Grants for Native American Tribal Organizations

HIV infection and substance use are comorbid conditions that bidirectionally and synergistically influence the deleterious outcomes in people who suffer from substance use disorders (SUD). The persistence and transcriptional reactivation of HIV lead to the development of neuropathological complications. Strategies to address viral latency include silencing of HIV transcription and reactivation and clearance. The goal of this initiative is to support research aimed at (1) identification of targets and pathways by which transcriptional activity of HIV can be suppressed in HIV reservoirs including the CNS in people with SUD, and (2) application of emerging small molecule drug discovery approaches to identify novel compounds that can be utilized as pharmacological probes and as drugs to suppress HIV transcription in people with HIV-SUD comorbidity.

This funding opportunity supports researchers conducting feasibility trials of mind and body interventions for high-priority health conditions, aiming to gather essential data for future large-scale clinical studies.

This Notice of Funding Opportunity (NOFO) solicits R01 grant applications that propose independent research projects that are within the scientific mission areas of the National Institute on Deafness and Other Communication Disorders (NIDCD). This program is intended to support Early Stage and New Investigators from diverse backgrounds, including those from groups underrepresented in the health-related sciences. Investigators from diverse backgrounds, including those from underrepresented groups (e.g., seeNOT-OD-20-031, Notice of NIHs Interest in Diversity), are eligible to apply. Investigators from categories A-C are particularly encouraged to work with their institutions to apply. Preliminary data are not required for this NOFO. All applications require a letter of affirmation from the applicant institution documenting the Investigators eligibility. Applications that do not include this letter will be administratively withdrawn.

This notice of funding opportuntity (NOFO) encourages applications for investigator-initiated multi site clinical trials (e.g., efficacy, effectiveness, or pragmatic trials) to study the effects of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions), and/or multicomponent interventions that include physical, psychological, and/or nutritional approaches in NCCIH- designated areas of high research priority. Clinical Coordinating Centers (CCC) should develop and implement the proposed fully powered multi-site clinical trial (Phase III and beyond). The objective of a CCC application is to present the scientific rationale and a comprehensive scientific and operational plan for the clinical trial. CCCapplications are expected to describe plans for project management, participant recruitment and retention strategies, performance milestones, scientific conduct, and dissemination of results. CCC applications submitted under this NOFO will utilize a two-phase, milestone-driven cooperative agreement (UG3/UH3) funding mechanism. In addition, an accompanying Data Coordinating Center (DCC) application (U24), submitted under PAR-24-087 proposing a data analysis and data management plan for the clinical project is required. Both a CCC application and a corresponding DCC application need to be submitted simultaneously for consideration by NCCIH. For additional information about the mission, strategic vision, and research priorities of NCCIH, applicants are encouraged to consult the NCCIH website: (https://nccih.nih.gov/about/plans). Applicants are encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO.

This funding opportunity supports researchers conducting multi-site clinical trials to evaluate complementary and integrative health approaches that combine physical and psychological therapies, aiming to gather essential data for future larger-scale studies.

HIV infection and substance use are comorbid conditions that bidirectionally and synergistically influence the deleterious outcomes in people who suffer from substance use disorders (SUD). The persistence and transcriptional reactivation of HIV lead to the development of neuropathological complications. Strategies to address viral latency include silencing of HIV transcription and reactivation and clearance. The goal of this initiative is to support research aimed at (1) identification of targets and pathways by which transcriptional activity of HIV can be suppressed in HIV reservoirs including the CNS in people with SUD, and (2) application of emerging small molecule drug discovery approaches to identify novel compounds that can be utilized as pharmacological probes and as drugs to suppress HIV transcription in people with HIV-SUD comorbidity.

This notice of funding opportunity (NOFO), utilizing the U24 grant funding mechanism, encourages applications for a collaborating Data Coordinating Center (DCC) application that accompanies an investigator-initiated multi site clinical trial (Phase III and beyond) application submitted under companion PAR-21-243. The DCC application must be specific to the companion Clinical Coordinating Center (CCC) application. The objective of the DCC application is to propose a comprehensive plan that provides overall project coordination, and administrative, data management, and biostatistical support for the proposed clinical trial. Both a DCC application and a corresponding CCC application need to be submitted simultaneously for consideration by NCCIH. Trials for which this NOFO applies must be relevant to the research mission of NCCIH and considered a high priority by the Center. For additional information about the mission, strategic vision, and research priorities of NCCIH, applicants are encouraged to consult the NCCIH website (http://www.nccih.nih.gov). Applicants are encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn.Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

This funding opportunity supports U.S. educational institutions in developing programs that train a diverse workforce in research related to diabetes, digestive diseases, and kidney health, through skills courses and research experiences.

The purpose of this funding opportunity is to support the development of Clinical Outcome Assessments (COA) for Substance Use Disorders (SUD). The COA development plan is expected to progress into the FDA drug development tool qualification program. This notice of funding opportunity (NOFO) utilizes the UG3/UH3Phased Innovation Awards Cooperative Agreement grant mechanism that includes two phases. The applications responding to this NOFO should contain a COA development plan that will cover both UG3 and UH3 phases. In the first 2-year UG3 phasethe project must have a set of operational milestones to be completed by the end of this period. Once NIDA program has evaluated the progress of the UG3 phase and determined that the UG3 phase has been successfully completed, it transitions to the UH3 phase to be funded for three additional years.The goal of this NOFO is to expand the armamentarium of COA that are FDA qualified as drug development tool (DDT) in the context of use (COI) of a SUD. Achieving this goal will greatly facilitate the development of treatments for SUDs. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

Recreational boating facility projects. Past projects have included ramps and service docks to gain access to the water, purchase of aquatic weed harvesting equipment, navigation aids and dredging waterway channels. These grants may be used by counties, towns, cities, villages, tribes, sanitary districts, public inland lake protection and rehabilitation districts and qualified lake associations for recreational boating facility projects. FOR GRANT REQUESTS IN EXCESS OF $250,000: Applications for RBF grants exceeding $250,000 are encouraged to be submitted to your regional DNR grants specialists in time for the June 1st, or September 1st, application deadlines. These larger grant requests take extra processing time and therefore are highly recommended for earlier evaluation, in the first two quarters of the fiscal year. Contact your regional DNR grants specialist as soon as possible, if you have a larger project and you are planning to apply for a RBF grant. DNR grants specialists can help with scheduling and grant processing.

This funding opportunity supports the development of innovative informatics tools to improve cancer research and management, targeting researchers and institutions focused on enhancing data handling and analysis in the field of oncology.

This funding opportunity supports the development of innovative informatics technologies to improve cancer research and management, targeting researchers and organizations focused on cancer biology, treatment, prevention, and health disparities.

This funding opportunity provides support for the ongoing development and maintenance of valuable informatics tools and resources that enhance cancer research and management, benefiting researchers and the broader cancer community.

This funding opportunity supports collaborative projects among scholars in the humanities, encouraging interdisciplinary research that leads to significant scholarly outputs, with a focus on diverse perspectives and sustainable contributions to humanistic knowledge.

This funding opportunity supports researchers in developing innovative informatics methods and algorithms to improve cancer research and management across various areas, including diagnosis, treatment, and prevention.

The purpose of this Notice of Funding Opportunity (NOFO) is to support the development and validation of reagents/tools to support research to characterize cellular and molecular constituents of the bat immune system and for the study of protective innate and adaptive immune mechanisms in bats. The Research Resource Program established by this NOFO will participate within a collaborative research network to advance understanding of the bat immune response. This NOFO will support the establishment and operation of a Bat Immunology Research Resource Program for the development and validation of reagents/tools for use in immunological studies using the bat model system. The recipient will participate in the Bat Immunology Network, which will consist of the Research Resource Program, the research projects supported by RFA-AI-23-068, and possible other participants as determined by NIAID. The Research Resource Program will conduct reagent/tool development and validation using appropriate systems, which includes testing against multiple bat species. While other members of the Bat Immunology Network may assist in validation efforts, reagent/tool validation is the responsibility of the Research Resource Program. Reagents/tools developed by the Research Resource Program will be provided to the research projects of the Bat Immunology Network. Reagents/tools will be made available to the broader research community through technology transfer arrangements, deposition to nonprofit repositories, and/or timely transfer to industry for commercialization. Areas of high priority include, but are not limited to, the development and validation of the following: Soluble immune molecules (e.g., cytokines, chemokines) for use in tissue culture or in vivo animal studies Antibodies or other probes/detection markers for use in cellular phenotyping, functional studies and/or immunoassays

The purpose of this Notice of Funding Opportunity (NOFO) is to support research to characterize cellular and molecular constituents of the bat immune system and to understand protective innate and adaptive immune mechanisms in bats. Research projects supported by this NOFO will form a collaborative research network to advance understanding of the bat immune response. This NOFO will support research projects to characterize the bat immune system, including defining protective innate or adaptive immune molecules and mechanisms. As little is known about the bat immune system, projects may be descriptive in nature or may be supported by limited preliminary data. Projects should emphasize the strength of the conceptual framework and the potential of the project to advance understanding of the bat immune system. Projects may propose the development of critical reagents for the project, though those development and validation activities may be transferred to the Research Resource Program after award. Research areas of high priority include, but are not limited to, the following: Characterization of the cellular constituents of the bat immune system Dissection of the molecules and pathways involved in the regulation of the bat innate and/or adaptive immune system Mechanistic studies of bat immunity, including intrinsic immunity and regulation of inflammation Studies on the quality, magnitude, and kinetics of bat immune responses during pathogenic infection and after pathogen clearance Role of metabolism or other intrinsic factors in bat immune regulation Structural studies of bat immune proteins

This funding opportunity supports researchers in developing small molecule chemical probes to investigate biological processes related to mental health, aging, drug addiction, and eye diseases.

HSGP is comprised of three interconnected grant programs: State Homeland Security Program (SHSP), Urban Area Security Initiative (UASI) and Operation Stonegarden (OPSG). These risk-based grants assist state, local, tribal and territorial efforts in preventing, protecting against, mitigating, responding to and recovering from acts of terrorism and other threats. HSGP provides grantees with the resources required for implementation of the National Preparedness System and working toward the National Preparedness Goal of a secure and resilient nation. Together, these three grant programs fund a range of preparedness activities, including planning, organization, equipment purchase, training, exercises and management and administration across all core capabilities and mission areas.

US DOT Pipeline and Hazardous Materials Safety Administration (PHMSA) provides funding to Washington state for tribal, state, and local governments to sustain and enhance hazardous materials-related emergency preparedness. The funding is specifically targeted to increase effectiveness in safely and efficiently handling hazardous materials accidents and incidents and to encourage a comprehensive approach to emergency training and planning by incorporating the unique challenges of responses to transportation situations. The HMEP grant program was established in 1990 by the Hazardous Materials Transportation Uniform Safety Act. In 1993, PHMSA began issuing grants to assist States, Territories, and Native American Tribes to "develop, improve, and carry out emergency plans" within the National Response System and the Emergency Planning and Community Right-To-Know Act of 1986. The HMEP grant program is designed to allow grantees the flexibility to implement training and planning programs that address differing needs for each location based on demographics, emergency response capabilities, commodity flow studies, and hazard analysis. Relevant trainings are found in the National Fire Protection Association (NFPA) 472: Standard for Competence of Responders to Hazardous Materials/Weapons of Mass Destruction Incidents publication and the Occupational Safety and Health Administration (OSHA) regulations found in 29 CFR § 1910.120. Governors in each State, or their counterparts within Territories or Tribes, designate an agency to receive the HMEP grant funds. Agencies submit grant applications to PHMSA annually requesting funds for proposed activities. PHMSA reviews and evaluates applications to make certain the proposed activities support the program mission to ensure the safe transportation of hazmat. If approved, PHMSA offers the agency a Notice of Grant Award (NGA) for acceptance and signature. Once executed, the agency may distribute grant funds in accordance with the planned activities identified in the grant application within the State, Territory, or Tribe to Local Emergency Planning Committees (LEPCs) and first responder organizations.