Grants for Native American tribal organizations - Food and Nutrition

The objective of this research proposal is to develop physiologically based pharmacokinetic (PBPK) model-based mechanistic in vitro in vivo correlations (IVIVCs) for two major types of long acting injectables (LAIs) such as crystalline suspensions and polymer-based implants by considering their distinct characteristics. The goal of the project is to develop a bottom-up mechanistic PBPK model for these two LAI categories by accounting for the influence of critical formulation attributes of each LAI drug product type to predict its in vivo release mechanism. The model formulation parameters and relevant physiology should be informed with suitable in vitro and in vivo experiments. A suitable preclinical animal model can be used to validate the PBPK model based IVIVCs for both LAI suspensions and polymer based implants. The use of PBPK modelling provides a unique opportunity to understand how the physicochemical properties of drug molecules/polymer, implant specific properties, critical formulation attributes, and physiology, among other things, influence the in vivo release mechanisms of LAI drug products and their disposition characteristics. Moreover, once developed, a mechanistic PBPK model can help to define the 'safe space' for critical formulation attributes relevant to the reference listed drug (RLD) product, explain sources of PK variability and extrapolate predictions to human subjects by leveraging animal model data and by accounting for species-specific physiological differences.

This funding opportunity supports research projects that investigate the relationship between HIV and aging, focusing on improving health outcomes for older adults living with HIV, particularly in diverse and underserved populations.

This funding opportunity supports researchers and organizations in improving and sustaining software tools for biomedical and health-related research by adopting best practices and enhancing collaboration within the scientific community.

This funding opportunity provides financial support to local governments, tribal governments, and non-profit organizations in Arizona to enhance urban and community forestry initiatives that promote tree planting, care, and climate resilience.

This grant provides funding to North Dakota organizations for tailored workforce initiatives that address regional employment challenges, including talent attraction, retention, and infrastructure investments.

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit grant applications from neutral, independent institutions and/or organizations to support meetings (e.g., conferences, workgroups, roundtables) that convene a broad range of multiple stakeholders, including those with relevant expertise, to explore, research, and address issues related to medical products, policy, and surveillance methods and systems. Support includes, but is not limited to the design, planning, execution, synthesis, summary, and communication of findings from these forums to a broad range of organizations and individuals.

This funding opportunity provides financial support to schools and child nutrition programs to enhance access to locally sourced foods while integrating agricultural education activities.

This grant provides funding to organizations working to improve environmental justice and community resilience in underserved areas of Arizona, California, Nevada, and Hawaii by addressing issues like air quality, water contamination, and public health disparities.

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit research designed to capacitate, transform, and scale the delivery of HIV testing, prevention, and care services through pharmacists and pharmacies in US and/or global settings. This includes theadvancement of training curricula to enable pharmacy students, pharmacists, pharmacies, and pharmacy systems to deliver the spectrum of needed HIV services with ease, equity, and effectiveness. This NOFO uses the R01 grant mechanism, while RFA-MH-25-186 uses the R21 mechanism. Projects that lack preliminary data or that propose to pilot a novel intervention may be most appropriate for the R21 mechanism. Applications with preliminary data and those proposing large-scale clinical trials or longitudinal analyses should consider using the R01 mechanism.

This grant provides funding to support early-career researchers from diverse backgrounds in developing independent careers focused on Alzheimer's disease and related dementias through mentored training and research opportunities.

This grant provides funding to nonprofit organizations, schools, and community groups in the Mille Lacs Lake Watershed area to support projects that promote environmental stewardship, community beautification, and economic vitality.

This funding opportunity provides financial support to Vermont-based early childhood education centers and K-12 schools to develop programs that integrate local agriculture into their educational environments, enhancing child nutrition and community engagement.

This funding opportunity provides financial support to Vermont municipalities, nonprofits, and government entities for the development, restoration, and maintenance of public recreational trails, including projects for both motorized and non-motorized activities.

This funding opportunity provides $1 million to various organizations to develop and implement strategies for effectively sharing clinical practice guidelines, particularly in underserved communities, to improve healthcare quality and equity.

This funding opportunity supports nonprofit organizations and tribal governments in Colorado, Utah, and Western Kansas that are working to improve health outcomes and promote social justice for underserved communities through innovative and collaborative initiatives.

This funding opportunity supports a central hub for collaboration between the FDA and the generic drug industry, focusing on research and development of complex generics to improve access to safe and effective medications.

This grant provides funding for innovative research on non-malignant blood disorders, focusing on understanding and improving treatments for conditions related to hematology, and is open to universities, nonprofits, and government entities.

This funding opportunity provides $40,000 to recognized Tribal governments for projects that promote sustainable farming and ranching practices, emphasizing environmental restoration and the integration of traditional ecological knowledge.

This funding opportunity supports collaborative projects and initiatives that promote healthy, resilient rural communities in Maine, focusing on areas like affordable housing, economic development, and climate change planning.

This funding opportunity provides financial support for a wide range of organizations to develop innovative therapies for ultra-rare cancers, addressing unmet medical needs in this challenging area.