U.S. students pursuing combined clinical and research doctoral degrees, enabling them to conduct their Ph.D. dissertation research within the NIH's Intramural Research Program while receiving mentorship and professional development.

This grant provides funding to collaborative groups focused on improving undergraduate biology education by integrating research discoveries with innovative teaching practices, particularly emphasizing inclusivity and diverse perspectives.

This grant provides funding to a single organization to lead and manage a national initiative that connects researchers and educators with essential artificial intelligence resources and infrastructure.

This funding opportunity supports alumni of U.S. government-sponsored exchange programs in Lebanon to implement innovative projects that promote good governance, social cohesion, and cultural heritage while encouraging diversity and inclusion.

This funding opportunity supports research organizations previously involved in studying the effects of prenatal substance exposure on child development, enabling them to continue and expand their collaborative efforts in a nationwide longitudinal study.