Federal Health Grants

This funding opportunity supports researchers in developing innovative theories and methods to better understand the complex genetic and non-genetic factors influencing human traits and health, with a focus on interdisciplinary approaches and diverse perspectives.

The purpose of this program is to address the public health crisis caused by escalating opioid misuse, opioid use disorder (OUD), and opioid-related overdose across the nation. States and territories are expected to use the resources to: (1) increase access to U.S. Food and Drug Administration (FDA)-approved medications for the treatment of opioid use disorder (MOUD); (2) support the continuum of prevention, harm reduction, treatment, and recovery support services for OUD and other concurrent substance use disorders; and (3) support the continuum of care for stimulant misuse and use disorders, including those involving cocaine and methamphetamine.

Amendment 1 (June 25, 2024): The purpose of this Amendment 1 is to: 1) make administrative updates to Section 1.1, 1.2, 2.1.2, 3.1, 3.2 and 5.2.6; 2) replace Section 2.1.1 with new language pertaining to Federally Funded Research and Development Centers (FFRDCs) and Government Entities. Additionally, Section 4.2, Evaluation Criteria #2 is updated to remove the reference to Government Entities (removal is not highlighted in yellow); 3) change references from Abstract to Solution Summaries (intent behind the document is unchanged); 4) update proposal submission instructions in Section 3.2; and 5) update Section 5.1 to remove the Stage 2 Notification Letter. All changes are highlighted in yellow.Also, please note that the title of this opportunity has bee revised to eliminate confusion. The opportunity should have been titled, "Master Announcement Instruction (MAI)" instead of "ARPA-H BDF Tool Box".The Master Announcement Instructions (MAI) is a new ARPA-H announcement that aims to create standard tiered proposal submission requirements, so the amount of work required to write a proposal is commensurate with the size of the proposed effort. It also aims to reduce the up-front work required to submit cost information to reduce the barrier to entry for non-traditional performers. Module announcements that link to this MAI will provide more specific instructions about how the proposal requirements vary across tiers of effort.All responsible sources capable of satisfying the Governments needs may submit a proposal to a Module Announcement. Specifically, universities, non-profit organizations, small businesses and other than small businesses are eligible and encouraged to propose to Module Announcements.NOTE: Proposals shall NOT be submitted against the MAI. Proposals shall only be submitted against a Module Announcement.

This funding opportunity provides support for mid-career and senior researchers to gain new skills and knowledge in dental, oral, and craniofacial research by collaborating with experts in different scientific fields.

This funding opportunity provides financial support to a wide range of organizations for improving public health surveillance and treatment practices for inherited bleeding disorders, ultimately aiming to enhance health outcomes for affected individuals.

This Notice of Funding Opportunity (“NOFO”) solicits applications for the State Digital Equity Capacity Grant Program (“Capacity Grant Program” or “Program”), the second of three digital equity programs authorized by the Infrastructure Investment and Jobs Act of 2021, Division F, Title III, Public Law 117-58, 135 Stat. 429, 1209 (November 15, 2021) (“Infrastructure Act” or “IIJA”) also known as the (“Digital Equity Act” or “DE Act”). The Digital Equity Act appropriated $2.75 billion to be awarded by the Assistant Secretary of Commerce for Communications and Information (“Assistant Secretary”) to promote digital inclusion activities and achieve digital equity. The Digital Equity Act consists of three funding programs: (1) the $60 million State Digital Equity Planning Grant Program; (2) the $1.44 billion State Digital Equity Capacity Grant Program; and (3) the $1.25 billion Competitive Grant Program. NTIA released the Notice of Funding Opportunity for the State Digital Equity Planning Grant Program (“Planning Grant Program”) on May 13, 2022, making funds available to States and Territories to develop State Digital Equity Plans (“Digital Equity Plans”). The Capacity Grant Program will provide funds to States and U.S. Territories to implement the State Digital Equity Plans developed pursuant to the State Digital Equity Planning Grant Program. The Digital Equity Plans identify the barriers to achieving digital equity faced by certain populations defined by the statute (i.e. “Covered Populations”), and include measurable objectives to promote: (1) the availability and affordability of access to broadband technology; (2) online accessibility and inclusivity of public resources and services; (3) digital literacy; (4) awareness of online privacy and cybersecurity; and (5) the availability and affordability of consumer devices and technical support for those devices. In addition, this NOFO establishes a competitive process to make both State Digital Equity Planning Grant Program funds and State Digital Equity Capacity Grant Program funds available to Native Entities to carry out digital equity and inclusion activities consistent with the Digital Equity Act. These proposed projects must include measurable objectives and evaluation criteria as part of their program design and will likewise address barriers to digital equity and promote the availability and affordability of access to broadband technology, online accessibility and inclusivity of public resources and services, digital literacy, awareness of online privacy and cybersecurity, and the availability and affordability of consumer devices and technical support for those devices. Because funding for States and U.S. Territories is based on a statutory allocation formula and funding for Native Entities will be determined through a separate competitive process, this NOFO is divided into sections to help clarify specific requirements applicable to different entities applying for funding. The procedures through which States and U.S. Territories can seek funding are outlined in Section II. Procedures for Native Entities to obtain funding are addressed in Section III. The remaining sections are common to both types of entities. Recognizing that achieving digital equity for all people, including Indigenous peoples of the United States and Territories, is a matter of social and economic justice, this NOFO seeks to enable any entity that is awarded a grant under this Program to better understand, measure, and address systemic barriers to digital equity and, in collaboration with the communities most impacted, co-create the conditions necessary for long-lasting and meaningful change to ensure a sustainable future. Focusing investments on creating these conditions for change will allow entities awarded a grant under this Program to address the causes of socioeconomic disparities and will result in improved outcomes in health, education, economic stability, and quality of life among the Covered Populations.

The purpose of the Delta Health Systems Implementation Program (DSIP) is to improve healthcare delivery in rural areas by implementing projects that will improve the financial sustainability of hospitals and allow for increased access to care in rural communities. These projects focus on financial and operational improvement, quality improvement, telehealth, and workforce development in hospitals in the in the rural counties and parishes of the Delta region. This program supports HRSA's collaboration with the Delta Regional Authority.

This funding opportunity supports U.S. institutions and organizations in developing centers that integrate advanced translational science into cancer clinical trials, enhancing research on precision medicine and rare cancers.

The purpose of this funding opportunity is to develop artificial intelligence tools and experimental assays to identify new pharmacotherapeutics with lower toxicity and higher efficacy for substance use disorders (SUD) Areas of interest include but are not limited to: 1) Development of AI tools to identify potential target combinations, design new molecules, conduct virtual preclinical studies to predict efficacy and toxicity, and model in vitro and in vivo polypharmacology 2) Development of assays to assess the effects of compounds on multiple targets or functions

This funding opportunity provides support for research projects that utilize health information technology to improve healthcare access, quality, and outcomes for underserved populations in the U.S. experiencing health disparities.

This funding opportunity provides financial support to U.S. state and territorial governments to implement comprehensive programs aimed at reducing tobacco use and its health impacts.

The grant titled "BRAIN Initiative: Engineering and optimization of molecular technologies for functional dissection of neural circuits" aims to support the development and enhancement of molecular tools that can specifically target brain cells, enabling the observation and control of neural circuits in experimental animals.

This funding opportunity supports researchers conducting early phase clinical trials on natural products, such as botanicals and dietary supplements, to evaluate their effects on health and inform future studies.

The Agency for Toxic Substances and Disease Registry (ATSDR) Environmental Medicine and Health Systems Intervention Section seeks to maintain and strengthen the Pediatric Environmental Health Unit (PEHSU) program as a network of experts providing evidence-based scientific and medical information and consultative advice on health issues that arise from environmental exposures throughout the vulnerable stages of reproduction and pediatric development. Five interrelated strategies will be used to achieve the expected outcomes: (1) Education of healthcare professionals (2) Education of and outreach to communities (3) Consultations (4) Referrals (5) Partnerships. This notice of funding opportunity intends to build upon established PEHSU capabilities and to reaffirm and strengthen collaboration between ATSDR, the US Environmental Protection Agency (EPA), and the PEHSU National Program Office (NPO) recipient that will manage day-to-day operations of the national PEHSU network. The recipient will work collaboratively with each regional PEHSU to maintain and strengthen effectiveness of the PEHSU network, execute program strategies, and achieve desired outcomes.

The United States Agency for International Development (USAID) is offering funding through its MOMENTUM program to enhance the capacity of local organizations in high-burden countries to improve maternal, newborn, and child health services, voluntary family planning, and reproductive health care.

This funding opportunity provides financial support for researchers to develop innovative screening methods and therapies for newborn conditions, aiming to improve early detection and management of potentially serious health issues in infants.

The purpose of the NINDS Alzheimers Disease and Alzheimers Disease-Related Dementias (AD/ADRD) Advanced Postdoctoral Career Transition Award to Promote Diversity (K99/R00) program is to support of a cohort of new and talented, independent investigators from diverse backgrounds conducting AD/ADRD research. The program is designed to facilitate a timely transition of promising postdoctoral researchers from diverse backgrounds (e.g., see NIHs Interest in Diversity) from their mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition in order to help awardees establish independent research programs in the AD/ADRD field. This FOA is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial. Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor.

This(NOFO) aims to innovate, implement, and evaluate approaches to One Health laboratory diagnostic network optimization and specimen transport in Liberia. This multi-component NOFO is designed to address the inter-dependence of a comprehensive, resource-mapped, accredited national and sub-national laboratory network, the physical transportation architecture required to transfer network commodities (namely human, animal, and environmental specimens) point-to-point, and the optimization of digital communication, information, and supply chain systems necessary to sustain the network itself.

This Notice of Funding Opportunity (NOFO) invites applications from institutions/organizations that propose to establish a Research Resource Center (RRC) for the NIDDK Nutrition Obesity Research Centers (NORC) Program. The NORC Program consists of eleven Centers across the nation that support and enhance the national research effort in nutrition and obesity through cutting-edge basic, clinical, translational, and health disparities research in nutrition science and obesity. In collaboration with the existing NORC program, the RRC will (1) provide administrative support for the entire NORC Program, (2) establish and curate a NORC Program website and centralized repository of research resources , (3) implement a multipronged approach to support and grow the early-to-midcareer research workforce, including individuals from diverse backgrounds, with a goal of maximizing national outreach and impact, (4) administer and manage a NORC Opportunity Program to address gaps and promote collaboration, and (5) manage a Pilot and Feasibility Program.This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn.

Funding Opportunity Description Developing medical countermeasures to protect civilians against intentional and accidental toxic chemical exposure that can lead to mass casualties is a major goal of the biodefense program at NIH. More specifically, this goal is executed by the Chemical Countermeasures Research Program (CCRP) at NIAID in partnership with several other ICs across the NIH (NIH Strategic Plan and Research Agenda for Medical Countermeasures Against Chemical Threats). NIAMS has been a critical and active partner in this trans-NIH effort since the CCRP’s inception in 2006. In order to broaden its research base and raise the awareness of the scientific community at large about the urgent need for effective countermeasures against chemical threats, the CCRP is encouraging its IC partners to issue IC-specific FOAs to further engage their respective research disciplines that are not currently engaged in the medical countermeasure research field. This initiative is a response to that request. The intent of the initiative is to encourage the NIAMS skin research community to contribute to the basic understanding of injuries caused by those toxic chemicals identified by the U.S. Department of Homeland Security as high consequence public health threats and to explore the local and systemic mechanisms of chemical wound development, healing, and long-term consequences. It is envisaged that such initiative will benefit both the national civilian defense program as well as the basic skin wound healing research at large. This initiative will emphasize understanding commonalities in the fundamental mechanisms of skin injuries caused by vesicants such as sulfur mustard, Lewisite, nitrogen mustard, phosgene oxime, and arsenicals, which may be different from thermal burn. The investigators are also encouraged to collaborate with researchers in tissues other than skin that are affected by the vesicants (e.g., eyes and lung) to find commonalities of injury mechanisms shared with skin. It is hoped that the fundamental knowledge gained would ultimately lead to the discovery and characterization of potential shared therapeutic targets (e.g., in signal transduction pathways and inflammation process) and the development of broad-spectrum medical countermeasures. This FOA is intended for investigators who are not currently supported under the CCRP’s CounterACT program but whose research interests are relevant to skin chemical injuries and to skin wound healing in general. It is assumed that the proposed project will represent a new direction for the applicant, which requires the applicant’s research lab to acquire new skills (e.g., handling toxic chemicals), gather new resources (e.g., establishing collaborative or contractual relationships with facilities certified to utilize restricted/controlled chemicals) and generate new preliminary data. Therefore, this FOA uses a planning mechanism (R34) to support such investigators to commence the preparatory steps toward this new line of study. This means that the applicants do not need to present preliminary data supporting the proposed study in concept, nor publication records and specific skills and proficiency in experimental execution in the chemical medical countermeasures field. However, the PD/PI should demonstrate prior experience in wound healing research and general knowledge relating to skin injury and healing. It is expected that a successful outcome of a proposed project is that the investigator has added within the laboratory (if needed) personnel with the skills and expertise to conduct studies in this area, established a working relationship with facilities certified for toxic chemicals (if needed), and gathered sufficient preliminary data to support a more comprehensive research project suitable under the other more translationally-focused CCRP FOAs.