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Grants for Small businesses - Federal

Explore 1,841 grant opportunities

2027 Technical Assistance for Specialty Crops
$500,000
U.S. Department of Agriculture (Foreign Agricultural Service)
Federal

Application Deadline

Aug 14, 2026

Date Added

Jun 11, 2026

This program provides funding to U.S. organizations, including government agencies and nonprofits, to help overcome trade barriers and boost exports of specialty crops in international markets.

Agriculture
Nonprofits
BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)
$2,250,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 28, 2027

Date Added

Mar 20, 2024

This funding opportunity supports the development of innovative technologies for recording and modulating the human central nervous system, aimed at advancing preclinical research toward future human applications.

Science and Technology
Public and State controlled institutions of higher education
Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders (R61/R33 - Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2028

Date Added

Oct 29, 2024

This funding opportunity supports researchers and organizations in developing and validating biomarkers for neurological and neuromuscular disorders to improve clinical trials and patient care.

Health
State governments
DoW Neurofibromatosis Synergistic Idea Award
$6,400,000
U.S. Department of Defense (Defense Health Agency Contracting Activity - DHACA)
Federal

Application Deadline

Sep 22, 2026

Date Added

Jun 26, 2026

This grant provides funding for collaborative research projects that unite multiple experts to tackle complex challenges in understanding and treating neurofibromatosis, a genetic disorder that causes tumors on nerve tissue.

Science and Technology
Nonprofits
Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)
$40,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 10, 2026

Date Added

Sep 27, 2024

This funding opportunity provides financial support for clinical trial sites to access investigational treatments for ALS patients while collecting important safety and outcome data to advance research in the disease.

Health
Public and State controlled institutions of higher education
Manufacturing Systems Integration
Contact for amount
National Science Foundation
Federal
Rolling

Application Deadline

Not specified

Date Added

Jan 3, 2025

This grant provides funding for researchers and organizations to explore innovative digital technologies that improve the integration and efficiency of manufacturing systems, fostering collaboration and advancing industry competitiveness.

Science and Technology
For profit organizations other than small businesses
Improved Oil and Gas Recovery and Produced Water Management Technologies
$20,000,000
U.S. Department of Energy (National Energy Technology Laboratory)
Federal

Application Deadline

Sep 8, 2026

Date Added

Jul 7, 2026

This funding opportunity provides financial support for research and development projects that improve oil and gas recovery efficiency and enhance the management of produced water, targeting a wide range of domestic entities including universities, businesses, and government organizations.

Energy
Public and State controlled institutions of higher education
DoD Lupus, Transformative Vision Development Award
$250,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Aug 24, 2026

Date Added

May 6, 2026

This funding opportunity supports researchers and organizations developing innovative interventions to improve the quality of life for individuals living with lupus, including military service members and their families.

Health
Nonprofits
Training-based Workforce Development for Advanced Cyberinfrastructure (CyberTraining)
$1,000,000
National Science Foundation
Federal

Application Deadline

Jan 21, 2027

Date Added

May 22, 2025

This program provides funding to educational institutions and organizations to develop training and resources that enhance skills in advanced cyberinfrastructure for researchers and students across various scientific fields.

Science and Technology
Public and State controlled institutions of higher education
Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research (U01, Clinical Trial Not Allowed)
$500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Mar 10, 2027

Date Added

Sep 19, 2025

This funding opportunity supports diverse organizations in conducting innovative research to better understand and address cardiovascular disease in individuals with type 1 diabetes.

Health
State governments
DoW Arthritis Clinical Research Award
$3,250,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Oct 22, 2026

Date Added

May 4, 2026

This funding opportunity supports clinical research aimed at improving arthritis care and outcomes for Service Members, Veterans, and their families, with a focus on prevention, early diagnosis, and effective treatment strategies.

Health
Nonprofits
Agriculture and Food Research Initiative Competitive Grants Program Foundational and Applied Science Program
$900,000
U.S. Department of Agriculture (National Institute of Food and Agriculture)
Federal

Application Deadline

Dec 31, 2026

Date Added

Jul 13, 2026

This funding opportunity supports research and projects that improve agricultural practices, food safety, and sustainability, targeting a wide range of eligible applicants including universities, nonprofits, and businesses involved in agriculture.

Agriculture
Public and State controlled institutions of higher education
DoW Orthopaedic, Applied Research Award
$950,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Nov 18, 2026

Date Added

May 22, 2026

This funding opportunity supports research projects that develop practical solutions for treating and rehabilitating military personnel with orthopaedic injuries, aiming to improve recovery and return to duty.

Science and Technology
Nonprofits
NIDCD Research Grants for Translating Basic Research into Clinical Practice (R01 Clinical Trial Optional)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 12, 2027

Date Added

Dec 17, 2024

This funding opportunity supports collaborative research projects that translate basic scientific discoveries into practical clinical applications for diagnosing and treating communication disorders, targeting a wide range of eligible applicants including universities, nonprofits, and small businesses.

Health
State governments
FreeSol Broad Agency Announcement
$99,000,000
U.S. Department of Defense (Space Systems Command)
Federal

Application Deadline

Feb 23, 2029

Date Added

Oct 6, 2025

This grant provides funding for innovative research and development projects that enhance U.S. space and cyber technologies, targeting businesses, universities, and research institutions focused on improving space domain awareness and combat capabilities.

Science and Technology
For profit organizations other than small businesses
DoW Vision, Investigator-Initiated Research Award
$1,200,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Nov 12, 2026

Date Added

May 4, 2026

This funding opportunity supports innovative research projects aimed at improving the diagnosis, treatment, and understanding of eye injuries and visual dysfunctions related to military service, benefiting service members, veterans, and their families.

Health
Nonprofits
Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2028

Date Added

Oct 31, 2024

This grant provides funding for researchers to investigate and validate genetic variants linked to congenital anomalies, aiming to improve understanding and treatment of these conditions.

Health
State governments
DoW Peer Reviewed Medical, Discovery Award
$385,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Jul 30, 2026

Date Added

May 11, 2026

This funding opportunity supports innovative and high-risk medical research projects that aim to improve the health of military personnel, veterans, and their families, as well as contribute to broader civilian health outcomes.

Health
Nonprofits
Maximizing Investigators Research Award (MIRA) for Early Stage Investigators (ESI)
$1,375,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 2, 2026

Date Added

Sep 16, 2025

This funding opportunity provides financial support to early stage researchers in the U.S. to develop innovative and flexible biomedical research programs that align with the mission of the National Institute of General Medical Sciences.

Science and Technology
Public and State controlled institutions of higher education
Development and Testing of a Multi-use Frameworks Playbook for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U01 Clinical Trial Not Allowed)
$300,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 9, 2026

Date Added

Jun 7, 2025

This funding opportunity supports the development of standardized frameworks for creating and validating artificial intelligence tools that integrate imaging and multimodal health data, aimed at improving precision medicine in clinical settings.

Health
Public and State controlled institutions of higher education