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Grants for Small businesses - Federal

Explore 1,962 grant opportunities

ROSES 2025: C.2 Solar System Science
$1,000,000
National Aeronautics and Space Administration
Federal

Application Deadline

Nov 12, 2026

Date Added

Jul 12, 2025

This funding opportunity provides financial support for researchers and organizations conducting studies and developing tools related to planetary science, with a focus on understanding the Solar System and the potential for life beyond Earth.

Science and Technology
Public and State controlled institutions of higher education
Establishing a Center for the Advancement of Substance Use Disorder (SUD) Pharmacotherapeutics through Training and Preclinical Support (U54 Clinical Trial Not Allowed)
$3,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 30, 2026

Date Added

Aug 29, 2025

This funding opportunity provides resources to academic researchers and organizations to establish a center that will train and support the development of new medications for substance use disorders, bridging the gap between scientific research and practical treatment solutions.

Health
Public and State controlled institutions of higher education
DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award
$2,000,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Sep 30, 2026

Date Added

May 5, 2026

This funding opportunity supports research projects that advance promising therapeutic candidates for amyotrophic lateral sclerosis (ALS) from preclinical stages to readiness for clinical trials, emphasizing the development of effective treatments and relevant biomarkers.

Health
Nonprofits
BROAD AGENCY ANNOUNCEMENT (BAA) for Extramural Biomedical and Human Performance Research and Development Department of Defense
$10,000,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Jul 31, 2028

Date Added

Jul 27, 2023

This funding opportunity supports innovative research projects that improve military medicine and human performance, targeting challenges faced by Special Operations Forces and benefiting both military and civilian populations.

Science and Technology
Nonprofits
Engineering for Civil Infrastructure (ECI)
Contact for amount
National Science Foundation
Federal

Application Deadline

Not specified

Date Added

Jun 12, 2018

This grant provides funding for researchers focused on improving civil infrastructure through innovative engineering solutions that enhance resilience to climate change and natural hazards.

Science and Technology
City or township governments
Institute of Education Sciences (IES): National Center for Special Education Research (NCSER): Research Training Programs in Special Education
$800,000
U.S. Department of Education
Federal

Application Deadline

Oct 1, 2026

Date Added

Aug 7, 2026

This grant provides funding to support early career researchers and training programs focused on improving educational outcomes for children and youth with disabilities in the United States.

Education
Nonprofits
Institute of Education Sciences (IES): National Center for Education Research (NCER): Statistical and Research Methodology in Education
$900,000
U.S. Department of Education
Federal

Application Deadline

Oct 1, 2026

Date Added

Aug 7, 2026

This grant provides funding for organizations to develop and improve statistical and research methods that enhance education research, particularly in areas like artificial intelligence and assessment analysis.

Education
Nonprofits
Advanced Cyber Effects for Strategic Operations
$99,980,000
U.S. Department of Defense
Federal

Application Deadline

Jul 10, 2030

Date Added

Sep 29, 2025

This grant provides funding for innovative research and development of cyber operations prototypes to enhance the U.S. Department of Defense's capabilities in the cyber domain, targeting a wide range of eligible applicants including universities, businesses, and research organizations.

Science and Technology
For profit organizations other than small businesses
Bioengineering Partnerships with Industry (U01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 27, 2027

Date Added

Nov 7, 2024

This funding opportunity supports collaborations between academic institutions and industry partners to develop innovative bioengineering technologies that address critical biomedical challenges.

Education
State governments
NSF National Quantum Virtual Laboratory - Quantum Testbeds
$10,000,000
National Science Foundation
Federal

Application Deadline

Apr 6, 2027

Date Added

May 14, 2025

This funding opportunity supports large-scale projects that advance quantum technology through collaborative research and development among academia, industry, and government, specifically targeting the design and implementation of scalable quantum systems.

Science and Technology
Public and State controlled institutions of higher education
UNITED STATES MILITARY ACADEMY Broad Agency Announcement
Contact for amount
U.S. Department of Defense (Dept of the Army -- Materiel Command)
Federal

Application Deadline

Mar 31, 2027

Date Added

May 28, 2025

This funding opportunity supports innovative research proposals from a wide range of organizations to advance military capabilities and address critical challenges facing the Army and the nation.

Science and Technology
Public and State controlled institutions of higher education
Instrumentation Grant Program for Resource-Limited Institutions
$250,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 26, 2029

Date Added

Aug 28, 2025

This funding opportunity provides financial support for resource-limited U.S. institutions to acquire advanced scientific instruments that enhance biomedical research and education, particularly benefiting students from underserved backgrounds.

Health
Public and State controlled institutions of higher education
DoW Traumatic Brain Injury and Psychological Health, Clinical Trial Award
$4,100,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Oct 15, 2026

Date Added

May 7, 2026

This funding opportunity supports clinical trials aimed at improving the treatment and management of traumatic brain injury and psychological health conditions affecting service members, veterans, and the general public.

Health
Nonprofits
NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 5, 2029

Date Added

Jul 9, 2025

This funding opportunity supports U.S.-based researchers and institutions conducting large-scale observational studies or validating biomarkers related to dental, oral, and craniofacial health.

Health
Public and State controlled institutions of higher education
NCI Community Oncology Research Program (NCORP) Academic Community Sites (UG1 Clinical Trials Not Allowed)
$73,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 18, 2026

Date Added

May 29, 2025

This funding opportunity provides financial support to academic institutions and their community partners to conduct cancer research and improve access to clinical trials for diverse patient populations.

Health
Public and State controlled institutions of higher education
DoD Breast Cancer, Transformative Breast Cancer Consortium Award
$35,000,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Sep 30, 2026

Date Added

May 5, 2026

This funding opportunity supports large-scale, collaborative research projects aimed at significantly advancing the understanding, prevention, and treatment of breast cancer, involving multiple institutions and disciplines.

Science and Technology
Nonprofits
Transformative Non-Invasive/Minimally Invasive Technologies for Imaging the Olfactory System Across Scales (R01 CT Optional)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Aug 21, 2028

Date Added

Jul 18, 2025

This funding opportunity supports the development of advanced imaging technologies to study the human olfactory system, targeting researchers and organizations focused on improving understanding and treatment of olfactory disorders.

Science and Technology
Public and State controlled institutions of higher education
Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2028

Date Added

Nov 1, 2024

This funding opportunity supports clinical trials that evaluate effective mental health interventions and services for individuals transitioning from acute care to long-term support, particularly for underserved populations.

Health
State governments
DoW Pancreatic Cancer Research Program, Idea Development Award
$700,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Oct 7, 2026

Date Added

May 5, 2026

This funding opportunity supports innovative research projects aimed at improving early detection, treatment, and outcomes for individuals affected by pancreatic cancer, particularly benefiting Service Members, Veterans, and their families.

Health
Nonprofits
NSF STEM K-12
$750,000
National Science Foundation
Federal
Rolling

Application Deadline

Not specified

Date Added

Aug 23, 2025

This funding opportunity supports a wide range of projects aimed at improving STEM education and learning outcomes in schools and informal settings across the United States, targeting institutions, organizations, and individuals involved in education and research.

Education
Public and State controlled institutions of higher education