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Grants for Small businesses - Federal

Explore 1,962 grant opportunities

NIH Directors Pioneer Award (DP1 Clinical Trial Optional)
$700,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 9, 2026

Date Added

Dec 12, 2025

This funding opportunity supports innovative researchers in the biomedical and health fields who propose groundbreaking ideas that could significantly advance scientific knowledge and improve human health.

Health
Public and State controlled institutions of higher education
Freedom Shield: Global Forced Labor Import Prohibition Initiative
$18,000,000
U.S. Department of Labor (Bureau of International Labor Affairs)
Federal

Application Deadline

Sep 21, 2026

Date Added

Aug 12, 2026

This funding opportunity provides substantial financial support to a wide range of organizations working to combat forced labor in global supply chains.

Employment Labor and Training
Nonprofits
DoW Vision, Translational Research Award
$1,600,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Nov 12, 2026

Date Added

May 4, 2026

This funding opportunity supports innovative research aimed at developing new treatments and technologies for vision-related injuries and dysfunctions resulting from military service.

Health
Nonprofits
Pathways to Enable Open-Source Ecosystems
$1,500,000
National Science Foundation
Federal

Application Deadline

Not specified

Date Added

Jun 2, 2025

This program provides funding to U.S.-based organizations to develop and sustain open-source ecosystems that support community-driven innovations in science and technology.

Science and Technology
Public and State controlled institutions of higher education
Public Wireless Supply Chain Innovation Fund Grant Program Solutions for AI-Native RAN
$25,000,000
U.S. Department of Commerce (National Telecommunications and Information Admini)
Federal

Application Deadline

Sep 9, 2026

Date Added

Jul 15, 2026

This funding opportunity provides substantial financial support to U.S.-based companies developing and demonstrating innovative AI-driven solutions for next-generation wireless networks, with a focus on enhancing the security and competitiveness of the telecommunications supply chain.

Science and Technology
For profit organizations other than small businesses
Pioneering Aerospace Capabilities, Engineering and Research (PACER)
$50,000,000
U.S. Department of Defense (Air Force -- Research Lab)
Federal
Rolling

Application Deadline

May 10, 2043

Date Added

Jul 26, 2023

This grant provides funding for research and development of innovative aerospace technologies to improve military air vehicle performance and capabilities.

Science and Technology
Small businesses
BJA FY 2026 Public Safety and Mental Health Initiative
$3,000,000
U.S. Department of Justice (Bureau of Justice Assistance)
Federal

Application Deadline

Sep 25, 2026

Date Added

Aug 17, 2026

This funding opportunity provides financial support to state and local governments, along with designated mental health agencies, to develop coordinated interventions that improve mental health and substance use treatment, reduce burdens on law enforcement, and enhance public safety in communities.

Law Justice and Legal Services
State governments
DoW Vision, Clinical Trial Award
$2,600,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Nov 12, 2026

Date Added

May 4, 2026

This funding opportunity supports clinical trials aimed at improving the treatment and management of eye injuries and visual dysfunction in Service Members, Veterans, and their families.

Health
Nonprofits
Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 21, 2026

Date Added

May 23, 2025

This funding opportunity supports research projects that develop and test culturally relevant health interventions to improve health outcomes in Native American, Alaska Native, and Native Hawaiian communities, emphasizing community engagement and sustainability.

Health
State governments
Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)
$100,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 16, 2027

Date Added

Oct 29, 2024

This funding opportunity provides financial support for researchers to explore and generate preliminary data on understudied proteins linked to rare diseases, with a focus on enhancing knowledge and tools for future studies.

Health
State governments
DoWs Energy, Installations, and Environment Innovation Partners Programs
Contact for amount
U.S. Department of Defense (Washington Headquarters Services)
Federal

Application Deadline

Jan 8, 2028

Date Added

Feb 28, 2025

This funding opportunity supports a variety of organizations and individuals in developing innovative projects that promote environmental stewardship and energy resilience on military installations, enhancing their operational effectiveness and sustainability.

Environment
Nonprofits
Supporting Implementation of the REIF in the Great Lakes Region of Africa
$14,490,000
U.S. Department of State (Bureau of African Affairs)
Federal

Application Deadline

Sep 9, 2026

Date Added

Aug 11, 2026

This funding opportunity provides financial support to organizations working to improve mining governance and promote responsible investment in critical minerals across the Great Lakes Region of Africa, specifically targeting the Democratic Republic of the Congo, Rwanda, Burundi, and Uganda.

Business and Commerce
Nonprofits
DoW Duchenne Muscular Dystrophy, Idea Development Award
$500,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Sep 18, 2026

Date Added

Jun 18, 2026

This funding opportunity supports innovative research projects aimed at developing effective treatments for Duchenne muscular dystrophy, targeting both pediatric and nonambulatory populations, and is open to independent researchers from various sectors worldwide.

Science and Technology
Nonprofits
Investigator Initiated Innovation in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 7, 2027

Date Added

Nov 19, 2024

This grant provides funding for researchers to develop innovative computational tools and methods that enhance genomic research and data science, with a focus on broad applications to improve human health.

Education
State governments
Silvio O. Conte Digestive Diseases Research Core Centers (P30-Clinical Trial Optional)
$750,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 10, 2027

Date Added

Sep 3, 2025

This funding opportunity supports U.S.-based research centers focused on digestive and liver diseases, providing resources and collaboration to enhance scientific discovery and innovation in this field.

Health
Public and State controlled institutions of higher education
MPS Astronomical Sciences Research Programs (MPS Astro)
$100,000,000
National Science Foundation
Federal

Application Deadline

Nov 16, 2026

Date Added

Aug 18, 2026

This funding opportunity supports innovative research and technology development in astronomical sciences for eligible organizations and researchers, fostering advancements in our understanding of the universe.

Science and Technology
City or township governments
DoW, Peer Reviewed Cancer, Impact Award
$2,000,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Oct 5, 2026

Date Added

May 7, 2026

This funding opportunity supports advanced cancer research projects that aim to improve patient care and treatment outcomes for military personnel, veterans, and their families.

Health
Nonprofits
Special Program Announcement for Office of Naval Research Research Opportunity: FY27 Communications and Networking Applied Research
$500,000
U.S. Department of Defense (Office of Naval Research)
Federal

Application Deadline

Nov 16, 2026

Date Added

Jun 17, 2026

This funding opportunity supports applied research in communications and networking technologies to enhance the operational effectiveness of the Navy and Marine Corps, targeting a wide range of eligible entities including academic institutions, private industry, and nonprofit organizations.

Science and Technology
Nonprofits
DoW Alzheimers Transforming Care Award
$1,900,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Sep 24, 2026

Date Added

May 4, 2026

This funding opportunity supports innovative research and clinical trials aimed at improving dementia care for Service Members, Veterans, their families, and caregivers, with a focus on practical solutions that enhance quality of life and reduce caregiver burden.

Health
Nonprofits
Request for Information - Gauging Investor Interest in the Development and Commercialization of Subsurface Energy Technologies
Contact for amount
U.S. Department of Energy (National Energy Technology Laboratory)
Federal

Application Deadline

Oct 5, 2026

Date Added

Sep 4, 2026

This request seeks input from investors and technology providers on subsurface energy technologies to inform government strategies and foster public-private partnerships in the development and commercialization of innovative energy solutions.

Energy
For profit organizations other than small businesses