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Grants for Small businesses - Federal

Explore 1,962 grant opportunities

Atopic Dermatitis Research Network Clinical Research Centers
$750,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 24, 2026

Date Added

Nov 19, 2025

This funding opportunity supports U.S.-based research centers focused on understanding the biological mechanisms of atopic dermatitis, promoting studies that involve human subjects and aim to improve public health through innovative clinical and translational research.

Health
Public and State controlled institutions of higher education
NIAID Clinical Trial Implementation Cooperative Agreement (U01 Clinical Trial Required)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 5, 2029

Date Added

Jun 28, 2025

This funding opportunity provides financial support for clinical trials focused on infectious, immunologic, and allergic diseases, aimed at organizations and researchers ready to implement their planned studies with enhanced oversight.

Health
Public and State controlled institutions of higher education
Injury Prevention and Control Research and State and Community Based Programs - RFA-SH-18-000
Contact for amount
U.S. Department of Health and Human Services (Centers for Disease Control and Prevention - ERA)
Federal

Application Deadline

Sep 30, 2030

Date Added

Oct 19, 2023

This funding opportunity provides financial support to a wide range of organizations, including state governments, universities, and nonprofits, to develop and implement programs focused on preventing injuries and promoting public health in communities across the U.S.

Health
State governments
Unlocking Dataset Value for AI-Enabled Scientific Discovery (AI Datasets)
$5,000,000
National Science Foundation
Federal

Application Deadline

Nov 4, 2026

Date Added

Jul 22, 2026

This funding opportunity provides support for a wide range of organizations to improve the usability and analytical value of existing scientific datasets through artificial intelligence and advanced data processing methods, fostering interdisciplinary research and innovation.

Science and Technology
Public and State controlled institutions of higher education
Mechanics of Materials and Structures (MOMS)
Contact for amount
National Science Foundation
Federal

Application Deadline

Not specified

Date Added

Jun 12, 2018

This grant provides funding for researchers focused on advancing the understanding and application of mechanics in materials and structures, particularly in areas like deformation, fracture, and innovative computational methods.

Science and Technology
City or township governments
DoW Neurofibromatosis Investigator-Initiated Research Award
$6,040,000
U.S. Department of Defense (Defense Health Agency Contracting Activity - DHACA)
Federal

Application Deadline

Sep 22, 2026

Date Added

Jun 26, 2026

This funding opportunity supports innovative research projects aimed at improving the understanding, diagnosis, and treatment of neurofibromatosis, a genetic disorder that causes tumors on nerve tissue, and is open to a wide range of researchers and institutions.

Science and Technology
Nonprofits
DoW, Ovarian Cancer, Ovarian Cancer Clinical Trial Academy Early-Career Investigator Award
$1,400,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Oct 1, 2026

Date Added

May 5, 2026

This funding opportunity supports early-career researchers in ovarian cancer by providing financial resources and mentorship to develop their skills in conducting impactful clinical trials and translational research.

Health
Public and State controlled institutions of higher education
Rfa-Tp-18-000
Contact for amount
U.S. Department of Health and Human Services (Centers for Disease Control and Prevention - ERA)
Federal

Application Deadline

Sep 30, 2030

Date Added

Nov 26, 2025

This funding opportunity provides financial support to a variety of organizations, including state governments, universities, and nonprofits, to implement innovative public health programs focused on preventing injuries and promoting safety in communities.

Health
State governments
BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)
$10,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 4, 2027

Date Added

May 28, 2025

This funding opportunity supports innovative research projects that develop scalable technologies for mapping brain connectivity, aimed at enhancing our understanding of brain function in health and disease, and is open to a wide range of eligible organizations, including universities and nonprofits.

Science and Technology
Public and State controlled institutions of higher education
DoW Traumatic Brain Injury and Psychological Health, Health Services Research Award
$4,000,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Oct 15, 2026

Date Added

May 7, 2026

This funding opportunity provides up to $4 million for high-impact health services research projects that improve the prevention, diagnosis, and treatment of traumatic brain injury and psychological health issues affecting service members, veterans, and their families.

Health
Nonprofits
Academic-Industrial Partnerships (AIP) to Translate and Validate In Vivo Imaging Systems (R01 Clinical Trial Optional)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 5, 2026

Date Added

Nov 7, 2024

This funding opportunity supports collaborations between academic researchers and industry partners to develop and validate advanced imaging technologies that improve cancer detection and treatment.

Education
State governments
Validation Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U54 Clinical Trials Not Allowed)
$3,200,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 2, 2026

Date Added

Jun 7, 2025

This funding opportunity provides financial support for institutions and organizations to establish a center that rigorously evaluates and validates AI-driven clinical decision support tools that integrate imaging and multimodal health data to improve patient outcomes.

Health
Public and State controlled institutions of higher education
Long Range Broad Agency Announcement (LRBAA) 24-01
Contact for amount
U.S. Department of Homeland Security (DHS), Science and Technology Directorate (S&T)
Federal
Rolling

Application Deadline

May 31, 2029

Date Added

Mar 18, 2025

This grant invites industry and academic researchers to propose innovative solutions that enhance homeland security across various mission areas, including counterterrorism, cybersecurity, and public safety.

Science and Technology
For profit organizations other than small businesses
Reissue of RFA-FD-23-001- Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01 Clinical Trials Required)
$3,600,000
U.S. Department of Health & Human Services (Food and Drug Administration)
Federal

Application Deadline

May 16, 2028

Date Added

Jul 12, 2025

This funding opportunity provides financial support for clinical trials aimed at developing new treatments for rare diseases, benefiting a wide range of organizations involved in medical research and product development.

Agriculture
Nonprofits
Glioblastoma Therapeutics Network (GTN) (U19 Clinical Trial Required)
$3,500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 1, 2026

Date Added

Sep 18, 2025

This funding opportunity is designed to support collaborative research teams from multiple institutions in developing and testing new therapeutic agents for treating adult glioblastoma, a type of brain cancer, through clinical trials.

Health
Nonprofits
Avant Garde/Avenir Awards for Investigators Conducting High Risk/High Reward Research on HIV and Substance Use (or Substance Use Disorders) (DP1 Clinical Trial Optional)
$3,500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 25, 2026

Date Added

May 29, 2025

This funding opportunity supports innovative researchers exploring groundbreaking solutions at the intersection of HIV and substance use disorders, aiming to improve prevention, treatment, and care for affected individuals.

Health
Public and State controlled institutions of higher education
Translational Neural Devices (R61/R33 - Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 28, 2027

Date Added

Oct 31, 2024

This funding opportunity supports the development and clinical testing of innovative neural devices designed to treat nervous system or neuromuscular disorders, encouraging diverse participation and collaboration among various institutions and organizations.

Health
State governments
Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional)
$6,250,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 15, 2027

Date Added

Dec 17, 2024

This funding opportunity provides financial support for innovative research projects focused on improving health outcomes for women, children, pregnant and lactating women, and individuals with disabilities through multisite clinical trials and observational studies.

Health
Public and State controlled institutions of higher education
Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed)
$275,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 16, 2026

Date Added

Nov 19, 2024

This funding opportunity supports innovative research projects that analyze and integrate existing data to improve understanding of cancer risk and outcomes, targeting a wide range of eligible organizations and researchers.

Health
Public and State controlled institutions of higher education
Subsistence Network (SUBNET) Broad Agency Announcement (BAA-0004-21)
Contact for amount
Defense Logistics Agency (DLA), Department of Defense (DoD)
Federal

Application Deadline

Jan 1, 2027

Date Added

Mar 20, 2025

This funding opportunity supports research and development in the military subsistence supply chain, inviting industry, educational institutions, and small businesses to innovate in food production, safety, and logistics for military personnel.

Food and Nutrition
For profit organizations other than small businesses