Grants for For Profit Organizations Other Than Small Businesses

**HEAL Initiative: INTERACT INTEgRAtive Back Pain Longitudinal Cohort Teams (UC2 Clinical Trial Optional)** aims to fund research teams to enhance the understanding and treatment of chronic low back pain through longitudinal data collection, interdisciplinary approaches, and collaboration with existing HEAL projects, while promoting inclusivity and diverse perspectives in the research process.

This funding opportunity is designed to support public-private partnerships that leverage artificial intelligence to improve the resilience and competitiveness of U.S. manufacturing through innovative research and workforce development.

This is a Notice of Intent to Issue Funding Opportunity Announcement No. DE-FOA-0003348; titled Puerto Rico Energy Resilience Fund: Resilient Communities Program. This Notice of Intent is for informational purposes only and DOE is not seeking comments on the information contained in the notice. If issued, DOE will be seeking applications for awards under the Puerto Rico Energy Resilience Fund for activities to improve the resilience of the Puerto Rican electric grid, including renewable energy and storage solutions for vulnerable households and communities. The Notice can be downloaded at https://infrastructure-eXCHANGE.energy.gov.

This funding opportunity provides financial support to organizations that assist socially and economically disadvantaged individuals and very small businesses in Northern Illinois, helping them access capital and improve their financial readiness through legal, accounting, and advisory services.

This funding opportunity supports junior faculty in obstetrics and gynecology who are dedicated to advancing their research careers in women's reproductive health.

This grant provides funding to nonprofit organizations and government units in Dickinson County, Kansas, for projects that enhance community well-being in areas such as arts, education, health, and youth services.

The National Cancer Institute intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications forresearch on the confluence of cancer stigma and HIV stigma in HIV-positive individuals diagnosed with cancer. This NOFO will utilize the R01 grant mechanism (clinical trial optional). Up to six (6) R01 awards are expected to be funded as part of the initiative. Research projects search project will advance the current understanding of the confluence of cancer stigma and HIV stigma among people with HIV (PWH) diagnosed with cancer; assess the impact of these two converging stigmas on cancer outcomes among PWH with cancer; leverage stigma reduction interventions at multiple levels to intervene on modifiable mechanisms of stigma that contribute to negative cancer outcomes among PWH with cancer; and promote research in diverse domestic and international contexts, focusing on regions in which the HIV-cancer burden is elevated. The NOFO is expected to be published in late Summer 2024 with an expected application due date in late Fall 2024. Details of a pre-application webinar will be announced after the publication of the NOFO. This Notice is being provided to allow sufficient time for potential applicants with relevant expertise and insights to consider applying for this NOFO. Potential applicants are encouraged to view the presentation of this initiative to the Joint Virtual Meeting of the NCI Board of Scientific Advisors and the National Cancer Advisory Board available at https://videocast.nih.gov/watch=54859 beginning at 3 hour, 39 minutes. Presentation slides are downloadable at: https://deainfo.nci.nih.gov/advisory/joint/0624/Vanderpool.pdf.

This grant provides funding for a Data Coordinating Center to support research projects focused on preventing stillbirth, emphasizing collaboration and equity in addressing disparities in vulnerable populations.

This funding opportunity invites research institutions to join a collaborative effort aimed at advancing stillbirth research, particularly focusing on reducing stillbirth rates in vulnerable populations through innovative scientific approaches.

The National Cancer Institute (NCI) intends to issue a notice of funding opportunity (NOFO) for the Research Specialist Award (R50) specifically for clinician scientists supporting NCI-funded clinical trials research. The Research Specialists Award is designed to encourage the development of stable research career opportunities for exceptional clinician scientists who want to continue to participate in the NCI clinical trials networks through leadership in the 1) development of clinical trials, 2) implementation of NCI clinical trials in their institutions, and 3) national service to the NCI clinical trials networks through participation in the scientific review committees, monitoring committees and other activities, but not serve as principal investigator of research project grants. This Notice of Intent to Publish is being provided to allow sufficient time for applicants to develop strong applications. Applications are limited to four per institution per receipt date including new (A0) and resubmissions (A1). NCI-designated cancer center consortia are considered one institution. NCI seeks a broad representation of institutions for this award mechanism and may take this into account when making funding decisions. The NOFO is expected to be published in late summer 2024 with only one expected application due date of November 5, 2024.

The "Notice of Intent to Publish a Notice of Funding Opportunity for Centers on the Demography and Economics of Aging, Including Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD) (D Centers) (P30 Clinical Trial Optional)" grant aims to fund the development or renewal of research centers focused on advancing aging research in demography, economics, and related social sciences, with a particular emphasis on Alzheimer's disease and related dementias, while promoting innovative research, addressing health disparities, and fostering interdisciplinary collaboration.

The "Notice of Intent to Publish a Notice of Funding Opportunity for Centers on the Demography and Economics of Aging and Alzheimer's Disease and Alzheimer's Disease Related Dementias Coordinating Center" grant is intended to fund the development or renewal of a coordinating center that will serve as a hub for various research centers, enhancing their scientific impact, fostering synergies, promoting inclusivity, and raising the profile of aging and Alzheimer's disease research.

This grant provides funding to nonprofit organizations and local government entities in Herington, Kansas, to support community development projects that improve the quality of life for residents.

The National Cancer Institute intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for pilot/exploratory research on the confluence of cancer stigma and HIV stigma in HIV-positive individuals diagnosed with cancer. This NOFO will utilize the R21 grant mechanism (clinical trial optional), which is intended to encourage exploratory/developmental research by providing support for the early and conceptual stages of project development. Up to three (3) R21 awards are expected to be funded as part of the initiative. Research projects will advance the current understanding of the confluence of cancer stigma and HIV stigma in people with HIV (PWH) diagnosed with cancer; investigate the resultant impact of these dual stigmas on cancer outcomes among PWH with cancer; and promote research in diverse domestic and international contexts, focusing on regions in which the HIV-cancer burden is elevated. Pilot interventional research, which addresses modifiable mechanisms of stigma that contribute to negative cancer outcomes among PWH with cancer, is also suitable for this funding mechanism. The NOFO is expected to be published in late Summer 2024 with an expected application due date in late Fall 2024. Details of a pre-application webinar will be announced after the publication of the NOFO. This Notice is being provided to allow sufficient time for potential applicants with relevant expertise and insights to consider applying for this NOFO. Potential applicants are encouraged to view the presentation of this initiative to the Joint Virtual Meeting of the NCI Board of Scientific Advisors and the National Cancer Advisory Board available at https://videocast.nih.gov/watch=54859 beginning at 3 hour, 39 minutes. Presentation slides are downloadable at: https://deainfo.nci.nih.gov/advisory/joint/0624/Vanderpool.pdf.

The County of Maui's Green Grants program offers approximately $1.7 million in funding to support projects promoting sustainability. Managed by the Department of Environmental Management’s Environmental Protection & Sustainability Division (EP&S), the program aims to advance critical initiatives in environmental protection, restoration, and sustainable development across Maui County. This aligns with the broader mission of fostering a more resilient and environmentally conscious community. The grants target a wide range of beneficiaries, including individuals, non-profit organizations, and for-profit businesses. The program particularly encourages projects led by, or with a focus on, women, youth, and traditional native Hawaiian practices and approaches. The overall impact goal is to enhance environmental protection, restore wetlands, promote renewable energy, encourage green building, and facilitate the acquisition of essential equipment for sustainability initiatives, ultimately contributing to a more sustainable Maui County. The Green Grants program prioritizes several key areas through its distinct funding streams. These include the Environmental Protection Grant, which supports invasive species management, environmental restoration, conservation, and sustainability (with a specific allocation for Waikapū community beautification). The Wetlands Restoration Grant focuses on organizations dedicated to wetland restoration. The Renewable Energy Grant supports initiatives promoting renewable energy and energy efficiency. The Green Building and Resilient Housing Grant encourages sustainable building practices, with a portion designated for Living Building Challenge participants. Finally, the Equipment Purchase Grant assists in acquiring necessary equipment for all sustainability and environmental initiatives. Expected outcomes include tangible improvements in environmental health, increased adoption of renewable energy, more sustainable building practices, and enhanced capacity for environmental initiatives through equipment acquisition. For instance, the Wetlands Restoration Grant aims to advance critical restoration efforts, while the Renewable Energy Grant seeks to enhance energy efficiency. The Green Building and Resilient Housing Grant promotes sustainable design and construction. Measurable results would include the number of restored wetlands, reduction in invasive species, new renewable energy installations, and the implementation of green building projects. The project period for grants is a full year, with options to align with either the Fiscal Year (July 1, 2024–June 30, 2025) or Calendar Year (January 1, 2025–December 31, 2025) in 2025.

This grant provides funding for innovative medical research aimed at improving the health and readiness of military personnel, veterans, and their families by accelerating the development of life-saving healthcare products and technologies for use in combat and austere environments.

The Indiana Department of Health’s (IDOH) Maternal and Child Health Division aims to fund community-based organizations, local health departments, hospitals, and not-for-profit organizations in Indiana. The primary goal is to implement evidence-based or promising practice programs focused on teen pregnancy prevention and positive youth development. This initiative aligns with the IDOH's mission to improve maternal and child health outcomes across the state by empowering youth to make healthy decisions and avoid risky behaviors. The funding is provided by the Family and Youth Services Bureau and the IDOH, Maternal and Child Health Division (MCH). The program's target beneficiaries are youth within Indiana, with an intentional focus on high-risk groups. These include youth in or aging out of foster care, those in the child welfare system, idle youth (not working or in school), school dropouts, youth living in poverty, youth in juvenile centers, traditionally underserved racial or ethnic groups, LGBTQIA+ youth, and runaway or homeless youth. The impact goals are to reduce teen pregnancy rates, promote self-regulation, encourage healthy relationships, and foster goal setting through a positive youth development framework. The priorities and focuses of this grant include providing evidence-based sexual risk avoidance education curricula that normalize voluntarily refraining from non-marital sexual activity. Programs should also emphasize the benefits of self-regulation, success sequencing, healthy relationships, and goal setting. Applicants may also implement the Teen Café Model alongside an evidence-based curriculum. Additionally, the program prioritizes teaching youth skills to avoid risky behaviors, explaining how alcohol and drug use increases vulnerability, defining "consent" and "active consent," and teaching the importance of attaining self-sufficiency before engaging in sexual activity. Where appropriate, mentoring, counseling, and adult supervision should be provided to support these objectives. Expected outcomes include a decrease in teen pregnancy rates among participating youth, an increase in youth demonstrating self-regulation and goal-setting behaviors, and improved decision-making regarding sexual activity. Measurable results will likely be tracked through participant engagement, knowledge acquisition on consent and risk avoidance, and, ultimately, a reduction in pregnancy rates within the target populations. The strategic priority is to equip Indiana's youth with the knowledge and skills necessary for positive development and to avoid the risks associated with early sexual activity, thereby improving long-term health and well-being outcomes. The theory of change posits that by providing comprehensive, evidence-based education and support, at-risk youth will be empowered to make informed choices that lead to healthier lives and a reduced incidence of teen pregnancy. Projects are scheduled to start October 1, 2024, and conclude September 30, 2026, contingent on federal funding availability.

The County of Maui's Green Grants program, managed by the Department of Environmental Management’s Environmental Protection & Sustainability Division (EP&S), is a significant initiative providing approximately $1.7 million in funding to support projects that promote sustainability. This program aligns with the county's mission to enhance environmental protection and sustainability within Maui. The grants aim to foster a greener future for the region by supporting a diverse range of environmental projects. The program targets a broad spectrum of beneficiaries, including individuals, non-profit organizations, and for-profit businesses. A particular emphasis is placed on projects led by, or with a focus on, women, youth, and traditional native Hawaiian practices and approaches. The impact goals are centered around environmental restoration, conservation, and sustainability. This includes initiatives in areas such as invasive species management and broader environmental protection efforts, contributing to the overall ecological well-being of Maui County. Key priorities for the Green Grants include supporting initiatives that address environmental challenges and promote sustainable practices. The program has a specific allocation for an Environmental Protection Grant, totaling $490,000 for FY25, which will fund initiatives in invasive species management, environmental restoration, conservation, and sustainability. Additionally, up to $10,000 is specifically allocated for Waikapū community beautification projects, highlighting a focus on local community engagement and improvement. The expected outcomes and measurable results include tangible environmental improvements across Maui County, such as reduced invasive species, restored natural habitats, and enhanced conservation efforts. The program anticipates projects that will contribute to a more sustainable environment, with a particular emphasis on community-led initiatives and the integration of traditional ecological knowledge. Projects are expected to run for a full year, with options for alignment to either Fiscal Year (July 1, 2024–June 30, 2025) or Calendar Year (January 1, 2025–December 31, 2025) 2025, allowing for flexible project planning and execution to maximize impact.

To obtain a copy of the Funding Opportunity Announcement (FOA) please go to the ARPA-E website at https://arpa-e-foa.energy.gov. To apply to this FOA, Applicants must register with and submit application materials through ARPA-E eXCHANGE (https://arpa-e-foa.energy.gov/Registration.aspx). For detailed guidance on using ARPA-E eXCHANGE, please refer to the ARPA-E eXCHANGE User Guide (https://arpa-e-foa.energy.gov/Manuals.aspx). ARPA-E will not review or consider concept papers submitted through other means. For problems with ARPA-E eXCHANGE, email ExchangeHelp@hq.doe.gov (with FOA name and number in the subject line). Questions about this FOA? Check the Frequently Asked Questions available at http://arpa-e.energy.gov/faq. For questions that have not already been answered, email ARPA-E-CO@hq.doe.gov. Agency Overview: The Advanced Research Projects Agency Energy (ARPA-E), an organization within the Department of Energy (DOE), is chartered by Congress in the America COMPETES Act of 2007 (P.L. 110-69), as amended by the America COMPETES Reauthorization Act of 2010 (P.L. 111-358), as further amended by the Energy Act of 2020 (P.L. 116-260): (A) to enhance the economic and energy security of the United States through the development of energy technologies that (i) reduce imports of energy from foreign sources; (ii) reduce energy-related emissions, including greenhouse gases; (iii) improve the energy efficiency of all economic sectors; (iv) provide transformative solutions to improve the management, clean-up, and disposal of radioactive waste and spent nuclear fuel; and (v) improve the resilience, reliability, and security of infrastructure to produce, deliver, and store energy; and (B) to ensure that the United States maintains a technological lead in developing and deploying advanced energy technologies. ARPA-E issues this Funding Opportunity Announcement (FOA) under its authorizing statute codified at 42 U.S.C. 16538. The FOA and any cooperative agreements or grants made under this FOA are subject to 2 C.F.R. Part 200 as supplemented by 2 C.F.R. Part 910. ARPA-E funds research on, and the development of, transformative science and technology solutions to address the energy and environmental missions of the Department. The agency focuses on technologies that can be meaningfully advanced with a modest investment over a defined period of time in order to catalyze the translation from scientific discovery to early-stage technology. For the latest news and information about ARPA-E, its programs and the research projects currently supported, see: http://arpa-e.energy.gov/. ARPA-E funds transformational research. Existing energy technologies generally progress on established learning curves where refinements to a technology and the economies of scale that accrue as manufacturing and distribution develop drive improvements to the cost/performance metric in a gradual fashion. This continual improvement of a technology is important to its increased commercial deployment and is appropriately the focus of the private sector or the applied technology offices within DOE. In contrast, ARPA-E supports transformative research that has the potential to create fundamentally new learning curves. ARPA-E technology projects typically start with cost/performance estimates well above the level of an incumbent technology. Given the high risk inherent in these projects, many will fail to progress, but some may succeed in generating a new learning curve with a projected cost/performance metric that is significantly better than that of the incumbent technology. ARPA-E funds technology with the potential to be disruptive in the marketplace. The mere creation of a new learning curve does not ensure market penetration. Rather, the ultimate value of a technology is determined by the marketplace, and impactful technologies ultimately become disruptive that is, they are widely adopted and displace existing technologies from the marketplace or create entirely new markets. ARPA-E understands that definitive proof of market disruption takes time, particularly for energy technologies. Therefore, ARPA-E funds the development of technologies that, if technically successful, have clear disruptive potential, e.g., by demonstrating capability for manufacturing at competitive cost and deployment at scale. ARPA-E funds applied research and development. The Office of Management and Budget defines applied research as an original investigation undertaken in order to acquire new knowledgedirected primarily towards a specific practical aim or objective and defines experimental development as creative and systematic work, drawing on knowledge gained from research and practical experience, which is directed at producing new products or processes or improving existing products or processes. Applicants interested in receiving financial assistance for basic research (defined by the Office of Management and Budget as experimental or theoretical work undertaken primarily to acquire new knowledge of the underlying foundations of phenomena and observable facts)1 should contact the DOEs Office of Science (http://science.energy.gov/). Office of Science national scientific user facilities (http://science.energy.gov/user-facilities/) are open to all researchers, including ARPA-E Applicants and awardees. These facilities provide advanced tools of modern science including accelerators, colliders, supercomputers, light sources and neutron sources, as well as facilities for studying the nanoworld, the environment, and the atmosphere. Projects focused on early-stage R for the improvement of technology along defined roadmaps may be more appropriate for support through the DOE applied energy offices including: the Office of Energy Efficiency and Renewable Energy (http://www.eere.energy.gov/), the Office of Fossil Energy and Carbon Management (https://www.energy.gov/fecm/office-fossil-energy-and-carbon-management), the Office of Nuclear Energy (http://www.energy.gov/ne/office-nuclear-energy), and the Office of Electricity (https://www.energy.gov/oe/office-electricity). Program Overview: The Nuclear Energy Waste Transmutation Optimized Now (NEWTON) program will support the research and development of technologies that enable the transmutation of used nuclear fuel (UNF) to alleviate the impact of storage in permanent disposal facilities. This program seeks to fund the development of novel technologies that increase the overall capacity factor, power output, and efficiency of particle generation systems (including but not limited to proton, neutron, and/or photon), by reducing beam trip magnitude and duration (referred to as loss of beam). Additional technologies will focus on increasing the throughput of transmutation by developing target materials that maximize transmutation rates and are easily processible to remove the transmuted material. The United States does not currently have an active facility for the permanent disposal of used nuclear fuel derived from the civilian nuclear sector. Used nuclear fuel comprises several classes of isotopes that could be processed in different ways due to their economic value. Firstly, uranium (U), which comprises greater than 95% of the mass of UNF, can be reprocessed and converted back into fuel for light-water reactors through the addition of small amounts of uranium-235 (U-235). Secondly, plutonium (Pu) and minor actinides (MAs), such as neptunium (Np), americium (Am), and curium (Cm), which together comprise roughly 1.5% of UNF by mass, are produced from nuclear fission. Many of these isotopes are fissionable and could be incorporated into fuels designed for advanced reactor concepts. Intermediate-lived fission products (ILFPs) including strontium-90 (Sr-90) and caesium-137 (Cs-137) have relatively short half-lives of roughly 30 years and have applications in radioisotope thermoelectric generators for space applications. However, ILFPs are largely destined for permanent disposal in a deep geological repository. The major long-lived fission products (LLFPs) have half-lives exceeding 200,000 years and have few commercial applications. LLFPS include selenium-79 (Se-79), technetium-99 (Tc-99), tin-126 (Sn-126), iodine-129 (I-129), and caesium-135 (Cs-135). The last class of isotopes are the stable isotopes produced from nuclear fission and resulting decay. These isotopes could be extracted from UNF, but no commercial processing of these have been undertaken. A deep geological disposal facility for the disposition of UNF in the U.S. has been estimated to cost $96.18 billion over the 150-year lifetime, after which the facility would cease to accept new waste. This facility would be able to store 70,000 metric tons (MT) of unprocessed UNF, which is insufficient for the existing volume of civilian waste. Densification of the waste can be accomplished through removal of the plutonium, minor actinides, and ILFP components of the UNF. Removal of 99.9% of these components would allow a densification factor of 225, based on current disposal requirements, thus allowing a single repository to store upwards of approximately 16 million MT of UNF. The LLFPs are responsible for many of the engineered barriers that are required to be built in the repository due to their long half-lives and environmental mobility. Removal of these LLFPs could decrease the capital expenditure of a permanent geological repository while also improving safety. To view the FOA in its entirety, please visit https://arpa-e-foa.energy.gov.

The United States Agency for International Development (USAID) is seeking applications for a cooperative agreement(s) from qualified entities to implement the Rebuilding Cubas Nascent Civil Society program. Eligibility for this award is not restricted. USAID intends to make an award to the applicant(s) who best meets the objectives of this funding opportunity based on the merit review criteria described in this NOFO subject to a risk assessment. Eligible parties interested in submitting an application are encouraged to read this NOFO thoroughly to understand the type of program sought, application submission requirements and selection process.