Federal Science and Technology Grants

This funding opportunity supports research on the origins, evolution, and distribution of life in the universe, primarily aimed at U.S.-based institutions and eligible international collaborators.

This funding opportunity provides financial support to federally recognized tribes for conservation efforts aimed at protecting and recovering endangered marine and anadromous species.

This grant provides funding for research projects that advance scientific and engineering knowledge to support military and civil missions, targeting a wide range of eligible applicants including educational institutions, non-profits, small businesses, and minority-serving organizations.

This funding opportunity provides $1.8 million to Mississippi State University’s ASSURE program to develop and deliver specialized training in unmanned aircraft systems for emergency management and first responders across the nation.

The DoD Reconstructive Transplant, Advanced Technology Development Award is a funding opportunity aimed at supporting research that translates promising preclinical findings into products or knowledge-based resources that can improve reconstructive transplantation, particularly for military service members, veterans, and their families, with a budget not exceeding $1.0M for single PI applications and $1.5M for multiple PI applications.

This program provides funding to support scientists and engineers returning to academic research after a break, helping them reengage with innovative projects or acquire new skills to advance their careers.

This funding opportunity is designed to support innovative research and development projects that enhance military logistics, supply chain resilience, and operational readiness for the Department of Defense.

This NOFO seeks proposals from eligible applicants for activities to establish and operate a CHIPS Manufacturing USA Institute focused on digital twins with integrated physical assets and computational capabilities (digital assets) to tackle important semiconductor-industry manufacturing challenges. The CHIPS Manufacturing USA Institute will join an existing network of seventeen Institutes designed to increase U.S. manufacturing competitiveness and promote a robust R infrastructure. The Institute will manage a portfolio of Institute-led projects and competitively funded Member-led projects, including Education and Workforce Development (EWD) activities, basic and applied research, and technology demonstrations.

This grant provides funding to U.S. universities to support early-career faculty members in developing innovative research related to space technology, specifically in advanced diagnostics for spacecraft atmospheric entry and autonomous spacecraft navigation using machine learning.

The FY24 PRMRP Lifestyle and Behavioral Health Interventions Research Award (LBIRA) supports clinical research and/or clinical trials using a combination of scientific disciplines including behavioral health, psychology, psychometrics, biostatistics and epidemiology, surveillance, and public health. Applications are required to address and provide a solution to one of the congressionally directed FY24 PRMRP Topic Areas and FY24 PRMRP Strategic Goals.The overall intent of the FY24 PRMRP LBIRA mechanism is to promote evidence-based and patient-centered approaches to improve health and/or disease-related outcomes and enhance the patient experience in defined populations. Research ideas may include, but are not limited to: Development and testing for efficacy of lifestyle interventions and symptom management approaches to minimize disease risk and maximize quality of life. Studies to investigate the impact of prevention, diagnostics, treatment, or health care delivery approaches on health outcomes. Studies to assess the relationship(s) between behavioral, cognitive, and/or social functioning in relation to disease or condition initiation, progression, detection, treatment, and rehabilitation. Studies to examine and improve quality of life or decision-making. Population-focused studies to identify behavioral and lifestyle predictors of disease and/or disease progression.Pre-Application (Letter of Intent) Submission Deadline: 5:00 p.m. Eastern time (ET), May 13, 2024

LIGHT intends to shine a light on the lymphatic system, illuminating the unseen both literally via novel diagnostic approaches and figuratively through insight gained into the critical role the lymphatic system plays in health as well as its impacts when dysfunctional. LIGHT aims to improve the lives of tens of millions of Americans by creating agile tools that are scalable, accessible, accurate and clinically useful to detect lymphatic structure and function. Multiple diagnostic technologies will enable targeted interventions that result in better patient outcomes and reduced treatment costs, and will advance our understanding of lymphatic dysfunction, a key factor in the pathophysiology of many important diseases. Signs and symptoms of lymphatic dysfunction do not manifest until the disease has progressed, and current assessment tools neither adequately appraise lymphatic anatomy nor measure lymphatic function. The Government reserves the right to select for negotiation all, some, one, or none of the proposals received in response to this ISO. If warranted, portions of resulting awards may be segregated into prepriced options. In the event the Government desires to award only portions of a proposal, negotiations will commence upon selection notification. The Government reserves the right to fund proposals in phases with options for continued work, as applicable. The Government reserves the right to request any additional, necessary documentation to support the negotiation and award process. The Government reserves the right to remove a proposal from award consideration should the parties fail to reach agreement on award terms, conditions, cost, and/or if the proposer fails to provide requested additional information in a timely manner. In all cases, the Government will have sole discretion to negotiate all instrument terms and conditions with selectees. ARPA-H will apply publication or other restrictions, as necessary, if it is determined that the research resulting from the proposed effort will present a high likelihood of disclosing sensitive information including Personally Identifiable Information (PII), Protected Health Information (PHI), financial records, proprietary data, any information marked Sensitive but Unclassified (SBU), etc. Any award resulting from such a determination will include a requirement for ARPA-H concurrence before publishing any information or results on the effort. ARPA-H seeks proposals from all eligible entities (see Section 2 Eligibility Information) to accomplish the LIGHT Program goals as described in this solicitation package. Ultimately, ARPA-H intends to negotiate multiple Other Transaction agreements (OTs) and/or Cooperative Agreements (CAs) with proposers whose proposals are most advantageous to the Government and are poised to meet the goals of the LIGHT program. Proposals are expected to use innovative approaches that may include both existing and novel technology, enabling revolutionary advances in medicine and healthcare. The LIGHT program aims to develop a comprehensive diagnostic toolkit to assess lymphatic structure and function, and potential performers should consider an approach to ensure the final technology includes an imaging modality plus biomarkers and/or genetic integration. Initially proposers should consider primary lymphatic 5 diseases as the targeted disease state; however, consideration of other chronic conditions associated with lymphatic dysfunction is encouraged. Specifically excluded are proposals that represent an evolutionary or incremental advance in the current state of the art, including clinical trials of an otherwise developed product. Additionally, proposals directed towards policy changes, traditional education and training, or center coordination, formation, or development, and construction of physical infrastructure are outside the scope of the ARPA-H mission.

This funding opportunity supports early-career researchers and medical residents conducting impactful cancer research relevant to military health, with a focus on improving the quality of life for service members and their families.

This grant provides funding for research on how dam operations impact riparian plant communities along the Colorado River, specifically targeting organizations affiliated with the Colorado Plateau Cooperative Ecosystem Studies Unit.

This initiative seeks input from gas turbine manufacturers and suppliers in the U.S. to identify challenges in the domestic supply chain and inform future investments for reliable electricity generation.

This funding opportunity is designed to support domestic industrial facilities in recovering critical minerals and materials from byproducts, enhancing the U.S. supply chain and reducing reliance on foreign sources.

This funding opportunity provides financial support for CESU partners to develop and improve a flood disturbance model that simulates forest dynamics in floodplain ecosystems along the Upper Mississippi River.

The Confronting Hazards, Impacts and Risks for a Resilient Planet Program (CHIRRP) invites projects focusing on innovative and transformative research that advances Earth system hazard knowledge and risk mitigation in partnership with affected communities. Hazards compounded by changing climates, rising populations, expanding demands for resources, aging infrastructure, and increasing reliance on technology are putting our economy, well-being, and national security at risk. Researchers, academics, and community leaders will work together to develop community-driven research questions and actionable, science-based solutions that increase community resilience now and in the future. CHIRRP projects are expected to advance understanding, forecasting and/or prediction of future Earth system hazards and risks, engage communities in development of research questions and approaches, and produce actionable, science-based solution pathways for adaptation methodologies, products, and services. CHIRRP projects may evaluate a single or system of cascading hazards, impacts, and risks at a local, regional, or global scale through the lens of transformative earth system science research. Competitive projects will engage community partners at all stages of a project from development to implementation. CHIRRP currently supports planning, conference, RCNs, EAGER, and RAISE proposals that support development of community partnerships, provide training for effective community engagement, catalyze ideas, and/or support the initial conceptualization, planning and collaboration activities aimed at formulating new and sound plans for future large-scale projects. CHIRRP Elements CHIRRP projects will demonstrate convergence of three essential elements: (1) Equitable Community Partnerships; (2) an Earth System Science approach to advance knowledge of hazards, impacts, and risks and (3) Actionable Solutions that increase resilience. The initiative seeks solutions to existing as well as next-generation Earth system hazards1. Build Equitable Community Partnerships: CHIRRP projects will serve a community and equitably co-produce project research questions and solutions. CHIRRP teams will bring together community members with direct knowledge of hazard impacts and community priorities and researchers with expertise in the natural and human dimensions of the Earth system. Partners may include, but are not limited to, local governments, Tribal Nations, civil society organizations, youth groups, and non-government organizations (NGOs). Robust partnerships are responsive to community priorities, may involve a social science component, and lead to actionable solutions that increase community resilience. Advance Earth System Science: Generating practical and foundational knowledge on many of the nation's most urgent challenges requires a systems approach to understand the highly interdependent and complex natural and human components of the Earth system. CHIRRP projects will innovate and advance Earth System Science approaches that explore dynamic interactions and couplings among natural and social processes that affect Earths capacity to sustain the well-being of communities, infrastructure, and national security.Evaluate Actionable Science-Based Solutions: CHIRRP deliverables include co-produced innovative, science-based actionable solution pathways that mitigate future hazards, impacts, and risks. Multiple solutions may exist, and new solutions may emerge in the future. CHIRRP projects will inform pathways to resilience through evaluation of different solutions informed by the advancement of earth systems knowledge delivered from the project. An understanding of risk, vulnerability and resilience necessarily entails an understanding of relevant social dynamics including methods and analysis to identify how the impacts of hazards may disproportionately affect specific segments of a community or region. Solutions should be responsive to community priorities, including objectives such as reducing Earth system hazard related risk, increasing resilience, and advancing equity.1National Academies of Sciences, Engineering, and Medicine. 2022. Next Generation Earth Systems Science at the National Science Foundation. Washington, DC: The National Academies Press. https://doi.org/10.17226/26042 [placeholder to add URL link in the text]. [Placeholder to insert CHIRRP image here.]

To obtain a copy of the Funding Opportunity Announcement (FOA) please go to the ARPA-E website at https://arpa-e-foa.energy.gov. To apply to this FOA, Applicants must register with and submit application materials through ARPA-E eXCHANGE (https://arpa-e-foa.energy.gov/Registration.aspx). For detailed guidance on using ARPA-E eXCHANGE, please refer to the ARPA-E eXCHANGE User Guide (https://arpa-e-foa.energy.gov/Manuals.aspx). ARPA-E will not review or consider concept papers submitted through other means. For problems with ARPA-E eXCHANGE, email ExchangeHelp@hq.doe.gov (with FOA name and number in the subject line). Questions about this FOA? Check the Frequently Asked Questions available at http://arpa-e.energy.gov/faq. For questions that have not already been answered, email ARPA-E-CO@hq.doe.gov. Agency Overview: The Advanced Research Projects Agency Energy (ARPA-E), an organization within the Department of Energy (DOE), is chartered by Congress in the America COMPETES Act of 2007 (P.L. 110-69), as amended by the America COMPETES Reauthorization Act of 2010 (P.L. 111-358), as further amended by the Energy Act of 2020 (P.L. 116-260): (A) to enhance the economic and energy security of the United States through the development of energy technologies that (i) reduce imports of energy from foreign sources; (ii) reduce energy-related emissions, including greenhouse gases; (iii) improve the energy efficiency of all economic sectors; (iv) provide transformative solutions to improve the management, clean-up, and disposal of radioactive waste and spent nuclear fuel; and (v) improve the resilience, reliability, and security of infrastructure to produce, deliver, and store energy; and (B) to ensure that the United States maintains a technological lead in developing and deploying advanced energy technologies. ARPA-E issues this Funding Opportunity Announcement (FOA) under its authorizing statute codified at 42 U.S.C. 16538. The FOA and any cooperative agreements or grants made under this FOA are subject to 2 C.F.R. Part 200 as supplemented by 2 C.F.R. Part 910. ARPA-E funds research on, and the development of, transformative science and technology solutions to address the energy and environmental missions of the Department. The agency focuses on technologies that can be meaningfully advanced with a modest investment over a defined period of time in order to catalyze the translation from scientific discovery to early-stage technology. For the latest news and information about ARPA-E, its programs and the research projects currently supported, see: http://arpa-e.energy.gov/. ARPA-E funds transformational research. Existing energy technologies generally progress on established learning curves where refinements to a technology and the economies of scale that accrue as manufacturing and distribution develop drive improvements to the cost/performance metric in a gradual fashion. This continual improvement of a technology is important to its increased commercial deployment and is appropriately the focus of the private sector or the applied technology offices within DOE. In contrast, ARPA-E supports transformative research that has the potential to create fundamentally new learning curves. ARPA-E technology projects typically start with cost/performance estimates well above the level of an incumbent technology. Given the high risk inherent in these projects, many will fail to progress, but some may succeed in generating a new learning curve with a projected cost/performance metric that is significantly better than that of the incumbent technology. ARPA-E funds technology with the potential to be disruptive in the marketplace. The mere creation of a new learning curve does not ensure market penetration. Rather, the ultimate value of a technology is determined by the marketplace, and impactful technologies ultimately become disruptive that is, they are widely adopted and displace existing technologies from the marketplace or create entirely new markets. ARPA-E understands that definitive proof of market disruption takes time, particularly for energy technologies. Therefore, ARPA-E funds the development of technologies that, if technically successful, have clear disruptive potential, e.g., by demonstrating capability for manufacturing at competitive cost and deployment at scale. ARPA-E funds applied research and development. The Office of Management and Budget defines applied research as an original investigation undertaken in order to acquire new knowledgedirected primarily towards a specific practical aim or objective and defines experimental development as creative and systematic work, drawing on knowledge gained from research and practical experience, which is directed at producing new products or processes or improving existing products or processes. Applicants interested in receiving financial assistance for basic research (defined by the Office of Management and Budget as experimental or theoretical work undertaken primarily to acquire new knowledge of the underlying foundations of phenomena and observable facts) should contact the DOEs Office of Science (http://science.energy.gov/). Office of Science national scientific user facilities (http://science.energy.gov/user-facilities/) are open to all researchers, including ARPA-E Applicants and awardees. These facilities provide advanced tools of modern science including accelerators, colliders, supercomputers, light sources and neutron sources, as well as facilities for studying the nanoworld, the environment, and the atmosphere. Projects focused on early-stage R for the improvement of technology along defined roadmaps may be more appropriate for support through the DOE applied energy offices including: the Office of Energy Efficiency and Renewable Energy (http://www.eere.energy.gov/), the Office of Fossil Energy and Carbon Management (https://www.energy.gov/fecm/office-fossil-energy-and-carbon-management), the Office of Nuclear Energy (http://www.energy.gov/ne/office-nuclear-energy), and the Office of Electricity (https://www.energy.gov/oe/office-electricity). SBIR/STTR Program Overview: The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs are Government-wide programs authorized under Section 9 of the Small Business Act (15 U.S.C. 638). The objectives of the SBIR program are to (1) stimulate technological innovation in the private sector, (2) strengthen the role of Small Business Concerns in meeting Federal R needs, (3) increase private sector commercialization of innovations derived from Federal R activities, (4) foster and encourage participation by socially and economically disadvantaged and women-owned Small Business Concerns, and (5) improve the return on investment from Federally funded research and economic benefits to the Nation. The objective of the STTR program is to stimulate cooperative partnerships of ideas and technologies between Small Business Concerns and partnering Research Institutions through Federally funded R activities. ARPA-E administers a joint SBIR/STTR program in accordance with the Small Business Act and the SBIR and STTR Policy Directive issued by the U.S. Small Business Administration (SBA). ARPA-E provides SBIR/STTR funding in three phases (Phase I, Phase II, and Phase IIS). Program Overview: The Technologies to Emend and Obviate SYnthetic Nitrogens Toll on Emissions (TEOSYNTE) program aims to lower nitrous oxide (N2O) emissions from the cultivation of corn and sorghum used for United States ethanol production by 50%. The program will emphasize plant and microbial bio-design strategies that lower the application of synthetic nitrogen (N) fertilizer on corn and sorghum fields while maintaining crop yields and reducing 50% of N2O emissions. Lowering the requirements of synthetic N fertilizer will also lower costs to farmers, as the cost of fertilizer is a significant portion of the operating expenses of a farm. This program will enable technologies to reduce N fertilizer consumption and N2O emissions. These technologies will transform agriculture and lower the N2O contribution to the carbon intensity (CI) of ethanol produced today for light duty vehicles and in the future for sustainable aviation fuel. Technologies developed under the TEOSYNTE program must achieve specific targets as outlined in Section I.E. in order to meet the programs objectives to reduce greenhouse gas (GHG) emissions and N fertilizer usage over multiple seasons while maintaining crop yields. To view the FOA in its entirety, please visit https://arpa-e-foa.energy.gov.

This funding opportunity supports U.S.-based researchers and institutions in advancing space weather science and its operational applications, with a focus on transitioning research findings into practical use.

The DoD Bone Marrow Failure, Idea Development Award is a funding opportunity aimed at supporting innovative and scientifically sound research ideas that contribute to understanding and curing bone marrow failure diseases, with a particular emphasis on hypothesis-driven studies linked to clinical trials, open to both established and early-career investigators.