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Grants for Small businesses - Federal

Explore 1,859 grant opportunities

High-efficiency Nitrogen Oxidation (HNO3)
Contact for amount
U.S. Department of Defense (DARPA - Defense Sciences Office)
Federal

Application Deadline

Feb 5, 2026

Date Added

Dec 2, 2025

This funding opportunity is designed for researchers and organizations developing innovative methods to produce nitric acid more efficiently and sustainably, reducing reliance on traditional ammonia-based processes.

Science and Technology
State governments
Notice of Intent to Publish a Funding Opportunity Announcement for Intellectual and Developmental Disabilities Research Centers 2025 (P50 Clinical Trial Optional)
$18,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 15, 2025

Date Added

May 13, 2025

This funding opportunity is designed to support research centers that focus on improving the diagnosis, treatment, and prevention of intellectual and developmental disabilities through collaborative and interdisciplinary research efforts.

Health
State governments
National Alzheimers Coordinating Center (U24 Clinical Trial Not Allowed)
$10,350,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 17, 2025

Date Added

May 13, 2025

This funding opportunity supports U.S. institutions in establishing a national center to coordinate and enhance research on Alzheimer's Disease and related dementias through data collection, integration, and collaboration efforts.

Health
Public and State controlled institutions of higher education
Heterogeneous Architectures For Quantum
Contact for amount
Defense Advanced Research Projects Agency
Federal

Application Deadline

Oct 14, 2025

Date Added

Sep 15, 2025

This grant provides funding for innovative research and development of advanced quantum computing systems that integrate various architectural approaches to significantly improve performance, targeting a wide range of organizations including universities, businesses, and research centers.

Science and Technology
Public and State controlled institutions of higher education
Cellular Senescence Network (SenNet): SenNet Data Coordination, Integration and Organizational Center (U24 or UM1)
$3,400,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 13, 2025

Date Added

May 29, 2025

This funding opportunity supports the establishment of a center to coordinate research on cellular senescence, aiming to improve health outcomes by identifying tissue-specific markers and developing new therapeutic strategies, targeting a wide range of eligible applicants including educational institutions, nonprofits, and businesses.

Health
State governments
Emerging Health Innovators (EHI) Initiative
$1,050,000
Advanced Research Projects Agency for Health
Federal

Application Deadline

Not specified

Date Added

Mar 18, 2025

This funding opportunity supports early-career researchers and community-based organizations in developing innovative health technologies and interventions to improve health outcomes.

Health
Nonprofits
Early Childhood Comprehensive Systems SEED Project: Scaling Effective Early Childhood Systems Development (ECCS SEED)
$875,000
U.S. Department of Health and Human Services (Health Resources and Services Administration)
Federal

Application Deadline

Jul 10, 2026

Date Added

Dec 15, 2025

This funding opportunity provides support to a variety of organizations, including state and local governments and nonprofits, to improve early childhood health and services for families from pregnancy to age five through coordinated systems and evidence-based practices.

Health
State governments
Small Business Innovation Research (SBIR) Program
$1,000,000
U.S. Department of Education (Institute of Education Sciences)
Federal

Application Deadline

Not specified

Date Added

Sep 12, 2025

This program provides funding to small U.S. businesses to develop and commercialize innovative education technology products that address critical challenges in learning and teaching.

Science and Technology
For profit organizations other than small businesses
Genomic Community Resources (U24 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 25, 2026

Date Added

Mar 1, 2023

This funding opportunity supports the development and sharing of valuable genomic resources for researchers and organizations involved in basic and clinical genomics, ensuring broad access and community engagement.

Education
State governments
Early-stage Biomedical Data Repositories and Knowledgebases (R24 Clinical Trial Not Allowed)
$350,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 25, 2026

Date Added

Aug 30, 2023

This funding opportunity supports the development of new or improved biomedical data repositories and knowledgebases to enhance research and promote data sharing in the biomedical community.

Education
State governments
Space Development Agency Broad Agency Announcement Proliferated Warfighter Space Architecture Systems, Technologies, and Emerging Capabilities
Contact for amount
Space Development Agency
Federal

Application Deadline

Jan 14, 2026

Date Added

Mar 18, 2025

This grant provides funding for innovative technologies and systems that enhance military space operations, targeting industry, academia, and research organizations capable of advancing communication, navigation, tracking, and battle management capabilities.

Science and Technology
State governments
Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers (P50 Clinical Trial Optional)
$1,500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

May 18, 2026

Date Added

Jun 20, 2023

This funding opportunity provides financial support for research centers focused on improving mental health treatments and services for youth and adults in the U.S. through innovative approaches and collaboration among diverse stakeholders.

Health
State governments
NCI Small Grants Program for Cancer Research (NCI Omnibus) (R03 Clinical Trial Optional)
$50,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2026

Date Added

Oct 21, 2024

This funding opportunity provides financial support for small-scale cancer research projects that can be completed quickly, targeting a wide range of organizations, including universities, nonprofits, and businesses, to advance cancer prevention, diagnosis, and treatment.

Education
State governments
Unmanned Robotic Rafting Bays for Military Use
$250,000
U.S. Department of Defense (DoD)
Federal

Application Deadline

Not specified

Date Added

Feb 27, 2025

This funding opportunity is designed for small businesses and innovators to develop autonomous robotic systems for military river crossings, enhancing safety and efficiency in contested environments.

Science and Technology
Small businesses
OVC FY25 Specialized Human Trafficking Assistance: Supporting Survivor Engagement in Anti-Trafficking Programming
$1,200,000
U.S. Department of Justice (Office for Victims of Crime)
Federal

Application Deadline

Feb 24, 2026

Date Added

Dec 31, 2025

This funding opportunity provides financial support to organizations that aim to enhance survivor involvement in anti-human trafficking programs by developing training, resources, and collaborative networks.

Law Justice and Legal Services
Nonprofits
Infrastructure for Population Dynamics Research Program (iPOP)
$4,179,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 19, 2025

Date Added

May 15, 2025

This funding opportunity provides financial support to a variety of institutions for developing research infrastructure that enhances the study of population dynamics, focusing on issues like fertility, mortality, and migration, particularly as they relate to health outcomes and disparities.

Health
State governments
National Center on Program Management and Quality Assurance
$7,000,000
U.S. Department of Health & Human Services (Administration for Children and Families - OHS)
Federal

Application Deadline

Not specified

Date Added

Jun 27, 2025

This funding opportunity provides $7 million to a single organization to enhance leadership and management practices in Head Start programs nationwide, focusing on training, technical assistance, and workforce development for low-income children's education and family services.

Income Security and Social Services
Independent school districts
NCI Research Specialist (Core-based Scientist) Award (R50 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 3, 2025

Date Added

Aug 9, 2023

This grant provides salary support for scientists with advanced degrees who contribute specialized expertise to NCI-funded cancer research programs within core facilities, promoting career stability without requiring independent investigator roles.

Education
State governments
Substance Use/Substance Use Disorder Dissertation Research Award (R36 Clinical Trials Not Allowed)
$50,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Jan 3, 2025

This funding opportunity supports doctoral candidates conducting research on substance use and addiction, focusing on innovative approaches to prevention, treatment, and health disparities among underserved populations.

Education
State governments
New World Screwworm Grand Challenge
$5,000,000
U.S. Department of Agriculture (Animal and Plant Health Inspection Service)
Federal

Application Deadline

Feb 23, 2026

Date Added

Jan 22, 2026

This funding opportunity provides up to $100 million to support innovative research and solutions aimed at preventing the spread of the New World Screwworm, targeting a wide range of eligible applicants including universities, non-profits, and government agencies.

Agriculture
Public and State controlled institutions of higher education