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Grants for Small businesses - Federal

Explore 1,859 grant opportunities

ITV - Industrial Technology Validation Program
$400,000
U.S. Department of Energy
Federal

Application Deadline

Jan 29, 2026

Date Added

Dec 23, 2025

This program provides funding for technology developers and industrial facilities to collaboratively test and validate innovative energy-efficient technologies in real-world industrial settings, enhancing their performance and adoption.

Energy
Small businesses
Seeking Products to Address Social Needs impacting Substance Use Disorders (SUD) (R41/R42 Clinical Trial Optional)
$295,924
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2025

Date Added

Sep 28, 2023

This funding opportunity is designed to support small businesses in developing innovative technologies that address social needs impacting substance use disorders, with a focus on improving access to care and reducing barriers for at-risk individuals.

Education
Small businesses
Focused Technology Research and Development (R01 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 22, 2026

Date Added

Nov 15, 2024

This funding opportunity supports innovative projects that develop new tools and technologies to advance biomedical research, targeting a wide range of eligible applicants including universities, nonprofits, and businesses.

Health
State governments
Advancing Learning Health Care Research in Outpatient Mental Health Treatment Settings (R34 Clinical Trial Optional)
$225,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 16, 2025

Date Added

Nov 25, 2024

This funding opportunity supports research collaborations between academic institutions and community behavioral health organizations to improve outpatient mental health and substance use treatment through evidence-based practices.

Education
State governments
Mass Market Solutions for Leveraging Robotics and AI Technologies for Home Construction Demonstration
$10,000,000
U.S. Department of Housing and Urban Development (Office of Policy Development and Research)
Federal

Application Deadline

Jul 13, 2026

Date Added

May 13, 2026

This funding opportunity provides financial support for organizations to develop and demonstrate innovative robotics and AI technologies that improve efficiency and reduce costs in home construction, ultimately increasing housing availability across the United States.

Housing
Nonprofits
Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders(U01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 22, 2026

Date Added

Jan 13, 2025

This funding opportunity supports researchers and organizations in validating biomarkers for neurological and neuromuscular disorders to improve clinical trials and patient care.

Science and Technology
Public and State controlled institutions of higher education
Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2025

Date Added

Jan 24, 2024

This funding opportunity provides financial support to small U.S.-based businesses for the development and validation of analytical methods to measure biomarkers related to neurological and neuromuscular disorders, with an emphasis on enhancing inclusivity and collaboration in research.

Health
Small businesses
NIOSH Exploratory/Developmental Grant Program (R21)
$200,000
U.S. Department of Health & Human Services (Centers for Disease Control and Prevention - ERA)
Federal

Application Deadline

Nov 21, 2025

Date Added

Jan 14, 2025

This funding opportunity supports innovative research projects aimed at improving workplace safety and health by addressing significant occupational hazards in various organizations across the United States.

Health
State governments
Biomedical Technology Optimization and Dissemination Center (BTOD)(RM1-Clinical Trial Not Allowed)
$850,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 27, 2026

Date Added

Mar 7, 2023

This funding opportunity provides financial support to U.S.-based organizations for the late-stage development and dissemination of biomedical technologies that have shown laboratory feasibility, aiming to enhance their accessibility and usability in the research community.

Health
State governments
U.S. Embassy Libya ALUMNI ENGAGEMENT INNOVATION FUND (AEIF) 2026
$35,000
U.S. Department of State (U.S. Mission to Libya)
Federal

Application Deadline

May 10, 2026

Date Added

Apr 20, 2026

This grant provides funding for alumni of U.S. government-sponsored exchange programs to implement innovative community projects that promote economic growth, stability, and collaboration between the United States and Libya.

International Development
Individuals
Chemical Screening and Optimization Facility (X01 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Apr 3, 2026

Date Added

May 19, 2023

This grant provides researchers with access to advanced facilities and technical support for developing non-hormonal contraception and reproductive health products, without direct funding.

Health
State governments
DoD Toxic Exposures Investigator-Initiated Research Award
$770,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Oct 16, 2025

Date Added

Jun 6, 2025

This funding opportunity supports independent researchers in studying the prevention, diagnosis, and treatment of diseases related to military toxic exposures, benefiting Service Members, Veterans, and their families.

Science and Technology
City or township governments
Radar Signal Processing Improvements for Probability of Detection
$250,000
U.S. Department of Defense (DoD)
Federal

Application Deadline

Not specified

Date Added

Feb 19, 2025

This grant provides funding for small businesses to develop innovative radar signal processing techniques that improve the detection of long-range projectiles for the U.S. Army, while maintaining current operational performance.

Science and Technology
Small businesses
NSF-NIST Interaction in Basic and Applied Scientific Research in BIO, ENG MPS
$25,000
National Science Foundation
Federal

Application Deadline

Feb 18, 2026

Date Added

Feb 19, 2026

This funding opportunity provides supplemental support for NSF-funded researchers to collaborate with NIST scientists, enhancing their scientific projects in biological sciences, engineering, and mathematical and physical sciences through access to advanced measurement tools and expertise.

Science and Technology
Public and State controlled institutions of higher education
Mechanistic links between diet, lipid metabolism, and tumor growth and progression (UH2 Clinical Trial Not Allowed)
$200,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 23, 2025

Date Added

Oct 31, 2024

This funding opportunity supports researchers at higher education institutions and nonprofits to explore how dietary fats influence cancer growth and progression through molecular mechanisms, with a focus on preclinical studies.

Education
State governments
Industrialization and Translation of Extracellular Vesicles for use in Regenerative Medicine (U43/U44 Clinical Trials Not Allowed)
$1,972,828
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 6, 2025

Date Added

Jun 7, 2025

This funding opportunity supports small U.S.-based businesses in developing and scaling innovative therapies using extracellular vesicles for regenerative medicine applications, such as tissue and organ repair.

Health
Small businesses
ROSES 2025: Research Opportunities in Space and Earth Science
$5,000,000
National Aeronautics and Space Administration (NASA Headquarters)
Federal

Application Deadline

May 31, 2026

Date Added

Jul 12, 2025

This funding opportunity supports a wide range of research and technology development in Earth and space sciences, aimed at U.S.-based institutions, nonprofits, private entities, and government organizations, to advance NASA's strategic mission goals.

Science and Technology
Public and State controlled institutions of higher education
Glioblastoma Therapeutics Network (GTN; U19 Clinical Trial Required)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

May 27, 2026

Date Added

Sep 18, 2025

This funding opportunity supports diverse research teams in developing innovative therapies for adult glioblastoma, focusing on translating promising treatments into early clinical trials.

Health
State governments
Gabriella Miller Kids First Training and Outreach Core (U24 Clinical Trials Not Allowed)
$800,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 30, 2025

Date Added

May 15, 2025

This funding opportunity supports organizations in developing training and outreach initiatives to enhance the use of pediatric research data, focusing on childhood cancer and congenital anomalies.

Health
State governments
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions with NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Aug 16, 2023

This funding opportunity supports students enrolled in dual-degree medical and research training programs, helping them develop into independent physician-scientists through mentored research and clinical training.

Education
State governments