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Grants for Small businesses - Federal

Explore 1,962 grant opportunities

Forecast to Renew the Funding Opportunity Announcement for Multiple Chronic Disease Research Centers Coordinating Center (U24 Clinical Trial Not Required)
$20,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 26, 2025

Date Added

May 28, 2025

This funding opportunity supports organizations in coordinating research efforts to address multiple chronic diseases and reduce health disparities, particularly in underserved communities.

Health
State governments
Sustainable Regional Systems Research Networks
$30,000,000
National Science Foundation
Federal

Application Deadline

May 15, 2024

Date Added

Jan 27, 2024

The United States is made up of regional systems comprising interdependent urban and rural systems and every community category between urban and rural. Urban systems and rural systems are interdependent for the provisioning of food, energy sources, water, other materials and natural resources, markets, manufactured goods, and medical resources. These systems are also connected by ecological processes that both influence and are influenced by human behavior. The vital interconnection of urban-rural systems underscores the critical need for the advancement of sustainable regional systems (SRS). The goal of this solicitation is to fund convergent research and education that will advance sustainable regional systems science, engineering, and education to facilitate the transformation of current regional systems to enhance sustainability. To further the advancement of SRS science, engineering, and education, NSF will support proposals for Sustainable Regional Systems Research Networks (SRS RNs). Sustainable regional systems are connected urban and rural systems that are transforming their structures and processes collaboratively with the goal of measurably and equitably advancing the well-being of people and the planet. The purpose of the SRS RNs competition is to develop and support interdisciplinary, multi-organizational teams working collaboratively to produce cutting-edge convergent research, education, and outreach that addresses grand challenges in sustainable regional systems. SRS RNs will study multiscale regional systems to further SRS science, engineering, and education. Key elements will include new data, methods, and models to understand interactions between natural, human-built, and social systems; improved understanding of interdependencies, mutual benefits, and trade-offs of different wellbeing outcomes for humans and the environment; new and generalizable theories of change relevant to SRS;theco-production of knowledge; andexploration of conceptsof social equity in sustainable regional systems across spatial and temporal scales. SRS RN outcomes will have the potential to inform societal actions for sustainability across urban systems and the connected rural communities that make up regional systems. Subject to availability of funds and quality of proposals, this SRS RN solicitation will support: SRS RN Awards.These awards will supportfundamental convergent research, education, and outreach that addressesengineering, chemistry, biology, geosciences, mathematics, statistics, environmental, data, computational, education, and social, behavioral, and economic sciences ofsustainable regional systems in partnerships thatmay embrace universities, colleges, federal, state, and local governments, tribal communities, non-governmental and international bodies, non-profit organizations, industry, practitioners, and other community groups. The award size is up to $15 million totalwith a duration of 5 years. SRS RNs will conduct innovative and pioneering fundamental research and education that is of a scale and complexity that would not be possible within a single organization, center, or through the normal collaborative modes of NSF research support in core programs.

Science and Technology
For profit organizations other than small businesses
BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)
$350,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 28, 2025

Date Added

May 23, 2025

This funding opportunity supports the development of innovative computational tools to analyze complex brain data, inviting a diverse range of researchers and organizations to enhance our understanding of neural circuits and their functions.

Science and Technology
Public and State controlled institutions of higher education
DoD Peer Reviewed Cancer, Virtual Cancer Center Director Award
$1,750,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Oct 15, 2024

Date Added

Jun 18, 2024

The DoD Peer Reviewed Cancer, Virtual Cancer Center Director Award is a funding opportunity for established cancer researchers to create and lead a virtual cancer center, which aims to foster collaboration, mentorship, and innovative research among early career investigators across different cancer disciplines, with a focus on convergent science and the development of collaborative seed projects.

Science and Technology
Nonprofits
Supplemental and Alternative Crops
$460,000
U.S. Department of Agriculture (National Institute of Food and Agriculture)
Federal

Application Deadline

Jun 25, 2026

Date Added

May 11, 2026

This funding opportunity supports research and extension projects that promote the development and adoption of nontraditional crops, helping farmers diversify their operations and improve economic resilience across the United States.

Agriculture
Public and State controlled institutions of higher education
Discovery of in vivo Chemical Probes for the Nervous System
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 5, 2026

Date Added

Sep 30, 2025

This funding opportunity provides financial support for researchers developing innovative chemical probes to study biological processes in the nervous system, focusing on understanding brain function and neurological diseases.

Science and Technology
Public and State controlled institutions of higher education
Strengthening national laboratory and HIV epidemiologic monitoring capacities and systems to enhance an efficient, resilient and self-reliant response to HIV, TB and related public health threats in the Kingdom of Eswatini under PEPFAR
$5,000,000
U.S. Department of Health and Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 17, 2026

Date Added

Oct 17, 2025

This grant provides funding to strengthen laboratory and disease monitoring systems in Eswatini, enhancing the country's ability to effectively respond to HIV, tuberculosis, and other public health threats.

Health
State governments
Geothermal Resources’ Value in Implementing Decarbonization (GRID)
$1,500,000
Department of Energy, Office of Clean Energy Demonstrations (OCED)
Federal

Application Deadline

Sep 9, 2024

Date Added

Jul 17, 2024

The Geothermal Resources’ Value in Implementing Decarbonization (GRID) FOA aims to advance the Biden-Harris Administration's goals for a carbon-pollution-free electricity sector by 2035 and a net-zero emissions economy by 2050. The program focuses on regional grid modeling studies to quantify geothermal power's potential contribution to a decarbonized grid. Eligible applicants must submit a Letter of Intent by July 24th, 2024, and full applications by September 9th, 2024. The program offers funding between $500,000 and $1,500,000, with an estimated total funding of approximately $7 million.

Energy
Small businesses
Leveraging Nursing Research to Advance Healthy School Environments for All
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Apr 27, 2026

Date Added

May 29, 2025

This funding opportunity supports a variety of organizations in conducting research to improve health and educational outcomes for youth by creating healthier school environments.

Health
State governments
Advancing Genomic Medicine Research (R21 Clinical Trial Optional)
$250,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 11, 2025

Date Added

Nov 20, 2024

This funding opportunity supports innovative research projects that aim to improve the use of genomic information in clinical care, particularly for diverse populations, with a focus on health outcomes and addressing disparities.

Education
State governments
DoW Peer Reviewed Medical, Impact Award
$3,600,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Aug 6, 2026

Date Added

May 11, 2026

This funding opportunity supports researchers in developing practical medical solutions that improve health outcomes for military service members, veterans, and their families by translating scientific discoveries into clinical applications.

Science and Technology
Nonprofits
Rural Healthcare Provider Transition Project
$800,000
U.S. Department of Health & Human Services (Health Resources and Services Administration)
Federal

Application Deadline

Apr 14, 2025

Date Added

Jul 15, 2024

This funding opportunity provides financial support to small rural hospitals and health clinics to help them improve their healthcare services and transition to a value-based care system for better patient outcomes.

Health
State governments
Promoting Technology for the Common Good and Countering Authoritarian Influence
$1,973,359
U.S. Department of State (Bureau of Democracy Human Rights and Labor)
Federal

Application Deadline

Aug 31, 2026

Date Added

Aug 17, 2026

This funding opportunity provides financial support for organizations to develop ethical technology initiatives that promote human rights and counter authoritarian influences globally.

Science and Technology
Nonprofits
NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed)
$100,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2025

Date Added

Nov 20, 2024

This funding opportunity provides financial support to early-career researchers in the dental and craniofacial fields to conduct pilot studies that will help them secure larger research grants in the future.

Health
State governments
DoW Tuberous Sclerosis Complex, Exploration-Hypothesis Development Award
$350,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Aug 6, 2026

Date Added

May 6, 2026

This funding opportunity supports innovative researchers exploring groundbreaking ideas in tuberous sclerosis complex, aiming to generate preliminary data for future studies that benefit service members, veterans, and the public.

Health
Nonprofits
Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders (OUD/StUD) (R43/R44 - Clinical Trial Optional)
$3,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 14, 2025

Date Added

Mar 28, 2022

This funding opportunity is designed for U.S.-based small businesses to develop FDA-regulated treatments and diagnostic tools for individuals struggling with opioid and stimulant use disorders.

Education
Small businesses
DRL Protecting Workers in Southeast Asia Against Cyber Scam Operations
$800,000
DOS-DRL (Bureau of Democracy Human Rights and Labor)
Federal

Application Deadline

Jun 18, 2024

Date Added

May 3, 2024

The U.S. Department of State, Bureau of Democracy, Human Rights, and Labor (DRL) announces an open competition for organizations interested in eliminating labor abuses and conditions of forced labor connected to cyber scam operations in Southeast Asia.

International Development
Nonprofits
Manufacturing in America E2G Grant Initiative
$5,000,000
U.S. Small Business Administration
Federal

Application Deadline

Not specified

Date Added

May 4, 2026

This initiative provides funding to organizations that deliver hands-on training and technical assistance to small manufacturing businesses in the U.S. to enhance their productivity and competitiveness.

Business and Commerce
Public and State controlled institutions of higher education
Rural Communities Opioid Response Program (RCORP)-Planning
$200,000
U.S. Department of Health and Human Services (Health Resources and Services Administration)
Federal

Application Deadline

Jul 8, 2026

Date Added

Dec 16, 2025

This funding opportunity provides financial support to rural organizations for planning and building partnerships to address opioid use disorder and enhance community health systems.

Health
State governments
Notice of Intent to Publish a Funding Opportunity Announcement for The Confluence of Cancer Stigma and HIV Stigma in HIV-positive Individuals Diagnosed with Cancer (R01 Clinical Trial Optional)
$500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Dec 10, 2024

Date Added

Jul 22, 2024

The National Cancer Institute intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications forresearch on the confluence of cancer stigma and HIV stigma in HIV-positive individuals diagnosed with cancer. This NOFO will utilize the R01 grant mechanism (clinical trial optional). Up to six (6) R01 awards are expected to be funded as part of the initiative. Research projects search project will advance the current understanding of the confluence of cancer stigma and HIV stigma among people with HIV (PWH) diagnosed with cancer; assess the impact of these two converging stigmas on cancer outcomes among PWH with cancer; leverage stigma reduction interventions at multiple levels to intervene on modifiable mechanisms of stigma that contribute to negative cancer outcomes among PWH with cancer; and promote research in diverse domestic and international contexts, focusing on regions in which the HIV-cancer burden is elevated. The NOFO is expected to be published in late Summer 2024 with an expected application due date in late Fall 2024. Details of a pre-application webinar will be announced after the publication of the NOFO. This Notice is being provided to allow sufficient time for potential applicants with relevant expertise and insights to consider applying for this NOFO. Potential applicants are encouraged to view the presentation of this initiative to the Joint Virtual Meeting of the NCI Board of Scientific Advisors and the National Cancer Advisory Board available at https://videocast.nih.gov/watch=54859 beginning at 3 hour, 39 minutes. Presentation slides are downloadable at: https://deainfo.nci.nih.gov/advisory/joint/0624/Vanderpool.pdf.

Health
State governments