Grants for Small businesses - Federal

This funding opportunity supports research to uncover genetic factors related to mental disorders in diverse populations, particularly those of non-European ancestry, while promoting community engagement and career development for early-career researchers.

The DoD Kidney Cancer, Clinical Trial Award is a funding opportunity aimed at supporting the implementation of clinical trials that have the potential to significantly impact the treatment or management of kidney cancer, with a focus on new products, pharmacologic agents, devices, clinical guidance, and emerging approaches and technologies.

This funding opportunity is designed to support the establishment of collaborative research centers that enhance the study and treatment of bone, muscle, and orthopaedic conditions through shared resources and multidisciplinary approaches.

This funding opportunity supports researchers in analyzing existing oral health data or developing new statistical methods to improve data analysis, with a focus on establishing causal relationships rather than just identifying correlations.

This funding opportunity supports small businesses developing innovative technologies for rare diseases and pediatric populations, helping them bridge the gap between research and commercialization.

This ISO seeks solution summary and proposal submissions for projects that fall within the scope of the ARPA-H mission Resilient Systems Office (RSO). RSOs interest areas will address systemic challenges across the healthcare and public health landscape by investing in cutting-edge technologies that address long-standing gaps in the quality, efficacy, and consistent availability of care.Aspects of todays health and public health systems remain fragile due to systemic challenges, which include rising healthcare costs, inadequate healthcare coverage for significant populations, outdated infrastructure, and health disparities among different demographic groups. Acute challenges, such as hospital closures, supply chain disruptions, staffing shortages, cyber-attacks, public health crises, and the emergence of new diseases, further exacerbate existing fragilities, making it more difficult to maintain high standards of care. These challenges are compounded by the fact that systems remain fragmented, hindering the ability to gain comprehensive insights, make informed decisions, develop tailored interventions, and share critical health information between stakeholders.RSO seeks solution summaries and proposals that drive innovations to enhance the adaptability, reliability, and interoperability of the health ecosystem. Of interest are innovations that foster flexibility and enable adaptation to system stressors, so that people and systems remain well-positioned to deliver high-quality care and improve health outcomes. The following interest areas categorize the ground-breaking research we seek to support:Sociotechnical System Innovation: Innovate user-centric digital health tools, platforms, technologies, and intervention models that improve outcomes across the health continuum, including prevention, diagnosis, and treatment of physical, mental, and behavioral health. Approaches to build trust in the healthcare system and distribute high-quality health guidance in an understandable manner that improves patient outcomes. Novel real-time measurement tools to track health outcomes, evaluate post-market performance of new interventions, and enable convergence on the most effective strategies to improve the quality of care, especially for underserved communities. Other population centered innovations to create more resilient communities and subpopulations. Innovations might include aggregate improvements to quality of care and better physical, mental, and behavioral health outcomes for the health ecosystem.Health Ecosystem Integration: Novel ways to collect, protect, secure, integrate, analyze, communicate, and present health data, including but not limited to advances in privacy, cyber security, artificial intelligence with enhanced patient safety properties, low-code or no-code technologies, semantic approaches, and rapid integration techniques. Strategies and technologies to leverage homes, community centers, pharmacies, and other accessible locations to enable new modalities of high-quality care, expand the reach of clinical research, or integrate end-user feedback to rapidly iterate prototype designs. Approaches to strengthen the connectivity and interoperability of health data and devices to 5 enable the safe, secure, and seamless exchange of information among healthcare providers, researchers, and stakeholders. Other novel approaches to increase the interoperability of health-related systems in support of improved health outcomes and enhanced transparency across the health ecosystem.Adaptive Antifragile Solutions: Creative approaches to enhance the stability and dependability of the health ecosystem through new adaptive paradigms, methods that anticipate and mitigate disruptions before they occur, and enhancements to emergency response. Approaches that enable health infrastructure to rapidly integrate information from new sensors; create decision support tools; adapt supply chains, manufacturing, and logistics; and better leverage the workforce during public health emergencies. Novel methods to engineer resilient tissues, microbiomes, and biophysical systems to combat disease or maintain health. Other novel approaches to enhance adaptability and reduce fragility within the health ecosystem.Proposals are expected to use innovative approaches to enable revolutionary advances in science, technology, systems, or methodology. Specifically excluded are proposals that represent an evolutionary or incremental advance in the state of the art or technology that has reached the clinical trial stage. Additionally, proposals directed towards policy changes, traditional education and training, or center coordination, formation, or development, and construction of physical infrastructure are outside the scope of the ARPA-H mission

This funding opportunity provides financial support for innovative breast cancer research projects aimed at preventing the disease, understanding its recurrence, or improving treatment, targeting both early-stage and more developed studies from a range of eligible organizations and researchers.

**AMENDED on DECEMBER 11 2023**: The latest revision is posted as Amendment 18. Potential applicants are strongly encouraged to review the Amendment in its entirety, as it updates several sections. Specifically, ATTACHMENT 1: SPECIFIC TOPICS now includes Basic Research Topics N1-N4, with white papers due by 11:59pm EST on 5 February 2024. White papers may not be considered if they are received after this deadline. In addition, submissions to the general thrust areas in accordance with the requirements detailed in the BAA are also welcome. ** Please note that all correspondence must be sent to the appropriate Agency contact identified in Section 7. Agency Contacts. **

This funding opportunity is designed for U.S.-based small businesses to develop innovative diagnostic and treatment solutions that address health issues arising from non-disordered drug use, such as opioid and stimulant-related complications.

This funding opportunity supports research using human-derived ex vivo models to explore how HIV interacts with addictive substances, focusing on their effects on the brain and immune system.

This funding opportunity supports research on how inflammasome activation affects neurocognitive disorders and immune function in individuals with HIV and substance use disorders, encouraging studies that explore the interactions between these factors.

**CYCLE 4 POSTED ON 10 APRIL 2024. SEE ATTACHED UPDATED ANNOUNCEMENT FOR SPECIFIC TOPICS OF INTEREST IN CYCLE 4 AND SUBMISSION INFORMATION** **CYCLE 3, ORIGINALLY POSTED ON 21 MARCH 2023, IS UPDATED TO INCLUDE A QUESTION AND ANSWER DOCUMENT AND TO UPDATE THE SUBMISSION DATE TO 5 MAY 2023 BY 1700 EASTERN TIME** **CYCLE 3 POSTED ON 21 MARCH 2023. SEE ATTACHED UPDATED ANNOUNCEMENT FOR SPECIFIC TOPICS OF INTEREST IN CYCLE 3 AND SUBMISSION INFORMATION** **CYCLE 2 POSTED ON 8 FEBRUARY 2021. SEE ATTACHED UPDATED ANNOUNCEMENT FOR SPECIFIC TOPICS OF INTEREST IN CYCLE 2 AND SUBMISSION INFORMATION** Purpose: Future Army forces will need to conduct cross-domain maneuver (CDM) and at times, operate semi-independently, disbursed, and while communications and infrastructure such as Global Positioning System (GPS) are disrupted or denied. Robotics and Autonomous Systems (RAS) will play a key role in expanding the operational reach, situational awareness, and effectiveness of maneuver forces in CDM. The Combat Capabilities Development Command (CCDC) Army Research Laboratory (ARL) is focused on developing fundamental understanding and informing the art-of-the-possible for warfighter concepts through research to greatly improve air and ground based autonomous vehicle perception, learning, reasoning, communication, navigation, and physical capabilities to augment and increase the freedom of maneuver in complex and contested environments. The Scalable, Adaptive, and Resilient Autonomy (SARA) program is focused on developing and experimentally accelerating emerging research in autonomous mobility and maneuverability, scalable heterogeneous and collaborative behaviors, and human agent teaming to realize adaptive and resilient Intelligent Systems that can reason about the environment, work in distributed and collaborative heterogeneous teams, and make op-tempo decisions to enable Autonomous Maneuver in complex and contested environments. In order to achieve this vision, advancements are needed in following: Novel methods for all-terrain ground and aerial maneuver to interact with and move through complex environments. Methods for scalable and heterogeneous collaborative behaviors in support of collaborative air and ground manned-unmanned teaming operations. Techniques for improved perception, decision-making, and adaptive behaviors for fully autonomous maneuver in contested environments. Methods, metrics, and tools to facilitate, simulate, and enable testing and evaluation of emerging approaches for intelligent and autonomous systems under Army relevant constraints and environments Experimental testbeds to develop and refine knowledge products to inform and transition technology to Army stakeholders.

TheNational Institute of Allergy and Infectious Diseases (NIAID),intendstopublish a Notice of Funding Opportunity (NOFO) tosolicit applications for a Center of Excellence (CoE) for Systems Modeling of Infection and Immunity across Biological Scales that will: Develop and conduct innovative computational multi-scale modeling research for NIAID priority biomedical questions, including HIV/AIDS; Coordinate the NIAID and broader modeling community that conducts research on infectious- and immune-mediated diseases, through model and data sharing, opportunity funds, educational activities, and community-organizing activities; Conduct innovative research and coordination activities to improve data and model sharing in the NIAID and broader modeling community; Foster a diverse community of new and existing investigators dedicated to Infectious and Immune-mediated Disease (IID) multi-scale modelingand collaboration between experimental and computational scientists; Serve as point of contact to NIAID for the modeling community and pivot research activities to address acutely emerging NIAID needs, such as outbreaks, epidemics, or pandemics; Establish community development and educational opportunities in IID multi-scale modeling for students, post-doctoral fellows, and new/early-stage investigators; Enable new approaches for multi-scale model sharing and reproducibility aligned with theFAIR (Findable, Accessible, Interoperable, and Reusable) principles and theNIAID Data Ecosystem Portal. This Notice isbeing provided toallow potential applicants sufficient timetodevelop meaningful collaborations andprojects. Potentialapplicantsareencouraged tousethistimetodevelop leadership teams to cover the full range of expertise and experience to develop the coordinating cores and research projects that will represent and enable strong scientific and operational connections between the CoE and the larger IID modeling community. This NOFO will utilize theU54 activity code.Details for a pre-application webinar will be provided in the published NOFO.

This grant provides funding to organizations that train commercial truck and bus drivers, focusing on recruiting veterans, their families, and individuals from underserved communities to improve safety and job placement in the transportation industry.

This funding opportunity supports late-stage preclinical studies using adult stem cells to advance regenerative medicine therapies, specifically for researchers who have previously received NIH funding in this area.

This grant provides funding to small businesses developing innovative tools for bioenergy crop engineering to enhance sustainable energy production and reduce carbon emissions.

GCJ seeks to advance victim-survivor-centered investigations and prosecutions of perpetrators of atrocities committed in Burma since 2011, by supporting the implementation of the justice and accountability components of UN General Assembly resolution A/RES/78/219 with respect to the situation of human rights of Rohingya and other ethnic and/or religious minority groups in Myanmar. A successful project will result in the advancement of victim-survivor-centered investigations and prosecutions of perpetrators of atrocities committed in Burma since 2011.

This program provides financial support to agricultural producers and cooperatives for developing and marketing value-added products, helping to increase income and expand market opportunities.

This program provides funding to various organizations and entities to enhance direct sales of locally produced agricultural products, improving access to fresh food in communities across the U.S.

This funding opportunity supports researchers conducting fully remote clinical trials to evaluate the effectiveness of complementary and integrative health interventions, utilizing mobile health technologies without any in-person contact.