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Grants for Small businesses - Federal

Explore 1,755 grant opportunities

Long Range Broad Agency Announcement (LRBAA) 24-01
Contact for amount
U.S. Department of Homeland Security (DHS), Science and Technology Directorate (S&T)
Federal
Rolling

Application Deadline

May 31, 2029

Date Added

Mar 18, 2025

This grant invites industry and academic researchers to propose innovative solutions that enhance homeland security across various mission areas, including counterterrorism, cybersecurity, and public safety.

Science and Technology
For profit organizations other than small businesses
Reissue of RFA-FD-23-001- Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01 Clinical Trials Required)
$3,600,000
U.S. Department of Health & Human Services (Food and Drug Administration)
Federal

Application Deadline

May 16, 2028

Date Added

Jul 12, 2025

This funding opportunity provides financial support for clinical trials aimed at developing new treatments for rare diseases, benefiting a wide range of organizations involved in medical research and product development.

Agriculture
Nonprofits
ROSES 2025: Research Opportunities in Space and Earth Science
$5,000,000
National Aeronautics and Space Administration (NASA Headquarters)
Federal

Application Deadline

May 31, 2026

Date Added

Jul 12, 2025

This funding opportunity supports a wide range of research and technology development in Earth and space sciences, aimed at U.S.-based institutions, nonprofits, private entities, and government organizations, to advance NASA's strategic mission goals.

Science and Technology
Public and State controlled institutions of higher education
Glioblastoma Therapeutics Network (GTN; U19 Clinical Trial Required)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

May 27, 2026

Date Added

Sep 18, 2025

This funding opportunity supports diverse research teams in developing innovative therapies for adult glioblastoma, focusing on translating promising treatments into early clinical trials.

Health
State governments
National Cancer Institute Program Project Applications for the Years 2023, 2024, and 2025 (P01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

May 25, 2026

Date Added

Dec 14, 2022

This funding opportunity supports collaborative cancer research projects that integrate multiple disciplines and require at least three interconnected research initiatives, aimed at advancing knowledge in cancer biology, prevention, diagnosis, treatment, or control.

Education
Independent school districts
Translational Neural Devices (R61/R33 - Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 28, 2027

Date Added

Oct 31, 2024

This funding opportunity supports the development and clinical testing of innovative neural devices designed to treat nervous system or neuromuscular disorders, encouraging diverse participation and collaboration among various institutions and organizations.

Health
State governments
Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional)
$6,250,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 15, 2027

Date Added

Dec 17, 2024

This funding opportunity provides financial support for innovative research projects focused on improving health outcomes for women, children, pregnant and lactating women, and individuals with disabilities through multisite clinical trials and observational studies.

Health
Public and State controlled institutions of higher education
Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed) - PAR-25-096
$200,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 7, 2026

Date Added

Nov 19, 2024

This grant provides funding for researchers to analyze and integrate existing cancer-related data to improve understanding of cancer risk, prevention, and outcomes, particularly in underrepresented populations.

Education
State governments
Subsistence Network (SUBNET) Broad Agency Announcement (BAA-0004-21)
Contact for amount
Defense Logistics Agency (DLA), Department of Defense (DoD)
Federal

Application Deadline

Jan 1, 2027

Date Added

Mar 20, 2025

This funding opportunity supports research and development in the military subsistence supply chain, inviting industry, educational institutions, and small businesses to innovate in food production, safety, and logistics for military personnel.

Food and Nutrition
For profit organizations other than small businesses
Tick-Borne Disease Therapeutic/Diagnostic Research Award
$1,325,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Oct 22, 2026

Date Added

May 4, 2026

This funding opportunity supports innovative research projects aimed at developing new treatments and diagnostic methods for Lyme disease and other tick-borne illnesses, particularly benefiting military personnel, Veterans, and the general public.

Health
Nonprofits
Environmental Engineering
$10,000,000
National Science Foundation
Federal
Rolling

Application Deadline

Not specified

Date Added

Jun 2, 2025

This funding opportunity supports innovative research projects that aim to reduce pollution and improve environmental and human health through interdisciplinary approaches in environmental engineering.

Science and Technology
Nonprofits
Dynamics, Control and Systems Diagnostics
Contact for amount
National Science Foundation
Federal
Rolling

Application Deadline

Not specified

Date Added

Mar 30, 2022

This funding opportunity supports researchers in engineering and related fields to explore and improve the behavior, diagnostics, and control of dynamic systems through innovative theoretical, computational, or experimental approaches.

Science and Technology
Public and State controlled institutions of higher education
DoW Military Burn, Patient-Centered Research Award
$1,800,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Oct 21, 2026

Date Added

May 6, 2026

This funding opportunity supports clinical research aimed at improving burn care for military personnel injured in combat or training, particularly in challenging environments where resources are limited.

Health
Nonprofits
Advancing Global Health
$250,000,000
U.S. Department of State (Bureau of Global Health Security and Diplomacy)
Federal

Application Deadline

Feb 14, 2027

Date Added

May 1, 2026

This funding opportunity provides financial support to organizations working to strengthen the health system in the Philippines by improving disease management, service delivery, and public health capacity.

Health
Nonprofits
Chemical Process Systems (CPS)
Contact for amount
National Science Foundation
Federal
Rolling

Application Deadline

Not specified

Date Added

Apr 27, 2026

This program provides funding for researchers and organizations to advance innovative chemical and biochemical processes that improve efficiency, sustainability, and resilience in manufacturing, energy, and environmental applications.

Science and Technology
Public and State controlled institutions of higher education
Open Topics Broad Agency Announcement
$10,000,000
Strategic Environmental Research and Development Program
Federal

Application Deadline

Aug 21, 2026

Date Added

Aug 26, 2025

This funding opportunity supports private sector organizations, including small businesses and nonprofits, in developing innovative environmental technologies and methods to enhance military readiness and resilience for the U.S. Department of Defense.

Environment
For profit organizations other than small businesses
Clean Water State Revolving Fund (CWSRF)
Contact for amount
U.S. Environmental Protection Agency
Federal
Rolling

Application Deadline

Not specified

Date Added

Oct 9, 2025

This program provides low-interest loans to states and eligible entities for various water quality improvement projects, including wastewater treatment and stormwater management, to enhance public health and environmental sustainability.

Environment
Nonprofits
Innovative Solutions Opening
Contact for amount
US Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Mar 5, 2029

Date Added

Jun 19, 2025

This funding opportunity is designed for innovators and organizations developing transformative healthcare technologies that enhance access and affordability, particularly in underserved areas.

Health
For profit organizations other than small businesses
NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens
$200,000
U.S. Department of Health & Human Services (Food and Drug Administration)
Federal

Application Deadline

Apr 1, 2027

Date Added

Jul 12, 2025

This funding opportunity provides financial support to educational institutions, nonprofits, and government entities to enhance surveillance of antibiotic resistance in bacteria found in retail food, particularly raw meats and seafood.

Health
Public and State controlled institutions of higher education
DoW Epilepsy Virtual Post-Traumatic Epilepsy Research Center Leadership Award
$1,600,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Aug 17, 2026

Date Added

May 22, 2026

This funding opportunity supports the establishment of a virtual research center led by a Director and Deputy Director to advance research and improve care for post-traumatic epilepsy, particularly benefiting military service members, veterans, and the general public.

Health
Nonprofits