Federal Science and Technology Grants

This funding opportunity provides financial support to a wide range of organizations, including governments, educational institutions, and nonprofits, to increase awareness and improve public health responses to Alpha-gal Syndrome, a tick-borne allergy affecting reactions to mammalian meat.

This funding opportunity provides financial support for a wide range of organizations to conduct innovative research and development in forensic science, enhancing tools and methods used in criminal justice.

This funding opportunity provides support for clinical researchers to develop independent careers in patient-centered and comparative effectiveness research, focusing on improving healthcare delivery for underserved populations in the U.S.

This funding opportunity supports innovative, time-sensitive research projects that enhance ongoing clinical studies related to arthritis, musculoskeletal, and skin diseases by leveraging existing patient data and samples.

The "FY25 Ocean Acidification Coastal Research: Uniting Investigations and Shipboard Experiments (OA CRUISE)" grant aims to fund projects that enhance coastal research on ocean acidification, particularly in relation to the upcoming East Coast Ocean Acidification Cruise (ECOA-4) in summer 2026, focusing on the impacts of ocean chemistry changes on marine ecosystems and coastal communities.

This program provides funding for researchers to analyze publicly available data about Mars to improve our understanding of its surface, climate, and potential for supporting life.

This grant provides over $8 million to U.S.-based individuals and organizations for innovative projects that combine solar energy systems with cattle grazing to promote sustainable land use and support rural economies.

The purpose of this NOFO is to solicit applications for the Exploratory Advanced Research (EAR) Program to award cooperative agreements. The NOFO will result in the distribution of up to $2,000,000.The EAR program addresses the need for longer-term, higher risk breakthrough research with the potential for transformational improvements to plan, build, renew, and operate safe, congestion free, and environmentally sound transportation systems. The overall goal of this NOFO is to collect diverse pedestrian data, provide researchers access to this data, and encourage novel approaches for analysis of diverse data in support of increasing the safety and mobility of all people. The authority to enter into a cooperative agreement for this effort is found under 23 U.S.C. 502(b)(3)(C ). And funding for this effort is provided in in BIL (P. L. 117-58) Sec. 11101(c)(1)(A).

This funding opportunity provides financial support to Sea Grant Programs for creating hands-on aquaculture internships that help develop workforce skills in the U.S. aquaculture industry for students and interested individuals, including veterans and commercial fishers.

The Office of Sciences (SC) mission is to deliver scientific discoveries and major scientific tools to transform our understanding of nature and advance the energy, economic, and national security of the United States (U.S.). SC is the Nations largest Federal sponsor of basic research in the physical sciences and the lead Federal agency supporting fundamental scientific research for our Nations energy future. Science for energy, economic and national securitybuilding a foundation of scientific and technical knowledge to spur discoveries and innovations for advancing the Departments mission. SC supports a wide range of funding modalities from single principal investigators to large team-based activities to engage in fundamental research on energy production, conversion, storage, transmission, and use, and on our understanding of the earth systems. The frontiers of scienceexploring natures mysteries from the study of fundamental subatomic particles, atoms, and molecules that are the building blocks of the materials of our universe and everything in it to the DNA, proteins, and cells that are the building blocks of life. Each of the programs in SC supports research probing the most fundamental disciplinary questions.The 21st Century tools of scienceproviding the nations researchers with 28 state-of-the-art national scientific user facilities, the most advanced tools of modern science, propelling the U.S. to the forefront of science, technology development, and deployment through innovation.SC is an established leader of the U.S. scientific discovery and innovation enterprise. Over the decades, SC investments and accomplishments in basic research and enabling research capabilities have provided the foundations for new technologies, businesses, and industries, making significant contributions to our nations economy, national security, and quality of life.

This funding opportunity provides financial support to specific projects aimed at improving the criminal justice system, preventing juvenile delinquency, and assisting crime victims, as designated by Congress.

This grant supports researchers in mathematical and statistical sciences to develop innovative tools and theories that address challenges in computation and big data, while fostering collaboration and training for early-career scientists.

This funding opportunity supports innovative research and development of high-temperature geothermal energy technologies to unlock vast electricity production potential from deep rock formations across the United States.

The U.S. National Science Foundations Directorate for Technology, Innovation and Partnerships (TIP) is charged with accelerating use-inspiredand translationalresearch and development (R) to advance U.S. competitiveness in key technology focus areas. The Use-Inspired Acceleration of Protein Design (USPRD) initiative will accelerate the translation of novel approaches to protein design and enable new applications of importance to the U.S. bioeconomy. Significant advances have been made in the ability of researchers to predict the three-dimensional (3D) structure of proteins from primary sequence, and to use that information to design proteins with desired characteristics. These advances have been enabled by: macromolecular modeling; training data available in repositories such as the Protein Data Bank (PDB); the application of artificial intelligence (AI) and machine learning; and high-throughput protein characterization. The improved accuracy of in-silico design has reduced the number of constructs that need to be validated in costly and time-consuming wet lab experiments. USPRD aims to advance protein design and its applications to the next level by: A. Accelerating the use of protein design technologies to enable applications beyond human therapeutics, e.g., applications to advanced materials, biomanufacturing, agriculture and food security, environmental remediation, sustainability, and climate-related challenges. B. Extending the range of accurate prediction models to enable the design of enzymes and families of enzymes. This will require models and tools that account for the dynamic nature of protein structures. USPRD seeks significant breakthroughs in the application of protein design through: a) Use-driven activities that design novel proteins with specific characteristics and demonstrate their application, e.g., the design and characterization of specific enzymes or enzyme families that promote sustainability by degrading specific bio-contaminants. b) Infrastructure components, such as software tools, datasets, and characterization services that can readily be accessed by protein designers. c) Designer-facing components that will ensure the accessibility of the infrastructure components and collaboration with protein designers engaged in the third-party use-driven activities. d) Ecosystem components, such as standards and roadmaps, that help coordinate the actions of multiple parties within the emerging ecosystem. This may also include open-source software and/or data repositories. e) Workforce components focused on the training of translational talent with the skills and passion to engage in use-driven protein design activities. USPRD will use the Ideas Lab process (see PAPPG Chapter II.F.6),starting with an intensive meeting that brings together multiple diverse perspectives. A key aim of this Ideas Lab workshop will be to identify an aggressive (but attainable) set of use-driven activities together with the infrastructure component breakthroughs, designer-facing components, and ecosystem components required to realize them. USPRD includes two tracks: Track I. Use-driven application for small binders. Track II. The design and use of enzymes and families of enzymes.

This funding opportunity provides financial support for cultural and educational programs that promote mutual understanding and cooperation between the United States and Mexico, targeting nonprofit organizations, educational institutions, and individuals who collaborate with Mexican partners.

This funding opportunity is designed to empower emerging leaders in the space sector across the Middle East and North Africa by providing training and resources to enhance collaboration with the United States in space policy and commerce.

This funding opportunity is designed to support the University of Wisconsin in conducting research and developing innovative tools in forensic science to improve public safety and the criminal justice system.

Priority Program Areas: A successful proposal will include a robust calendar of activities through serial programming spanning at least two months and directly address at least one of the three key programming areas: Digital Policy, STEM Education and Workforce Development: Programming to expand understanding of emerging technologies and digital policy challenges such as cybersecurity, Intellectual Property Rights, artificial intelligence, fintech, and quantum computing, as well as initiatives to expand technical and soft skills through participatory and interactive workshops on STEM fields, digital trade, digital arts, gaming, and related business practices for online activities for SMEs and/or use of the existing makerspaces at the American Centers. Climate Solutions, Health Security and Sustainability: Programming to achieve measurable goals to improve environmental protection and preservation, climate change adaptation, pollution reduction, renewable energy, climate-smart agriculture, transboundary water challenges, clean energy, and health security and public health preparedness. Information Literacy and Research Skills: Workshops to build critical thinking skills to find, evaluate, organize, use, and communicate information in all its various formats, including through the use of data, digital media, and AI, and develop audiences ability to conduct research and evaluate and use information responsibly and ethically using American Spaces databases and open education resources.

This grant provides funding for interdisciplinary research teams from various institutions to tackle significant biological questions and promote diversity in science education and outreach.

The NSF Engineering (ENG) Directorate has launched a multi-year initiative, theProfessional Formation of Engineers, to create and support an innovative and inclusive engineering profession for the 21stcentury. Professional Formation of Engineers (PFE) refers to the formal and informal processes and value systems by which people become engineers. It also includes the ethical responsibility of practicing engineers to sustain and grow the profession in order to improve quality of life for all peoples. The engineering profession must be responsive to national priorities, grand challenges, and dynamic workforce needs; it must be equally open and accessible to all. Professional Formation of Engineers includes, but is not limited, to: Introductions to the profession at any age; Development of deep technical and professional skills, knowledge, and abilities in both formal and informal settings/domains; Development of outlooks, perspectives, ways of thinking, knowing, and doing; Development of identity as an engineer and its intersection with other identities; and Acculturation to the profession, its standards, and norms. The goal of the Research in the Formation of Engineers (RFE) program is to advance our understanding of professional formation. It seeks both to deepen our fundamental understanding of the underlying processes and mechanisms that support professional formation and to demonstrate how professional formation is or can be accomplished. Ultimately RFE aims to transform the engineer-formation system, and thus the impact of proposed projects on this system must be described. Principal Investigators (PIs) should provide a roadmap detailing how they envision the proposed research will eventually broadly impact practice within the engineer-formation system, even if these activities are not within the scope of the submitted proposal. In order to accomplish its goals, RFE welcomes proposals in two categories: Research Projects, and Design and Development Projects. Research Projects address fundamental questions of professional formation, while Design and Development Projects provide new approaches to achieving professional formation. Additional details are provided below. Projects in both categories should address the iterative cycle in which research questions that advance understanding are informed by practice and the results of research are, in turn, translated into practice. In other words, proposals should explain how the research results will travel, translate, transfer, or scale. Successful projects identify specific target audiences, effective communication channels, and novel partnerships to ensure effective propagation and scaling. Proposal titles should begin with either Research: or Design and Development: as appropriate. Research Projects Research proposals are particularly welcome in the following areas: Research that addresses lifelong learning by the engineering workforce. Research on the impact of engineering education research. Proposals addressing this topic could investigate questions such as: How can we measure the impacts of engineering education research? What are effective strategies for scaling reforms? How can we translate knowledge from research to practice? What are the roles of technologies, networks and communities in achieving impact? RFE does not support efficacy, effectiveness, or scale-up studies for specific interventions. Research that addresses culture change in engineering education. Included in this topic are investigations of normative cultures of engineering at any level in the engineering education ecosystem and how these cultures may disadvantage certain groups. Research that addresses engineering formation at the two-year college and graduate education levels in both formal and informal settings. Research that investigates engineering in P?12 settings. Research in this area could include understanding of approaches to engineering in P?12, how to develop engineering ways of thinking, or the relationship between practices within the sciences and mathematics and engineering thinking. Research on the transitions between education levels, e.g., from high school to two-year college, high school to four-year college/university, two-year college to four-year college/university, undergraduate to graduate school, education settings to the workforce or professoriate, etc. Research that addresses the relationship between engineering and the public. Proposals addressing this topic could consider the social impact of engineering solutions, citizen engineering, education of an informed public, etc. Research that develops or adapts novel methodologies and frameworks appropriate for studying the professional formation of engineers, and especially minoritized, marginalized, or underserved populations. Research that addresses ways in which new technologies (such as artificial intelligence and machine learning) are changing engineering education. Proposals submitted to the Research Projects category should have clear research questions informed by an appropriate theoretical framework and a research design that includes sampling, data collection, and data analysis methods. This category will not support proposals that seek funding primarily to develop tools, curriculum, or laboratories, or that seek to implement classroom innovations that have already been shown to be effective in engineering. The program will evaluate the value of proposals by considering the impact and the cost. Research track projects that are small, exploratory, or speculative are especially encouraged. Larger Research track projects should have a correspondingly larger impact. Design and Development Projects RFE supports Design and Development projects (see https://www.nsf.gov/publications/pub_summ.jsp?ods_key=nsf13126) that seek to develop and test new approaches in the following areas: Graduate education. Transitions between education levels, e.g. high school to two year college, high school to 4 year college/university, two year college to 4 year college/university, undergraduate to graduate school, education settings to the workforce or professoriate, etc. K12, especially approaches to develop engineering thinking, or providing links between engineering, science, and mathematics Proposals in this category should propose the design and development of new approaches that are informed by existing literature and theory. There should be clear objectives and the evaluation plan should be designed to determine if those objectives have been met. Projects cannot be solely demonstration projects, but must add to the engineering education literature to inform future work.