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Grants for Small businesses - Federal

Explore 1,962 grant opportunities

Partnerships with MCC Program
$750,000
Millennium Challenge Corporation
Federal

Application Deadline

Aug 26, 2025

Date Added

Aug 27, 2025

This program provides funding for innovative partnerships that help reduce poverty through economic growth in developing countries, focusing on initiatives like infrastructure resilience and women's entrepreneurship.

International Development
Nonprofits
A.12 Hemispheric Airborne Measurements of Air Quality (HAMAQ) Science Team
Contact for amount
National Aeronautics and Space Administration (NASA Headquarters)
Federal

Application Deadline

Jul 21, 2026

Date Added

Apr 21, 2026

This funding opportunity supports U.S.-based institutions conducting airborne research to improve understanding of air quality and atmospheric pollutants on a hemispheric scale.

Science and Technology
Public and State controlled institutions of higher education
Molecular Mechanisms of Combination Adjuvants (MMCA) (R01 Clinical Trial Not Allowed)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 10, 2025

Date Added

Jan 14, 2025

This funding opportunity supports researchers at various institutions to investigate how combining vaccine adjuvants can improve immune responses, ultimately leading to better vaccine designs for different diseases.

Health
State governments
Elucidating Mechanisms Associated with HIV Related Co-Morbidities in Populations Experiencing Health Disparities (R01 - Clinical Trials Not Allowed)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 24, 2025

Date Added

Mar 2, 2024

This grant provides funding for research aimed at understanding the factors that contribute to health disparities in HIV and aging among racial and ethnic minorities, low-income populations, and other underserved groups, focusing on how multiple health conditions affect their overall well-being and quality of life.

Food and Nutrition
State governments
DRL Increase Access to Due Process in Uzbekistan
$500,000
DOS-DRL (Bureau of Democracy Human Rights and Labor)
Federal

Application Deadline

May 10, 2024

Date Added

Mar 12, 2024

The U.S. Department of State, Bureau of Democracy, Human Rights, and Labor (DRL) announces an open competition for organizations interested in submitting applications for projects that increase transparency in citizens’ rights to due process. Uzbekistan’s constitution and law prohibit arbitrary arrest and detention and provide for the right of any person to challenge the lawfulness of his or her arrest or detention in court. Additionally, by law a judge must review any decision to arrest accused individuals or suspects. Judges grant arrest warrants in most cases. Detention without formal charges is limited to 48 hours, although a prosecutors may request that a judge extend detention an additional 48 hours, after which the person must be charged or released. Judges typically grant such requests, and the judge who issues such an extension is often the same one who presided over the trial, which creates incentives to cover up violations. The arresting authority is required to notify a relative of a detainee of the detention and to question the detainee within 24 hours of arrest. Visibility into arrest procedures and treatment of detainees is low, even for family members of detainees and Uzbekistani civil society engaged on the issue of due process. 2 Through this award, DRL aims to support the safe, secure, and professional collection of credible information on political detainees by Uzbekistani media, Civil Society Organizations, (CSOs) and human rights defenders, for human rights reporting and advocacy and to improve the capacity of Uzbekistani CSOs to advocate for transparency and improved conditions in detention facilities.

International Development
Nonprofits
Scientific Feasibility (SciFy)
Contact for amount
U.S. Department of Defense (DARPA - Information Innovation Office)
Federal

Application Deadline

Aug 25, 2024

Date Added

Mar 2, 2024

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative and revolutionary computational approaches that measure the feasibility of technical claims to enable accurate assessments of scientific content. This publication constitutes a Broad Agency Announcement (BAA) as contemplated in Federal Acquisition Regulation (FAR) 6.102(d)(2) and 35.016 and 2 C.F.R. § 200.203. Any resultant award negotiations will follow all pertinent laws and regulations, and any negotiations and/or awards for procurement contracts will use procedures under FAR 15.4, Contract Pricing, as specified in the BAA. The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals in the following areas of interest: feasibility assessment of scientific content and testing and evaluation of feasibility assessment methods. Proposed research should investigate innovative approaches that enable revolutionary advances in science or systems. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice. Multiple awards are anticipated. The amount of resources made available under this BAA will depend on the quality of the proposals received and the availability of funds.

Science and Technology
City or township governments
Neutralization In Challenging Environments Using Lethal Effects (NICELE)
Contact for amount
U.S. Department of Defense (Office of Naval Research)
Federal

Application Deadline

Jun 9, 2025

Date Added

Dec 12, 2024

This grant provides funding for innovative technologies that enhance the detection and neutralization of underwater threats, targeting researchers and companies specializing in explosive ordnance disposal and underwater robotics.

Science and Technology
Public and State controlled institutions of higher education
Accelerating Product Excellence in Innovation and for Clinical Adoption (APEx) (U24 Clinical Trial Not Allowed)
$4,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jul 10, 2026

Date Added

May 28, 2025

This funding opportunity provides financial support to institutions and organizations for developing and advancing innovative therapies and diagnostic tools in tissue engineering and regenerative medicine, with a focus on preparing these technologies for clinical use.

Science and Technology
Public and State controlled institutions of higher education
Rare Diseases Are Not Rare! 2025 Challenge
$3,000
U.S. Department of Health and Human Services (National Center for Advancing Translational Sciences)
Federal

Application Deadline

Not specified

Date Added

Dec 24, 2025

This competition invites artists, researchers, and advocates to create innovative media that raises awareness and promotes collaborative treatment strategies for the millions affected by rare diseases in the U.S.

Health
Individuals
Impact of Initial Influenza Exposure on Immunity in Infants (U01 Clinical Trial Not Allowed)
$3,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 4, 2026

Date Added

Jul 9, 2025

This funding opportunity supports research to understand how infants' first encounters with influenza, through infection or vaccination, shape their long-term immune responses, with a focus on developing a universal flu vaccine.

Health
Public and State controlled institutions of higher education
USAID Sahel Information Integrity -Annual Program Statement (APS)
$15,000,000
U.S. Agency for International Development - Senegal USAID-Dakar
Federal

Application Deadline

Jul 30, 2024

Date Added

Jul 1, 2024

USAID/Senegals Sahel Regional Office (USAID/Senegal/SRO) ADDENDUM #1 - CALL FOR CONCEPT PAPERS USAID Strengthening Information Integrity and Resilience (IIR) in the Sahel USAID Sahel Information Integrity Annual Program Statement No. 72068524APS00003 Issuance Date: June 28, 2024 Closing Date: July 30, 2024 Questions Due Date for this APS Addendum: July 9, 2025 Dear Prospective Applicants: This is an Addendum to the USAID Sahel Information Integrity Annual Program Statement (APS) (No.72068524APS00003). All interested organizations should carefully review both this Addendum AND the full APS, which can be found here in grants.gov . Important information contained in the APS announcement is not necessarily repeated in this specific Addendum. This activity is authorized under the Foreign Assistance Act of 1961, as amended. Through this Addendum #1 to APS No. 72068524APS00003, USAID/Senegal/SRO is requesting the submission of concept papers focused on Strengthening Information Integrity and Resilience (IIR) in the Sahel. Concept papers should describe a nimble and adaptive approach for supporting key actors in local and regional information ecosystems to be more effective in advancing information integrity and resilience in their local and regional systems. TARGET COUNTRIES: All three objectives of this activity (as outlined under technical focus below) must be addressed in all of the following countries, which fall under the management authority of USAID/Senegal/SRO: Burkina Faso Chad Mauritania Objective 2 under this APS (which relates to strengthening regional networks) may also create opportunities for partner organizations in Cabo Verde, The Gambia, Guinea-Bissau, Mali, Niger, and Senegal based on prior approval from USAID. Under this Addendum, subject to the availability of funds, USAID anticipates making one award. USAID also reserves the right to make no awards. The total USAID funds anticipated is $15,000,000. USAID contemplates a start date for the award beginning on or about December 1, 2024, with a period of performance of up to five years. Applicants should send general questions about the below information by email to USAID primary and secondary points of contact, Ms. Aminata Diallo, at amdiallo@usaid.gov and Robert Almosd at ralmosd@usaid.gov, respectively. See " related Documents" Tab for the full Addendum Thank you for your interest in USAID Programs. Sincerely,

Information and Statistics
Nonprofits
Navys Grants for Improvement of Navy Ship Repair or Alterations Capability
$5,000,000
U.S. Department of Defense (NAVSEA HQ - N00024)
Federal

Application Deadline

Aug 14, 2025

Date Added

Jul 16, 2025

This funding opportunity provides financial support to shipyards and training organizations to improve the repair capabilities and workforce skills for non-nuclear U.S. Navy vessels.

Infrastructure
For profit organizations other than small businesses
NINDS Ruth L. Kirschstein National Research Service Award (NRSA) for Training of Postdoctoral Fellows (F32 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2025

Date Added

Mar 8, 2024

This grant provides funding to support promising postdoctoral researchers in neuroscience, enabling them to receive advanced training and mentorship in a focused research environment.

Health
Public and State controlled institutions of higher education
Inspiring Generations Of New Innovators To Impact Technologies In Energy 2026 (IGNIITE 2026)
$500,000
U.S. Department of Energy (Advanced Research Projects Agency Energy )
Federal

Application Deadline

Aug 26, 2026

Date Added

Jul 28, 2026

This funding opportunity provides financial support and mentorship to early career scientists and engineers in the U.S. to develop innovative energy technologies that address critical challenges in the energy sector.

Opportunity Zone Benefits
Individuals
Limited Competition: Small Grant Program for NIAMS K01, K08, K23, and K25 Recipients (R03) (Clinical Trials Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 20, 2025

Date Added

May 6, 2025

This funding opportunity provides financial support to early-career researchers currently holding specific NIAMS career development awards, helping them advance their research projects and transition to independent research careers in arthritis, musculoskeletal, and skin diseases.

Health
State governments
Strengthening global health security through local partnerships in Uganda
$15,000,000
U.S. Department of Health and Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Aug 14, 2026

Date Added

Aug 23, 2025

This funding opportunity provides financial support to a wide range of organizations working in Uganda to strengthen public health systems and enhance the country's ability to respond to infectious disease threats.

Health
State governments
BJA FY25 Tribal Justice Infrastructure: Physical Plant and Corrections Operations Support Program
$1,350,000
U.S. Department of Justice (Bureau of Justice Assistance)
Federal

Application Deadline

Apr 10, 2026

Date Added

Mar 19, 2026

This program provides funding to tribal organizations and institutions to improve justice system facilities and enhance corrections operations in Native American communities across the United States.

Law Justice and Legal Services
Native American tribal organizations
Centers on the Demography and Economics of Aging, Including Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD) (D and E Centers) (P30 Clinical Trial Optional)
$600,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 10, 2025

Date Added

Oct 17, 2024

Grant Title: Centers on the Demography and Economics of Aging, Including Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD) (D and E Centers) (P30 Clinical Trial Optional) aims to support interdisciplinary research centers that focus on the social science aspects of aging, particularly related to health disparities, economic impacts, and caregiving for dementia, while fostering collaboration among diverse scholars and institutions.

Health
State governments
FY 2025 NIST Small Business Innovation Research Program Phase II
$400,000
U.S. Department of Commerce (National Institute of Standards and Technology)
Federal

Application Deadline

Jun 14, 2025

Date Added

Apr 17, 2025

This funding opportunity provides financial support to small businesses that previously received Phase I SBIR grants from NIST, enabling them to further develop their innovative projects into commercially viable products or services.

Science and Technology
Small businesses
Disruptive DC Converters For Grid Resilient Infrastructure To Deliver Sustainable Energy (DC-Grids)
$10,000,000
U.S. Department of Energy (Advanced Research Projects Agency Energy )
Federal

Application Deadline

Mar 3, 2025

Date Added

Nov 8, 2024

This funding opportunity supports innovative projects that develop advanced high-voltage direct current technologies to enhance the resilience and sustainability of the U.S. energy grid, targeting domestic entities and collaborations focused on improving power transmission systems.

Opportunity Zone Benefits
Public and State controlled institutions of higher education