Grants for State Governments

This funding opportunity supports outstanding graduate students transitioning to postdoctoral research focused on Down syndrome, providing financial resources for their training and research in this important field.

The National Heart, Lung, and Blood Institute (NHLBI) intends to publish a Request for Applications (RFA) seeking applications for a multisite clinical trial that will test a screening approach to identify coronary atherosclerosis and test interventions to reduce the progression of coronary atherosclerosis. There will be only one award for this RFA. The planned RFA will utilize the UG3/UH3 activity code with details provided below. The planned RFA will support a Clinical Coordinating Center (CCC) and will run in parallel with a companion RFA for a collaborating Data Coordinating Center (DCC) application.This RFA will accept only an application that is part of a collaborative pair of applications. The pair must include one application to the CCC UG3/UH3 Notice of Funding Opportunity (NOFO) plus one application to the companion DCC U24 NOFO.Both a CCC application and a collaborating DCC application must be submitted on the same due date for consideration by NHLBI. CCC (UG3/UH3) applications submitted without a collaborative DCC (U24) application will be deemed incomplete and will not proceed to review. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The planned RFAs are expected to be published in Summer 2024 with an expected application due date in Fall 2024.

The National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) with other NIH Institutes and Centers (ICs), intends to publish a new Notice of Funding Opportunity (NOFO) to solicit applications for multi-PI team-based, challenging, high impact projects to improve understanding of mechanisms of chronic pain in children and adolescents and to accelerate the development of age appropriate, patient/family centered prevention and therapeutic approaches. This research will seek to advance an integrated understanding of the biological, psychological, and social factors that contribute to pediatric chronic pain. NIH is interested in pain research in infants, children, and adolescents that includes those with intellectual and physical disabilities and/or those who experience health disparities (e.g., diverse race/ethnicity, sexual and gender minorities, socioeconomically disadvantaged, medically underserved communities, people with limited English proficiency). NIH encourages applicants to consider community-engaged research and interdisciplinary, collaborative applications to be developed in partnership with patient communities and/or community organizations where possible. The long-term goal is to develop improved knowledge of specific pediatric pain conditions as well as pain associated with diverse diseases/disorders, to improve understanding of pain in the context of child development and to facilitate the stratification of patients with specific pain conditions and co-morbidities to accelerate chronic pain prevention and therapeutic clinical trials. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in May 2024 with an expected application due date in Fall 2024. This NOFO will utilize the UC2 Research Project Cooperative Agreements activity code. Details of the planned NOFO are provided below.

NIA intends to publish a Notice of Funding Opportunity (NOFO) soliciting applications that aim to develop Common Data Elements (CDEs) for Alzheimers disease (AD) and AD-Related Dementias (ADRD) using Real-World Data (RWD) from electronic health records and Centers for Medicare Medicaid Services (CMS) claims. The CDEs will foster data harmonization and interoperability among data systems that involve disparate and unaligned RWD. By reducing the efforts required for data harmonization in using RWD for cross-sectional and longitudinal analysis, the NOFO may enable researchers to utilize RWD more efficiently and produce real-world evidence in a faster manner. The NOFO is expected to be published in March 2024 with an expected application due date in June 2024. Please note that these time frames are simply estimations, and they may change. The NOFO is expected to utilize the Resource-Related Research Projects Cooperative Agreements (U24) activity code. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Additional details regarding the planned NOFO are below.

This grant provides funding for research projects aimed at improving the diagnosis and treatment of health conditions related to the September 11, 2001, terrorist attacks, specifically for individuals who were exposed in New York City and surrounding areas.

Please note that this program requests optional Notices of Intent, which are due via NSPIRES by April 8, 2024. See the full posting on NSPIRES for details. Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package. The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) 2024 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2024. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates (Tables 2 and 3), a table that provides a very top level summary of proposal contents (Table 1), and the full text of the ROSES-2024 "Summary of Solicitation", may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2024. This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2024table2 and http://solicitation.nasaprs.com/ROSES2024table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH24ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on C.8 Lunar Data Analysis Program (.pdf) to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read C.1 Planetary Science Research Program Overview (.pdf) from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview. Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2024 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at sara@nasa.gov, but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list. Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2024 blog feed for amendments, clarifications, and corrections to at https://science.nasa.gov/researchers/solicitations/roses-2024/, and (3) The ROSES-2024 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar).

This grant provides funding for research projects focused on improving health outcomes through lifestyle medicine for individuals affected by the 9/11 attacks, including responders and survivors receiving care under the WTC Health Program.

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for research on diabetes, its complications, and related endocrine and metabolic diseases. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in Spring 2024 with an expected application due date in Summer 2024. This NOFO will utilize the P30 activity code. Details of the planned NOFO are provided below.

With this solicitation, NIJ seeks to fund proposals for rigorous research and evaluation projects examining the impact of court and other criminal justice tools, practices, and policies on the administration of justice and public safety in state, local, and tribal jurisdictions. In FY2024, the solicitation is focused on four research priorities and their impact on charging, case flow, outcomes, and other prosecution functions: 1) advance prosecution practice and resource management; 2) promote fair prosecution and impartial administration of justice; 3) build prosecution data resources, research capacity, and transparency; and 4) enhance the prosecution workforce and court workgroup.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the National Institute of Neurological Disorders and Stroke (NINDS), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and National Heart, Lung and Blood Institute (NHLBI), intend to publish a Notice of Funding Opportunity (NOFO) to solicit applications for Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRCs). These Centers promote collaborative basic, translational, and clinical research and provide important resources that can be used by the national muscular dystrophy research communities. The Centers also provide outstanding environments for the training of new researchers capable of addressing high priority objectives in muscular dystrophy research. Center investigators are expected to participate in important community outreach efforts to increase awareness of their research activities among people with lived experience and the related advocacy communities and to incorporate community perspectives into the conduct of patient-centered research. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in Spring 2024 with an expected application due date in Summer 2024. Only New and Renewal applications will be eligible. This NOFO will utilize the P50 activity code. Details of the planned NOFO are provided below.

This funding opportunity provides financial support to state, tribal, local, and territorial public health systems to enhance their preparedness and response capabilities for various public health emergencies.

The Rural eConnectivity Program (ReConnect) Program provides loans, grants, and loan/grant combinations to facilitate broadband deployment in rural areas. In facilitating the expansion of broadband services and infrastructure, the program will fuel long-term economic development and opportunities in rural America. The ReConnect Program is authorized by the Consolidated Appropriations Act, 2018 (Pub. L. 115-141), which directs the program to be conducted under the Rural Electrification Act of 1936 (7 U.S.C. 901 et seq ). The policies and procedures for the ReConnect Program are codified in a final rule, 7 CFR part 1740, that was published in the Federal Register on February 26, 2021 (86 FR 11603). The Rural Utilities Service (RUS), a Rural Development agency of the United States Department of Agriculture (USDA), is issuing a Notice of Funding Opportunity (NOFO) to announce that it is accepting applications for the ReConnect Program. In addition, the NOFO defines requirements that are determined at the time a funding announcement is published, as outlined in the regulation. Beginning on March 22, 2024, applications can be submitted through the RUS on-line application portal until 11:59 a.m. Eastern on May 21, 2024. Applications will not be accepted after May 21, 2024 until a new application opportunity has been opened with the publication of an additional NOFO in the Federal Register . The Agency encourages applicants to consider projects that will advance the following key priorities: Assisting rural communities recover economically through more and better market opportunities and through improved infrastructure. Ensuring all rural residents have equitable access to Rural Development programs and benefits from Rural Development funded projects. Reducing climate pollution and increasing resilience to the impacts of climate change through economic support to rural communities. All applicants should carefully review and prepare their applications according to instructions in the ReConnect Program Application Guide and program resources. This Program Guide and program resources can be found at https://www.usda.gov/reconnect/forms-and-resources. Applications must be submitted through the RUS on-line application system available on the program web site at https://www.usda.gov/reconnect/. Please submit any ReConnect questions or comments using our Contact Us Form.

This Notice of Funding Opportunity (NOFO) invites applications for a U54 Specialized Center (henceforth: Consortium) to provide resources, expertise, and coordination to advance innovative, high-quality research on palliative care for those with serious illness across the lifespan. This research infrastructure will encompass Alzheimers disease and Alzheimers disease-related dementias (AD/ADRD), cancer, and other serious illnesses and populations relevant to the partnering Institutes, Centers, and Offices (ICOs). NIH currently funds many palliative care research projects across the ICOs, and there is a need for a structure to leverage synergies, coordinate efforts, develop the scientific workforce, and address remaining gaps in the field. The goals of this initiative include generating new scientific knowledge, in part through supporting pilot and exploratory studies; fostering development of early- and mid-career palliative care investigators; serving as a national platform to provide research resources and facilitate high-quality palliative care research; engaging healthcare systems and community-based organizations as research partners and settings for palliative care research; and disseminating research findings, best practices, data, and other impactful resources to the palliative care research and clinical communities. An important focus of the Consortiums work will be on facilitating research to understand and address disparities in access, quality, and use of palliative care services for health disparities populations or in underserved areas.

This solicitation is offered for support of two types of projects, a TCUP Hub and faculty-led topical interest groups (TIGs). The TCUP Hub will serve the entire TCUP-eligible community with activities such as convening workshops (including the TCUP Leaders' Forum), coordinating faculty/student exchanges, organizing professional development opportunities, and overseeing TCUP Fellowship opportunities with eligible agencies. The Hub will connect people and organizations to facilitate relationships, expand and diversify networks, and support TCUP faculty and staff in building capacity in areas they identify. It will curate shared resources, expertise, and experiences to build the capacity of TCUP institutions. Also, it will build and support a sense of community among all TCUP institutions and elevate the voices within them. Only one Hub will be supported, either to a single institution or to a collaborative submission from multiple institutions. Interested parties may find that a collaborative submission from multiple institutions is more feasible, engaging two or more TCUP institutions to synergistically leverage their different strengths in realizing the Hub's mission. Multiple institutions submitting collaboratively may better address the multiplicity of TCUP institutions, which vary geographically, administratively, and in modes of governance. Clearly, some activities may be best pursued by enlisting specialists as consultants. Two types of collaborative proposals are acceptable: simultaneous submission of proposals from multiple organizations submitting a unified set of certain proposal sections, as well as information unique to each organization, such as unique budgets, key personnel, and activities; or submission of a collaborative proposal from one organization, with collaborating institutions included through subawards (subawards are permitted only to TCUP-eligible institutions; proposers should confer with the TCUP program staff prior to submission). All collaborative proposals submitted from multiple organizations must be submitted via Research.gov. Additionally, this solicitation is offered for support of independent, faculty-led topical interest groups (TIGs) that focus on professional development of faculty and formation of science, technology, engineering, and mathematics (STEM) discipline networks (e.g., engineering, genomics, Indigenous research, environmental science). Up to two new TIGs may be supported. [1] Executive Order 13021 defines Tribal Colleges and Universities ("tribal colleges") as those institutions cited in section 532 of the Equity in Educational Land-Grant Status Act of 1994 (7 U.S.C. 301 note), and other institutions that qualify for funding under the Tribally Controlled Community College Assistance Act of 1978, (25 U.S.C. 1801 et seq.), as well as Navajo Community College as authorized in the Navajo Community College Assistance Act of 1978, Public Law 95-471, Title II (25 U.S.C. 640a note). The term "Alaska Native-serving institution" means an institution of higher education that is an eligible institution under section 1058(b) of the Higher Education Act; and that, at the time of submission, has an undergraduate enrollment that is at least 20 percent Alaska Native students. The term "Native Hawaiian-serving institution" means an institution of higher education that is an eligible institution under section 1058(b) of the Higher Education Act; and that, at the time of submission, has an undergraduate enrollment that is at least 10 percent Native Hawaiian students. Most TCUP-eligible institutions of higher education are two-year or community colleges. See the Who May Submit Proposals section in this solicitation for further details.

This funding opportunity supports research projects that investigate the long-term impacts of disasters on healthcare systems serving vulnerable populations in the U.S., aiming to improve access and reduce health disparities.

The Texas Water Development Board's Agricultural Water Conservation Program focuses on promoting water conservation in the agricultural sector through various initiatives, including Ag Conservation Loans and Grants. These efforts aim to support infrastructure improvements and innovative practices for efficient water use among political subdivisions, state agencies, and producers. The grant program offers up to $1.5 million annually, encouraging applications from political subdivisions and state agencies, with producers also eligible to participate in projects. A local match, typically 50%, is required. The program emphasizes collaboration with stakeholders to implement best management practices, education, and outreach to optimize irrigation efficiency and water conservation across Texas.

The National Science Foundation's Directorates for Engineering (ENG), Computer and Information Science and Engineering (CISE), Mathematical Physical Sciences (MPS), and Social, Behavioral and Economic Sciences (SBE) are coordinating efforts to create fundamental understanding that will enablecontinued effective use of an essential common resource, the electromagnetic spectrum. Existing approaches to spectrum management and regulationhave struggled with the ever-increasing demands for spectrum created by continual emergence of new scientific, military, and commercial applications, powered by steady advances in wireless technologies. Development of fundamentally new models and paradigms of spectrum access and management, along with enabling technologies, is needed before it becomes too costly to accommodate new innovations and essential services, or too late to sustain the digital transformation and growth of key industries and public services. This program seeks to develop the intellectual capital enabling the U.S. to smoothly and quickly transition to effective new ways of using and managing the radio and optical spectrum after the end of the current spectrum era of long-term exclusive-use license auctions, thereby sustaining and advancing the social, economic, scientific, and U.S. national leadership benefits derived from the electromagnetic spectrum.

This notice of funding opportunity (NOFO) will support projects proposing mechanistic studies that will transform our understanding of polysubstance use in addiction. These hypothesis-based, exploratory projects may investigate mechanisms of polysubstance use at the behavioral, cognitive, cellular, circuit, genetic, epigenetic, pharmacological and/or computational levels. Research on substance use disorders (SUDs) has primarily focused on individual substances although polysubstance use is prevalent. Polysubstance use is the use of more than one addictive substance within a defined interval; the use may be sequential (use of multiple substances on separate occasions), or concurrent/simultaneous. Limiting studies to an individual addictive substance overlooks potential interactions between substances and could influence the translational potential of preclinical research findings. Results from several studies have demonstrated that the use of multiple addictive substances produces pharmacokinetic and behavioral profiles that are distinct from those produced by a single substance. Despite this recognition, little is known about the precise pharmacological mechanisms and interactions that may contribute to such outcomes, or co-morbidities resulting from co-use. There is also a significant lack in our understanding of how the activity of discrete cells, genes, circuits, expression of receptors, ion channels, intrinsic excitability or signaling mechanisms in the reward systems synergize when exposed to distinct classes of drugs simultaneously or sequentially. Even less is known about these mechanisms in brain regions and circuits that underlie negative reinforcement, or how neurotransmitters, neuromodulators or stress interact within these circuits to contribute to the behavioral and pharmacological profiles observed following polysubstance use. In addition, there is a need for behavioral models of polysubstance use that have translational potential. Research Objectives: The National Institute on Drug Abuse (NIDA) seeks to stimulate innovative research that will transform our understanding of the basic mechanisms that underlie polysubstance use in addiction. These studies will investigate novel neurobiological, pharmacological and/or behavioral mechanisms underlying the biobehavioral outcomes of polysubstance use. Research areas and questions of programmatic interest include, but are not limited to: Identification and/or characterization of molecules, genes, cells (including non-neuronal cells), neural pathways, circuits, receptors, ion channels, intrinsic excitability, pharmacological and signaling mechanisms mediating the effects of polysubstance use. Mechanisms underlying the association of early adolescent polysubstance use with SUD’s in adulthood. Sex differences in the development and trajectory of polysubstance use. What are the roles of organizational and activational effects of sex steroids on discrete brain regions and neural circuits, and how is this altered with exposure to polysubstance use? What are the developmental determinants? Are there developmental windows during which polysubstance use would be facilitated? What are the pharmacologic, pharmacokinetic and pharmacodynamic interactions that can impact toxicity, or the SUD trajectory? How do environmental factors interact with brain circuits to influence the development and trajectory of SUDs involving polysubstance use? How does stress interact with brain circuits to influence the development and trajectory of SUDs involving polysubstance use? Are there neurobehavioral risk phenotypes for progression to polysubstance use? What are the neurocognitive and neurobehavioral changes that occur through experience with different patterns of polysubstance use? Applications Not Responsive to this Notice of Funding Opportunity (NOFO) The following types of studies are not responsive to this NOFO and will not be reviewed: The major goal of the project is not targeted at delineating the basic mechanisms underlying polysubstance use in addiction. Projects limited exclusively to the phenomenology of polysubstance use, consequences of polysubstance use, or those focused exclusively on the development of tools or animal models. Projects that do not focus on combinations of two or more addictive substances with well-justified translational and public health relevance. Projects that do not include a psychostimulant, opioid, or cannabinoid in the polysubstance combination. Alcohol may be included in the polysubstance combination. Research that does not pertain to at least one of the stages of the substance use trajectory, including, but not limited to initiation, escalation, withdrawal and/or relapse. Other application considerations: Collaborative research teams to foster the sharing of conceptual and/or technical expertise are strongly encouraged. Applicants using animal models are encouraged to use models reflective of chronic and voluntary drug intake. Preliminary data are not required but may be included if available. In the absence of preliminary data, a strong premise should be provided for testing a novel hypothesis based upon the scientific literature as well as evidence of the team’s ability to carry out the proposed studies through published or technical preliminary data.

The Accion Opportunity Fund, in partnership with LegalZoom, the NBA, WNBA, and NBA G-League, has launched a grant program designed to support small business owners and emerging entrepreneurs across the United States. This initiative provides grants ranging from $1,000 to $10,000, along with free LegalZoom services valued up to $500. Administered by the nonprofit Accion Opportunity Fund, the program's core mission aligns with empowering business owners by offering essential tools and resources for starting and growing their ventures. This collaboration reflects a shared commitment to fostering entrepreneurship and investing in the success of small businesses nationwide. The program targets two primary beneficiary groups: existing small businesses and emerging entrepreneurs. Existing small businesses applying for the $10,000 grant and LegalZoom services must be U.S.-based, have been in operation for at least 3 months, have an annual revenue under $1 million, possess an active business bank account, and not be in an ineligible industry. Those in business for 12 months or more need to provide their most recent business tax return, while those in business for 3 to 12 months require specific formation documents or licenses. Emerging entrepreneurs, seeking LegalZoom services, must also be U.S.-based and either be in operation for less than 3 months or provide a business idea summary. The program's priorities and focuses revolve around encouraging entrepreneurship and providing tangible support to small business owners. This includes offering direct financial assistance through grants, as well as crucial legal and business formation resources via LegalZoom. The initiative aims to provide a "perfect play" for businesses, signifying a holistic approach to support that addresses both financial needs and structural requirements for growth. By focusing on both established and nascent ventures, the program seeks to create a robust entrepreneurial ecosystem. Expected outcomes and measurable results include the successful establishment and growth of small businesses, increased access to legal services for entrepreneurs, and a reduction in the barriers faced by new and existing ventures. While specific quantitative metrics for success beyond the grant distribution are not explicitly detailed, the underlying theory of change suggests that by providing financial capital and legal support, businesses will be better equipped to sustain operations, expand, and contribute to local economies. The program's design, with its clear eligibility criteria, is structured to ensure that resources are directed to businesses poised for positive impact and growth.

This funding opportunity supports the establishment of facilities that will produce and distribute specialized brain cell access tools for neuroscience research, enabling scientists to better study and manipulate specific brain cell types.