Grants for Public housing authorities - Science and Technology

The objective of this research proposal is to develop physiologically based pharmacokinetic (PBPK) model-based mechanistic in vitro in vivo correlations (IVIVCs) for two major types of long acting injectables (LAIs) such as crystalline suspensions and polymer-based implants by considering their distinct characteristics. The goal of the project is to develop a bottom-up mechanistic PBPK model for these two LAI categories by accounting for the influence of critical formulation attributes of each LAI drug product type to predict its in vivo release mechanism. The model formulation parameters and relevant physiology should be informed with suitable in vitro and in vivo experiments. A suitable preclinical animal model can be used to validate the PBPK model based IVIVCs for both LAI suspensions and polymer based implants. The use of PBPK modelling provides a unique opportunity to understand how the physicochemical properties of drug molecules/polymer, implant specific properties, critical formulation attributes, and physiology, among other things, influence the in vivo release mechanisms of LAI drug products and their disposition characteristics. Moreover, once developed, a mechanistic PBPK model can help to define the 'safe space' for critical formulation attributes relevant to the reference listed drug (RLD) product, explain sources of PK variability and extrapolate predictions to human subjects by leveraging animal model data and by accounting for species-specific physiological differences.

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to develop systemic drug delivery platforms for medical countermeasures (MCMs). The Hermes program is explicitly seeking transformative approaches enabling the development of delivery platforms with systemic biodistribution, exceptional endosomal escape efficiency, and minimal toxicity. Successful proposals will include a detailed description of the proposed delivery platform including 1) screening pipeline, 2) reporter systems for monitoring biodistribution and expression in animal models, 3) methods to monitor immunogenicity/toxicity, and 4) chosen therapeutic cargo and justification. Systemic delivery platforms developed under the Hermes effort will be transferred to U.S. Government stakeholders for further development.

This grant provides funding for collaborative biomedical and behavioral research projects between U.S. institutions and Finnish researchers, focusing on areas like population health and disease prevention.

This funding opportunity supports researchers in developing innovative small animal and human cellular models to study the complex interactions between the central nervous system and the immune system in individuals living with HIV who are on antiretroviral therapy.

With this solicitation, NIJ seeks to fund proposals for rigorous research and evaluation projects examining the impact of court and other criminal justice tools, practices, and policies on the administration of justice and public safety in state, local, and tribal jurisdictions. In FY2024, the solicitation is focused on four research priorities and their impact on charging, case flow, outcomes, and other prosecution functions: 1) advance prosecution practice and resource management; 2) promote fair prosecution and impartial administration of justice; 3) build prosecution data resources, research capacity, and transparency; and 4) enhance the prosecution workforce and court workgroup.

With this solicitation, NIJ seeks proposals for rigorous research and evaluation projects that inform policy and practice in the field of youth justice and delinquency prevention. Specifically, this solicitation seeks proposals for studies that advance knowledge and understanding in the following two categories: 1. Youth Justice Reinvestment Studies which evaluate the effectiveness, including cost-effectiveness, of youth justice system reforms and subsequent reinvestments into programs that serve youth in their communities. 2. Prevention and Intervention Program Effectiveness Studies which evaluate the effectiveness of school and community-based prevention and intervention programs.

This funding opportunity supports research centers focused on improving mental health and addressing health disparities related to HIV/AIDS, particularly for early-career and underrepresented researchers.

This funding opportunity supports experienced researchers in expanding their expertise and exploring new research directions in the fields of hearing, balance, smell, taste, voice, speech, and language sciences through intensive career development and basic experimental studies involving human participants.

This program provides researchers access to advanced genomic sequencing and genotyping services to help identify genetic factors related to health and disease.

This funding opportunity provides financial support for research and evaluation projects that explore the impact of forensic science on the criminal justice system, targeting a wide range of eligible applicants including government agencies, educational institutions, and nonprofit organizations.

This funding program provides financial support to public and private water providers, municipalities, and nonprofit organizations for projects that develop alternative water supplies and implement water conservation technologies in South Florida.

This grant provides funding for a variety of organizations to conduct multidisciplinary research on how addictive substances affect specific neural cell populations in the brain, aiming to create a comprehensive inventory of these neural ensembles and develop tools for analysis and visualization.

This funding opportunity supports community-driven research projects aimed at improving health outcomes and reducing disparities for Native Hawaiian and Pacific Islander populations through innovative interventions and studies.

This funding opportunity supports U.S.-based researchers and organizations in developing advanced 3-D tissue models for drug screening, aiming to improve drug testing and accelerate therapeutic discovery while reducing reliance on animal models.

This funding opportunity provides financial support for a wide range of organizations to conduct research and analysis on kidney diseases, focusing on participant recruitment, tissue analysis, and collaborative scientific discovery.

This funding opportunity supports the development of a cloud-based platform for storing and analyzing genetic data related to Alzheimer's disease, aimed at enhancing collaboration among researchers from various institutions and disciplines.

This funding opportunity supports innovative projects in Washington state that convert industrial waste into valuable resources, encouraging collaboration among various sectors to promote sustainability and strengthen local economies.

This funding opportunity provides financial support to various organizations for the development and maintenance of specialized laboratory animal colonies and biological resources essential for advancing biomedical research.

This funding opportunity is designed for eligible entities to develop and maintain fast electric vehicle charging stations along key highways in North Carolina, promoting a robust and accessible EV infrastructure.

This funding opportunity supports research institutions and organizations in studying the factors that influence research integrity, aiming to prevent misconduct and promote ethical research practices.