Grants for Small businesses - Federal

The National Institutes of Health (NIH) has announced a funding opportunity titled Co-infection and Cancer (R01 Clinical Trial Not Allowed) under Funding Opportunity Number PAR-25-082. This initiative, led by the National Cancer Institute (NCI), is aimed at advancing research into the roles of co-infection in cancer development and progression. Co-infection is defined as the occurrence of two or more infections, whether simultaneous or sequential, involving pathogens or non-pathogenic agents, including viruses, bacteria, and parasites. The goal of this program is to explore how these co-infections contribute to cancer risk and progression and identify potential strategies for cancer prevention and treatment. The program encourages investigations that focus on co-infections with known oncogenic agents, excluding human immunodeficiency virus (HIV), and seeks studies that can lead to new opportunities in cancer treatment and prevention. In addition to pathogenic agents, research that includes the role of non-pathogenic agents, such as those in the microbiome, will be considered responsive. The program supports projects that delve into uncharted areas of co-infection and cancer, with an emphasis on mechanistic and epidemiologic research that could have practical implications for cancer control. Applicants are encouraged to focus on differences in cancer susceptibility, progression, and survival among diverse populations, including those that are racially or ethnically diverse, as well as medically underserved communities. International collaborations are also supported, particularly for studies in low- and middle-income countries where infection-associated cancers are more prevalent. The first submission date is January 5, 2025, with application due dates beginning on February 5, 2025. Budgets are not limited but must align with the scope of the project, and the maximum project period is five years. Applications must be submitted electronically through NIH's ASSIST system or Grants.gov. Eligible applicants include higher education institutions, nonprofits, for-profit organizations, and foreign entities. The program seeks to support well-developed research projects backed by preliminary data. Studies that focus solely on co-infection with HIV or involve only a single pathogen will not be considered responsive. Evaluation criteria include the scientific merit of the project, innovation, and feasibility, as well as the expertise of the research team. This funding opportunity offers a unique chance to explore how co-infections contribute to cancer and potentially uncover new strategies for prevention and treatment across diverse populations.

This funding opportunity provides $5 million to support the deployment and commercialization of innovative technologies in public transportation, aimed at federal, state, local, and tribal governments, as well as public transit providers and educational institutions.

This funding opportunity provides financial support to small businesses in the U.S. for conducting early-phase clinical trials of innovative treatments for neurological disorders.

The National Aeronautics and Space Administration (NASA) Headquarters has released a solicitation, titled Early Stage Innovations (ESI), as an appendix to the Space Technology Mission Directorate (STMD) umbrella NASA Research Announcement (NRA) titled "Space Technology Research, Development, Demonstration, and Infusion 2024 (SpaceTech REDDI 2024), on April 4, 2024. The ESI solicitation is available by opening the NSPIRES homepage at https://nspires.nasaprs.com/, selecting Open under "Solicitations," and searching "Early Stage Innovations (ESI24)" under Keywords. The Space Technology Research Grants (STRG) Program within STMD seeks proposals from accredited U.S. universities to develop unique, disruptive, or transformational space technologies that have the potential to lead to dramatic improvements at the system level performance, weight, cost, reliability, operational simplicity, or other figures of merit associated with spaceflight hardware or missions. The projected impact at the system level must be substantial and clearly identified. Only accredited U.S. universities are eligible to submit proposals. Teaming is permitted see solicitation for complete eligibility requirements as well as teaming restrictions. A Principal Investigator (see solicitation for restrictions) or Co-Investigator may participate in no more than two proposals in response to this solicitation. NASA encourages submission of ESI proposals on behalf of tenure-track or tenured faculty members at all U.S. universities and especially encourages proposals submitted on behalf of and/or that include as team members women, members of underrepresented minority groups, and persons with disabilities. The solicitation exclusively seeks proposals that are responsive to one of the following two topics: Topic 1 Computational Materials Engineering for Lunar Metals Welding Topic 2 Passive Lunar Dust Control through Advanced Materials and Surface Engineering NASA anticipates addressing other topics in future ESI Appendix releases. The financial and programmatic support for ESI comes from the Space Technology Research Grants Program within the Space Technology Mission Directorate. Awards are planned to start in January 2025. NASA plans to make approximately 6 awards as a result of this ESI solicitation, subject to the receipt of meritorious proposals. The actual number of awards will depend on the quality of the proposals received; NASA reserves the right to make no awards under this solicitation. STMD is strongly committed to ensuring that proposal review is performed in an equitable and fair manner that reduces the impacts of any unconscious biases. To this end, this Appendix will employ a Dual-Anonymous Peer Review (DAPR) process to evaluate proposals. Using DAPR, not only are proposers not told the identities of the reviewers, but the identities of the proposers (personnel and organization names) will not be shared with the reviewers until after the technical review of all anonymized proposals has been completed. All proposals must be submitted electronically through NSPIRES by an authorized organizational representative. Notices of Intent (strongly encouraged) are due by May 9, 2024, with proposals due on or before June 6, 2024, 5 pm Eastern. Detailed submission instructions and due dates are provided in the solicitation. Potential proposers and their proposing organizations are urged to familiarize themselves with the submission system, ensure they are registered in NSPIRES, and submit the required proposal materials well in advance of the deadline. All technical and programmatic comments and questions may be addressed by email to the Space Technology Research Grants Program Executive, at hq-esi-call@mail.nasa.gov. Responses to inquiries will be answered by email and may also be included in the Frequently Asked Questions (FAQ) documents located on the NSPIRES page associated with the solicitation; anonymity of persons/institutions who submit questions will be preserved.

This funding opportunity supports innovative clinical research to explore the brain mechanisms behind substance use disorders, targeting a wide range of researchers and institutions dedicated to addressing addiction challenges.

This funding opportunity provides financial support for researchers to analyze and integrate existing data to better understand cancer risk, prevention, and treatment outcomes, particularly focusing on innovative methodologies and addressing health disparities.

This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change.Considering the current healthcare challenges that we face today, the goal of achieving better health outcomes is a moving target that requires daring and adaptable solutions. HSF awardees will develop innovative technologies, tools, and platforms that can be applied to a broad range of diseases. The following interest areas define the ground-breaking research we seek to support:Breakthrough Technologies: Paradigm shifting technologies that will change how we approach the diagnosis, treatment, and impact of diseases and conditions. Novel approaches to improve maternal and fetal medicine, decrease maternal morbidity and mortality during birth, and the post-partum period. Efforts should include new technology to monitor, detect, and/or treat maternal and/or fetal complications with less invasive and traumatic methods. Foundational advances in genetic, epigenetic, cellular, tissue, and organ replacement therapies that enable personalized medical interventions at scale in a manner that is accessible, cost-effective, and designed to impact the communities of greatest need. Interventions that target and reverse disease pathogenesis and/or enhance plasticity to address diseases of the nervous, neuromuscular, skeletal, lymphatic, cardiovascular, and other organ systems. Novel approaches to diagnose and treat diseases of the lymphatic system, particularly rare diseases, with a focus on the effects of genetic expression in the lymphatic system and/or models demonstrating the relationship between lymphatic dysfunction and health and disease.Transformative Tools: Novel, agile solutions that will move from bench to bedside quickly, facilitating revolutionary advances in medical care. Development of tools that counter idiosyncratic, off-target, or chronic effects of medicines that are commonly used or that are being used experimentally to treat or prevent disease. Development of bionics to restore sight, hearing, taste, or smell. Site-selective neuromodulation to regulate specific physiological functions and treat chronic health conditions such as inflammation, pain, and metabolic or endocrine disorders. Synthetic biology approaches to diagnosing, treating, and/or curing a multitude of diseases. Novel physics and/or chemistry-based approaches to improve imaging that reduces cost, increases availability, expands capability, improves resolution, reduces exposure to radiation, and accommodates pediatric patient populations. Integrated sensing and delivery devices for treating and diagnosing chronic health conditions, including mental health conditions or substance use disorders. Miniaturization of complex hardware to enable broader access to pediatric and other patient populations, as well as portability, such as diagnostic, treatment, imaging, or other devices.Platform Systems: Adaptable, multi-application systems and technologies that are reconfigurable for a wide variety of clinical needs Novel molecular platform approaches, including the modulation of host systems, delivery to targets with spatial and temporal precision, and mitigation of off-target effects to accelerate interventions that dramatically improve health outcomes. New approaches to accelerate and routinize mammalian and microbial cellular engineering to enable next generation therapeutic applications, develop multiscale interventions, and automate hypothesis generation and discovery to expand those applications to disease states in which cellular therapies have not traditionally been employed. Innovative approaches at the intersection of artificial intelligence, high performance computing (including quantum computing) and biological systems, including enabling de novo design of biomolecules with entirely new phenotypes.Other high-quality submissions that propose revolutionary technologies that meet the goals of HSF will be considered even if they do not address the topics listed above.Proposals are expected to use innovative approaches to enable revolutionary advances in medicine and healthcare, and the science and technology underlying these areas. While approaches that are disease agnostic are encouraged, ARPA-H welcomes proposals that bring radically new insights to address specific diseases including, but not limited to, cancer, diabetes, neurological diseases, pediatric and maternal/fetal health, infectious diseases, and cardiovascular disease.Specifically excluded are proposals that represent an evolutionary or incremental advance in the current state of the art or technology that has reached the clinical trial stage. An example of this type of proposal might include the request to fund clinical trials of an otherwise developed product. Additionally, proposals directed towards policy changes, traditional education and training, or center coordination, formation, or development, and construction of physical infrastructure are outside the scope of the ARPA-H mission.

With this solicitation, BJA seeks to support new and innovative strategies for preventing and reducing crime, improving community safety, and strengthening criminal justice system outcomes. BJA seeks to accomplish this by promoting collaborations with the field to identify, define, and respond to emerging or chronic crime problems or justice system challenges. BJA is looking for strategies that address these issues, including trying new approaches, addressing gaps in responses, building or translating research knowledge, or building capacity.

This funding opportunity supports multidisciplinary research aimed at improving the understanding and treatment of asthma and allergic diseases, inviting applications from various institutions and organizations involved in clinical and translational research.

This grant provides funding to support research and initiatives that promote diversity, equity, inclusion, and accessibility for individuals with disabilities in STEM fields and education.

This project seeks to develop and prototype advanced electronic warfare solutions for unmanned platforms, inviting technology vendors to collaborate and innovate in addressing current gaps in electromagnetic spectrum operations.

This funding opportunity provides financial support for researchers to plan and prepare for clinical trials focused on infectious, immunologic, and allergic diseases, ensuring they have the necessary resources and documentation for future trial implementation.

This funding opportunity supports research initiatives aimed at preventing community violence among youth and young adults, particularly those addressing racial and ethnic disparities, with grants available to governments, educational institutions, and non-profits.

This program provides funding to state and local governments for improving criminal justice data sharing and decision-making, promoting transparency and accountability in law enforcement, courts, and corrections.

With this solicitation, BJA, in coordination with the Office of Juvenile Justice and Delinquency Prevention (OJJDP) and the Office of Victims of Crime (OVC), seeks applications to provide a range of training and technical assistance (TTA) to grantees and the field at large under the Community Based Violence Intervention and Prevention Initiative (CVIPI). This will build on the portfolio of existing providers and add new expertise in the following areas: trauma-informed practices and workforce development for Community Violence Intervention (CVI) organizations and staff, mass casualty shooting reviews, law enforcement engagement with CVI programs, TTA network support and coordination, and strategic communications.

This funding opportunity supports postdoctoral researchers in biomedical and behavioral fields, providing mentorship and resources to help them develop into independent scientists.

This funding opportunity provides financial support to organizations working to improve HIV prevention and treatment for Haitian migrants and their descendants in the Dominican Republic, focusing on overcoming barriers to healthcare access and enhancing treatment outcomes.

The Saltonstall-Kennedy Act established a fund (known as the S-K fund) used by the Secretary of Commerce to provide grants or cooperative agreements for fisheries research and development projects addressing aspects of U.S. fisheries, including, but not limited to, harvesting, processing, marketing, and associated business infrastructures (seesection IV, F; Funding Restrictions). Under this authority, grants and cooperative agreements are made on a competitive basis (subject to availability of funding) to assist in carrying out projects to expand domestic and foreign markets related to U.S. commercial and recreational fisheries. The term U.S. fisheries refers to any marine fishery (including the Great Lakes) that encompasses commercial, recreational, charter, subsistence, wild capture, and aquaculture that is, or may be, engaged in by citizens or nationals of the United States or other eligible applicants. The objective of the S-K Research and Development Program, referred to throughout this document as the S-K Competitive Grant Program, is to promote U.S. fisheries by assisting the fishing community to address marketing and research needs. The term fishing community means harvesters, marketers, growers, processors, recreational fishermen, charter fishermen, fishermen, and persons providing them with goods and services. Proposals submitted to this competition must address at least one of the following priorities: Promotion, and Marketing; Development, Infrastructure and Capacity Building; Science or Technology that Enhances Sustainable U.S. Fisheries. This Notice of Funding Opportunity (NOFO) includes information on application requirements and criteria for proposals requesting a maximum of $500,000 in Federal funding for up to a two-year period. Matching funds are not required, nor will they be considered during the evaluation process. Awards are anticipated to start no earlier than September 1, 2025. NOTE: No awards will be funded under this current NOFO. Pre-Proposal submissions under this NOFO are eligible to submit a full proposal under a separate Notice of Funding Opportunity (NOFO), NOAA-NMFS-FHQ-2025-26868, which will post in Grants.gov on September 26, 2024. NEW REGISTRATION REQUIREMENTS: All applicants must complete and maintain three registrations: Sam.gov, Grants.Gov, and eRA Commons. The registration process for all three systems can take 4 to 6 weeks, so applicants should begin activity as soon as possible. SUBMISSION CHECKLIST FOR ERA REQUIREMENTS Below is a submission checklist for eRA Requirements. This is not an exhaustive list of everything you need for a successful application. All items below should be checked before you submit your application in Grants.gov. SAM.gov Registration and approved UEI eRA Commons Registration Grants.gov Registration PD/PI Account Created PD/PI Commons ID entered exactly on Box 4 on the SF-424 UEI entered exactly on Box 8c. of the SF-424 Congressional District formatted correctly (ex. VA-001) All PDFs flattened File sizes are less than 100 MB File page sizes are 8 12 x 11 File names are shorter than 50 characters (including spaces) File names do not include invalid characters (, diacritical marks) If you have any questions, please reach out to the eRA HelpDesk or the Agency Contact listed in your NOFO.

This funding opportunity provides technical assistance to local governments in economically distressed communities with populations of 50,000 or less, helping them improve financial management and pursue economic revitalization efforts.

The Lithium-Ion Battery Recycling Prize is a grant opportunity for creative individuals, entrepreneurs, and businesses to address challenges in the lithium-ion battery recycling supply chain. The goal of this phased prize competition is to develop and demonstrate processes that can capture 90% of all discarded or spent lithium-ion batteries in the United States for recovery of key materials. The continuation of the prize will award a total of $7.4 million in cash prizes and voucher support over the next 3 years. This includes a new competition track for new competitors and previous participants, as well as additional support for Phase III winning teams. Breakthrough, a new public contest, aims to incentivize innovative solutions from battery industry entrepreneurs that align with the prize goal. Up to $2.4 million in cash prizes and voucher funding will be awarded to up to 10 winners. Winners will also have the opportunity to advance to Phase IV of the competition. Qualified lithium-ion battery recyclers and second-life testing organizations are also being sought as Evaluation Entities for Phase IV. More information about becoming an Evaluation Entity can be found on the American-Made website.