Federal Health Grants

This funding opportunity supports U.S. institutions in developing educational programs for psychiatry residents to enhance their research skills and encourage careers in mental health research.

This funding opportunity supports research and training in mathematical modeling to improve the prevention and management of infectious diseases in healthcare settings, targeting early-career modelers and collaboration with public health institutions.

This funding opportunity invites research institutions to join a collaborative effort aimed at advancing stillbirth research, particularly focusing on reducing stillbirth rates in vulnerable populations through innovative scientific approaches.

This funding opportunity provides financial support for the development of innovative informatics tools that will help researchers effectively utilize the human pangenome reference to advance genomics research across various applications.

This funding opportunity provides financial support to various organizations for developing and implementing public health strategies aimed at improving brain health and addressing the challenges of Alzheimer’s disease and related dementias, particularly for underserved populations.

To advance the field of patient-centered clinical decision support through research that tests tools and resources in real-world settings. The mission of the Agency for Healthcare Research and Quality (AHRQ) is to produce evidence to make healthcare safer, higher quality, and more accessible, equitable, and affordable, and to work within the U.S. Department of Health and Human Services and with other partners to make sure the evidence is understood and used. The purpose of this Notice of Funding Opportunity (NOFO) is to conduct research on patient-centered clinical decision support (PC CDS), a nascent area within the larger field of CDS. Through the AHRQ-funded Patient Centered Outcomes Research (PCOR) CDS Initiative and the CDS Innovation Collaborative specifically, PC CDS resources are now publicly available for interested researchers to further build upon, develop, and test, in real-world settings. Innovative research is needed to understand how to make traditional, clinician-facing CDS more patient-centered, while also engaging patients, families, and caregivers in a co-design process to design and implement these tools. BACKGROUND Clinical decision support refers to digital tools that are used to help inform patient care. Patient-centered clinical decision support (PC CDS), in contrast to traditional clinician-facing CDS, is CDS that focuses on the patient, or their caregiver, and facilitates their active involvement in healthcare decision-making with their clinicians. PC CDS uses information from patient-centered outcomes research findings and/or patient-specific information and has the potential to be transformative by enabling higher-quality care delivery and improved outcomes. PC CDS can also support shared decision making (SDM), which AHRQ defines as a collaborative process in which patients and clinicians work together to make healthcare decisions informed by evidence, the care team's knowledge and experience, and the patient's values, goals, preferences, and circumstances. PC CDS can also support shared care planning enabling patients, caregivers, and clinicians to work together to tailor a clinical plan to align with a given patients priorities and goals. PC CDS is a developing field and has the potential to increase the quality and experience of patient care. AHRQ’s CDS Initiative is supported by the Patient Centered Outcomes Research Trust Fund (PCOR TF) and is guided by AHRQ’s PCOR TF strategic framework (https://www.ahrq.gov/pcor/strategic-framework/index.html). Since 2016, AHRQ’s PCOR CDS Initiative has been building tools, concepts, frameworks, and conducting pilot projects. Much of AHRQ’s recent effort has focused on patient-centered CDS, and several past projects have generated resources that could be highly useful to the developing PC CDS field. Examples of these projects include AHRQ’s PC CDS Learning Network and CDS Connect, as well as a project that assessed the current state and future directions with PC CDS. Additional information for CDS projects is available on the PCOR CDS Initiative webpage. AHRQ’s most recent PC CDS project, the CDS Innovation Collaborative, or CDSiC, is a multi-component stakeholder-driven initiative that produced a rich set of resources and tested concepts around different aspects of PC CDS. As part of the CDSiC, four workgroups were formed, each around a specific area of PC CDS, with the charge to create products (e.g., frameworks, guides, checklists) that could be used in the clinical field to establish or measure use of PC CDS. These products could address clinical workflows or the development of CDS technologies, among other areas related to PC CDS. During the first two years of the CDSiC, these workgroups created numerous products that addressed PC CDS in different areas. These areas included CDS outcomes, trust and patient-centeredness, and scaling and dissemination. One workgroup also focused on the existing standards and regulatory frameworks that could impact the future uptake and use of PC CDS. Applicants can examine, using these products and tools, how PC CDS can support shared decision making and care planning among individuals with complex needs including older adults, people living with multiple chronic conditions, frailty, disabilities, and/or socioeconomic disadvantage and how this may foster the delivery of person-centered care. They may also study strategies to scale and spread effective tools including use in lower resourced and safety net instituions. Applicants responding to this NOFO must propose to use the resources developed by AHRQ's PCOR CDS Initiative, or any of the many products developed by the ongoing CDSiC, to further explore their usefulness, impact, and practical application in real-world settings. For example, CDSiC products that could be used may include the Taxonomy of Patient Preferences, Integration of Patient-Centered CDS into Shared Decision Making, Approaches to Measuring Patient-Centered CDS Workflow and Lifeflow Impacts, or the PC CDS Performance Measurement Inventory User Guide. Links to and descriptions of the products are available on the CDSiC Stakeholder Center webpage (https://cdsic.ahrq.gov/cdsic/cdsic-stakeholder-community-outreach-center ) The CDSiC's Innovation Center (https://cdsic.ahrq.gov/cdsic/innovation-center) developed a comprehensive report around measurement of PC CDS and created two pilot dashboards that can help clinicians understand and use Patient Generated Health Data. Additional information on other PCOR CDS projects is available at https://cds.ahrq.gov/about. Examples of Highly Responsive Projects include: A community hospital with a large priority population, selects from the CDSiC portfolio of projects generated by the Trust and Patient-Centeredness workgroup. The recipient selects the source credibility product from the Trust and Patient Centeredness workgroup and conducts a study to understand how their population perceives the information they receive from within their existing electronic health record (EHR) system. Patients provide input, and the approach is assessed against existing CDS tools, as well as the definition of PC CDS as defined by the CDSiC, to assess their level of patient-centeredness. A small startup company is developing applications (apps) to help patients improve their healthcare. The startup leverages two products from the CDSiC standards and regulatory frameworks workgroup: Advancing Standardized Representations for Patient Preferences to Support Patient-Centered Clinical Decision Support and an Environmental Scan that reveals opportunities to evolve standards and regulatory frameworks to advance PC CDS. The company works with a patient advocacy organization to co-design the patient-facing PC CDS app, uses standards to leverage existing patient generated health data (PGHD), and incorporates a final assessment as to the level of patient-centeredness of their technology. A primary care physician group is working to reduce clinician burnout with the goal of improving patient outcomes. The group looks at the CDSiC’s Taxonomy of Patient Preferences and assesses how they can incorporate these concepts into restructured workflows. The group then also uses CDSiC’s product called Approaches to Patient-Centered CDS Workflow and Lifeflow Impact, which provides a framework to help identify the optimal point for a patient-centered CDS tool’s deployment in a patient’s lifeflow. Their study will also assess how increased patient-centeredness in their CDS tools do not inadvertently have a negative impact on clinician workflows or experience. All projects are encouraged to: Incorporate Clinical Quality Language (CQL) and other HL7 standards into their project design, if appropriate for developing, integrating, (or modifying) their CDS with their EHR system or other health information technology (Health IT) components to become more patient-centered. OBJECTIVES AND SCOPE This NOFO aims to support innovative collaborative research to understand how clinical decision support tools in real-world settings can be improved to become more patient centered. Recipients will become part of an existing community of researchers who have an interest in PC CDS including AHRQ, the CDSiC, and other researchers. Interested applicants may include health information technology experts, patient advocates and representatives, clinicians, electronic health record developers, policymakers, payors, as well as leaders from research and academic medical institutions. All projects must: Utilize one or more of the products from the CDSiC or the PCOR CDS Initiative, which are available on the project website: cdsic.ahrq.gov, or another resource available from the PCOR CDS Initiative (cds.ahrq.gov), which includes the PC CDS Learning Network, CDS Connect, or AHRQ's Evaluation project that assessed the current state and future directions with PC CDS; If CDSiC products are used specifically, applicants must identify if any other frameworks are being used to evaluate the performance of their PC CDS (e.g., RE-AIM or other); Apply the definition of patient-centered CDS (available here: https://cdsic.ahrq.gov/cdsic/patient-centered-clinical-cds-infographic) and describe the degree to which each of the 4 elements are incorporated into the patient-centered CDS tool: knowledge, patient data, delivery, and use. Apply an equity lens, consistent with AHRQ's PCOR Strategic Framework. Apply at least 1 of the 4 priorities from AHRQ's PCOR Strategic Framework. Include meaningful and substantial participation from patients and/or patient representatives in the co-design, implementation, and evaluation of their research, to also be reflected in the proposed budget. Fully describe their research ecosystem. If developing or extending a digital tool, be mobile friendly to be more accessible to a broader population (for example, a patient-facing portal, website, etc.). If the research or tool will be incorporated into an EHR system, the facility must have a mature, functioning EHR system (e.g., the facility is not planning any significant system upgrade or migration). Otherwise, an alternative means to test and evaluate the selected CDS product can be described. If the research strategy intends to modify an existing clinical workflow that is currently clinician-focused, to become a patient-centric or patient-facing approach, then the strategy must include an evaluation component to characterize the performance of the PC CDS tool versus the previous clinician-facing workflow. If the proposed project plans to promote implementation of SDM, it should align with AHRQ’s definition of SDM (available here: https://www.ahrq.gov/sdm/about/index.html) and include at least one validated measure of SDM in its evaluation.

This funding opportunity supports high-risk, multi-center observational studies aimed at improving understanding and treatment of diabetes, digestive diseases, and kidney-related conditions, targeting a wide range of eligible public and private institutions.

Proposals should include at least two of the following points: HIV prevention activities among: Adolescent boys aged 14 24 years old Young men aged 25 29 years old Males 30+ years old Campaigns to address Gender Based Violence and how it contributes to the spread of HIV to the above mentioned groups Community based interventions to address: Male friendly sexual reproductive health activities Interventions aimed at reducing risky sexual behavior among young boys and adult men aged 14 to 30+. Activities that are not typically funded include, but are not limited to: HIV medicines, diagnostics and services HIV Testing Prevention services and commodity procurement for adolescent friendly/reproductive health/post-rape Construction or building improvements, renovations or repairing a facility Office equipment such as duplicating machines, computer etc. Sports equipment or uniforms for a national sports team

This grant provides funding to support postdoctoral researchers transitioning to independent faculty positions, focusing on innovative research in pain management and substance use disorders.

This funding opportunity supports the development of innovative molecular and genetic tools for neuroscientific research, enabling precise access to specific brain cell types across various vertebrate species, with a strong emphasis on collaboration, inclusivity, and resource sharing.

This grant provides funding to organizations already involved in breast and cervical cancer prevention to expand their services and address cardiovascular disease risk factors among underserved women.

The FY 2024 Children’s Mental Health Initiative (CMHI) funding opportunity, overseen by SAMHSA's Center for Mental Health Services, aims to support state and local governments, territories, and tribes in implementing and expanding comprehensive mental health services for children and youth up to age 21 who are at risk of or diagnosed with serious emotional disturbances (SED). The initiative provides grants to strengthen Systems of Care (SOC), focusing on sustainable infrastructure to support mental health outcomes and the well-being of children, youth, and their families. Applications for FY 2024 are due by February 14, 2024, with an estimated 23 awards. Grants provide up to $3,000,000 annually for state applicants and up to $1,000,000 for political sub-divisions, territories, and tribal organizations, with a four-year project period. The core objectives of the CMHI program include establishing or enhancing SOC frameworks that integrate cross-agency collaboration, policy development, and evidence-based interventions for children and families. Funded projects must conduct a needs assessment within the first four months, focusing on gaps in services and identifying disparities based on race, ethnicity, and other social determinants. Required services include 24-hour mental health crisis support, intensive case management, therapeutic foster care, and transition services to support youth moving to adult systems. Recipients are also expected to provide culturally appropriate mental health services for underserved populations, including racial minorities, LGBTQ+ youth, and those in rural areas. Eligible applicants must register in eRA Commons, Grants.gov, and SAM.gov. A cost match is required, with recipients matching $1 for every $3 of federal funds in the first three years, and $1 for each $1 in the fourth year. Applications should include a project narrative limited to 10 pages, detailed budget documentation, and a Disparity Impact Statement (DIS) to address behavioral health disparities. Key personnel must include a Project Director and a Lead Family Coordinator, each with a minimum 0.75 FTE. Evaluation criteria include the program’s feasibility, organizational capacity, sustainability plan, and commitment to evidence-based practices. Proposals will be scored on their effectiveness in meeting SAMHSA’s program goals, including improvements in the SOC, reduction in behavioral health disparities, and long-term sustainability. Funded projects must report progress annually and submit performance data through SAMHSA’s SPARS system, tracking program impact on mental health outcomes and service reach within the target population.

This funding opportunity supports doctoral students from underrepresented backgrounds in mental health research to complete their dissertation projects and advance their careers in the field.

This funding opportunity supports research projects that aim to improve access to and effectiveness of treatment for Alcohol Use Disorder, particularly for underserved populations, by addressing barriers and enhancing care delivery.

The purpose of the THCGME Program is to support the training of residents inprimary care residency training programs in community-based ambulatory patientcare centers. These residency programs will prepare residents to provide high-qualitycare, particularly in rural and underserved communities, and develop competenciesto serve these diverse populations and communities. These notices announce theopportunity to apply for funding under the THCGME Program.This funding will support both the direct expenses associated with sponsoring approvedgraduate medical residency training programs and indirect expenses associated with theadditional costs relating to teaching residents in residency training programs.Two award types are available:1. Expansion awards for an increased number of resident Full-Time Equivalent (FTE)positions at existing HRSA THCGME Programs.2. New awards to support new resident FTE positions at new Teaching Health Centers(THCs). New THCs are those applicants seeking funding for residency programs thathave never received payment under the HRSA THCGME Program for the applicableresidency program in any previous fiscal year.As described in 340H(h)(2)(B), all resident FTEs for whom THCGME support is requested mustbe above the programs resident FTE baseline and must not put the program above the numberapproved by or awaiting approval by, the relevant accrediting body. Please review programobjectives for more information.

This program provides funding to local organizations in Arkansas to help reduce poverty and support low-income individuals through services like employment, education, housing, nutrition, and health.

This is a non-competitive funding opportunity intended to fund a single award. The National Institute of Neurological Disorders and Stroke is announcing its intent to issue a single source cooperative agreementto the Hennepin Healthcare Research Institute to submit a renewal application to complete the phase II Hyperbaric Oxygen Brain Injury Treatment (HOBIT) clinical trial.

This funding opportunity is designed to improve access to quality health services for women and children in five provinces of Afghanistan, focusing on critical health issues such as maternal and newborn health, family planning, and nutrition.

This funding opportunity supports researchers who have received a specific career development award to conduct small-scale projects that will help them become independent investigators.

The NIAID Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional), designated as PAR-22-241, is a funding opportunity issued by the NIH's National Institute of Allergy and Infectious Diseases (NIAID). The program targets New Investigators (NI) and At-Risk Investigators from underrepresented backgrounds in the biomedical, clinical, behavioral, and social sciences. New Investigators are those who have not previously secured substantial independent NIH funding, while At-Risk Investigators are those with previous funding but face a lack of funding in the following fiscal year unless a new grant is awarded. This initiative aligns with the goals of the 21st Century Cures Act to encourage new researchers, foster early independence, and support a more diverse scientific workforce. This funding announcement supports research relevant to the NIAID mission, including the study and treatment of infectious, immunologic, and allergic diseases. Research areas of focus include microbiology, immunology, infectious diseases, AIDS, transplantation, and emerging diseases. Although clinical trials are optional, applicants proposing NIH-defined clinical trials must consult with NIAID before submission. The funding opportunity is open to projects that advance diversity in the R01 investigator pool and those promoting representation from underrepresented groups in line with NIH’s interest in enhancing diversity across all health-related fields. To apply, investigators must be affiliated with U.S.-based higher education institutions or eligible nonprofits and for-profit organizations. This opportunity is also open to minority-serving institutions, such as Hispanic-serving Institutions, HBCUs, and Tribally Controlled Colleges and Universities. Non-domestic (non-U.S.) entities are not eligible, although foreign components of U.S. organizations are permitted. An essential part of the application process is an Eligibility Certification Letter from the applicant institution verifying the applicant’s eligibility and alignment with the program’s diversity objectives. Applications missing this letter will be considered incomplete. Funding levels are based on the project’s actual needs and are not capped, with a project duration of up to five years. NIAID also expects applicants to allocate funding in their budgets for mandatory attendance at a workshop designed to foster networking, collaboration, and professional growth among awardees, to be held every three years starting in 2025. Additional support for necessary accommodations for researchers with disabilities may also be included in the budget. The application process requires thorough adherence to NIH’s submission guidelines, which include registrations with SAM, Grants.gov, eRA Commons, and the acquisition of a UEI. Applications are accepted electronically through the NIH ASSIST system, Grants.gov Workspace, or a system-to-system solution. The next deadline cycle follows NIH’s standard due dates, with submissions due at 5:00 PM local time. Applicants are advised to submit early to address potential errors before the due date. Applications will be evaluated on scientific merit and alignment with program priorities, using criteria focused on the significance of the research, investigator qualifications, project innovation, approach, and institutional environment. Specific review criteria for clinical trials include the adequacy of study design, data management, and statistical analysis plans. Following peer review, recommended applications will receive secondary review by the NIAID advisory council. Final award decisions consider both scientific merit and relevance to NIAID’s mission and diversity goals.