Federal Science and Technology Grants

TheMacrosystems Biology and NEON-Enabled Science (MSB-NES): Research on Biological Systems at Regional to Continental Scalesprogram will support quantitative, interdisciplinary, systems-oriented research on biosphere processes and their complex interactions with climate, land use, and changes in species distributionatregional to continental scales as well as training activities to broaden participation of researchers in Macrosystems Biology and NEON-EnabledScience. MSB-NES projects that use data and/or resources fromthe National Ecological Observatory Network(NEON) are encouraged. Substantive NEON-enabled projects rely on data and/or samples collected by NEON and/or co-locate research activities at NEON sites. Projects may develop tools that will explicitly enhance the processing, use, and/or analysis of NEON data or collections, in the context of addressing a specific research question or hypothesis. However, proposals primarily focused on tool development that can be used for a broad class of research questions or for topics that meet the needs of a community of researchers should be directed toward the Infrastructure Innovation for Biological Research (Innovation) or Infrastructure Capacity for Biological Research (Capacity) programs in the Division of Biological Infrastructure.

The FY24 KCRP Postdoctoral and Clinical Fellowship Award supports recent doctoral or medical school graduates in pursuit of innovative, high-impact kidney cancer research during their postdoctoral and/or clinical fellowship and allows them to obtain the necessary experience for an independent career as a leader in kidney cancer research. Applicants must demonstrate that the proposed research has high potential to lead to, or make, significant advancements in kidney cancer research and/or patient care. Applicants for this award must also exhibit a strong desire to pursue a career in kidney cancer research, with clear evidence for a researcher development plan that will lead to a successful independent career in kidney cancer. The critical components of this award mechanism are: Impact: Research supported by the FY24 KCRP Postdoctoral and Clinical Fellowship Award will have the potential for a major impact and accelerate progress toward ending kidney cancer. The impact may be short term or long term, but must move beyond an incremental advance. Applications are expected to identify the kidney cancer patients or at-risk individuals who would ultimately benefit from the proposed research. Research Strategy: The research proposed as part of the Postdoctoral and Clinical Fellowship Award must have high potential to lead to or make breakthroughs in kidney cancer. The scope of the research may include innovative, high-risk/high-reward research in the early stages of idea development or research already supported by preliminary data with the potential to make significant advancements toward clinical translation. The research strategy should demonstrate sound rationale, logical reasoning, and, if available, preliminary data. The proposed research should show evidence of rigorous experimental design, sufficient experimental details, appropriate controls, a statistical plan, and consideration of pitfalls and alternatives. Principal Investigator (PI): Under this award mechanism, the postdoctoral or clinical fellow is considered the PI and, as such, is expected to write the project narrative, researcher development plan, and other application components, with appropriate guidance from the mentor. While the PI is not required to have previous experience in kidney cancer research, the proposed project and researcher development plan must focus on kidney cancer. Applications must emphasize the PIs potential for success in becoming an independent kidney cancer researcher based on their qualifications, achievements/honors (including first-author publications and funding), and letters of recommendation. Mentor: The mentor (or co-mentor, if applicable) must possess the appropriate experience in kidney cancer research and/or patient care, to include recent publications and a record of active funding, and clearly demonstrate a commitment to guiding the PIs research and development as a researcher. If the mentor is not an experienced kidney cancer researcher, then formal co mentorship by an established kidney cancer researcher is required. The application must include information about the mentors experience in conducting innovative research and how they intend to support the PIs endeavors in kidney cancer. Mentorship by an investigator without an established record of mentoring pre- and/or postdoctoral trainees may be offset by the overall strength of the researcher development plan. Researcher Development Plan: Applications must provide details on the suitability of the PIs overall researcher development plan for attaining the goals of this award mechanism. Applications must elaborate on the qualities of the research environment in which the candidate will work, provide details on the individualized kidney cancer-focused researcher development plan, and describe how it will facilitate the PIs career development as an independent, innovative kidney cancer researcher. A multidisciplinary research approach to kidney cancer is highly encouraged, but not required; however, if there are multidisciplinary aspects, they should be clearly outlined in the application. Organizational-Level Emphasis: The following areas of emphasis are broadly applicable to many CDMRP programs, not just the KCRP. Investigators are encouraged to consider addressing these areas in their applications if doing so is appropriate for their line of research, addresses the FY24 KCRP strategic priorities and/or focus areas described in Section II.A.1 and Section II.A.2. Nuclear Medicine: Innovative research involving nuclear medicine and related techniques to support early diagnosis, more effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies. Womens Health: CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women's health outcomes and/or advancing knowledge for women's health. Metastatic Cancer Task Force: A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 KCRP priorities. Rigorous Study Design: All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (https://www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies. Military Service Involvement: Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. Research involving human subjects and human anatomical substances is permitted; however, clinical trials are not allowed under this program announcement. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes. Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials. For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes: (1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies. (2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. (3) Outcomes research and health services research that do not fit under the definition of clinical trial. Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule. The funding instrument for awards made under the program announcement will be grants (31 USC 6304). The anticipated direct costs budgeted for the entire period of performance for an FY24 KCRP Postdoctoral and Clinical Fellowship Award should not exceed $195,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information. Awards supported with FY24 funds will be made no later than September 30, 2025. The CDMRP expects to allot approximately $2.18M to fund approximately seven Postdoctoral and Clinical Fellowship Award applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

This funding opportunity supports researchers investigating health issues related to military toxic exposures, providing financial resources for studies ranging from basic research to clinical trials.

This grant provides funding for researchers and organizations to conduct laboratory analysis of samples returned from space missions, supporting advancements in space and Earth sciences.

This program provides funding for early-career ocean scientists to conduct research, promote diversity in STEM, and engage in professional development through mentorship and collaboration at U.S.-based host organizations.

This funding opportunity is designed for government representatives and agencies in Guam, the Commonwealth of the Northern Mariana Islands, and Hawaii to implement projects that control and mitigate the impact of the invasive Brown Treesnake on local ecosystems and economies.

This grant invites academic institutions, private companies, and nonprofit organizations to propose innovative research projects that advance national security and defense technologies, with a focus on disruptive solutions across various domains.

Project Title: Natural Resources Support Beale AFB, CA A cooperative agreement is being offered ONLY to members of the Cooperative Ecosystem Studies Units (CESU) Program Region(s) identified above. Award will be made upon mutual agreement and acceptance of the terms and conditions contained in the request for proposal and the of the recipients CESU Master Agreement. Note the established CESU.Program indirect rate is 17.5%. Responses to this Request for Statements of Interest will be used to identify potential organizations for this project. Approximately $899,050.00 is expected to be available to support this project for the base period. Additional funding may be available to the successful recipient for optional tasks and/or follow on work in subsequent years. NOTE: This project will be awarded under the authority of 10 USC 670c-1, Sikes Act: For projects for the implementation and enforcement of integrated natural resources management plans, priority shall be given to award to Federal and State agencies having responsibility for the conservation or management of fish or wildlife. Period of Performance. The base period of agreement will extend 18 months from date of award. There may be up to four 18-month follow-on periods based on availability of funding. Description of Anticipated Work: See attached Statement of Objectives NOTE: At this time we are only requesting that you demonstrate available qualifications and capabaility for performing similar or same type of work.1. Statements of Interest are due by 12:00 P.M., Central Time, on 15 July 2024.2. Submit your Statement of Interest via e-mail attachments or direct questions to: Sandy JustmanGrants SpecialistUSACE, Fort Worth DistrictEmail: Sandra.justman@usace.army.milOffice: 817-886-1073David LeptienProject ManagerUSACE, Fort Worth DistrictEmail: david.b.leptien@usace.army.milOffice: 402-889-5570

This funding opportunity is for research institutions and organizations that are partners in the Great Basin Cooperative Ecosystem Studies Unit, aimed at developing advanced hydrodynamic models to study water flow between Bear River Bay and Gilbert Bay in the Great Salt Lake.

This initiative seeks input from energy stakeholders to identify and develop large-scale electric grid projects that can meet the increasing energy demands of industries like data centers and advanced manufacturing.

NOTICE: Amended May 14, 2024. The proposal due date has been delayed to June 10, 2024. Also, a FAQ has been posted under other documents on the right of this NSPIRES page. Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package. The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) 2024 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2024. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates (Tables 2 and 3), a table that provides a very top level summary of proposal contents (Table 1), and the full text of the ROSES-2024 "Summary of Solicitation", may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2024. This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2024table2 and http://solicitation.nasaprs.com/ROSES2024table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH24ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on C.8 Lunar Data Analysis Program (.pdf) to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read C.1 Planetary Science Research Program Overview (.pdf) from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview. Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2024 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at sara@nasa.gov, but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list. Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2024 blog feed for amendments, clarifications, and corrections to at https://science.nasa.gov/researchers/solicitations/roses-2024/, and (3) The ROSES-2024 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar).

The U.S. National Science Foundation seeks to build research capacity and infrastructure to address complex and compounding national and global crises whose solutions require a human-centered approach. To help generate effective and long-lasting solutions that benefit the entire U.S. public, NSF is providing this funding opportunity to inform possible future Centers for Research and Innovation in Science, the Environment and Society (CRISES). The envisioned centers will catalyze new research and research-based innovations to address seemingly intractable problems that confront our society. They will develop evidence-based solutions that address fundamental quality-of-life issues, such as those involving the environment, extreme weather and sustainability; workforce and the economy; equity and access to opportunities; and well-being. CRISES supports planning proposals to catalyze ideas that will potentially inform or serve as the basis for a larger, center-scale program. This opportunity supports researchers in the social, behavioral and economic sciences who use empirical methods to grapple with crises that impact individuals, families, organizations, regions, nations or our entire planet. The Centers for Research in Science, the Environment and Society initiative invites proposals to take the first steps toward developing large-scale interdisciplinary research activities that will address todays crises and ultimately enhance peoples quality of life. NSF's Social, Behavioral and Economic Sciences Directorate supports research to understand the social and behavioral aspects of our rapidly changing world and how these issues are affected by our social, economic and natural environments. Fundamental and use-inspired research supported by the directorate advances our understanding of people, organizations and society, while revealing emerging opportunities to address challenges affecting our ability to live healthy and productive lives.

The Energy Storage Pilot Demonstrations program, managed by the Office of Clean Energy Demonstrations (OCED), supports pilot-scale demonstrations for non-lithium, long-duration energy storage solutions. The program aims to advance technical maturity, reduce uncertainty in cost and performance, generate operational datasets, and increase investor and end-user confidence. The total DOE funding available is up to $100 million, with project funding ranging from $5 million to $20 million DOE share, requiring a minimum of 50 percent non-Federal cost share. Projects must demonstrate long-duration (10 hour) discharge capabilities and have a clear path to commercialization.

This initiative provides up to $100,000 in technical assistance vouchers to businesses and organizations seeking to commercialize scientific innovations through collaboration with experts at U.S. Department of Energy National Laboratories.

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to develop systemic drug delivery platforms for medical countermeasures (MCMs). The Hermes program is explicitly seeking transformative approaches enabling the development of delivery platforms with systemic biodistribution, exceptional endosomal escape efficiency, and minimal toxicity. Successful proposals will include a detailed description of the proposed delivery platform including 1) screening pipeline, 2) reporter systems for monitoring biodistribution and expression in animal models, 3) methods to monitor immunogenicity/toxicity, and 4) chosen therapeutic cargo and justification. Systemic delivery platforms developed under the Hermes effort will be transferred to U.S. Government stakeholders for further development.

This funding opportunity provides financial support to nonprofit universities, colleges, and research institutions in the U.S. to advance aquaculture research and technology, aiming to improve seafood production and sustainability.

The "DoD Multiple Sclerosis, Investigator-Initiated Research Award" is a grant that supports high-quality research projects aimed at improving understanding, patient care, and quality of life for those with Multiple Sclerosis, and encourages applications from both established and early-career investigators, with a focus on projects that can provide relevant preliminary or published data.

The U.S. Geological Survey (USGS) is offering a funding opportunity to a CESU partner to facilitate development of the OpenET software system and evapotranspiration (ET) data production, data assessments, and data quality, thereby advancing OpenET capabilities to operational viability. Fulfillment of these duties will require OpenET software system architecture expertise; development expertise for multi-sensor data fusion frameworks; and coordination and management of the OpenET science team among related OpenET consortium activities. Research objectives will support water mission planning and external OpenET partners and data user communities through deliverables that refine remote sensing ET estimates used for water management decisions for human and natural use.

This funding opportunity provides financial support for projects that help young individuals develop careers in the commercial fishing industry by offering training and resources to address workforce challenges.

This funding opportunity supports researchers in developing innovative small animal and human cellular models to study the complex interactions between the central nervous system and the immune system in individuals living with HIV who are on antiretroviral therapy.