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Grants for Small businesses - Federal

Explore 1,853 grant opportunities

Investigational New Drug (IND)-enabling and Early-Stage Development of Medications to Treat Alcohol Use disorder and Alcohol-Associated Organ Damage (U43/U44 Clinical Trial Optional)
$1,500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Dec 4, 2024

Date Added

Jan 21, 2022

This funding opportunity provides financial support to small businesses developing new medications for treating alcohol use disorder and related organ damage, helping them advance their research towards FDA approval.

Health
Small businesses
NIDDK Centers for Diabetes Translation Research (P30 Clinical Trial Optional)
$400,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 10, 2025

Date Added

Dec 10, 2024

This funding opportunity supports the establishment of research centers that focus on translating diabetes prevention and treatment innovations into real-world practices, particularly for underserved populations facing health disparities.

Food and Nutrition
State governments
National Center on Head Start Early Learning, Health and Family Engagement
$15,000,000
U.S. Department of Health & Human Services (Administration for Children and Families - OHS)
Federal

Application Deadline

Not specified

Date Added

Jun 27, 2025

This funding opportunity provides $15 million to organizations that will develop training and support resources for Head Start programs, focusing on improving early learning, health, and family engagement for children and families.

Income Security and Social Services
City or township governments
Addressing Challenges in Detecting New Drugs: Instrumentation for Alternative Analytical Methods (R43/R44 - Clinical Trials Optional)
$3,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 19, 2025

Date Added

Nov 5, 2024

This funding opportunity is designed for small businesses to develop affordable and innovative devices that can quickly and accurately detect both known and unknown drugs in biological samples, particularly in resource-limited settings like emergency departments and health centers.

Education
Small businesses
Limited Competition: Revision Applications of Existing NIH Centers for AIDS Research (CFAR) and Developmental Centers for AIDS Research (D-CFAR) Grants (P30 Clinical Trial Not Allowed)
$1,500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Mar 24, 2025

Date Added

Dec 20, 2023

This funding opportunity supports existing Centers for AIDS Research in expanding training and research initiatives focused on HIV and health disparities, particularly for underrepresented groups and early-career investigators.

Health
Small businesses
NIMH Mentoring Networks for Mental Health Research Education (R25 Clinical Trial Not Allowed)
$200,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

May 25, 2025

Date Added

Mar 3, 2023

This funding opportunity supports the creation of mentoring networks that provide professional development and career guidance for graduate students, postdoctoral scholars, and early-career researchers in mental health, helping them advance towards independent research careers.

Health
State governments
NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required) PAR-25-049
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 6, 2026

Date Added

Nov 8, 2024

This funding opportunity supports multi-center clinical trials aimed at improving treatments for neurological emergencies, such as traumatic brain injury and status epilepticus, by leveraging a collaborative network and infrastructure.

Health
State governments
Effect of HIV and Substance Use Comorbidity on the Placenta and Maternal Outcomes (R01 Clinical Trial Optional)
$2,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 15, 2024

Date Added

Oct 30, 2023

This grant provides funding for research on how HIV and substance use affect placental health and maternal outcomes, targeting a wide range of institutions and researchers focused on these critical health issues.

Education
State governments
Ideas Lab: Personalized Engineering Learning
$3,000,000
National Science Foundation
Federal

Application Deadline

May 8, 2024

Date Added

Sep 27, 2023

An Ideas Lab is an intensive meeting that brings together multiple diverse perspectives to focus on finding innovative cross-disciplinary solutions to a grand challenge problem (see below and PAPPG Chapter II.F.6. for more information about this type of proposal). The goal of the Personalized Engineering Learning Ideas Lab is to extend engineering education research to enable advanced personalization in pedagogy and assessment in a K-12 or higher education context. The following broad areas have been identified as possible avenues to advance knowledge: personalized engineering education, multimodal sensing for personalized learning systems and team-based personalized learning. This Ideas Lab aims to bring together experts from diverse scientific, engineering and education backgrounds to develop innovative technologies and solutions to achieve personalized learning for engineering education. This Ideas Lab is organized by the Office of Emerging Frontiers and Multidisciplinary Activities (EFMA), the Division of Engineering Education and Centers (EEC), and the Division of Civil, Mechanical and Manufacturing Innovation in the Directorate for Engineering (ENG); the Division of Information and Intelligent Systems (IIS) in the Directorate for Computer and Information Science and Engineering (CISE); the Division of Behavioral and Cognitive Sciences in the Directorate for Social, Behavioral and Economic Sciences (SBE); the Division of Graduate Education, the Division of Research on Learning in Formal and Informal Settings, and the Division of Undergraduate Education in the Directorate for STEM Education (EDU); and the Division of Translational Impacts in the Directorate for Technology, Innovation and Partnerships (TIP). INFORMATIONAL WEBINAR: The Emerging Frontiers and Multidisciplinary Activities (EFMA) Office will host an informational webinar in October 2023 to discuss the Ideas Lab: Personalized Engineering Learningsolicitationandtoanswer questions. Details on how to join this webinar will be posted on the EFMA Website.

Science and Technology
For profit organizations other than small businesses
DoD Melanoma, Idea Award
$560,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Oct 1, 2025

Date Added

May 27, 2025

This funding opportunity supports innovative research projects aimed at improving the understanding, prevention, and treatment of melanoma, particularly for military and Veteran populations.

Science and Technology
Nonprofits
OJJDP FY25 Family-Based Alternative Justice
$750,000
U.S. Department of Justice (Office of Juvenile Justice Delinquency Prevention)
Federal

Application Deadline

May 8, 2026

Date Added

Mar 26, 2026

This funding opportunity provides financial support to organizations that help families at risk of involvement in the justice system by offering rehabilitation services and resources to keep parents and children together.

Law Justice and Legal Services
County governments
Bipartisan Infrastructure Law (BIL) Accelerating CO2 Conversion Technology Development and Deployment Biological, Catalytic, and Mineralization Pathways
$8,000,000
U.S. Department of Energy (National Energy Technology Laboratory)
Federal

Application Deadline

Apr 11, 2025

Date Added

Jan 16, 2025

This funding opportunity provides financial support for universities, businesses, and organizations to develop and implement innovative technologies that convert carbon dioxide into useful products, helping to combat climate change and promote sustainability.

Energy
Public and State controlled institutions of higher education
Research Grants for Preventing Interpersonal Violence and Suicide Among Youth and Young Adults (R01)
$1,200,000
U.S. Department of Health and Human Services (Centers for Disease Control and Prevention)
Federal

Application Deadline

Jul 1, 2026

Date Added

Aug 8, 2025

This funding opportunity provides financial support for research projects aimed at developing and evaluating innovative strategies to prevent interpersonal violence and suicide among youth and young adults aged 10 to 24.

Health
State governments
Global Health Security
$21,600,000
Agency for International Development (Philippines USAID-Manila)
Federal

Application Deadline

Feb 28, 2025

Date Added

Dec 13, 2024

This funding opportunity provides financial support to local Philippine organizations to strengthen the country's capacity to prevent and respond to infectious disease threats through a collaborative, multi-sectoral approach.

Health
Nonprofits
STTR Solutions to Enable Population Genomic Screening (R41/R42 Clinical Trial Optional)
$2,150,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Dec 2, 2024

Date Added

Aug 19, 2024

This funding opportunity supports small businesses in developing innovative technologies and services for population-wide genomic screening to improve primary care for common genetic conditions.

Health
Small businesses
ROSES 2024: C.11 Discovery Data Analysis Program
$2,000,000
National Aeronautics & Space Administration (NASA Headquarters)
Federal

Application Deadline

Nov 13, 2024

Date Added

Oct 1, 2024

This grant provides funding for researchers to analyze and interpret data from various NASA planetary missions, encouraging innovative scientific investigations and collaborations in the field.

Science and Technology
Nonprofits
Resource-Related Research Projects for Development of Animal Models and Related Materials (R24 Clinical Trials Not-Allowed)
$5,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 25, 2025

Date Added

May 22, 2025

This funding opportunity supports the development and enhancement of animal models and related biological tools that are broadly applicable to various areas of biomedical research, aimed at improving our understanding of human diseases and advancing therapeutic interventions.

Health
State governments
NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 7, 2024

Date Added

Feb 8, 2023

This funding opportunity announcement (FOA) encourages applications for multi-center clinical trials focused on neurological emergencies. Successful applicants will collaborate and conduct the trial within the NIH SIREN Network. The NIH SIREN Clinical Coordinating Center (CCC) will work with the successful applicants to implement the proposed trial efficiently and the SIREN Data Coordinating Center (DCC) will provide statistical and data management support. The NIH SIREN hubs and their affiliated clinical sites will provide on-site implementation of the clinical protocols.The NIH SIREN Network will also be uniquely poised to collaborate with other US and international consortia necessary to conduct larger, definitive trials of promising interventions for neurological emergencies.Multi-center clinical trials in stroke treatment, recovery, or prevention supported by NINDS will be conducted in the NIH StrokeNet, and not within SIREN. Applicants do not need to be part of the existing SIREN infrastructure to apply under this FOA.

Health
State governments
DoD, Melanoma, Idea Award
$400,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Aug 26, 2024

Date Added

May 9, 2024

The FY24 MRP Idea Award supports innovative, untested, exploratory, high-risk/potentially high-reward concepts, theories, paradigms, and/or methods that address at least one of the FY24 MRP Focus Areas in Section II.A.1. Key aspects of the Idea Award: The intent of the Idea Award is to generate novel research avenues for investigation; therefore, novelty and innovation should be key aspects of the proposed research. Research supported by the Idea Award must introduce a new paradigm, challenge existing paradigms, look at existing problems from new perspectives, or exhibit other highly creative qualities. The proposed project must be exploratory, hypothesis-driven, or hypothesis-generating research and be based on a well-developed study design and plan of analysis. Principal Investigators (PIs) new to the melanoma field are encouraged to apply. The Idea Award is NOT intended to expand or extend previously published findings or continue a line of research already established and /or funded in the PIs laboratory. Incremental advances, the next logical step, or merely switching the object or method of inquiry from one cancer to melanoma is not considered innovative. The expected outcome of research supported by this award is the generation of robust preliminary data to be used as a foundation for future melanoma-focused research projects. Inclusion of preliminary data is discouraged. PIs proposing projects already supported by significant preliminary data and/or other funding sources should consider applying to other FY24 MRP funding opportunities for which the inclusion of preliminary data is more appropriate or required. Inclusion of preliminary data other than serendipitous findings is not consistent with the exploratory/innovative nature of this award. If preliminary data are included, they should be unanticipated outcomes or results from an unrelated project or study.

Science and Technology
Nonprofits
Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (R01 Clinical Trial Optional)
$150,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 3, 2025

Date Added

Jan 2, 2025

This funding opportunity is designed for researchers with existing NCI R01 grants to integrate innovative cancer research technologies into their projects, enhancing the study's impact and advancing the field of cancer research.

Education
State governments