Grants for Unrestricted

The NFRP Investigator-Initiated Research Award supports highly rigorous, high-impact research projects that have the potential to make an important contribution to NF research and/or patient care. Research projects may focus on any phase of research, excluding clinical trials. The rationale for a research idea may be derived from laboratory discovery, population-based studies, a clinicians firsthand knowledge of patients, or anecdotal data. Applications must include preliminary and/or published data that are relevant to NF and the proposed research project.

The Early Investigator Research Award supports NF-focused research opportunities for individuals in the early stages of their careers, under the guidance of a Designated Mentor. This opportunity allows for early-stage investigators to develop a research project, investigate a problem or question in NF research, and further their intellectual development as an NF researcher of the future. The postdoctoral investigator is considered the Principal Investigator (PI) of the application and must exhibit strong potential for, and commitment to, pursuing a career as an investigator at the forefront of NF research; however, the PI is not required to have previous NF research experience. Applications must include at least one mentor, appropriate to the proposed research project, who has experience in NF research and mentoring as demonstrated by a record of active funding, recent publications, and successful mentorship. The Designated Mentor can be a junior faculty member, in which case the PI is encouraged to include a co-mentor with a more robust track record in NF research and mentorship. The selected mentor(s) should also demonstrate a clear commitment to the development of the PI toward independence as an NF researcher.

The NFRP Synergistic Idea Award supports new ideas that represent synergistic approaches to NF research involving two or three Principal Investigators (PIs). These investigators should utilize their complementary and synergistic perspectives to address a central problem or question in NF research. This award is designed to support both new and pre-existing partnerships and encourages participation of PIs from other research fields. Applications must include preliminary and/or published data that are relevant to NF and the proposed research project.

The NFRP Exploration - Hypothesis Development Award supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in NF research. Studies supported by this award mechanism are expected to lay the groundwork for future avenues of scientific investigation. The proposed research project should include a well-formulated, testable hypothesis based on strong scientific rationale and study design. The presentation of preliminary and/or published data is not required.

The FY24 KCRP Postdoctoral and Clinical Fellowship Award supports recent doctoral or medical school graduates in pursuit of innovative, high-impact kidney cancer research during their postdoctoral and/or clinical fellowship and allows them to obtain the necessary experience for an independent career as a leader in kidney cancer research. Applicants must demonstrate that the proposed research has high potential to lead to, or make, significant advancements in kidney cancer research and/or patient care. Applicants for this award must also exhibit a strong desire to pursue a career in kidney cancer research, with clear evidence for a researcher development plan that will lead to a successful independent career in kidney cancer. The critical components of this award mechanism are: Impact: Research supported by the FY24 KCRP Postdoctoral and Clinical Fellowship Award will have the potential for a major impact and accelerate progress toward ending kidney cancer. The impact may be short term or long term, but must move beyond an incremental advance. Applications are expected to identify the kidney cancer patients or at-risk individuals who would ultimately benefit from the proposed research. Research Strategy: The research proposed as part of the Postdoctoral and Clinical Fellowship Award must have high potential to lead to or make breakthroughs in kidney cancer. The scope of the research may include innovative, high-risk/high-reward research in the early stages of idea development or research already supported by preliminary data with the potential to make significant advancements toward clinical translation. The research strategy should demonstrate sound rationale, logical reasoning, and, if available, preliminary data. The proposed research should show evidence of rigorous experimental design, sufficient experimental details, appropriate controls, a statistical plan, and consideration of pitfalls and alternatives. Principal Investigator (PI): Under this award mechanism, the postdoctoral or clinical fellow is considered the PI and, as such, is expected to write the project narrative, researcher development plan, and other application components, with appropriate guidance from the mentor. While the PI is not required to have previous experience in kidney cancer research, the proposed project and researcher development plan must focus on kidney cancer. Applications must emphasize the PIs potential for success in becoming an independent kidney cancer researcher based on their qualifications, achievements/honors (including first-author publications and funding), and letters of recommendation. Mentor: The mentor (or co-mentor, if applicable) must possess the appropriate experience in kidney cancer research and/or patient care, to include recent publications and a record of active funding, and clearly demonstrate a commitment to guiding the PIs research and development as a researcher. If the mentor is not an experienced kidney cancer researcher, then formal co mentorship by an established kidney cancer researcher is required. The application must include information about the mentors experience in conducting innovative research and how they intend to support the PIs endeavors in kidney cancer. Mentorship by an investigator without an established record of mentoring pre- and/or postdoctoral trainees may be offset by the overall strength of the researcher development plan. Researcher Development Plan: Applications must provide details on the suitability of the PIs overall researcher development plan for attaining the goals of this award mechanism. Applications must elaborate on the qualities of the research environment in which the candidate will work, provide details on the individualized kidney cancer-focused researcher development plan, and describe how it will facilitate the PIs career development as an independent, innovative kidney cancer researcher. A multidisciplinary research approach to kidney cancer is highly encouraged, but not required; however, if there are multidisciplinary aspects, they should be clearly outlined in the application. Organizational-Level Emphasis: The following areas of emphasis are broadly applicable to many CDMRP programs, not just the KCRP. Investigators are encouraged to consider addressing these areas in their applications if doing so is appropriate for their line of research, addresses the FY24 KCRP strategic priorities and/or focus areas described in Section II.A.1 and Section II.A.2. Nuclear Medicine: Innovative research involving nuclear medicine and related techniques to support early diagnosis, more effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies. Womens Health: CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women's health outcomes and/or advancing knowledge for women's health. Metastatic Cancer Task Force: A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 KCRP priorities. Rigorous Study Design: All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (https://www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies. Military Service Involvement: Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. Research involving human subjects and human anatomical substances is permitted; however, clinical trials are not allowed under this program announcement. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes. Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials. For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes: (1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies. (2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. (3) Outcomes research and health services research that do not fit under the definition of clinical trial. Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule. The funding instrument for awards made under the program announcement will be grants (31 USC 6304). The anticipated direct costs budgeted for the entire period of performance for an FY24 KCRP Postdoctoral and Clinical Fellowship Award should not exceed $195,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information. Awards supported with FY24 funds will be made no later than September 30, 2025. The CDMRP expects to allot approximately $2.18M to fund approximately seven Postdoctoral and Clinical Fellowship Award applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

NHTSA is responsible for reducing vehicle-related fatalities and injuries on our nations highways. Over the years, NHTSA has developed a significant body of evidence supporting the effectiveness of certain traffic safety laws, regulations and policies that can reduce traffic crashes. State legislatures effectuate traffic safety policy through enacting laws that aim to reduce fatalities and injuries due to motor vehicle crashes. In addition to other salient information, State legislators benefit from learning about the implementation and effectiveness of other jurisdictions traffic safety laws to provide a foundation to make informed decisions on effective traffic safety policy. Therefore, the tracking of laws, sharing of information regarding effectiveness and outcomes, legislative staff, and transportation stakeholders is critical to the publics safety. Since it is vital that information regarding effective traffic safety laws and legislative trends be available to the groups mentioned above, NHTSA seeks to engage an organization that serves legislators and staffs of the nation's 50 states and territories (hereafter, the term State will include the District of Columbia, Puerto Rico and U.S. territories) to educate members of state legislatures to canvass and review the various state laws addressing traffic safety issues that can form the basis for new or improvements to existing state traffic safety laws. In addition, NHTSA seeks to identify best practices for members of state legislatures to communicate and cooperate both at the intrastate and interstate level to develop effective traffic safety laws. The information gathered, research conducted, and materials created would also be available to stakeholders and the public to benefit a larger understanding of the ways laws at the State level influence overall safety.

This Funding Opportunity Announcement (FOA) aligns with DOEs Office of Resource Sustainabilitys Methane Emissions Mitigation and Quantification Program to minimize emissions of methane during production, processing, and transportation across the oil and natural gas industry, with the goal of eliminating methane emissions from carbon-based fuel supply chains by 2030. Effective methane emissions mitigation strategies are dependent upon accurate quantification of both intentional and fugitive emissions from all elements across the natural gas infrastructure, including low producing oil and gas wells. Therefore, there is a continual need to maintain a state-of-the-industry understanding methane emissions mitigation opportunities and operation performance, through collection of empirical data, across oil and natural gas production and delivery regions of the United States. This is to maximize the value of these efforts to the public with the goals of reducing GHG emissions and improving environmental health and engagement of the affected public, (largely in disadvantaged or frontline communities). The FOA objective is to make funds available to a variety of entities for the purpose of mitigating methane emissions from marginal conventional wells (MCWs) and other oil and natural gas assets; accelerating the commercialization, scale-up and application of innovative methane emissions reduction technologies; and advancing the characterization and reduction of methane emissions through multi-scale, measurement-informed data collection and analysis. Modification 000001 is issued to update Section I.B. of the FOA to include clarifications regarding: Objectives and Background under AOI 3b; Activities Not of Interest under AOI 1 (1a, 1b, and 1c) and AOI 3 (3a and 3b); and well site and field test location as it relates to AOI 2 (2a, 2b, and 2c)

This grant invites organizations and companies to collaborate on innovative health solutions aimed at reducing disease and mortality rates in low-and-middle-income countries.

The Health and Human Services Commission (HHSC) seeks qualified Applicants to implement a Nutrition Incentive Program (NIP) Project. The purpose of the NIP Project is to increase the purchase of fruits and vegetables by low-income households participating in the United States Department of Agriculture Supplemental Nutritional Assistance Program (SNAP). Services must be provided in accordance with the specifications contained in this Request for Application (RFA). Applicants should reference Section II, Scope of Grant Project, for further detailed information regarding the purpose, background, eligible population, eligible activities, and requirements.

Dear Prospective Applicants:The United States Agency for International Development Mission in Burundi (USAID Burundi) is seeking applications from qualified entities to implement a five-year Activity that focuses on Reproductive, Maternal, Newborn, and Child Health, Immunization, and Malaria (RMNCI+M) in Burundi, titled Kira Ukuze, as further described in Section A of this Notice of Funding Opportunity (NOFO). Eligibility for this award is not restricted.Eligible parties interested in submitting an application are encouraged to read this NOFO thoroughly to understand the type of program sought, application submission requirements, and selection process. Applications pursuant to this NOFO will be reviewed utilizing the following two-step process:Phase I: Technical ApplicationApplicants will submit a technical application that will be reviewed for responsiveness to the objectives of this NOFO and then evaluated according to the specific criteria provided in Section E. Eligible parties interested in submitting a technical application are encouraged to thoroughly read this NOFO to understand the type of activity sought, application submission requirements, and selection process. Selected applicants will advance to the Phase II of the selection process to submit a revised technical and cost application.Phase II: Revised Technical Application and Cost ApplicationApplicant(s) advancing to Phase II will receive a list of identified weaknesses, questions, and requests for clarifications resulting from the review of the technical applications. Responses to USAID Burundi feedback must be incorporated into the revised technical application. Subject to the availability of funds, USAID Burundi intends to make a single award to the applicant who best meets the objectives of this funding opportunity based on the merit review criteria described in Section E of this NOFO, subject to a risk assessment in accordance with ADS 303.3.9. While an award is anticipated as a result of this NOFO, USAID Burundi reserves the right to fund any or none of the initial technical applications submitted.

The Waccamaw Community Trust Fund, established by the Waccamaw Community Foundation, is currently accepting applications for grants ranging from $1,000 to $10,000, with individual awards capped at $5,000. This grant program is designed to support a broad spectrum of causes that ultimately aim to enhance the lives of individuals and families residing in Horry and Georgetown counties in South Carolina. The Foundation's mission, as evidenced by this fund, is deeply rooted in local community improvement, focusing on practical support for various non-profit activities. Funding is available for crucial operational aspects such as equipment and supplies, general operating support, and specific special projects or programs. The grant's target beneficiaries are the residents of Horry and Georgetown counties, with an overarching impact goal to improve their quality of life. While the grant duration is not explicitly mentioned, the emphasis is on immediate and sustained community benefit, with a preference for initiatives that can continue after the Foundation's support concludes. The Waccamaw Community Foundation prioritizes proposals that demonstrate sensitivity to emerging needs, offer innovative solutions to existing problems, or initiate promising pilot projects. A key focus is on reducing costs and increasing efficiency for nonprofit organizations, as well as directly impacting those in need. The Foundation also looks for clear plans for continued funding beyond its initial support, indicating a strategic priority on sustainable and long-term positive change. Eligibility for the grant program is strictly defined. Applicants must be IRS-determined 501(c)(3) public charities, government agencies, or recognized houses of worship that are exempt from income tax. Furthermore, organizations must provide programs and services within Horry and/or Georgetown counties and adhere to non-discrimination policies based on age, sex, race, color, sexual orientation, national/ethnic origin, or disability. This commitment to equitable service provision and local impact forms a core part of the Foundation's theory of change, believing that targeted and well-supported local initiatives lead to significant community-wide improvements.

This grant provides funding to establish a council and leadership academy for former unaccompanied children and their sponsors, focusing on empowering their voices, sharing best practices for their support, and enhancing their community leadership skills.

This grant provides funding to Manufacturing Extension Partnership Centers to assess the impact of disasters on small- and medium-sized manufacturers and help them access recovery resources and develop future risk mitigation plans.

This program provides funding to U.S. Manufacturing Extension Partnership Centers to enhance manufacturing capabilities, workforce development, and supply chain resilience for small and medium-sized manufacturers.

Dear Prospective Applicants: The United States Agency for International Development (USAID) is seeking applications for a Cooperative Agreement from qualified entities to implement the above-mentioned Program outlined in the subject NOFO. Eligibility for this award is not restricted. USAID intends to make a single award to the applicant(s) who best meets the objectives of this funding opportunity based on the merit review criteria described in this NOFO subject to a risk assessment. Eligible entities interested in submitting an application are encouraged to read this NOFO thoroughly to understand the type of activity sought, application submission requirements, and selection process. Subject to funding availability, USAID intends to provide up to $13,000,000.00 in total USAID funding to the USAID The Gambia Malaria Elimination Activity (GMEA or activity). To be eligible for award, the applicant must provide all information as required in this NOFO and meet eligibility standards in Section C of this NOFO. This funding opportunity is posted on www.grants.gov, and may be amended. It is the responsibility of the applicant to regularly check the website to ensure they have the latest information pertaining to this notice of funding opportunity and to ensure that the NOFO has been received from the internet in its entirety. USAID bears no responsibility for data errors resulting from transmission or conversion process. If you have difficulty registering on www.grants.gov or accessing the NOFO, please contact the Grants.gov Helpdesk at 1-800-518-4726 or via email at support@grants.gov for technical Assistance. USAID may not award to an applicant unless the applicant has complied with all applicable unique entity identifier and System for Award Management (SAM) requirements detailed in Section D.6.g. The registration process may take many weeks to complete. Therefore, applicants are encouraged to begin registration early in the process. Please send any questions to the point(s) of contact identified in Section G. The deadline for questions is shown above. Responses to questions received prior to the deadline will be furnished to all potential applicants through an amendment to this notice posted to www.grants.gov. Issuance of this notice of funding opportunity does not constitute an award commitment on the part of the Government nor does it commit the Government to pay for any costs incurred in preparation or submission of comments/suggestions or an application. Applications are submitted at the risk of the applicant. All preparation and submission costs are at the applicants expense. Please note that USAID reserves the right to cancel this process at any time without prior notice. Thank you for your interest in USAID programs.` Sincerely,

This grant invites government, academic, and industry collaborators to propose innovative research projects that enhance air warfare and weapons technology for the Navy and Marine Corps.

The United States Government, represented by the United States Agency for International Development (USAID) in the Republic of Peru, is designing an activity that aims to provide a demand-driven mechanism to help USAID empower local organizations that are current partners or prospective partners to effectively mobilize development funding and manage it to global standards, while successfully delivering strong development outcomes. According to USAID regulations, a local entity is: an individual, company or organization that (1) is legally organized under the laws of one of the above countries; (2) has its principal place of business or operations in one of the above countries; (3) is majority owned by individuals who are citizens or lawful permanent residents of the above countries; and (4) is managed by a governing body the majority of whom are citizens or lawful permanent residents of the above countries. This Request for Information (RFI) is not restricted to any organization category.This RFI has the following purposes:Gather ideas, strategies, and/or approaches on how to facilitate the empowerment of local organizations, thus contributing to the locally-led development in Peru.Request capability statements from interested entities capable of performing the work described in the RFI.USAID is conducting market research to collect information from local and foreign organizations with knowledge and experience in capacity building of different types of organizations (public, private, civil society, non-government organizations, etc.) focused on organizational strengthening. USAID/Peru plans to use the information gathered through this RFI to assist in designing an activity that aims to provide a demand-driven mechanism, empowering both current and prospective partners to effectively mobilize development funding and manage it to global standards, while successfully delivering strong development outcomes.Peru is one of USAIDs priority Missions for localization efforts. RFIs are a tool that USAID uses for market research. If findings of this RFI demonstrate local capacities are available, USAID might choose to restrict the solicitation to local organizations. It is anticipated this will be an acquisition instrument.This is not a request for applications or proposals. USAID/Peru is interested in understanding the critical factors involved in carrying out local capacity strengthening of local entities to improve the performance of a local system to produce locally valued and sustainable development outcomes.

This grant seeks to gather insights and support initiatives aimed at combating illegal fishing and related human rights abuses in the Gulf of Guinea, targeting local organizations, experts, and U.S. government partners involved in marine conservation and labor rights.

The "Ending the HIV Epidemic in the U.S. Ryan White HIV/AIDS Program Parts A and B" grant aims to reduce new HIV infections in the U.S. by focusing resources on the most affected areas and implementing strategies for early diagnosis, effective treatment, prevention, and rapid response to outbreaks, while also improving access to care and support services for those diagnosed with HIV.

Dear Prospective Applicants: The United States Agency for International Development (USAID or the Agency) is seeking applications for a Leader with Associate Award (LWA) from qualified entities to implement the above-mentioned program outlined in the subject NOFO. Eligibility for this award is not restricted. This competition covers both the initial Leader Award and all subsequent Associate Awards. USAID intends to make a single award to the applicant which best meets the objectives of this funding opportunity based on the merit review criteria described in this NOFO subject to a risk assessment. Eligible entities interested in submitting an application are encouraged to read this NOFO thoroughly to understand the type of activity sought, application submission requirements, and selection process. Subject to funding availability, USAID intends to provide up to $200,000,000.00 in total USAID funding (LWA including any future Associate Awards) to support the Sahel Regional Resilience Activity. The initial Leader Award is anticipated not to exceed $35M. Associate Awards may not exceed $75M. There will be no initial associate award(s) with the LWA, and there is no guarantee regarding the number or total estimated amount of Associate Awards. Please send any questions to the point(s) of contact identified in Section G. of attached NOFO . The deadline for questions is shown below . Responses to questions received prior to the deadline will be furnished to all potential applicants through an amendment to this notice posted to www.grants.gov. Issuance of this NOFO does not constitute an award commitment on the part of the Government nor does it commit the Government to pay for any costs incurred in preparation or submission of comments/suggestions or an application. Applications are submitted at the risk of the applicant. All preparation and submission costs are at the applicants expense. Please note that USAID reserves the right to cancel this process at any time without prior notice. Issue Date: June 7, 2024 Deadline for Questions: June 21, 2024 Closing Date: August 2, 2024 Closing Time: 17:30 GMT (Dakar local time) Subject: Notice of Funding Opportunity (NOFO) No.: 72068524RFA00013 Program Title: USAID Sahel Regional Resilience Activity Thank you for your interest in USAID programs.