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Grants for Small businesses - Federal

Explore 1,859 grant opportunities

Division of Physics: Investigator-Initiated Research Projects
$120,000,000
National Science Foundation
Federal

Application Deadline

Dec 9, 2025

Date Added

Sep 12, 2025

This funding opportunity provides financial support for a wide range of physics research projects at U.S. institutions, including universities and nonprofit organizations, to advance knowledge in various subfields of physics.

Science and Technology
Public and State controlled institutions of higher education
Genome Sequencing Center for the Gabriella Miller Kids First Pediatric Research Program (U24 Clinical Trial Not Allowed)
$6,600,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 30, 2025

Date Added

May 15, 2025

This funding opportunity provides financial support for a variety of organizations to advance genomic research in pediatric cancers and congenital anomalies, fostering collaboration and innovation in understanding and treating these conditions.

Health
State governments
Clinical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 22, 2026

Date Added

Oct 3, 2024

This funding opportunity supports U.S.-based institutions and organizations in validating candidate biomarkers for neurological and neuromuscular disorders to improve clinical decision-making and therapeutic development.

Health
State governments
FAA Aircraft Pilots Workforce Development Grant Program
$1,000,000
U.S. Department of Transportation (FAA - Aviation Next Gen)
Federal

Application Deadline

Jun 22, 2026

Date Added

May 20, 2026

This program provides funding to educational institutions, flight schools, and organizations to develop training initiatives that address the national shortage of qualified pilots and unmanned aircraft systems operators.

Workforce Development
Nonprofits
Mentored Career Development Program for Early Stage Investigators Using Nonhuman Primate Research Models (K01 Independent Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Jan 10, 2023

This funding opportunity supports early-stage researchers in the U.S. to develop expertise in using nonhuman primate models for biomedical research, with a focus on infectious diseases, neuroscience, and aging, through a structured mentorship program.

Health
State governments
Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42- Clinical Trial Optional)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2025

Date Added

Mar 9, 2024

This funding opportunity supports small businesses in the U.S. to develop innovative technologies that improve health outcomes and reduce disparities for minority populations.

Education
Small businesses
Next-Generation Geothermal Field Tests and Geothermal Resource Characterization and Confirmation
$25,000,000
U.S. Department of Energy (Golden Field Office)
Federal

Application Deadline

May 14, 2026

Date Added

Feb 26, 2026

This funding opportunity provides financial support for U.S.-based organizations to conduct innovative geothermal energy field tests and resource assessments, aiming to expand geothermal energy production across the country.

Energy
State governments
BJS FY25 National Prison Rape Statistics Program (NPRSP) Assessment
$500,000
U.S. Department of Justice (Bureau of Justice Statistics)
Federal

Application Deadline

May 4, 2026

Date Added

Apr 1, 2026

This funding opportunity supports organizations in evaluating and improving data collection efforts related to sexual victimization in correctional facilities across the United States.

Information and Statistics
Private institutions of higher education
Regional Alliances and Multistakeholder Partnerships to Stimulate (RAMPS) Cybersecurity Education and Workforce Development
Contact for amount
U.S. Department of Commerce (National Institute of Standards and Technology)
Federal

Application Deadline

May 28, 2026

Date Added

Apr 14, 2026

This funding opportunity supports the development of community partnerships to create cybersecurity training programs that address local workforce needs and prepare job-ready candidates in the U.S.

Workforce Development
Nonprofits
Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R21 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jul 6, 2026

Date Added

Nov 19, 2024

This funding opportunity supports innovative research projects aimed at improving drug therapies and precision medicine for pregnant individuals, breastfeeding mothers, neonates, and children, particularly those from underrepresented populations.

Health
Public and State controlled institutions of higher education
Microsystems Exploration
$2,000,000
Defense Advanced Research Projects Agency (DARPA)
Federal

Application Deadline

Oct 15, 2025

Date Added

Mar 18, 2025

This funding opportunity supports innovative research proposals from small businesses, academic institutions, and research organizations to develop high-risk, high-reward microsystem technologies for defense applications.

Science and Technology
Private institutions of higher education
Natural Product Multi-Site Clinical Trial Data Coordinating Center (Collaborative U24 Clinical Trial Required)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jul 14, 2026

Date Added

Oct 31, 2024

This funding opportunity supports the establishment of a Data Coordinating Center to manage and oversee multi-site clinical trials evaluating the effectiveness of natural products, aimed at U.S.-based research institutions and organizations.

Health
State governments
Mapping Machine Learning to Physics (ML2P)
Contact for amount
U.S. Department of Defense
Federal

Application Deadline

Dec 9, 2025

Date Added

Sep 29, 2025

This grant provides funding to a diverse range of organizations, including businesses and research institutions, to develop energy-efficient machine learning technologies that can be applied in energy-constrained environments, particularly for national defense.

Science and Technology
Public and State controlled institutions of higher education
Rapid Response Rural Data Analysis and Issue Specific Rural Research Studies
$600,000
U.S. Department of Health and Human Services (Health Resources and Services Administration)
Federal

Application Deadline

Jul 8, 2026

Date Added

May 7, 2026

This funding opportunity provides financial support for organizations to conduct rapid data analysis and targeted research on rural health issues, helping improve healthcare access and quality in underserved rural areas across the United States.

Health
State governments
HIV Prevention and Alcohol (R34 Clinical Trials Optional)
$225,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

May 7, 2026

Date Added

Nov 26, 2024

This funding opportunity provides financial support for pilot studies that develop and test innovative interventions aimed at preventing HIV in populations significantly affected by alcohol use, such as men who have sex with men, sex workers, and individuals recently released from incarceration.

Health
State governments
Title V Competitive Sexual Risk Avoidance Education
$450,000
U.S. Department of Health & Human Services (Administration for Children ; Families - ACYF/FYSB)
Federal

Application Deadline

Not specified

Date Added

Jun 7, 2025

This funding opportunity supports local organizations in underserved states and territories to implement educational programs that encourage youth aged 10 to 19 to avoid non-marital sexual activity and promote healthy life choices.

Youth
Nonprofits
Mitochondrial-associated Mechanisms of Neuropathological and Immunodeficient Aging in the Context of HIV and SUD (R01 Clinical Trials Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Mar 10, 2026

Date Added

Oct 1, 2024

This funding opportunity supports research projects that investigate how mitochondrial function affects brain health and immune aging in individuals living with HIV and substance use disorders, aiming to identify new therapeutic strategies.

Education
State governments
Resource-based Centers for Rheumatic Diseases Research
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 3, 2025

Date Added

May 28, 2025

This funding opportunity is designed to support the establishment of research centers that provide essential resources and infrastructure for advancing studies on rheumatic diseases, encouraging collaboration among researchers and institutions.

Health
State governments
Strengthening the HIV treatment and care program in Sierra Leone to accelerate progress to achieve epidemic control under the President's Emergency Plan for AIDS Relief (PEPFAR)
$12,000,000
U.S. Department of Health and Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 17, 2026

Date Added

Oct 17, 2025

This funding opportunity provides financial support to a wide range of organizations working to improve HIV treatment and care services in Sierra Leone, aiming to enhance healthcare delivery and strengthen local health systems.

Health
For profit organizations other than small businesses
Treating Hereditary Rare Diseases With In Vivo Precision Genetic Medicines
Contact for amount
U.S. Department of Health and Human Services (Advanced Research Projects Agency for Health)
Federal

Application Deadline

Dec 19, 2025

Date Added

Sep 29, 2025

This grant provides funding for multidisciplinary teams, including researchers, industry partners, and patient advocates, to develop innovative genetic therapies for rare hereditary diseases affecting millions of Americans, particularly children, by creating safe and effective one-time treatments.

Health
State governments