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Grants for Small businesses - Federal

Explore 1,859 grant opportunities

NIJ FY25 Research and Evaluation on Human Trafficking
$3,000,000
U.S. Department of Justice (National Institute of Justice)
Federal

Application Deadline

Jun 8, 2026

Date Added

May 5, 2026

This funding opportunity provides financial support for research and evaluation projects aimed at improving responses to human trafficking, particularly along the Southern Border, and is open to a wide range of organizations, including governments, educational institutions, and nonprofits.

Law Justice and Legal Services
State governments
Forecast to Publish a Funding Opportunity Announcement for Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia (U01 Clinical Trial Optional)
$10,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

May 1, 2026

Date Added

May 7, 2025

This funding opportunity supports collaborative research consortia focused on understanding the brain and body mechanisms involved in excessive alcohol use and Alcohol Use Disorder, aiming to improve prevention and intervention strategies.

Health
State governments
National Quantum and Nanotechnology Infrastructure
$10,000,000
National Science Foundation
Federal

Application Deadline

May 14, 2026

Date Added

Feb 16, 2026

This program provides funding to higher education institutions and their partners to create accessible research facilities for quantum and nanotechnology, supporting diverse users including underrepresented groups and small businesses across the U.S.

Science and Technology
Public and State controlled institutions of higher education
Strengthening tuberculosis (TB) prevention, diagnosis, treatment, and surveillance in Asia
$1,000,000
U.S. Department of Health and Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Jun 22, 2026

Date Added

Oct 2, 2025

This funding opportunity provides financial support to organizations working in India, the Philippines, and Vietnam to improve tuberculosis prevention, diagnosis, treatment, and surveillance efforts in these high-burden countries.

Health
Nonprofits
NIAID Physician-Scientist Pathway to Independence Award (K99/R00 Clinical Trial Required)
$698,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Jan 9, 2023

This funding opportunity supports postdoctoral researchers with clinical doctorate degrees in transitioning to independent faculty positions while leading their own clinical trials in biomedical research.

Health
State governments
Prevention, Control, and Mitigation of Harmful Algal Blooms Program
$1,000,000
U.S. Department of Commerce (DOC NOAA - ERA Production)
Federal

Application Deadline

Jul 9, 2026

Date Added

Mar 16, 2026

This funding opportunity provides financial support for U.S.-based researchers and organizations to develop and implement innovative technologies and strategies that prevent, control, or mitigate the impacts of harmful algal blooms on public health and coastal economies.

Environment
Nonprofits
Field Initiated Projects Program (Development) - 0204
$250,000
U.S. Department of Health and Human Services (Administration for Community Living)
Federal

Application Deadline

Not specified

Date Added

Sep 8, 2025

This funding opportunity provides financial support for innovative projects that develop practical solutions to improve the lives of individuals with disabilities, particularly those with the greatest support needs.

Science and Technology
State governments
Advanced Development and Validation of Emerging Biospecimen Science Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed)
$300,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 3, 2025

Date Added

Dec 17, 2024

This funding opportunity supports researchers and organizations developing innovative technologies to improve the quality and handling of cancer-related biospecimens, ultimately enhancing cancer research and addressing health disparities.

Education
State governments
Tuberculosis Research Advancement Centers (TRACs)
$3,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jul 10, 2026

Date Added

Dec 17, 2025

This funding opportunity provides financial support to research institutions and organizations to establish centers that advance tuberculosis research through collaboration, shared resources, and the development of new scientific leaders.

Health
Public and State controlled institutions of higher education
Solar, Heliospheric, and Interplanetary Environment Program
$600,000
National Science Foundation
Federal

Application Deadline

Not specified

Date Added

Oct 23, 2024

This grant provides funding for researchers focused on understanding solar activity and its effects on the Earth's environment, aiming to improve predictions of space weather events.

Science and Technology
Public and State controlled institutions of higher education
NIST MEP Disaster Assessment Program
$1,000,000
U.S. Department of Commerce (National Institute of Standards and Technology)
Federal

Application Deadline

May 8, 2026

Date Added

Jun 20, 2024

This funding opportunity provides financial support to Manufacturing Extension Partnership Centers to help small- and medium-sized manufacturers recover and improve resilience after major disasters.

Disaster Prevention and Relief
Nonprofits
Resilient Software Systems Capstone
$3,000,000
Defense Advanced Research Projects Agency
Federal

Application Deadline

Nov 5, 2025

Date Added

Sep 8, 2025

This initiative provides funding to defense contractors and formal methods developers to enhance cybersecurity in military software systems by integrating advanced verification tools.

Science and Technology
For profit organizations other than small businesses
Supporting life-saving HIV services and related health systems in Zambia on a pathway to self-reliance under the Presidents Plan for AIDS Relief (PEPFAR)
Contact for amount
U.S. Department of Health and Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 17, 2026

Date Added

Oct 17, 2025

This funding opportunity provides financial support to a variety of organizations to enhance HIV prevention, care, and treatment services in Zambia, while strengthening the local health systems and promoting national ownership of these initiatives.

Health
State governments
Infrastructure Investment and Jobs Act (IIJA) Mines Metals Capacity Expansion Piloting Byproduct Critical Minerals and Materials Recovery at Domestic Industrial Facilities
$75,000,000
U.S. Department of Energy (National Energy Technology Laboratory)
Federal

Application Deadline

Jan 15, 2026

Date Added

Nov 17, 2025

This funding opportunity provides financial support for pilot projects that recover critical minerals and materials from industrial processes in the U.S., targeting both coal-based and other industries to enhance domestic supply chain security.

Energy
Public and State controlled institutions of higher education
FY2026 Research Opportunities in Accelerator Stewardship and Accelerator Development
$3,000,000
U.S. Department of Energy (Office of Science)
Federal

Application Deadline

May 21, 2026

Date Added

Mar 13, 2026

This funding opportunity provides financial support for research and development in accelerator technology, targeting academic institutions, national labs, and for-profit companies to advance innovations that benefit multiple scientific fields and enhance domestic manufacturing capabilities.

Science and Technology
Public and State controlled institutions of higher education
ROSES 2025: A.7 Water Quality Applications
Contact for amount
National Aeronautics and Space Administration (NASA Headquarters)
Federal

Application Deadline

Dec 16, 2025

Date Added

Jul 12, 2025

This grant provides funding for research and technology development focused on improving water quality applications, targeting a wide range of organizations including government, private, and non-profit entities involved in environmental science.

Science and Technology
Public and State controlled institutions of higher education
New Generation of Glucose Control Technologies Incorporating AI/ML Tools/Strategies (R01 - Clinical Trial Optional)
$2,500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 17, 2026

Date Added

Jun 19, 2025

This funding opportunity supports innovative research projects that develop advanced glucose control technologies using artificial intelligence and machine learning to improve diabetes management for individuals with type 1 diabetes.

Health
Public and State controlled institutions of higher education
Catalytic Application Testing For Accelerated Learning Chemistries Via High-Throughput Experimentation And Modeling Efficiently (Catalchem-E)
$3,500,000
U.S. Department of Energy (Advanced Research Projects Agency Energy )
Federal

Application Deadline

Feb 25, 2026

Date Added

Nov 15, 2024

This funding opportunity supports multidisciplinary teams in the U.S. to accelerate the development of advanced catalysts for energy applications through high-throughput experimentation and artificial intelligence.

Opportunity Zone Benefits
Individuals
The Experimental Therapeutics Clinical Trials Network (ETCTN) Pharmacokinetic Resource Laboratory (U24 Clinical Trial Not Allowed)
$850,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 30, 2026

Date Added

Jun 28, 2025

This funding opportunity provides financial support for a U.S.-based organization to establish a centralized laboratory that will conduct essential drug behavior analyses for early phase cancer clinical trials, helping to improve the development of new cancer treatments.

Health
Public and State controlled institutions of higher education
Bidirectional Influences Between Adolescent Social Media Use and Mental Health (R01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 20, 2025

Date Added

Oct 31, 2024

This grant provides funding for research projects that explore the complex relationship between adolescent social media use and mental health, particularly focusing on risks, resilience factors, and the experiences of underserved youth.

Health
State governments