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Grants for Small businesses - Federal

Explore 1,962 grant opportunities

Reissue of RFA-FD-22-001 - Efficient and Innovative Natural History Studies Addressing Unmet Needs in Rare Diseases (R01 Clinical Trials Optional)
$600,000
U.S. Department of Health & Human Services (Food and Drug Administration)
Federal

Application Deadline

Feb 8, 2028

Date Added

Jul 12, 2025

This funding opportunity supports research projects that investigate the natural history of rare diseases, aiming to improve medical product development and patient outcomes through collaborative studies and innovative methodologies.

Health
Public and State controlled institutions of higher education
The NIDDK Disorders of Gastrointestinal Interoception Consortium Clinical Centers (DGIC)
$3,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 1, 2026

Date Added

Sep 19, 2025

This funding opportunity supports clinical research centers focused on understanding and improving treatments for various gastrointestinal disorders by exploring how the body senses and interprets internal signals, benefiting both adults and children.

Health
Public and State controlled institutions of higher education
DEVCOM Analysis Center Broad Agency Announcement For Applied Research
Contact for amount
U.S. Department of Defense (Dept of the Army -- Materiel Command)
Federal
Rolling

Application Deadline

Jan 4, 2028

Date Added

Jan 5, 2023

This funding opportunity is designed to support a wide range of research proposals from universities, nonprofits, businesses, and government entities that aim to advance the U.S. Army's technological capabilities and operational effectiveness.

Science and Technology
Nonprofits
NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Apr 5, 2029

Date Added

Jun 19, 2025

This funding opportunity provides financial support to U.S.-based small businesses that have completed a Phase II SBIR or STTR project, helping them advance their innovative products or technologies toward commercialization.

Health
Small businesses
DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Idea Award
$840,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Sep 30, 2026

Date Added

May 5, 2026

This funding opportunity supports innovative research projects aimed at developing new therapies for amyotrophic lateral sclerosis (ALS), particularly those that include biomarker development to measure treatment effects, and is open to a wide range of researchers and organizations.

Health
Nonprofits
DoW Peer Reviewed Cancer, Clinical Trial Award
$4,500,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Oct 5, 2026

Date Added

May 7, 2026

This funding opportunity supports clinical trials aimed at improving cancer treatment and management for various types of cancer, specifically targeting military populations and involving significant patient advocate participation.

Health
Nonprofits
NCI Community Oncology Research Program (NCORP) Research Bases (UG1 Clinical Trial Required)
$74,500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 18, 2026

Date Added

May 29, 2025

This funding opportunity provides financial support to U.S.-based organizations with established cancer research capabilities to develop and conduct multi-institutional clinical trials focused on cancer prevention, control, and care delivery in community settings.

Health
Public and State controlled institutions of higher education
Novel Experiential Technologies Assisting Individual Learning (NExT AI) Hubs
$1,600,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 2, 2026

Date Added

Jul 9, 2025

This funding opportunity supports research centers that will investigate how innovative artificial intelligence technologies can improve learning outcomes for children with specific learning disabilities affecting literacy and numeracy skills.

Science and Technology
State governments
DoW Orthopaedic, Clinical Research Award
$3,200,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Nov 18, 2026

Date Added

May 22, 2026

This funding opportunity supports clinical research and trials focused on improving recovery and treatment for military personnel with orthopaedic injuries, while also benefiting the general public.

Science and Technology
Nonprofits
Rfa-Dp-18-000
Contact for amount
U.S. Department of Health and Human Services (Centers for Disease Control and Prevention - ERA)
Federal

Application Deadline

Sep 30, 2030

Date Added

Nov 26, 2025

This funding opportunity provides support for states, universities, and nonprofit organizations to enhance existing public health and injury prevention programs through administrative supplements to their current CDC grants.

Health
State governments
DoW Reconstructive Transplant, Concept Award
$200,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Nov 4, 2026

Date Added

Jun 1, 2026

This funding opportunity supports innovative research projects aimed at improving reconstructive transplantation techniques and access for injured Service Members, Veterans, and the general public.

Science and Technology
Nonprofits
F24AS00298 Cooperative Agriculture
Contact for amount
U.S. Department of the Interior (Fish and Wildlife Service)
Federal
Rolling

Application Deadline

Mar 7, 2029

Date Added

Mar 7, 2024

This grant enables individuals or entities to engage in agricultural practices on National Wildlife Refuge lands to support wildlife conservation and habitat management efforts without the exchange of federal funds.

Agriculture
Individuals
DoW Neurofibromatosis Exploration-Hypothesis Development Award
$1,280,000
U.S. Department of Defense (Defense Health Agency Contracting Activity - DHACA)
Federal

Application Deadline

Sep 22, 2026

Date Added

Jun 26, 2026

This funding opportunity supports innovative research projects aimed at advancing the understanding of neurofibromatosis, encouraging a wide range of applicants, including academic institutions and nonprofits, to explore groundbreaking hypotheses that could lead to significant health improvements for affected individuals.

Science and Technology
Nonprofits
Biomechanics and Mechanobiology (BMMB)
$400,000
National Science Foundation
Federal

Application Deadline

Not specified

Date Added

Jun 12, 2018

This grant supports innovative research that explores the mechanical behavior of living systems, focusing on the intersection of engineering biomechanics and mechanobiology, and is intended for researchers in these fields.

Science and Technology
City or township governments
Foundational Research in Robotics
Contact for amount
National Science Foundation
Federal
Rolling

Application Deadline

Not specified

Date Added

Feb 12, 2020

This program provides funding for researchers and engineers to advance the field of robotics by developing intelligent systems that can sense, plan, and interact with their environments.

Science and Technology
Public and State controlled institutions of higher education
ERDC Broad Agency Announcement
Contact for amount
U.S. Department of Defense (Engineer Research and Development Center)
Federal
Rolling

Application Deadline

Not specified

Date Added

Apr 30, 2025

This funding opportunity invites U.S. institutions, including universities and small businesses, to propose innovative research projects that advance technologies and scientific understanding in areas like water management, infrastructure resilience, and environmental restoration, supporting both military and civil objectives.

Science and Technology
Nonprofits
MPS Physics Research Programs (MPS Physics)
$180,000,000
National Science Foundation
Federal
Rolling

Application Deadline

Not specified

Date Added

Aug 18, 2026

This funding opportunity supports foundational physics research across various fields, including quantum physics, particle physics, and cosmology, aimed at advancing scientific knowledge and innovation.

Science and Technology
City or township governments
ancient DNA for Modern Genomics (aDMG) Research Projects (U01 Clinical Trials Not Allowed)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 1, 2028

Date Added

Jun 3, 2026

This funding opportunity supports researchers and institutions working to combine ancient DNA with modern genomic data to enhance our understanding of human biology, evolution, and health-related traits.

Science and Technology
Public and State controlled institutions of higher education
Combinatorics
Contact for amount
National Science Foundation
Federal

Application Deadline

Sep 22, 2026

Date Added

Oct 10, 2024

This program provides funding for research and collaborative events in combinatorial mathematics, targeting universities, nonprofit organizations, and individual researchers across the United States.

Science and Technology
City or township governments
NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Apr 5, 2027

Date Added

Jun 19, 2025

This funding opportunity supports U.S. small businesses in developing innovative health-related technologies and solutions that can be commercialized to improve public health and safety.

Science and Technology
Small businesses