Grants for Nonprofits - Federal

The Public Affairs Section (PAS) at U.S. Embassy Tunis of the U.S. Department of State (hereafter referred to as PAS Tunis) is pleased to announce this Notice of Funding Opportunity (NOFO) through its Public Diplomacy Small Grants Program. This an Annual Program Statement (APS) outlines our funding priorities, the strategic themes we focus on, and the procedures for submitting requests for funding. Based on availability of funding, PAS Tunis will award grants, fixed amount awards, or cooperative agreements between a minimum of $10,000 and up to $250,000 (U.S. dollars) each for projects that advance the priorities outlined in this APS. Please carefully follow all instructions. Applications may be submitted at any time for consideration before the closing date of this annual program statement on August 31, 2024 at 11:59 p.m. U.S. EDT. Proposals will be reviewed, and awards made by no later than September 30, 2024, pending the availability of funds. Purpose of PAS Public Diplomacy Grants: PAS Tunis invites proposals for programs that strengthen cultural, educational, professional, and scientific ties between the United States and Tunisia through programming that highlights shared values, strengthens people-to-people ties and institutional linkages, and promotes bilateral cooperation. Competitive proposals should focus on at least one grant priority area outlined below. Proposals that do not address one of the grant priority areas outlined below will not be considered for funding. All proposed programs must include an American cultural element or connection with American expert(s), organization(s), or institutions in a specific field that will promote increased understanding of U.S. policies, values, and perspectives and incorporate cross-cutting approaches to diversity, equity, inclusion, and accessibility (DEIA). Examples of PAS Tunis PD Small Grant proposals include, but are not limited to: Subject-matter expert, academic, and professional lectures, seminars, and speaker programs that include U.S. speakers/experts. Programs that strengthen relationships and linkages between U.S. colleges/universities and Tunisian higher education institutions. Educational, artistic, and cultural programs, including programs that strengthen English language teaching and learning, musical and/or dance workshops, master classes, and performances, live theatre performances, art exhibitions, and culinary diplomacy initiatives. Programs that promote economic empowerment, entrepreneurship, diversity, inclusion, and accessibility, and/or that address environmental and urban development challenges. Cultural heritage conservation and preservation programming, including through the use new technologies, such as VR technology. (Note: PD funding cannot be used to support construction-related activities. End note.) Grant Priority Areas: Grant proposals should address at least one of the four Public Affairs priority areas outlined below: 1. Strengthening civil society and fostering shared interests in democracy, good governance, rule of law, and civic participation. Projects targeting this priority area could focus on advocacy and inclusion efforts for disabled persons and other disadvantaged groups, promoting media freedom and literacy, countering disinformation, strengthening civil society organizations, promoting local cultural heritage, traditional and modern art forms, and other forms of creative expression, and projects that engage emerging leaders in any of these fields through linkages with U.S. counterparts. 2. Advancing inclusive economic prosperity through programs aimed at helping Tunisian citizens, particularly youth, women, disabled persons, first generation Tunisian university students, and geographically marginalized populations fully benefit from economic development. Programs could focus on topics such as entrepreneurship, soft skills training, hospitality, ecotourism, environmental tourism, and creative economy industries, job creation, intellectual property rights and protection, corporate social responsibility, access to finance, and university linkage programs focused on such topics. 3. Fostering innovation together to address climate change and urban development challenges, conservation, science, and technology. Programs could focus on promoting STEM education and/or encouraging youth to pursue STEM careers, or on topics such as environmental conservation, climate change mitigation, technological innovations to tackle challenges related to climate change and urbanization (e.g., water management, waste management, urban planning, mitigating impact of built environment on cultural heritage preservation and green spaces, etc.) and involving communities in developing solutions to such challenges, and linkage programs with U.S. universities focused on such topics. 4. Strengthening the capacity of U.S. government exchange program alumni through programming in the priority areas listed above and bolstering engagement between alumni and the Embassy. Programs could include tailored training for alumni in areas such as project management, grant writing, business plan development and pitching startup ideas, developing and executing community service projects, advocacy for civic projects and policies, leadership, public speaking, DEIA-related training, and other soft skills training, including English language training and/or community service projects or other projects benefitting PAS Tunis priority audiences implemented by exchange program alumni. In addition to the specific requirements listed above, all proposals must: 1. Clearly indicate the primary grant priority area the program is focused on 2. Clearly indicate the key public diplomacy audience(s) that will be targeted by the program and the key activities to be delivered through the program 3. Identify the cities/districts in which activities will take place 4. Identify specific outcomes to be achieved by the end of the grant period 5. Clearly delineate how elements of the proposed program will have a multiplier effect and be sustainable beyond the life of the grant 6. Provide a traditional and/or social media plan for marketing program activities and outcome, if applicable 7. Identify any tools (surveys, beneficiary interviews, focus groups, etc.) that will be developed and used for Monitoring and Evaluation purposes Participants and Audiences: Proposals must focus on one of the priority areas specified above and target at least one of PAS Tunis key audiences, including: youth (14-35 years old), first-generation university/higher education students, alumni of U.S. government-funded exchange program, women, disabled persons, and other minority or geographically marginalized groups, including audiences outside of the Greater Tunis area, educators, media practitioners, policy makers, civil society organizations, and entrepreneurs and innovators. In addition, U.S. Embassy Tunis seeks creative proposals that build upon existing partnerships between U.S. organizations and Tunisian counterparts, as well as those that create new partnerships and expand operational capabilities of existing organizations. The following types of programs are not eligible for funding: Programs relating to partisan political activity; Programs that do not contain people-to-people exchanges or interactions; Charitable or development activities; Construction programs; Programs that support specific religious activities; Fund-raising; Lobbying for specific legislation or programs; Scientific research; Programs intended primarily for the growth or institutional development of the organization; and Programs that duplicate existing programs. Funding authority rests in the Smith-Mundt Act. The source of funding for this NOFO is Public Diplomacy Funding

This grant provides funding to nonprofit organizations serving culturally specific communities to enhance and expand support services for victims of sexual assault.

This funding opportunity supports postdoctoral researchers in the National Institute of Mental Health's intramural program as they transition to independent academic careers in mental health research.

In 2018, The National Park Service (NPS) was authorized under the Consolidated Appropriations Act, 2018: Public Law 115-141, Section 115, the Department of the Interior (DOI) to enter into cooperative agreements with, private nonprofit organizations designated by the Secretary of Labor under Title V of the Older Americans Act of 1965 to utilize the talents of older Americans in programs authorized by other provisions of law administered by the Secretary and consistent with such provisions of law. The Experienced Services Program is intended to augment the capacity of parks and provide needed subject-matter expertise to address short-term needs, unanticipated workloads, and new initiatives.The Experienced Services Program provides a cost-effective recruitment opportunity to obtain the services of non-Federal, experienced workers aged 55 and older. Through agreements with eligible nonprofit organizations, the NPS will be able to recruit and utilize the services of these workers on a project-specific basis to enhance its capacity to achieve its mission, goals, and objectives. Skilled and experienced older Americans, including veterans, will have the opportunity to put their talents and experience to use on a part-time to full-time basis. Enrollment in the program will not impact the retirement benefits of retired federal employees. The use of private non-profit organizations aligns with many of the Department of the Interior goals for fostering better relationships with the communities it serves and increasing the efficiency and effectiveness of NPS programs.

The NINDSintends to reissuePAR-23-027 to solicit applications for basic research projects on chemical warfare agents, toxic industrial chemicals, and pesticides that have primary or secondary effects on the nervous system. Chemical threats are toxic compounds that could be used in a terrorist attack or accidentally released from industrial production, storage, or shipping. Projects supported by this NOFO are expected to generate data that elucidate mechanisms of toxicity of these agents, possible new manifestations of toxic exposures, and potential new targets for therapeutic development. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in Winter 2024 with an expected application due date in Spring 2024. This NOFO will utilize the R01 activity code. Details of the planned NOFO are provided below.

The Office of the Public Affairs Advisor (PAA) at the U.S. Mission to NATO (USNATO) is pleased to announce that funding is available through its Public Diplomacy Small Grants Program. This is an Annual Program Statement, outlining our funding priorities, the strategic themes we focus on, and the procedures for submitting requests for funding. Please carefully follow all instructions below. Purpose of Small Grants: PAA invites proposals for programs and initiatives that help promote an increased understanding of NATOs role in promoting regional peace and security, as well as the rules-based international order. All programs must include a direct tie to the United States. This could be via American expert/s, organization/s, or institution/s in a specific field that will promote increased understanding of U.S. foreign policy interests within the Alliance. Examples of PAA Small Grants Program projects include, but are not limited to: Academic and professional lectures, seminars, and speaker programs Artistic and cultural workshops, performances, and exhibitions Professional and academic exchanges, programs, and trainings Digital engagements and content creation Establishing core leadership/influencer groups, such as a young leaders network Developing educational materials Priority Region: While activities targeting NATO Allies and partner countries will be prioritized, programs that support NATO objectives or increase understanding of NATO in other strategically important countries will also be considered. Priority Program Areas: USNATO PAA invites proposals for programs and initiatives on the following priority program areas: Countering disinformation and misinformation Media independence or media literacy NATO deterrence and defense, including its new military plans Hybrid security threats and emerging technologies Science and technology NATO and Africa, Asia, or Latin America NATO partnerships Russian malign influence in the Euro-Atlantic area The Peoples Republic of Chinas expanding use of economic, political, and military power Climate security Women, Peace, and Security Young professionals and next generation engagement We strongly encourage: New and creative approaches that utilize emerging technologies, innovative audience engagement, and targeted audience reach Programs that seek to reflect diversity of thought and backgrounds, gender balance, and focus on intersectionality Programs and initiatives that incorporate and empower emerging voices, such as youth audiences Product outputs with multiplying effects Product outputs in two or more languages Forthright analysis about the gaps in NATO strategies along with practical solutions to address deficiencies Implementation plans that incorporate evaluation components, such as key performance indicators (KPIs) to track a quantifiable measure of performance

The HBIIP program offers cost-share grants up to $5 million to fueling and distribution facilities for the expansion of renewable fuel infrastructure, aiming to increase the sales and use of higher blends of ethanol and biodiesel derived from U.S. agricultural products.

The WORC Initiative aims to fund grants that create economic mobility, address inequities for historically marginalized communities of color, rural areas, and other underserved and underrepresented communities. These grants are designed to produce high-quality employment outcomes for workers in the Appalachian, Delta, and Northern Border regions, enabling them to remain and thrive in their communities. The Initiative provides grant funds to help impacted communities develop local and regional workforce development solutions aligned with existing economic development strategies and community partnerships, promoting new, sustainable job opportunities and long-term economic vitality with a focus on equity and underserved populations. WORC Round 6 places a strong emphasis on three key focus areas: enhancing access to Good Jobs, prioritizing equity, and sustaining impact. Questions regarding this Funding Opportunity Announcement (FOA) Forecast may be emailed to DOL-ETA-DWG@dol.gov; however, please note there is limited information that may be shared with the public, as this FOA is currently under development. We encourage prospective applicants and interested parties to use the Grants.gov subscription option to register for future updates provided for this particular FOA.

This funding opportunity provides resources to schools and local governments to implement strategies and training aimed at preventing violence in K–12 educational settings.

The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the Research Units (RUs), one of the two scientific components of the Pancreatic Cancer Detection Consortium (PCDC), to conduct research on early detection of pancreatic ductal adenocarcinoma (PDAC) and characterization of its precursor lesions to identify those patients who are at high risk of progression to cancer. The PCDC will continue to address one of the four research priorities identified in the National Cancer Institute's 2014 Scientific Framework for Pancreatic Ductal Adenocarcinoma. The PCDC will support research for the development and testing of new molecular and imaging biomarkers for detecting PDAC early and for identifying those patients at high risk of PDAC (because of genetic factors or presence of precursor lesions) who could be candidates for early intervention. The PCDC-RUs will consist of multi-disciplinary teams and will undertake studies to: identify and test biomarkers measurable in bodily fluids for early detection of PDAC and/or its precursor lesions; determine which pancreatic cysts are likely to progress to cancer; develop molecular- and/or imaging-based approaches for screening populations at high risk of PDAC; use machine learning and computational approaches towards biomarker discovery and/or validation; and conduct biomarker validation studies. The PCDC-RUs will also collect longitudinal biospecimens for building a biorepository. Each PCDC-RU is expected to participate in collaborative activities with other PCDC-RUs and share ideas, biospecimens and data within the Consortium. The other scientific component of the PCDC will be the Management and Data Coordination Unit (MDCU). The PCDC-MDCU will provide support toward study design, protocol development, statistical analysis, coordination, harmonization, data management and stewardship for the trans-PCDC collaborative projects, including biorepository building effort.

Department of the Interior - Bureau of Land Management Arizona Invasive and Noxious Plant Management

This Notice of Funding Opportunity (NOFO) seeks proposals that address the critical issue of lack of transparency and accountability in the allocation and expenditure of public revenue by the South Sudanese transitional government. The transitional government faces significant challenges in managing public finances, leading to significant corruption and misallocation of resources. These issues have profound implications for the delivery of essential services such as healthcare, education, and humanitarian support. Despite commitments made in the 2018 peace agreement, progress towards improving fiscal transparency and accountability has been limited, as noted by independent reports and international organizations.

This funding opportunity supports innovative research to improve personalized probiotic treatments by studying individual biological factors that influence how people respond to probiotics.

This funding opportunity provides financial support for a variety of organizations and individuals to implement public diplomacy initiatives that promote cooperation and shared values between the United States and Finland, focusing on areas like economic prosperity, technology, global security, and youth exchanges.

This funding opportunity supports innovative research projects aimed at improving workplace safety and health by addressing significant occupational hazards in various organizations across the United States.

This funding opportunity supports the establishment of a 24-hour hotline to provide crisis intervention and resources for Indigenous victims and survivors of family violence, ensuring they receive culturally relevant and accessible services.

U.S. DEPARTMENT OF STATE Venezuela Affairs Unit (VAU) Public Diplomacy Section (PDS) Notice of Funding Opportunity (NOFO) Funding Opportunity Title: VAU PDS Annual Program Statement Funding Opportunity Number: FY2024VE006 Deadline for Applications: June 30, 2024 CFDA Number: 19.040 Public Diplomacy Programs Total Amount Available: $100,000 Maximum for Each Award: $25,000 A. PROGRAM DESCRIPTION The VAU of the U.S. Department of State is pleased to announce that funding is available through its Public Diplomacy Grants Program that strengthen people-to-people ties between the United States and the people of Venezuela through programs that highlight shared values and promote a peaceful, democratic transition. This is an Annual Program Statement, outlining our funding priorities, the strategic themes we focus on, and the procedures for submitting requests for funding. Please carefully follow all instructions below. Purpose of Public Diplomacy Grants: VAU Public Diplomacy Section (PDS) invites proposals that support democratic initiatives, higher education cooperation and an active citizenry in Venezuela, highlighting shared values, bilateral cooperation, and support for diversity, equality, accessibility, and inclusion. Priority Program Areas: VAU PDS will prioritize grant proposals that address the following themes: Strengthening independent media through capacity-building programs and other professional engagement; Promoting democratic values and citizen participation through education and outreach, particularly for marginalized groups, including youth, women, LGBTQI+, persons with disabilities, indigenous, and Afro-Venezuelans; and Building university partnerships and other higher-education exchanges that focus on curricula development, research capacity building, and tech transfer/intellectual property policies. PLEASE NOTE: All programs must include an American component, conveying an element of U.S. culture, history, and/or shared values. This must be a concrete element that establishes or strengthens ties between people in Venezuela and the United States. For example, competitive proposals will include a connection with U.S. experts, organizations, or institutions that promote increased understanding of U.S. policy and perspectives and/or increased bilateral cooperation that continues after the program has concluded. IMPORTANT NOTE: At this time no U.S. citizen can travel to Venezuela for in-person programs with this funding. Therefore, speakers and other activities with U.S. organizations need to be conducted through online engagement. Participants and Audiences: Venezuelans in Venezuela and their U.S. counterparts in the sectors represented in the priority program areas listed above. The following types of programs are not eligible for funding: Programs relating to partisan political activity; Charitable or development activities; Construction programs; Programs that support specific religious activities; Fund-raising campaigns; Lobbying for specific legislation or programs; Scientific research; Programs intended primarily for the growth or institutional development of the organization; Programs that duplicate existing programs; or Programs without an American component. Authorizing legislation, type, and year of funding: FY 2024 Public Diplomacy Funding. B. FEDERAL AWARD INFORMATION Length of performance period: up to 12 months Number of awards anticipated: 4 awards (dependent on available funding) Award amounts: awards may range from a minimum of $10,000 to a maximum of $25,000 Total potential available funding: $100,000 Type of Funding: Fiscal Year 2024 Public Diplomacy Funding Anticipated program start date: October 1, 2024 This notice is subject to availability of funding. Funding Instrument Type: Grant or Cooperative agreements. Cooperative agreements are different from grants in that VAU PDS staff are more actively involved in the grant implementation (Substantial Involvement). Program Performance Period: Proposed programs should be completed in 12 months or less. If interested in applying, please visit https://ve.mwp.usembassy.gov/wp-content/uploads/sites/11/2024/05/VENEZUELA-2024-VAU-PDS-APS-NOFO-FINAL-5-14-24.docx-1.pdf to review all information regarding this NOFO.

This funding opportunity supports U.S. higher education institutions and nonprofit organizations in developing collaborative curricula with Venezuelan universities to enhance academic exchange and educational development between the two countries.

The intent of the Breakthrough Award is to support promising research that has high potential to lead to or make breakthroughs in breast cancer. The critical components of this award mechanism are:Impact: Research supported by the Breakthrough Award will have the potential for a major impact and accelerate progress toward ending breast cancer. The impact may be near-term or long-term, but must move beyond a minor advancement and have the potential to lead to a fundamentally new approach that is significantly more effective than interventions already approved or in clinical development. Applications are expected to identify the breast cancer patients or at-risk individuals who would ultimately benefit from the proposed research.Research Scope: The Breakthrough Award is structured with four different funding levels. The levels are designed to support major (but not all) stages of research that will lead to clinical application. Each level has a defined research scope. It is the responsibility of the Principal Investigator (PI) to select the level that aligns with the scope of the proposed research. The funding level should be selected based on the research scope defined in the program announcement, and not on the amount of the budget.The current program announcement discusses the Breakthrough Award Level 4. Funding Levels 1, 2, and 3 are available under other program announcements (HT942524BCRPBTA12 for Levels 1 and 2 and HT942524BCRPBTA3 for Level 3). The PI is strongly encouraged to review the research scope defined under each funding level as described in the corresponding Breakthrough Award program announcements before submitting the pre-application. An application that does not meet the intent of Funding Level 4 will not be recommended for funding, even if it might meet the intent of a different funding level.The following is a general description, although not all-inclusive, of the scope of research projects that would be appropriate to propose under the current program announcement:Funding Level 4: Large-scale projects that will transform and revolutionize the clinical management and/or prevention of breast cancer. Human clinical trials are required. Large-scale trials, such as comparative effectiveness clinical trials, that will transform and revolutionize the clinical management and/or prevention of breast cancer and lead to unprecedented impact on patients lives, may fall under this mechanism. PIs are expected to have experience in successfully leading large-scale projects and demonstrated ability (through personal experience or via a commitment from a collaborating clinical investigator) to implement a clinical trial successfully. Where relevant, applications must demonstrate availability of and access to necessary data, human samples, cohort(s), and/or critical reagents. For proposed research that will require U.S. Food and Drug Administration (FDA) involvement, project readiness requirements at the time of application submission include: proof of availability of and access to clinical reagents (e.g., therapeutics) that meet regulatory compliance guidelines, proof of availability of and access to appropriate subject population(s), validated projections for patient recruitment, and submission of an Investigational New Drug (IND) or Investigational Device Exemption (IDE) application to the FDA, if applicable.Funding from this award mechanism must support a clinical trial. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For more information, a Human Subject Resource Document is provided at https://cdmrp.health.mil/pubs/pdf/Human%20Subjects%20Resource%20Document_DEC2022.pdf.Note: An invited oral presentation is a requirement for application review of Funding Level 4 projects, as described in Section II.D.2.b, Full Application Submission Content.Partnering PI Option: The Breakthrough Award encourages applications that include meaningful and productive partnerships between investigators. The Partnering PI Option is structured to accommodate two PIs. One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The other PI will be identified as a Partnering PI. Both PIs should contribute significantly to the development of the proposed research project including the Project Narrative, Statement of Work (SOW), and other required components. The PIs may have expertise in similar or disparate scientific disciplines, but each PI is expected to bring distinct contributions to the application. The application should clearly demonstrate that both PIs have equal intellectual input into the design of the project and will devote similar and appropriate levels of effort to the conduct of the project. It is expected that funding will be balanced between both PIs unless appropriately justified. New partnerships are encouraged, but not required. The application is expected to describe how the PIs unique expertise combined as a partnership will better address the research question, how the unique expertise that each individual brings to the application is critical for the research strategy and completion of the SOW, and why the work should be done together rather than through separate efforts. To meet the intent of the Partnering PI Option, applicants are discouraged from being named as a Partnering PI on multiple Breakthrough Award Level 4 applications unless they are clearly addressing distinct research questions. Applications where one PI is providing samples or investigational agents while the other PI is performing most or all of the research and analyses do not meet the intent of the Partnering PI Option. If recommended for funding, each PI will be named on separate awards to the recipient organization(s). Each award will be subject to separate reporting, regulatory, and administrative requirements. For individual submission requirements for the Initiating and Partnering PIs, refer to Section II.D.2, Content and Form of the Application Submission.Personnel: Applications are expected to include an appropriate and robust research team with the combined backgrounds and breast cancer-related expertise to enable successful conduct of the project.Consumer Advocates: Applications are required to include consumer advocate involvement. The research team must include two or more breast cancer consumer advocates, who will be integral throughout the planning and implementation of the research project. Consumer advocates should be involved in the development of the research question, project design, oversight, recruitment, and evaluation, as well as other significant aspects of the proposed project. Interactions with other team members should be well integrated and ongoing, not limited to attending seminars and semi-annual meetings. As lay representatives, the consumer advocates must be individuals who have been diagnosed with breast cancer, and they should be active in a breast cancer advocacy organization. Their role in the project should be independent of their employment, and they cannot be employees of any of the organizations participating in the application. Their role should be focused on providing objective input on the research and its potential impact for individuals with, or at risk for, breast cancer. The consumer advocates should have a high level of knowledge of current breast cancer issues and the appropriate background and/or training in breast cancer research to contribute to the project.Key Aspects of the BCRP Breakthrough Award Level 4 Mechanism: Preliminary data are required: Inclusion of preliminary data relevant to the proposed clinical trial is required. Study Population: The application should demonstrate the availability of and access to a suitable patient population that will support a meaningful outcome for the study. The application should include a discussion of how accrual goals will be achieved, as well as the strategy for inclusion of women and minorities in the clinical trial appropriate to the objectives of the study. Studies utilizing human biospecimens or datasets that cannot be linked to a specific individual, gender, ethnicity, or race (typically classified as exempt from Institutional Review Board [IRB] review) are exempt from this requirement. Intervention Availability: The application should demonstrate the documented availability of and access to the drug/compound, device, and/or other materials needed, as appropriate, for the proposed duration of the study. Personnel and Environment: The application should demonstrate the study teams expertise and experience in all aspects of conducting clinical trials, including appropriate statistical analysis, knowledge of FDA processes (if applicable), and data management. The application should include a study coordinator(s) who will guide the clinical protocol through the local IRB of record and other federal agency regulatory approval processes, coordinate activities from all sites participating in the trial, and coordinate participant accrual. The application should show strong institutional support and, if applicable, a commitment to serve as the FDA regulatory sponsor, ensuring all sponsor responsibilities described in the Code of Federal Regulations, Title 21, Part 312 (21 CFR 312), Subpart D, are fulfilled. Statistical Analysis and Data Management Plans: The application should include a clearly articulated statistical analysis plan, a power analysis reflecting sample size projections that will answer the objectives of the study, and a data management plan that includes use of an appropriate database to safeguard and maintain the integrity of the data. If required by a Regulatory Agency, the trial must use a 21 CFR 11-compliant database and appropriate data standards.A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, the CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 BCRP priorities.Innovative research involving nuclear medicine and related techniques to support early diagnosis, more effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies.The proposed research must be relevant to active-duty Service Members, Veterans, military beneficiaries, and/or the American public. Collaborations between researchers at military or Veteran institutions and non-military institutions are strongly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the partners bring to the research effort, ultimately advancing cancer research that is of significance to the Warfighter, military Families, and the American public.For the purposes of this funding opportunity, Regulatory Agency refers to the FDA or any relevant international regulatory agency unless otherwise noted.If the proposed clinical trial involves the use of a drug that has not been approved by the relevant Regulatory Agency for the country where the research will be conducted, then submission of an IND application, or equivalent, that meets all requirements under 21 CFR 312 may be required. It is the responsibility of the applicant to provide evidence from the IRB of record or the relevant Regulatory Agency if an IND, or equivalent, is not required. If an IND, or equivalent, is required, the regulatory application must be submitted to the relevant regulatory agency by the Breakthrough Award Level 4 application submission deadline. The IND, or equivalent, should be specific for the product and indication to be tested in the proposed clinical trial. For more information on IND applications specifically, the FDA has provided guidance at https://www.fda.gov/drugs/types-applications/investigational-new-drug-ind-application.If the investigational product is a device, then submission of an IDE, or equivalent, application that meets all requirements under 21 CFR 812 may be required. It is the responsibility of the applicant to provide evidence if an IDE, or equivalent, is not required. If an IDE, or equivalent, is required, the IDE application, or equivalent, must be submitted to the relevant Regulatory Agency by the Breakthrough Award Level 4 application submission deadline. The IDE, or equivalent, should be specific for the device and indication to be tested in the proposed clinical trial.The types of awards made under the program announcement will be cooperative agreements (31 USC 6305) based on anticipated substantial involvement on the part of CDMRP. Substantial involvement includes assistance, guidance, coordination, and/or participation by CDMRP staff in project activities, including but not limited to, Milestone Meetings wherein recommendations for continued funding will be made based on overall study progress.The anticipated direct costs budgeted for the entire period of performance for an FY24 BCRP BTA4 should not exceed $15M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $23.3M to fund approximately one Breakthrough Award Level 4 application. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

The Public Diplomacy Section (PD) of the U.S. Embassy in Luxembourg, U.S. Department of State, announces an open competition for organizations to submit applications to carry out programs strengthening bilateral ties between the United States and Luxembourg on Accelerating STEM and Climate Ambitions. The U.S. Embassy Luxembourg invites proposals from non-governmental organizations, think tanks, government institutions, academic institutions, and individuals for programs strengthening the bilateral ties between the United States and Luxembourg and Accelerating STEM and Climate Ambitions, including, but not limited to: Programs that raise awareness about space and satellite technology, space exploration, biotechnology, green technology, clean energy, climate change, the climate crisis, or sustainable finance. This could include educational programs for young people, trainings for educators, public debates, exhibits, speakers, etc. Educational programs with a focus on interactive STEM skills, such as computer programming, coding, and robotics, or programs about the importance of protecting the environment, clean air and water and sustainability measures. Projects that share American best practices in STEM and space research, climate change, sustainability, sustainable finance, renewables, environmental protection, or biotechnology by bringing U.S. experts to engage with Luxembourg audiences. All programs must engage Luxembourg audiences. All programs must include a U.S. element or connection with U.S. experts that will promote increased understanding of U.S. policy and perspectives. Any speaker paid with grant funding must hold U.S. citizenship. Please review the complete NOFO on the Funding Opportunities page on our website: https://lu.usembassy.gov/grants-program/ , or in the related documents tab on the announcement on grants.gov.