Agriculture Grants

The FDA seeks an application to continue to maintain, manage existing consortia groups convened and established by the Critical Path Institute. This is a renewal of the cooperative agreement #5U18FD005320 as part of the Critical Path Initiative. This is in support of Critical Path Initiative introduced in Section 566 of the Federal Food, Drug, and Cosmetic Act. This includes developing innovative, collaborative projects in research, education, and outreach for fostering drug product innovation, enabling the acceleration of development, manufacturing, and translational therapeutics, enhancing safety, efficacy, quality, and performance. This funding opportunity will provide support, depending on availability of FDA funding.

The intended outcome of this Notice of Funding Opportunity (NOFO) is to advance efforts for a nationally Integrated Food Safety System (IFSS) by supporting Manufactured Food Regulatory Program Standards (MFRPS), Food Protection Task Force (FPTF) programs, Dietary Supplement (DS) programs, and special projects. For the purposes of this NOFO, the term state encompasses all eligible organizations as defined in Section 3. MFRPS Development or Maintenance: The purpose of this Notice of Funding Opportunity (NOFO) section is to advance efforts for a nationally Integrated Food Safety System (IFSS) by assisting state manufactured food regulatory programs to achieve and maintain conformance with the most current version of the Manufactured Food Regulatory Program Standards (MFRPS). The MFRPS are intended to ensure that state manufactured food regulatory programs implement a high-quality regulatory program through the development and maintenance of a regulatory framework that builds on and emphasizes mutual reliance with all programs. Also, the program standards are intended to enhance food safety by establishing a uniform basis for measuring and improving the performance of manufactured food regulatory programs in the United States. Conformance with these program standards will help federal and state programs better direct their regulatory activities at reducing foodborne illness hazards in plants that manufacture, process, pack, or hold foods. Food Protection Task Force (FPTF): The purpose of this funding option is to establish and/or support a Food Protection Task Force (FPTF) with diverse membership representative of stakeholders across the state that is responsible for promoting the integration of an efficient statewide human and animal food (HAF) protection system that addresses state and region-specific needs and that maximize the protection of the public health. These efforts include: establishing a food safety/protection network of subject matter experts, fostering educational opportunities, developing replicable resources and systematically fostering communication, education, outreach, cooperation and collaboration within the states among federal, state, local, tribal and territorial HAF protection, public health, agriculture, and regulatory agencies, industry, academia, and consumers to initiate and/or support HAF protection activities to improve public health. A strong FPTF can also help improve human and animal food emergency surveillance, response, and post-response systems by focusing on preparedness, building strong communication channels, and establishing relationships with key players before food-related incidents occur. Dietary Supplements: The goal of this funding option is to facilitate the development of state driven dietary supplement regulatory framework and programs. The overall objective of this funding opportunity is to advance the adoption and implementation of the cGMPs for Dietary Supplements Rule codified at 21 CFR Part 111. Specifically, this track will provide funding support for dietary supplement training and program development activities. Special Projects: The purpose of this funding option is to develop and implement special projects that support innovation and integration in a IFSS using the MFRPS framework. This track will support other emerging food safety priorities that develop over the lifespan of the project. State programs will be expected to share project deliverables and resources developed with other programs.

The U.S. Food and Drug Administration (FDA) seeks applications to develop, implement, and evaluate a human abuse potential (HAP) study of botanical Kratom. FDA has previously warned consumers about the use of Kratom (Mitragyna speciosa), a plant indigenous to Southeast Asia. Kratom alkaloids have demonstrated both affinity and activity at receptor sites known to be associated with abuse, such as mu opioid receptors. Although Kratom use is prevalent, to date, clinical evaluations of its abuse potential have been limited. The proposed HAP study should be performed in accordance with the guidance for industry, "Assessment of Abuse Potential of Drugs," including (but not limited to) the selection of an appropriate comparator(s) and outcome measures, statistical analyses etc. Interested parties, will also complete the submission of an Investigational New Drug (IND) application and obtain Institutional Review Board (IRB) clearance.

Modified release (MR) oral drug products are considered to have a high risk for alcohol dose dumping (ADD) because they contain large quantities of drug(s), designed to release over a prolonged period of time. Accidental exposure of these products to alcohol can result in the relatively rapid release of large quantities of drug with severe side effects, including death. To mitigate this risk, the FDA recommends conducting an in vitro alcohol dose dumping assessment in 0%, 5%, 20%, and 40% alcoholic dissolution media for all prospective generic versions of MR oral drug products. To date, ADD assessments have not been harmonized globally. For instance, the U.S. FDA recommends testing up to 40% alcoholic media while the European Medicines Agency recommends testing up to 20% alcoholic media. This type of difference can present a challenge for formulators designing products for multiple markets, as historical data has shown release from MR oral products do not always follow a linear response (either increasing or decreasing) to increasing alcohol concentrations. In addition, interpretation of an ADD assessment may be limited by the inability of the test to predict in vivo behavior. The purpose of this research is to develop tools that 1) facilitate the development of MR generic drug products that have a low potential for ADD, 2) support regulatory decision making during the assessment of such products, and 3) provide evidence that enables FDA to develop more specific recommendations for efficiently demonstrating a low or comparative potential of alcohol dose dumping for MR oral drug products containing high risk drugs.

The purpose of this research is to systematically evaluate the diastereomeric composition of LEQVIO (Inclisiran), an FDA-approved, N-acetyl galactosamine (GalNAc)-conjugated siRNA drug, and to understand the biological/pharmacological activity of each diastereomer in LEQVIO through stereo chemically controlled synthesis and biological activity assessment using in vitro and animal models. The proposed studies will focus on 1) synthesis of each diastereomer of LEQVIO (Inclisiran) in stereo chemically pure form; 2) assessment of the biological activity of each stereo chemically pure diastereomer in inhibiting PCSK9 activity using in vitro assays and in a transgenic mouse model; 3) development of analytical methods to identify and characterize the stereochemical structure of each diastereomer in LEQVIO; and 4) assessment of the individual contribution of each diastereomer to the overall pharmacological activity of LEQVIO. Tools developed in this research can also be applied to other similar GalNAc-conjugated siRNAs specifically, and other siRNAs in general. Knowledge gained from this research will also contribute to the sameness evaluation of generic siRNAs, and to the quality control of oligonucleotide drugs.

The Food and Drug Administration's (FDA), Center for Drug Evaluation and Research (CDER), Office of New Drugs (OND), is announcing this Funding Opportunity Announcement (FOA) for a Cooperative Agreement. The proposed work directly supports the U.S. FDAs stated goal of protecting public health from unacceptable risks from nitrosamine impurities in human drugs. Although significant experimental and policy/regulatory initiatives have been undertaken in this area, there remains a need for further research into and development and refinement of translational and implementable practices that will protect the public against nitrosamine risks while ensuring continued safe access to critical therapeutic drugs. The aim is to improve the safety of human drugs with potential nitrosamine impurity liabilities. In addition to the work outlined above, the award recipient will assess how best to ensure that this research and practices development continues among industry members, non-profits, and/or academic institutions once the FDA funding for this cooperative agreement ends.

The purpose of this funding opportunity is to support the research and development necessary to advance non-invasive (e.g., quantitative tomography-based) technologies, including the development of apparatus, methods, study designs, and methods of data analysis, to characterize and compare the rate and extent to which a topically applied drug becomes available at or near a site of action within the skin in vivo. The expectation is that the funded work will produce an accurate, sensitive and reproducible approach that rapidly measures the (relative) amount of drug present in the skin at a series of depths below the skin surface, which can be utilized to monitor the cutaneous pharmacokinetics (PK) of the drug at selected depths (e.g., in the epidermis) by repeated, serial measurements over time. The intent is to support the eventual development of an alternative, scientifically valid, in vivo cutaneous PK-based approach that can be used to efficiently demonstrate the bioequivalence (BE) of topical products.

This grant provides financial support and resources to nonprofit organizations focused on alleviating food insecurity and promoting inclusivity in underserved communities across the United States.

The Historical Society of Michigan's U.P. Centennial Farms grant opportunity is available for Upper Peninsula farming families who have owned and operated a working farm of 10 or more acres continuously for at least 100 years. This program aims to recognize the historical significance of these farms and their contribution to the culture and development of Michigan. Once certified through the Michigan Centennial Farm Program, owners will receive a certificate and a display marker for their farm. The green-and-yellow markers are sponsored by UPPCO in their Upper Peninsula service area. The following Centennial Farms have been recognized by UPPCO: - Augustus Schaffer Farm (1857) in Ontonagon, certified on 02/01/1962 - James Daniels Farm (1865) in Ontonagon, certified on 01/18/1966 - Jermiah Penegor Farm (1850) in Ontonagon, certified on 06/16/1966 - Alex Rheault Farm (1866) in Houghton, certified on 9/22/1969 - Patrick DeLoughary Farm (1882) in Menominee, certified on 04/15/1982 - August and Sophia Krans Farm (1882) in Iron, certified on 03/08/1985 - Joel David and Anna Millard Farm (1857) in Ontonagon, certified on 05/10/1985 - Peder Olaus Olsen Farm (1884) in Iron, certified on 09/23/1985 - Fred A. and Regina Hall Farm (1889) in Iron, certified on 05/20/1986 - Carl Kunde Farm (1881) in Marquette, certified on 11/24/1986 And many more farms have been recognized.

This grant provides funding to eligible organizations focused on improving environmental health and justice in the Great Lakes region, particularly addressing water quality, lead hazards, and air quality in Wayne, Oakland, and Macomb counties in Michigan.

Grant Opportunity: Saginaw Bay Watershed Pollution Prevention/Chemical Collection Program Description: This grant opportunity is for the construction of a permanent facility to collect pesticides from farmers, homeowners, nurseries, etc. The facility will allow any end user of pesticides to dispose of unwanted materials at no cost. The project was completed in 1999 and is a joint project of the Saginaw County Department of Health and the Michigan Department of Agriculture. Grant Opportunity: Demonstrate Effectiveness of Biodegradable Two-Cycle Engine Oil Description: This grant opportunity is for field testing a soy-based oil that can be used as an alternative to petroleum-based oil in engines such as jet skis, outboard motors, and snowmobiles. The soy-based oil is environmentally preferable as it is 96% biodegradable and does not emit pollutants into the air and water. The funding will be used to demonstrate the safety and performance of the oil and document reductions in emissions into the environment. Grant Opportunity: Saginaw Bay Watershed Native Planting Preserve at Saginaw Valley State University Description: This grant opportunity aims to fund the development of a native planting preserve on the campus of Saginaw Valley State University. The preserve will include plants, signage, and walking trails. The project intends to encourage the use of native plantings in the general public and serve as a demonstration/research site at the university. Grant Opportunity: Alternative Energy from Agriculturally-Derived Pellet Fuel Description: This grant opportunity involves analyzing the technical and economic viability of manufacturing renewable pellet fuel derived from agricultural sources. The research includes studying the economic and environmental impact of using biomass combustion furnaces for heating residential and light industrial buildings. The project also includes developing a web-based interface for real-time telemetry information. Grant Opportunity: Conservation Tillage Risk Protection Program Description: This grant opportunity aims to demonstrate the use of conservation tillage in two subwatersheds of the Tittabawassee River. The

This grant supports nonprofit organizations and collaborations focused on climate justice, resilience, and ecosystem health, promoting systemic change through equity and agroecology initiatives.

This program provides funding to community groups and individuals to improve parks, trails, and public spaces in Lincoln through volunteer-led projects.

Forestry programs under the Southern Pine Beetle Initiative were developed to promote long term investments in Tennessee’s pine forests by providing cost share incentives to qualifying landowners. The Southern Pine Beetle Initiative (SPBI) was developed to encourage landowners to proactively manage their pine forest stands and make them more resilient to beetle infestations. Funds are provided by the USDA Forest Service and administered by the Tennessee Department of Agriculture Division of Forestry (TDF).

This funding opportunity provides financial support to private property owners in New York City for installing green roofs to help manage stormwater runoff.

Forestry programs under the Tennessee Agricultural Enhancement Program (TAEP) were developed to promote long term investments in Tennessee’s forests by providing cost share incentives to qualifying landowners. Forestry programs under the Tennessee Agricultural Enhancement Program (TAEP) were developed to promote long term investments in Tennessee’s forests by providing cost share incentives to qualifying landowners. The programs help promote sustainable forest management practices on family forestland, which provide multiple resource benefits such as timber, wildlife habitat, clean water, and soil protection.

Provide grants to address water quality impairments from nonpoint source pollution from agriculture and other sources. The ARCF provides cost-share assistance to Tennessee landowners to install Best Management Practices (BMPs) that reduce agricultural water pollution. This assistance is facilitated primarily through Soil and Water Conservation Districts although Resource Conservation and Development Councils, universities, and other agricultural associations may participate.

This program provides free pine seedlings to eligible family forest owners in Tennessee to promote reforestation and sustainable timber management on their land.

This program provides financial support to local agricultural producers in Frederick County, Maryland, to help them expand or diversify their operations through innovative practices and infrastructure improvements.

Title: Veteran Homeless and Employment Initiative Application Start Date: 07/01/2023 Application End Date: 06/30/2024 Eligible Applicants: Non Profits Award Amount: $635,050.00 Number of Awards: 1 Average Award Size: $635,050.00 Matching Required: No Summary: The Arizona Department of Veterans' Services (ADVS) is seeking grant applications for the Veteran Homeless and Employment Initiative. The initiative aims to support ongoing statewide collective impact efforts and implementation of three Veteran initiatives focused on ending Veteran homelessness, assisting with employment barriers, and providing a pathway to higher levels of care for Veterans. The grant will provide financial and technical assistance to support homeless Veterans in Maricopa County and throughout the state, as well as facilitate collaborations with new partners to serve Veterans in need. Project Objectives: - Host the Maricopa County StandDown, serving over 2,000 homeless and at-risk Veterans annually. - Provide financial assistance for bridge housing or mitigation throughout the year in Maricopa County. - Provide financial and technical assistance to 11 StandDowns throughout the state. - Assist Veterans with obtaining employment through referrals from employment service providers. - Lead a multi-agency team to ensure programmatic goals are met for homeless Veterans. Contact Information: Robert Davis Arizona Department of Veterans' Services 3839 North 3rd Street, Suite 209 Phoenix, AZ. 85012 Email: rdavis@azdvs.gov