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Grants for Small businesses - Federal

Explore 1,962 grant opportunities

Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 2, 2028

Date Added

May 13, 2025

This funding opportunity supports researchers in conducting innovative single-site clinical trials aimed at improving health outcomes related to heart, lung, blood, and sleep disorders, with a focus on addressing public health disparities.

Health
Public and State controlled institutions of higher education
Fundamental Research to Counter Weapons of Mass Destruction
$2,500,000
U.S. Department of Defense (Defense Threat Reduction Agency)
Federal

Application Deadline

Sep 30, 2034

Date Added

Oct 2, 2024

This funding opportunity supports innovative research to develop strategies and technologies for countering threats from weapons of mass destruction, targeting a wide range of applicants including universities, nonprofits, and businesses.

Science and Technology
Public and State controlled institutions of higher education
Injury Prevention and Control Research and State and Community Based Programs - RFA-GH-18-000
Contact for amount
U.S. Department of Health and Human Services (Centers for Disease Control and Prevention - ERA)
Federal

Application Deadline

Sep 30, 2030

Date Added

Oct 13, 2023

This funding opportunity provides financial support to a wide range of organizations, including state governments, universities, and non-profits, to develop and implement innovative programs focused on preventing and controlling injuries at the community level across the United States.

Health
County governments
Rfa-Cc-18-000
Contact for amount
U.S. Department of Health and Human Services (Centers for Disease Control and Prevention - ERA)
Federal

Application Deadline

Sep 30, 2030

Date Added

Nov 26, 2025

This funding opportunity provides financial support to a wide range of organizations, including states, universities, and nonprofits, to implement evidence-based initiatives aimed at preventing injuries and improving public health outcomes.

Health
State governments
Arctic Research Opportunities
$50,000,000
National Science Foundation
Federal

Application Deadline

Jan 15, 2027

Date Added

May 21, 2025

This funding opportunity supports U.S. researchers and organizations in studying the rapidly changing Arctic environment and its social systems, promoting interdisciplinary collaboration and long-term observations.

Science and Technology
Public and State controlled institutions of higher education
NCI Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 14, 2027

Date Added

Nov 21, 2024

This grant provides financial support to promising postdoctoral researchers in cancer-related fields, helping them transition to independent faculty positions through a structured mentorship and research development program.

Education
State governments
Bioengineering Research Grants (BRG) (R01 Clinical Trial Optional)
$500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 5, 2026

Date Added

Sep 10, 2025

This funding opportunity supports innovative bioengineering projects that integrate physical sciences with biomedical research to develop new technologies and methods for improving human health.

Science and Technology
Nonprofits
DE-FOA-0003646 Notice of Intent to Issue DE-FOA-0003647 Accelerating Scale-up and Pre-piloting of Emerging Chemical Technologies (ASPECT)
$58,000,000
U.S. Department of Energy (Golden Field Office)
Federal

Application Deadline

Sep 14, 2026

Date Added

Jul 15, 2026

This funding opportunity is designed to support a wide range of domestic organizations, including universities, businesses, and nonprofits, in developing and scaling innovative chemical production technologies that utilize alternative and waste feedstocks to enhance manufacturing and environmental performance.

Energy
For profit organizations other than small businesses
NIH Directors Early Independence Award (DP5 Clinical Trial Optional)
$350,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 10, 2026

Date Added

Dec 12, 2025

This funding opportunity supports exceptionally talented early-career scientists in launching independent research projects immediately after completing their doctoral or clinical training, providing substantial financial resources and institutional backing.

Health
Public and State controlled institutions of higher education
Wetland Mitigation Banking Program Fiscal Year (FY) 2026
$1,000,000
U.S. Department of Agriculture (Natural Resources Conservation Service)
Federal

Application Deadline

Sep 8, 2026

Date Added

Jul 23, 2026

This grant provides funding to various organizations, including local governments and nonprofits, to develop wetland mitigation banks that help agricultural producers comply with conservation regulations.

Agriculture
City or township governments
DoW Neurofibromatosis Research Academy - Scholar Award
$3,600,000
U.S. Department of Defense (Defense Health Agency Contracting Activity - DHACA)
Federal

Application Deadline

Sep 22, 2026

Date Added

Jun 26, 2026

This funding opportunity supports early-career researchers focused on advancing knowledge and treatment for neurofibromatosis disorders through innovative projects and mentorship within a collaborative research academy.

Science and Technology
Public and State controlled institutions of higher education
F26AS00084 Aquatic Invasive Species Grants to Great Lakes Tribes - Fiscal Year 2026 Great Lakes Restoration Initiative
$100,000
U.S. Department of the Interior (Fish and Wildlife Service)
Federal

Application Deadline

Dec 31, 2026

Date Added

May 8, 2026

This funding opportunity provides financial support to Great Lakes Tribes for developing and implementing plans to manage and control aquatic invasive species that threaten the region's ecosystems and waterways.

Environment
Native American tribal organizations
Mechanisms that Impact Cancer Risk after Bariatric Surgery (R01 Clinical Trial Optional)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2028

Date Added

Sep 6, 2024

This funding opportunity supports researchers investigating how bariatric surgery influences cancer risk through biological mechanisms, encouraging studies that go beyond weight loss to explore long-term health effects.

Education
State governments
DoW Hearing Restoration Focused Research Award
$1,200,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Sep 10, 2026

Date Added

May 5, 2026

This funding opportunity supports research projects aimed at developing therapies and diagnostic tools to address hearing loss and auditory system injuries relevant to military personnel and veterans.

Health
Nonprofits
Logistical Support for Citizen Security, counternarcotics, border security, criminal deterrence and Law Enforcement Projects in Honduras
$7,000,000
U.S. Department of State (Bureau of International Narcotics-Law Enforcement)
Federal

Application Deadline

Oct 16, 2026

Date Added

Aug 17, 2026

This grant provides funding to organizations that support law enforcement and public security initiatives in Honduras, focusing on combating drug trafficking and organized crime through logistical and operational assistance.

Law Justice and Legal Services
Nonprofits
INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required)
$3,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 15, 2028

Date Added

Sep 26, 2025

This funding opportunity supports innovative clinical trials aimed at improving health and quality of life for individuals with Down syndrome, inviting a wide range of organizations to apply for financial assistance in addressing critical health issues associated with the condition.

Health
Nonprofits
Clinical and Translational Science Award (UM1 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 28, 2027

Date Added

Sep 5, 2024

This funding opportunity supports medical research institutions in developing collaborative hubs to accelerate the translation of scientific discoveries into effective treatments and address health disparities through innovative research and training programs.

Health
State governments
DoW Spinal Cord Injury, Clinical Trial Award
$4,960,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Nov 12, 2026

Date Added

May 6, 2026

This grant provides funding for clinical trials aimed at improving treatment and management strategies for spinal cord injury, benefiting military Service Members, Veterans, and civilians through innovative research and community collaboration.

Health
Nonprofits
Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

May 7, 2027

Date Added

Apr 25, 2024

This grant provides funding for early-career scientists to conduct independent clinical trials while receiving mentorship and support to develop their research skills and achieve independence in their careers.

Health
State governments
DoW Ovarian Cancer, Clinical Trial Award
$2,800,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Oct 1, 2026

Date Added

May 5, 2026

This funding opportunity supports clinical trials aimed at improving the treatment and management of ovarian cancer, benefiting patients including Service Members, Veterans, and their families.

Health
Nonprofits