Grants for Special district governments - Federal

This funding opportunity provides financial support for conservation projects aimed at protecting endangered species and their habitats in Wyoming, targeting state and local governments, educational institutions, tribal governments, and nonprofit organizations.

This funding opportunity provides support for high-risk clinical trials focused on infectious, immunologic, and allergic diseases, encouraging innovative research that can lead to new treatments and therapies.

The DOE SC program in Advanced Scientific Computing Research (ASCR) hereby announces its interest in basic computer science and applied mathematics research in the fundamentals of Artificial Intelligence (AI) for science. Specifically, advancements in this area are sought that can enable the development of: Foundation models for computational science; Automated scientific workflows and laboratories; Scientific programming and scientific-knowledge-management systems; Federated and privacy-preserving training for foundation and other AI models for science; and Energy-efficient AI algorithms and hardware for science. The development of new AI techniques applicable to multiple scientific domains can accelerate progress, increase transparency, and open new areas of exploration across the scientific enterprise. SUPPLEMENTARY INFORMATION AI is one of the most powerful technologies of our time[1] and DOE is at the forefront of research and development in AI technologies for enabling scientific discovery and innovation. Core components of the scientific method remain unchanged: Observation, Hypothesis, Experiments, and Analysis. However, DOE recognizes that abundant sources of data, high-performance computing (HPC) and networking, energy-efficient algorithms, and AI-related technologies can be harnessed to significantly accelerate and expand the impact of scientific research. The breadth of applications spans climate science, cybersecurity and electric grid resilience, biotechnology, microelectronics, disaster response, and beyond. Research to address national priorities will require advances and AI innovations in high-level capabilities such as: monitoring and predicting the onset of real-world anomalies and extreme events; adaptive strategies to control the real-time behavior of complex systems, infrastructure, and processes; approaches for the optimal development and design of physical systems; decision-support for planning, risk, and policy formulation; and tools that synthesize scientific knowledge and accelerate the design, manufacturing, testing, and optimization of new technologies. The focus of ASCR research and development investments is on the underlying approaches for AI-enhanced scientific and engineering capabilities and to significantly transform the scientific method for accelerated discovery and innovation. Realizing the next generation of AI for science will require innovations in both hardware and algorithms. Future AI-enabled scientific workflows are expected to use Machine Learning (ML) to enhance numerical modeling and data analysis along with technologies that process natural and computer-programming languages. DOEs exascale supercomputers[2] are some of the Nations most powerful systems for large-scale AI training and for tasks integrating AI, modeling, simulation, and data analysis. These exascale and future systems complement the vast array of other AI-enabled HPC and edge systems, including automated laboratories and facilities, that will significantly accelerate scientific progress in the coming decades. DOEs scientific community has collectively articulated important research directions toward realizing the promise of AI for science and other DOE missions in the recently-released AI For Science, Energy, and Security report [1], building on the preceding AI for Science report [2], and complementing the report on Opportunities and Challenges from Artificial Intelligence and Machine Learning for the Advancement of Science, Technology, and the Office of Science Missions [3]. The research directions highlighted in these reports, and others, appear prominently in the National Artificial Intelligence Research and Development Strategic Plan [4]. This FOA addresses a broad spectrum of research priorities described in these documents that are critical to enabling trustworthy AI for scientific applications advancing human understanding and addressing national needs. [1] For additional background on the promise and importance of AI R, see the OMB/OSTP Memorandum on Multi-Agency Research and Development Priorities for the FY 2025 Budget (August 2023) https://www.whitehouse.gov/wp-content/uploads/2023/08/FY2025-OMB-OSTP-RD-Budget-Priorities-Memo.pdf, and the Executive Order on the Safe, Secure, and Trustworthy Development and Use of Artificial Intelligence (October 2023) https://www.whitehouse.gov/briefing-room/presidential-actions/2023/10/30/executive-order-on-the-safe-secure-and-trustworthy-development-and-use-of-artificial-intelligence/ [2] For more information on ASCRs exascale supercomputers, and other HPC resources, available as national user facilities, see https://science.osti.gov/ascr/Facilities/User-Facilities

The purpose of the Mentored Quantitative Research Career Development Award (K25) is to attract to NIH-relevant research those investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. The K25 award will provide support and "protected time" for a period of supervised study and research for productive professionals with quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial. Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor. Applicants proposing a clinical trial or an ancillary clinical trial as lead investigator, should apply to the companion FOA ().

This funding opportunity provides financial support to non-profits, local governments, and tribal entities to develop and implement programs that prevent and end homelessness, particularly for youth and vulnerable populations, while promoting access to essential resources and services.

This funding opportunity supports research projects aimed at reducing stigma related to HIV/AIDS in low- and middle-income countries, with a focus on improving health outcomes for affected populations.

This funding opportunity provides financial support for researchers to conduct early-phase clinical trials aimed at developing new treatments or diagnostic tools for heart, lung, blood, and sleep disorders in both adults and children.

This funding opportunity provides financial support to institutions and organizations for creating a centralized data hub and coordinating center that will enhance innovative research methodologies in biomedical science, focusing on alternatives to traditional animal models.

Addressing the Impact of Syndemics on the Health of People with HIV and Diseases and Conditions within the Missions of NIDDK and NHLBI (R01 Clinical Trial Optional)

This funding opportunity is designed to support non-profit organizations in expanding and implementing proven falls prevention programs for older adults, focusing on effective strategies for broader adoption within community and clinical settings.

This funding opportunity provides financial support for researchers to conduct secondary analyses of existing vision-related datasets to explore new scientific ideas and improve understanding of eye health and diseases.

The purpose of this notice of funding opportunity (NOFO) is to support basic and exploratory research projects to advance our understanding of T. pallidum bacterial pathogenesis.

This Notice of Funding Opportunity (NOFO) invites applications for a cooperative agreement to support, manage and facilitate Public-Private Partnerships and Collaborative activities as part of the Critical Path Initiative and to support regulatory science efforts. FDA and grantees will work together to develop innovative, collaborative projects in research, education, and outreach. These projects can help foster drug product innovation to 1) support efforts to accelerate drug product development; 2) support approaches to advanced manufacturing; 3) facilitate translation of basic science discoveries into therapeutics; and 4) facilitate approaches to enhance the safety, efficacy, quality, and performance of drug products. Projects are identified by FDA. Multiple awards may be funded under this NOFO and are directly dependent on drug development priorities and subject to the availability of funding.

This grant provides financial support for early-career researchers in dental, oral, and craniofacial fields to receive mentorship and develop their research skills, with a focus on enhancing diversity in the research workforce.

This funding opportunity provides financial support for conservation projects aimed at protecting and recovering threatened and endangered species and their habitats, targeting state and local governments, tribal governments, educational institutions, and nonprofit organizations.

This funding opportunity provides financial support for organizations to create transitional housing and comprehensive services for homeless youth aged 16 to 21, helping them achieve self-sufficiency and stable living conditions.

This funding opportunity provides financial support to state and local governments, tribal organizations, and other political subdivisions to conduct health assessments and implement strategies that reduce exposure to hazardous substances and promote environmental public health.

This funding opportunity supports community-driven research projects that assess environmental exposures and develop public health interventions to address health disparities in affected communities.

The NAWCA Canada program promotes partnerships between public agencies and groups interested in: a) protecting, improving, restoring, and managing an appropriate distribution and diversity of wetland ecosystems and other habitats for wetlands-associated migratory birds and other fish and wildlife in North America; b) maintaining and improving the current distributions of wetlands-associated migratory bird populations; and c) maintaining an abundance of waterfowl (ducks, geese, and swans) and other populations of wetlands-associated migratory birds consistent with the objectives of the North American Waterfowl Management Plan, U.S. Shorebird Conservation Plan, Waterbird Conservation Plan for the Americas, Partners in Flight Bird Conservation Plan, and other international obligations contained in the treaties and migratory bird conventions and other agreements with Canada, Mexico, and other countries. Proposals to the NAWCA Canada program should demonstrate how the activities of partners would encourage sustainable and effective programs for the long-term conservation of wetlands-associated migratory birds. NAWCA funds wetlands conservation projects that include: a) the acquisition of property containing wetlands ecosystems and associated habitats, including water rights, where the acquired land will be administered for its long-term conservation and for the benefit of migratory birds, fish, and other wildlife that depend on it; and/or b) restoration, enhancement, or management of wetlands ecosystems and associated habitats, where these activities will be conducted on lands and waters that will be administered for their long-term conservation and for the benefit of migratory birds, fish, and other wildlife that depend on them. NAWCA Canada proposals contribute to efforts to reduce climate pollution, support climate resilience, support land conservation and biodiversity efforts and leverage partnerships.

This grant provides funding for innovative research on immune mechanisms at mucosal surfaces in the respiratory, gastrointestinal, and urogenital tracts, aimed at advancing the understanding of mucosal immunology.