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Grants for Small businesses - Federal

Explore 1,853 grant opportunities

Mechanistic Research on Neuromodulation for Substance Use Disorders Treatment (R01 Basic Experimental Studies with Humans Required)
$1,500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Aug 14, 2025

Date Added

Sep 29, 2023

This funding opportunity supports research institutions and organizations conducting experimental studies with human participants to explore new brain stimulation techniques for treating substance use disorders.

Education
State governments
The Circular Supply Chains Accelerator
$12,500,000
U.S. Department of Energy (Golden Field Office)
Federal

Application Deadline

Jul 18, 2025

Date Added

Jan 17, 2025

This funding opportunity supports U.S.-based businesses, academic institutions, and non-profits in developing innovative solutions for sustainable supply chains that reduce waste and promote recycling, while also fostering community benefits and workforce development.

Energy
Public and State controlled institutions of higher education
NIJ FY25 Research and Evaluation on Violence Against Women
$3,700,000
U.S. Department of Justice (National Institute of Justice)
Federal

Application Deadline

May 14, 2026

Date Added

Mar 20, 2026

This funding opportunity supports research projects aimed at reducing violence against women and girls and improving responses within the criminal justice system, targeting issues such as domestic violence, sexual violence, and stalking.

Law Justice and Legal Services
State governments
Multi Modal Materials Analysis (MMoMA)
Contact for amount
U.S. Department of Defense (DARPA - Defense Sciences Office)
Federal

Application Deadline

Jul 8, 2026

Date Added

Jun 18, 2026

This funding opportunity is designed to support innovative research and development in advanced materials analysis technologies, targeting a wide range of organizations, including academic institutions and private companies, to enhance capabilities for defense applications such as material identification and forensic analysis.

Science and Technology
Nonprofits
Tobacco Regulatory Science Small Grant Program for New Investigators (R03 Clinical Trial Optional)
$150,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jul 14, 2026

Date Added

Jun 5, 2025

This funding opportunity provides financial support for early-stage researchers to conduct small-scale studies that inform public health policies related to tobacco use and regulation.

Health
Nonprofits
Cancer Tissue Engineering Collaborative: Enabling Biomimetic Tissue-Engineered Technologies for Cancer Research (R01 Clinical Trial Optional)
$400,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 5, 2025

Date Added

Nov 25, 2024

This funding opportunity supports researchers and organizations in developing advanced tissue-engineered technologies that mimic cancer biology to improve cancer detection, treatment, and prevention.

Education
State governments
Developing Digital Therapeutics for Substance Use Disorders (UG3/UH3 Clinical Trial optional)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jul 17, 2025

Date Added

Feb 28, 2024

This funding opportunity provides financial support for organizations to develop and validate digital therapeutic technologies designed to treat substance use disorders, with the goal of achieving FDA authorization.

Education
State governments
Safety and Efficacy of Amyloid-Beta Directed Antibody Therapy in Mild Cognitive Impairment and Dementia with Evidence of Lewy Body Dementia and Amyloid-Beta Pathology (U01 - Clinical Trial Required)
$6,700,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 24, 2025

Date Added

May 22, 2024

This grant provides funding for clinical trials investigating the safety and effectiveness of amyloid-beta antibody therapies in patients with mild cognitive impairment or dementia who also show signs of Lewy Body Dementia, with a focus on diverse and underrepresented populations.

Health
State governments
DOD Amyotrophic Lateral Sclerosis, Therapeutic Idea Award
$840,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Aug 27, 2025

Date Added

May 27, 2025

This funding opportunity supports innovative research projects aimed at developing new therapies for Amyotrophic Lateral Sclerosis (ALS), encouraging high-risk ideas that include biomarker development to guide future clinical applications.

Science and Technology
Nonprofits
Distance Learning and Telemedicine Grants
$750,000
U.S. Department of Agriculture (Rural Utilities Service)
Federal

Application Deadline

Jun 30, 2026

Date Added

May 4, 2026

This program provides funding to rural communities for projects that improve access to education and healthcare through advanced telecommunications technologies.

Science and Technology
Nonprofits
Verticals-enabling Intelligent Network Systems
$6,000,000
National Science Foundation
Federal

Application Deadline

Not specified

Date Added

May 21, 2025

This funding opportunity supports research and technology development in advanced telecommunications systems for various industries, including healthcare and transportation, targeting academic institutions, nonprofits, and businesses to foster innovation and collaboration.

Science and Technology
Public and State controlled institutions of higher education
Strategic Trade Facilitation in India: Promoting U.S.-India Technology Partnerships
$789,344
DOS-ISN (Bureau of International Security-Nonproliferation)
Federal

Application Deadline

May 29, 2024

Date Added

Mar 30, 2024

To implement a project aimed at advancing U.S. foreign policy and national security priorities by supporting initiatives that make decision-making structures and processes in fragile, conflict, or crisis-affected contexts more reflective of and responsive to the needs and perspectives of partner states to ensure strategic trade control systems meet international standards and by engaging on bilateral, regional and multilateral levels with foreign governments to aid in the establishment of independent capabilities to regulate transfers of weapons of mass destruction, WMD-related items, conventional arms, and related dual-use items, and to detect, interdict, investigate, and prosecute illicit transfers of such items.

International Development
City or township governments
DoD Tuberous Sclerosis Complex, Exploration-Hypothesis Development Award
$150,000
U.S. Department of Defense - Dept. of the Army -- U.S.AMRAA
Federal

Application Deadline

Aug 1, 2024

Date Added

Apr 22, 2024

The EHDA supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the TSC research field. The studies supported by this award mechanism are expected to generate preliminary data for future avenues of scientific investigation. The proposed research project should include a well-formulated, testable hypothesis based on a strong scientific rationale and study design. Applications should demonstrate the ability to achieve interpretable results in the absence of preliminary data supporting the hypothesis.The following are important aspects of the EHDA: Innovation: Innovative research may introduce a new paradigm, challenge existing paradigms, examine existing problems from new perspectives, or exhibit other highly creative qualities. Research that is an incremental advance upon published data is not considered innovative and is not consistent with the intent of the award mechanism. Although not all-inclusive, the following examples are ways in which the proposed research project may be innovative: Explores a novel idea and/or research question in TSC research and/or patient care. Uses or develops novel methods or technologies to address a question in TSC research and/or patient care. Applies or adapts existing methods or technologies for novel TSC research or clinical purposes that differ fundamentally from those originally intended.

Science and Technology
Nonprofits
Investigate Novel Therapeutic Interventions and Testing Strategies for Neurological Disorders Including to Treat, Modify and Prevent the Development of Epilepsy (U24 Clinical Trial Not Allowed)
$4,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 20, 2026

Date Added

Sep 24, 2025

This funding opportunity supports a wide range of organizations in developing innovative treatments and testing strategies to prevent and modify epilepsy and other neurological disorders.

Health
Nonprofits
DoW Breast Cancer, Clinical Research Extension Award
$8,400,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Jul 8, 2026

Date Added

May 5, 2026

This funding opportunity supports researchers aiming to enhance existing breast cancer clinical studies by extending follow-up activities, improving data analysis, and maximizing the use of previously collected patient data and biospecimens.

Health
Nonprofits
Injury Prevention and Control Research and State and Community Based Programs
Contact for amount
U.S. Department of Health and Human Services (Centers for Disease Control and Prevention - ERA)
Federal

Application Deadline

Oct 13, 2025

Date Added

Oct 20, 2023

This grant provides funding for state and community programs, as well as research initiatives, aimed at developing and promoting effective strategies to prevent and control injuries and violence, with a focus on health equity and community conditions.

Health
State governments
Quantum Computing for Computational Chemistry SBIR/STTR (QC3 SBIR/STTR)
$4,398,504
U.S. Department of Energy (Advanced Research Projects Agency Energy )
Federal

Application Deadline

Feb 6, 2025

Date Added

Dec 30, 2024

This funding opportunity is designed to support U.S.-based small businesses in developing innovative quantum computing solutions for complex energy-related challenges in computational chemistry and materials science.

Opportunity Zone Benefits
Small businesses
Notice of Intent to Publish (NOITP) a Funding Opportunity Announcement for Mentored Career Enhancement Awards to Build Cross-Disciplinary Knowledge and Skills for Comparative Studies of Human and Nonhuman Primate Species with Differing Life Spans (K18)
$1,500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 1, 2024

Date Added

Apr 23, 2024

This Notice informs that NIA intends to publish a Notice of Funding Opportunity (NOFO) inviting applications from mid-career investigators for mentored career enhancement awards focused on cross-disciplinary training to broaden and strengthen the investigator's capability to lead future comparative studies of the factors contributing to differences in life spans between human and nonhuman primate species. The NOFO is intended to provide support for experienced investigators with expertise in human and/or nonhuman primate (NHP) studies to do the following: 1) Augment or redirect their research program by acquiring expertise in other fields related to comparative primate research and aging 2) Develop collaborations with research fields with which they do not commonly interact This Notice is being provided to allow potential applicants sufficient time to identify potential mentors and prepare well-developed career enhancement plans. The NOFO is expected to be published in June 2024 with an anticipated application due date in November 2024. These are estimated time frames, and they may change. The NOFO is expected to utilize the K18 Career Enhancement Award activity code. It is expected that the NOFO will not allow clinical trials. Additional details of the planned NOFO are provided below.

Health
State governments
Ryan White HIV/AIDS Program Part D Coordinated HIV Services and Access to Research for Women, Infants, Children, and Youth (WICY) Existing Geographic Service Areas
$2,000,000
U.S. Department of Health and Human Services (Health Resources and Services Administration)
Federal

Application Deadline

Jul 13, 2026

Date Added

Dec 22, 2025

This funding opportunity provides financial support to organizations that deliver comprehensive HIV care and essential services for women, infants, children, and youth affected by HIV in designated geographic areas.

Health
State governments
NeuroNEXT Small Business Innovation in Clinical Trials (U44 Clinical Trial Optional)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2025

Date Added

Nov 13, 2024

This funding opportunity provides financial support to small businesses in the U.S. for conducting exploratory clinical trials or biomarker validation studies aimed at advancing therapies for neurological disorders.

Health
Small businesses