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Grants for Small businesses - Federal

Explore 1,747 grant opportunities

Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders (R61/R33 - Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2028

Date Added

Oct 29, 2024

This funding opportunity supports researchers and organizations in developing and validating biomarkers for neurological and neuromuscular disorders to improve clinical trials and patient care.

Health
State governments
Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)
$40,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 8, 2026

Date Added

Sep 27, 2024

This funding opportunity provides financial support for clinical trial sites to access investigational treatments for ALS patients while collecting important safety and outcome data to advance research in the disease.

Health
Public and State controlled institutions of higher education
Manufacturing Systems Integration
Contact for amount
National Science Foundation
Federal
Rolling

Application Deadline

Not specified

Date Added

Jan 3, 2025

This grant provides funding for researchers and organizations to explore innovative digital technologies that improve the integration and efficiency of manufacturing systems, fostering collaboration and competitiveness in the industry.

Science and Technology
For profit organizations other than small businesses
DoD Lupus, Transformative Vision Development Award
$250,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Aug 24, 2026

Date Added

May 6, 2026

This funding opportunity supports researchers and organizations developing innovative interventions to improve the quality of life for individuals living with lupus, including military service members and their families.

Health
Nonprofits
Training-based Workforce Development for Advanced Cyberinfrastructure (CyberTraining)
$1,000,000
National Science Foundation
Federal

Application Deadline

Jan 21, 2027

Date Added

May 22, 2025

This program provides funding to educational institutions and organizations to develop training and resources that enhance skills in advanced cyberinfrastructure for researchers and students across various scientific fields.

Science and Technology
Public and State controlled institutions of higher education
DoD Breast Cancer, Era of Hope Scholar Award
$4,900,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Jul 8, 2026

Date Added

May 5, 2026

This grant provides substantial funding to early-career researchers dedicated to innovative breast cancer research, emphasizing collaboration and the involvement of breast cancer advocates.

Science and Technology
Nonprofits
Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research
$4,500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jul 1, 2026

Date Added

Sep 19, 2025

This funding opportunity supports diverse organizations in conducting innovative research to better understand and address cardiovascular disease in individuals with type 1 diabetes.

Health
Private institutions of higher education
DoW Arthritis Clinical Research Award
$3,250,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Oct 22, 2026

Date Added

May 4, 2026

This funding opportunity supports clinical research aimed at improving arthritis care and outcomes for Service Members, Veterans, and their families, with a focus on prevention, early diagnosis, and effective treatment strategies.

Health
Nonprofits
NIDCD Research Grants for Translating Basic Research into Clinical Practice (R01 Clinical Trial Optional)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 12, 2026

Date Added

Dec 17, 2024

This funding opportunity supports collaborative research projects that translate basic scientific discoveries into practical clinical applications for diagnosing and treating communication disorders, encouraging partnerships between scientists and clinicians.

Health
State governments
FreeSol Broad Agency Announcement
$99,000,000
U.S. Department of Defense (Space Systems Command)
Federal

Application Deadline

Feb 23, 2029

Date Added

Oct 6, 2025

This grant provides funding for innovative research and development projects that enhance U.S. space and cyber technologies, targeting businesses, universities, and research institutions focused on improving space domain awareness and combat capabilities.

Science and Technology
For profit organizations other than small businesses
DoW Vision, Investigator-Initiated Research Award
$1,200,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Nov 12, 2026

Date Added

May 4, 2026

This funding opportunity supports innovative research projects aimed at improving the diagnosis, treatment, and understanding of eye injuries and visual dysfunctions related to military service, benefiting service members, veterans, and their families.

Health
Nonprofits
Novel Approaches to Support Therapeutic Development in Ultra-Rare Cancers
$1,500,000
U.S. Department of Health and Human Services (Food and Drug Administration)
Federal

Application Deadline

Jun 15, 2026

Date Added

May 5, 2026

This funding opportunity provides financial support for innovative projects that aim to improve the development of treatments for ultra-rare cancers, targeting both pediatric and adult populations, and is open to a variety of U.S.-based organizations and institutions.

Science and Technology
Public and State controlled institutions of higher education
Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2028

Date Added

Oct 31, 2024

This grant provides funding for researchers to investigate and validate genetic variants linked to congenital anomalies, aiming to improve understanding and treatment of these conditions.

Health
State governments
FY25-26 Consolidated Rail Infrastructure and Safety Improvements Grant Program
$2,039,246,480
U.S. Department of Transportation (DOT - Federal Railroad Administration)
Federal

Application Deadline

Jun 22, 2026

Date Added

Apr 21, 2026

This grant provides funding to a variety of public and private entities to improve the safety, efficiency, and reliability of rail transportation across the United States through infrastructure enhancements and advanced safety technologies.

Transportation
State governments
DoW Peer Reviewed Medical, Discovery Award
$385,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Jul 30, 2026

Date Added

May 11, 2026

This funding opportunity supports innovative and high-risk medical research projects that aim to improve the health of military personnel, veterans, and their families, as well as contribute to broader civilian health outcomes.

Health
Nonprofits
Maximizing Investigators Research Award (MIRA) for Early Stage Investigators (ESI)
$1,375,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 2, 2026

Date Added

Sep 16, 2025

This funding opportunity provides financial support to early stage researchers in the U.S. to develop innovative and flexible biomedical research programs that align with the mission of the National Institute of General Medical Sciences.

Science and Technology
Public and State controlled institutions of higher education
Rural Communities Opioid Response Program (RCORP)-Impact
$750,000
U.S. Department of Health and Human Services (Health Resources and Services Administration)
Federal

Application Deadline

Jun 22, 2026

Date Added

Dec 15, 2025

This funding opportunity provides financial support to rural communities for developing and expanding integrated services to prevent and treat substance use disorders, including opioid addiction, while fostering collaboration among local organizations and healthcare providers.

Health
State governments
DoW Peer Reviewed Medical, Clinical Trial Award
$20,000,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Sep 22, 2026

Date Added

May 11, 2026

This funding opportunity supports clinical trials that aim to improve medical treatments and interventions for military personnel, veterans, and their families.

Science and Technology
Nonprofits
Devcom Army Research Laboratory Broad Agency Announcement For Foundational Research
Contact for amount
U.S. Department of Defense (Dept of the Army -- Materiel Command)
Federal

Application Deadline

Nov 20, 2027

Date Added

Nov 21, 2022

This grant provides funding for researchers and organizations to conduct foundational and applied scientific research that supports the U.S. Army's mission to maintain technological superiority in future conflicts.

Science and Technology
Nonprofits
Transport Phenomena (TP)
Contact for amount
National Science Foundation
Federal
Rolling

Application Deadline

Not specified

Date Added

Apr 27, 2026

This program provides funding for researchers and organizations to advance fundamental knowledge and practical applications related to the transport of mass, energy, and momentum in various systems, including fluid dynamics and thermal transport.

Science and Technology
Public and State controlled institutions of higher education