Grants for Small businesses - Federal

This funding opportunity supports researchers and organizations in developing advanced tissue-engineered technologies that mimic cancer biology to improve cancer detection, treatment, and prevention.

This funding opportunity provides financial support for organizations to develop and validate digital therapeutic technologies designed to treat substance use disorders, with the goal of achieving FDA authorization.

This grant provides funding for clinical trials investigating the safety and effectiveness of amyloid-beta antibody therapies in patients with mild cognitive impairment or dementia who also show signs of Lewy Body Dementia, with a focus on diverse and underrepresented populations.

This funding opportunity supports innovative research projects aimed at developing new therapies for Amyotrophic Lateral Sclerosis (ALS), encouraging high-risk ideas that include biomarker development to guide future clinical applications.

This funding opportunity supports research and technology development in advanced telecommunications systems for various industries, including healthcare and transportation, targeting academic institutions, nonprofits, and businesses to foster innovation and collaboration.

To implement a project aimed at advancing U.S. foreign policy and national security priorities by supporting initiatives that make decision-making structures and processes in fragile, conflict, or crisis-affected contexts more reflective of and responsive to the needs and perspectives of partner states to ensure strategic trade control systems meet international standards and by engaging on bilateral, regional and multilateral levels with foreign governments to aid in the establishment of independent capabilities to regulate transfers of weapons of mass destruction, WMD-related items, conventional arms, and related dual-use items, and to detect, interdict, investigate, and prosecute illicit transfers of such items.

The EHDA supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the TSC research field. The studies supported by this award mechanism are expected to generate preliminary data for future avenues of scientific investigation. The proposed research project should include a well-formulated, testable hypothesis based on a strong scientific rationale and study design. Applications should demonstrate the ability to achieve interpretable results in the absence of preliminary data supporting the hypothesis.The following are important aspects of the EHDA: Innovation: Innovative research may introduce a new paradigm, challenge existing paradigms, examine existing problems from new perspectives, or exhibit other highly creative qualities. Research that is an incremental advance upon published data is not considered innovative and is not consistent with the intent of the award mechanism. Although not all-inclusive, the following examples are ways in which the proposed research project may be innovative: Explores a novel idea and/or research question in TSC research and/or patient care. Uses or develops novel methods or technologies to address a question in TSC research and/or patient care. Applies or adapts existing methods or technologies for novel TSC research or clinical purposes that differ fundamentally from those originally intended.

This grant provides funding for state and community programs, as well as research initiatives, aimed at developing and promoting effective strategies to prevent and control injuries and violence, with a focus on health equity and community conditions.

This funding opportunity is designed to support U.S.-based small businesses in developing innovative quantum computing solutions for complex energy-related challenges in computational chemistry and materials science.

This Notice informs that NIA intends to publish a Notice of Funding Opportunity (NOFO) inviting applications from mid-career investigators for mentored career enhancement awards focused on cross-disciplinary training to broaden and strengthen the investigator's capability to lead future comparative studies of the factors contributing to differences in life spans between human and nonhuman primate species. The NOFO is intended to provide support for experienced investigators with expertise in human and/or nonhuman primate (NHP) studies to do the following: 1) Augment or redirect their research program by acquiring expertise in other fields related to comparative primate research and aging 2) Develop collaborations with research fields with which they do not commonly interact This Notice is being provided to allow potential applicants sufficient time to identify potential mentors and prepare well-developed career enhancement plans. The NOFO is expected to be published in June 2024 with an anticipated application due date in November 2024. These are estimated time frames, and they may change. The NOFO is expected to utilize the K18 Career Enhancement Award activity code. It is expected that the NOFO will not allow clinical trials. Additional details of the planned NOFO are provided below.

This funding opportunity provides financial support to small businesses in the U.S. for conducting exploratory clinical trials or biomarker validation studies aimed at advancing therapies for neurological disorders.

This grant provides funding for innovative technologies that improve the Navy and Marine Corps' electronic warfare and surveillance capabilities, targeting researchers and companies developing advanced signal processing, countermeasures, and ISR systems.

This funding opportunity supports partnerships that include domestic academic institutions to develop innovative technologies for extracting and refining rare earth elements from unconventional sources, enhancing the U.S. supply chain and reducing environmental impact.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for identification of small molecules that function to elucidate the biology of disease as chemical probes or function as agonists or antagonists of disease target(s) for therapy or immunotherapy. The NOFO is intended to support discovery research for the identification of validated hits relevant to health-related outcomes of participating NIH Institutes. Stages of discovery research covered by this NOFO include: 1) assay development for specific biological targets and disease mechanisms relevant to the mission of participating NIH Institutes with the intent to screen for small molecule compounds that show potential as probes for use in advancing knowledge about the known targets, identifying new targets, or as pre-therapeutic leads; 2) screen implementation high throughput target-focused approaches or moderate throughput phenotypic- and fragment-based approaches to identify initial screening hits; 3) hit validation, including implementation of secondary assays that are orthogonal to the primary assay, advanced cheminformatics analysis and initial medicinal chemistry inspection to prioritize the hit set, and follow-up assays to characterize mode and mechanism of action of the validated hits; 4) hit-to-lead optimization, including SAR to optimize target engagement, selectivity and to minimize chemical liabilities, ADME, PK and PD studies, and, if appropriate, in vivo modeling to test efficacy or biological effects.

This funding opportunity provides financial support for researchers to analyze existing data on late talking children, particularly focusing on underrepresented populations, to better understand their developmental trajectories and improve language outcomes.

With this solicitation, OJJDP seeks to support states implementation of innovative and/or research-based, data-informed policies to improve juvenile justice system outcomes and sustainable strategies for reinvesting resulting costs saved or averted into effective delinquency prevention and intervention programs.Eligibility This solicitation is composed of two grant categories. Applicants must clearly designate the category for which they are applying. Category 1: Juvenile Justice System Reform State governments Category 2: Juvenile Justice System Reform Training and Technical Assistance Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public- and state-controlled institutions of higher education Private institutions of higher education For-profit organizations other than small businesses Small businesses

The Rural Energy for America Program (REAP) provides guaranteed loan financing and grant funding to agricultural producers and rural small businesses in Idaho for renewable energy systems and energy efficiency improvements. Eligible entities include agricultural producers with at least 50% income from agricultural operations and small businesses in rural areas, meeting specific criteria. The program supports a range of projects, including biomass, geothermal, hydropower, wind, and solar energy systems, as well as energy efficiency upgrades. Applications are accepted year-round, with specific deadlines for fiscal years 2023 and 2024.

This grant provides funding for early-phase clinical trials aimed at improving treatments for service-connected eye injuries and visual dysfunction in military personnel and veterans.

This funding opportunity supports clinical research to explore and validate new non-invasive brain stimulation techniques for treating substance use disorders, targeting a wide range of eligible applicants including universities, nonprofits, and businesses.

This program provides financial and technical support to private landowners and communities for restoring and conserving fish and wildlife habitats on private lands, benefiting endangered species and promoting biodiversity.