Grants for Public housing authorities - Food and Nutrition

The objective of this research proposal is to develop physiologically based pharmacokinetic (PBPK) model-based mechanistic in vitro in vivo correlations (IVIVCs) for two major types of long acting injectables (LAIs) such as crystalline suspensions and polymer-based implants by considering their distinct characteristics. The goal of the project is to develop a bottom-up mechanistic PBPK model for these two LAI categories by accounting for the influence of critical formulation attributes of each LAI drug product type to predict its in vivo release mechanism. The model formulation parameters and relevant physiology should be informed with suitable in vitro and in vivo experiments. A suitable preclinical animal model can be used to validate the PBPK model based IVIVCs for both LAI suspensions and polymer based implants. The use of PBPK modelling provides a unique opportunity to understand how the physicochemical properties of drug molecules/polymer, implant specific properties, critical formulation attributes, and physiology, among other things, influence the in vivo release mechanisms of LAI drug products and their disposition characteristics. Moreover, once developed, a mechanistic PBPK model can help to define the 'safe space' for critical formulation attributes relevant to the reference listed drug (RLD) product, explain sources of PK variability and extrapolate predictions to human subjects by leveraging animal model data and by accounting for species-specific physiological differences.

This funding opportunity supports researchers and organizations in improving and sustaining software tools for biomedical and health-related research by adopting best practices and enhancing collaboration within the scientific community.

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit grant applications from neutral, independent institutions and/or organizations to support meetings (e.g., conferences, workgroups, roundtables) that convene a broad range of multiple stakeholders, including those with relevant expertise, to explore, research, and address issues related to medical products, policy, and surveillance methods and systems. Support includes, but is not limited to the design, planning, execution, synthesis, summary, and communication of findings from these forums to a broad range of organizations and individuals.

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit research designed to capacitate, transform, and scale the delivery of HIV testing, prevention, and care services through pharmacists and pharmacies in US and/or global settings. This includes theadvancement of training curricula to enable pharmacy students, pharmacists, pharmacies, and pharmacy systems to deliver the spectrum of needed HIV services with ease, equity, and effectiveness. This NOFO uses the R01 grant mechanism, while RFA-MH-25-186 uses the R21 mechanism. Projects that lack preliminary data or that propose to pilot a novel intervention may be most appropriate for the R21 mechanism. Applications with preliminary data and those proposing large-scale clinical trials or longitudinal analyses should consider using the R01 mechanism.

This grant provides funding to support early-career researchers from diverse backgrounds in developing independent careers focused on Alzheimer's disease and related dementias through mentored training and research opportunities.

This funding opportunity provides $1 million to various organizations to develop and implement strategies for effectively sharing clinical practice guidelines, particularly in underserved communities, to improve healthcare quality and equity.

This funding opportunity supports a central hub for collaboration between the FDA and the generic drug industry, focusing on research and development of complex generics to improve access to safe and effective medications.

This grant provides funding for innovative research on non-malignant blood disorders, focusing on understanding and improving treatments for conditions related to hematology, and is open to universities, nonprofits, and government entities.

This funding opportunity supports high-risk, multi-center clinical trials aimed at improving treatment for diseases related to diabetes, digestive, kidney, and metabolic disorders, with a strong emphasis on community engagement and health equity.

This funding opportunity provides financial support for a wide range of organizations to develop innovative therapies for ultra-rare cancers, addressing unmet medical needs in this challenging area.

This grant provides funding to research institutions and organizations to study gastrointestinal disorders related to the body's ability to sense internal signals, with the goal of improving understanding and treatment options for these conditions.

This funding opportunity supports a wide range of research projects aimed at advancing medical knowledge and improving health, available to various organizations including universities, nonprofits, and businesses.

This program provides financial assistance to low-income families to improve their home's energy efficiency, helping them save on energy costs while ensuring their health and safety.

This grant provides financial support to nonprofit organizations that improve the lives of women, children, and families in Bertie and Hertford counties, North Carolina, focusing on health, education, and human services.

This grant provides funding to support the planning and preparation of high-risk, multi-center clinical studies focused on diabetes, kidney diseases, and related conditions, particularly benefiting underserved populations.

This grant provides funding to nonprofit organizations in Kent County that assist economically disadvantaged populations by addressing basic needs such as homelessness, hunger, and healthcare.

This grant provides funding to nonprofit organizations and community-benefit government agencies in Delaware to improve healthcare access and reduce health disparities for uninsured and underserved communities.

This grant provides funding to nonprofit organizations that serve the communities of Beaufort and Hyde counties in North Carolina, supporting various local initiatives that address community needs.

This funding opportunity supports researchers conducting innovative basic science studies involving human participants to explore fundamental biological and behavioral processes without focusing on product development or clinical outcomes.

This grant provides funding for innovative research on the effects of HIV on aging, targeting projects that explore the health and quality of life of older adults living with HIV.